-
1
-
-
0031695197
-
Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset
-
R. Brookmeyer Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset Am. J. Public Health 88 1998 1337 1342
-
(1998)
Am. J. Public Health
, vol.88
, pp. 1337-1342
-
-
Brookmeyer, R.1
-
2
-
-
0025175970
-
Survival of outpatients with Alzheimer-type dementia
-
J.S. Walsh Survival of outpatients with Alzheimer-type dementia Ann. Intern. Med. 113 1990 429 434
-
(1990)
Ann. Intern. Med.
, vol.113
, pp. 429-434
-
-
Walsh, J.S.1
-
3
-
-
0026075602
-
Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene
-
M.C. Chartier-Harlin Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene Nature 353 1991 844 846
-
(1991)
Nature
, vol.353
, pp. 844-846
-
-
Chartier-Harlin, M.C.1
-
4
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
A. Goate Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease Nature 349 1991 704 706
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
-
5
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
R. Sherrington Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease Nature 375 1995 754 760
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
-
6
-
-
0021207461
-
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
-
G.G. Glenner, and C.W. Wong Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein Biochem. Biophys. Res. Commun. 122 1984 1131 1135
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.122
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
7
-
-
0023009658
-
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments
-
I. Grundke-Iqbal Microtubule-associated protein tau. A component of Alzheimer paired helical filaments J. Biol. Chem. 261 1986 6084 6089
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 6084-6089
-
-
Grundke-Iqbal, I.1
-
8
-
-
0002792366
-
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau
-
M. Goedert Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau Proc. Natl. Acad. Sci. U. S. A. 85 1988 4051 4055
-
(1988)
Proc. Natl. Acad. Sci. U. S. A.
, vol.85
, pp. 4051-4055
-
-
Goedert, M.1
-
9
-
-
0027517625
-
Plaque-only Alzheimer disease is usually the lewy body variant, and vice versa
-
L.A. Hansen Plaque-only Alzheimer disease is usually the lewy body variant, and vice versa J. Neuropathol. Exp. Neurol. 52 1993 648 654
-
(1993)
J. Neuropathol. Exp. Neurol.
, vol.52
, pp. 648-654
-
-
Hansen, L.A.1
-
10
-
-
0142200945
-
Interactions of amyloidogenic proteins
-
B.I. Giasson Interactions of amyloidogenic proteins Neuromolecular Med. 4 2003 49 58
-
(2003)
Neuromolecular Med.
, vol.4
, pp. 49-58
-
-
Giasson, B.I.1
-
11
-
-
0028018919
-
Behavioral and anatomical deficits in mice homozygous for a modified β-amyloid precursor protein gene
-
U. Muller Behavioral and anatomical deficits in mice homozygous for a modified β-amyloid precursor protein gene Cell 79 1994 755 765
-
(1994)
Cell
, vol.79
, pp. 755-765
-
-
Muller, U.1
-
12
-
-
0028988801
-
β-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
-
H. Zheng β-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity Cell 81 1995 525 531
-
(1995)
Cell
, vol.81
, pp. 525-531
-
-
Zheng, H.1
-
13
-
-
0026442891
-
Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid β protein precursor
-
W. Wasco Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid β protein precursor Proc. Natl. Acad. Sci. U. S. A. 89 1992 10758 10762
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 10758-10762
-
-
Wasco, W.1
-
14
-
-
0034329291
-
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members
-
S. Heber Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members J. Neurosci. 20 2000 7951 7963
-
(2000)
J. Neurosci.
, vol.20
, pp. 7951-7963
-
-
Heber, S.1
-
15
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
D. Scheuner Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease Nat. Med. 2 1996 864 870
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
-
16
-
-
0033593027
-
V717F transgenic mouse model of Alzheimer's disease
-
V717F transgenic mouse model of Alzheimer's disease Proc. Natl. Acad. Sci. U. S. A. 96 1999 15233 15238
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 15233-15238
-
-
Bales, K.R.1
-
17
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
18
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
I. Grundke-Iqbal Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology Proc. Natl. Acad. Sci. U. S. A. 83 1986 4913 4917
-
(1986)
Proc. Natl. Acad. Sci. U. S. A.
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
-
19
-
-
0026595846
-
Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms
-
M. Goedert Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms Neuron 8 1992 159 168
-
(1992)
Neuron
, vol.8
, pp. 159-168
-
-
Goedert, M.1
-
20
-
-
0027338266
-
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
-
J. Biernat Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding Neuron 11 1993 153 163
-
(1993)
Neuron
, vol.11
, pp. 153-163
-
-
Biernat, J.1
-
21
-
-
0027308924
-
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
-
G.T. Bramblett Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding Neuron 10 1993 1089 1099
-
(1993)
Neuron
, vol.10
, pp. 1089-1099
-
-
Bramblett, G.T.1
-
22
-
-
0024745894
-
Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
-
M. Goedert Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease Neuron 3 1989 519 526
-
(1989)
Neuron
, vol.3
, pp. 519-526
-
-
Goedert, M.1
-
23
-
-
0028965635
-
Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform
-
J. Gotz Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform EMBO J. 14 1995 1304 1313
-
(1995)
EMBO J.
