Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs

Translational Neurodegeneration

Volumn 5, Issue 1, 2016, Pages

  Yan, Riqiang ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Alzheimer's disease; Amyloid deposition; Amyloid plaques; Amyloid precursor protein; Aspartyl protease; BACE1; Clinical trials; Drug discovery; Fragment based drug discovery; Secretase; Verubecestat; amyloid peptide

Indexed keywords

3 [2 (DIFLUOROMETHYL)PYRIDIN 4 YL] 7 FLUORO 3 (3 PYRIMIDIN 5 YLPHENYL) 1,2 DIHYDROISOINDOL 1 AMINE; 4 METHOXY 5'' METHYL 6' [5 (PROP 1 YN 1 YL)PYRIDIN 3 YL] 3' H DISPIRO[CYCLOHEXANE 1,2' INDENE 1',2'' IMIDAZOLE] 4'' AMINE; 5,6 DIHYDRO 2 IMINO 3 METHYL 6 [4 [5 (1 PROPYNYL) 3 PYRIDINYL] 2 THIENYL] 4 PYRIMIDINONE; ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AZD 3839; BACE1 INHIBITOR; BETA SECRETASE 1; BI 1181181; CNP 520; CTS 21166; DABIGATRAN; E 2609; JNJ 54861911; LY 2811376; LY 2886721; METFORMIN; NB 360; PLACEBO; PROTEIN INHIBITOR; RG 7129; ROSUVASTATIN; SIMVASTATIN; UNCLASSIFIED DRUG; WARFARIN;

ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; BIOPHYSICS; BRAIN FUNCTION; CLINICAL DEMENTIA RATING SCALE; COGNITION; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG SAFETY; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG TOLERABILITY; FRAGMENT BASED DRUG DISCOVERY; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEN BOND; IC50; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MILD COGNITIVE IMPAIRMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PATENT; PHARMACODYNAMICS; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); SINGLE DRUG DOSE; SUM OF BOXES SCORE; SURFACE PLASMON RESONANCE; TREATMENT DURATION; X RAY CRYSTALLOGRAPHY;

EID: 84979530150     PISSN: None     EISSN: 20479158     Source Type: Journal    
DOI: 10.1186/s40035-016-0061-5     Document Type: Article

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