Three-dimensional cellular microarray for high-throughput toxicology assays

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 1, 2008, Pages 59-63

  Lee, Moo Yeal ^a,b   Kumar, R Anand ^c   Sukumaran, Sumitra M ^b   Hogg, Michael G ^a,b   Clark, Douglas S ^c   Dordick, Jonathan S ^b  

^a Solidus Biosciences Inc   (United States)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^c University of California   (United States)

Author keywords

Cytochromes P450; In situ drug metabolism; In vitro cytotoxicity; On chip cell encapsulation

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4;

ARTICLE; CELL CULTURE; CELL ENCAPSULATION; CYTOTOXICITY; ELECTRONICS; HIGH THROUGHPUT SCREENING; IC 50; LIVER; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

ANIMALS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; COLLAGEN; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; EQUIPMENT DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHARMACOGENETICS; RATS; TECHNOLOGY, PHARMACEUTICAL; TOXICOLOGY;

EID: 38349104537     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0708756105     Document Type: Article

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