Use of high content image analyses to detect chemical-mediated effects on neurite sub-populations in primary rat cortical neurons

NeuroToxicology

Volumn 34, Issue 1, 2013, Pages 61-73

  Harrill, Joshua A ^a   Robinette, Brian L ^b   Freudenrich, Theresa ^b   Mundy, William R ^b  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Developmental neurotoxicity; High content image analysis; Neurite outgrowth

Indexed keywords

BETA 3 TUBULIN; BETA TUBULIN; BIS 1; CADMIUM CHLORIDE; DEXAMETHASONE; K 252A; METHYLMERCURY; MICROTUBULE ASSOCIATED PROTEIN 2; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN KINASE C INHIBITOR; RETINOIC ACID; SODIUM ORTHOVANATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL GROWTH; CELL MATURATION; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; DENDRITE; DEVELOPMENTAL TOXICITY; EXPOSURE; FEMALE; HIGH CONTENT IMAGING; IMAGE ANALYSIS; IMAGING; IN VITRO STUDY; NERVE CELL CULTURE; NERVE FIBER GROWTH; NEURITE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

ANIMALS; ANIMALS, NEWBORN; AUTOMATION, LABORATORY; BIOLOGICAL MARKERS; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IMAGE PROCESSING, COMPUTER-ASSISTED; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; NEURITES; NEUROTOXINS; RATS; RATS, LONG-EVANS; SUBTRACTION TECHNIQUE; TIME FACTORS; TOXICITY TESTS; TUBULIN;

ANIMALIA; RATTUS;

EID: 84870357944     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2012.10.013     Document Type: Article

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