Structural biology of presenilin 1 complexes

Molecular Neurodegeneration

Volumn 9, Issue 1, 2014, Pages

  Li, Yi ^a   Bohm, Christopher ^b   Dodd, Roger ^a   Chen, Fusheng ^b   Qamar, Seema ^a   Schmitt Ulms, Gerold ^b   Fraser, Paul E ^b   St George Hyslop, Peter H ^a,b  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Abeta; APH1; APP; Epsilon secretase; Gamma secretase; Gamma secretase inhibitor compounds; Gamma secretase modulator compounds; Lateral gate; Nicastrin; Notch; PEN 2; Presenilin; Structural biology

Indexed keywords

ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; ASPARTIC PROTEINASE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; MULTIPROTEIN COMPLEX; NICASTRIN; NOTCH RECEPTOR; PEPTIDASE; PEPTIDOMIMETIC AGENT; PRESENILIN 1; PRESENILIN 2; SIGNAL PEPTIDE PEPTIDASE; UNCLASSIFIED DRUG; PROTEIN BINDING; SECRETASE;

ALLOSTERISM; ALZHEIMER DISEASE; AUTOSOMAL DOMINANT INHERITANCE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; HUMAN; MEMBRANE STRUCTURE; MISSENSE MUTATION; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; ANIMAL; CELL MEMBRANE; CHEMISTRY; METABOLISM; MOLECULAR DOCKING; PROCEDURES;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL MEMBRANE; HUMANS; MOLECULAR DOCKING SIMULATION; PRESENILIN-1; PROTEIN BINDING; PROTEOLYSIS;

EID: 84924082166     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-9-59     Document Type: Review

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