3D models of epithelial-mesenchymal transition in breast cancer metastasis: High-throughput screening assay development, validation, and pilot screen

Journal of Biomolecular Screening

Volumn 16, Issue 2, 2011, Pages 141-154

  Li, Qun ^a   Chen, Chaoyu ^a   Kapadia, Amit ^a   Zhou, Qiong ^b   Harper, Mary Kay ^c   Schaack, Jerome ^a   LaBarbera, Daniel V ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b Division of Medical Oncology   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

3D spheroid culture; anti metastatic agents; EMT; high throughput screening; marine natural products; Vimentin

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; ANTINEOPLASTIC AGENT; AXITINIB; BIOLOGICAL MARKER; DASATINIB; ISONAAMIDINE B; JASPAMIDE; MIDOSTAURIN; MYCALOLIDE E; NATURAL PRODUCT; PAPUAMINE; UNCLASSIFIED DRUG; VIMENTIN;

ARTICLE; BREAST CANCER; BREAST CARCINOMA; CARCINOMA CELL; CELL VIABILITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOWN REGULATION; DRUG SCREENING; EPITHELIAL MESENCHYMAL TRANSITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; METASTASIS; MOLECULAR MODEL; PILOT STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; THREE DIMENSIONAL IMAGING; VALIDATION STUDY;

ANTINEOPLASTIC AGENTS; BIOLOGICAL PRODUCTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DEPSIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMIDAZOLES; MODELS, BIOLOGICAL; NEOPLASM METASTASIS; OXAZOLES; SMALL MOLECULE LIBRARIES; SPHEROIDS, CELLULAR; VIMENTIN;

OCIMUM;

EID: 79952000716     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110392995     Document Type: Article

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