, vol.14
, pp. 1304-1313
-
-
Gotz, J.1
-
24
-
-
0033532318
-
Phylogenetic diversity of the expression of the microtubule-associated protein tau: Implications for neurodegenerative disorders
-
C. Janke Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders Brain Res. Mol. Brain Res. 68 1999 119 128
-
(1999)
Brain Res. Mol. Brain Res.
, vol.68
, pp. 119-128
-
-
Janke, C.1
-
25
-
-
0031935017
-
Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their tau isoform distribution and phosphorylation
-
A. Delacourte Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their tau isoform distribution and phosphorylation Ann. Neurol. 43 1998 193 204
-
(1998)
Ann. Neurol.
, vol.43
, pp. 193-204
-
-
Delacourte, A.1
-
26
-
-
0033009603
-
Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: Tau pathologies with exclusively 'exon 10' isoforms
-
N. Sergeant Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively 'exon 10' isoforms J. Neurochem. 72 1999 1243 1249
-
(1999)
J. Neurochem.
, vol.72
, pp. 1243-1249
-
-
Sergeant, N.1
-
27
-
-
0034940160
-
Neurodegenerative tauopathies
-
V.M. Lee Neurodegenerative tauopathies Annu. Rev. Neurosci. 24 2001 1121 1159
-
(2001)
Annu. Rev. Neurosci.
, vol.24
, pp. 1121-1159
-
-
Lee, V.M.1
-
28
-
-
0032543684
-
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
-
M. Hutton Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 Nature 393 1998 702 705
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
-
29
-
-
14444284106
-
Tau is a candidate gene for chromosome 17 frontotemporal dementia
-
P. Poorkaj Tau is a candidate gene for chromosome 17 frontotemporal dementia Ann. Neurol. 43 1998 815 825
-
(1998)
Ann. Neurol.
, vol.43
, pp. 815-825
-
-
Poorkaj, P.1
-
30
-
-
0032560487
-
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
-
M.G. Spillantini Mutation in the tau gene in familial multiple system tauopathy with presenile dementia Proc. Natl. Acad. Sci. U. S. A. 95 1998 7737 7741
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 7737-7741
-
-
Spillantini, M.G.1
-
31
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction
-
S. Oddo Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction Neuron 39 2003 409 421
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
-
32
-
-
0344845132
-
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
-
S. Oddo Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease Neurobiol. Aging 24 2003 1063 1070
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 1063-1070
-
-
Oddo, S.1
-
33
-
-
0030833055
-
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
-
D.R. Borchelt Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins Neuron 19 1997 939 945
-
(1997)
Neuron
, vol.19
, pp. 939-945
-
-
Borchelt, D.R.1
-
34
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
-
D. Games Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein Nature 373 1995 523 527
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
-
35
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
L. Holcomb Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes Nat. Med. 4 1998 97 100
-
(1998)
Nat. Med.
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
-
36
-
-
0029742199
-
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
-
K. Hsiao Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice Science 274 1996 99 102
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
-
37
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
J. Lewis Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein Nat. Genet. 25 2000 402 405
-
(2000)
Nat. Genet.
, vol.25
, pp. 402-405
-
-
Lewis, J.1
-
38
-
-
0036850725
-
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein
-
B. Allen Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein J. Neurosci. 22 2002 9340 9351
-
(2002)
J. Neurosci.
, vol.22
, pp. 9340-9351
-
-
Allen, B.1
-
39
-
-
0036685608
-
Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration
-
M. Higuchi Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration Neuron 35 2002 433 446
-
(2002)
Neuron
, vol.35
, pp. 433-446
-
-
Higuchi, M.1
-
40
-
-
0037108953
-
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau
-
Y. Tatebayashi Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau Proc. Natl. Acad. Sci. U. S. A. 99 2002 13896 13901
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 13896-13901
-
-
Tatebayashi, Y.1
-
41
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
J. Lewis Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP Science 293 2001 1487 1491
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
-
42
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Aβ 42 fibrils
-
J. Gotz Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Aβ 42 fibrils Science 293 2001 1491 1495
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
-
43
-
-
4043167747
-
Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
-
S. Oddo Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome Neuron 43 2004 321 332
-
(2004)
Neuron
, vol.43
, pp. 321-332
-
-
Oddo, S.1
-
44
-
-
85030804653
-
Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
-
(in press)
-
Billings, L.M. et al. Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron (in press)
-
Neuron
-
-
Billings, L.M.1
-
45
-
-
13044287361
-
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
-
A.Y. Hsia Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models Proc. Natl. Acad. Sci. U. S. A. 96 1999 3228 3233
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 3228-3233
-
-
Hsia, A.Y.1
-
46
-
-
4043127719
-
Amyloid β-peptide: The inside story
-
B.P. Tseng Amyloid β-peptide: the inside story Current Alzheimer Research 1 2004 231 239
-
(2004)
Current Alzheimer Research
, vol.1
, pp. 231-239
-
-
Tseng, B.P.1
-
47
-
-
0037080160
-
Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice
-
L. Bondolfi Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice J. Neurosci. 22 2002 515 522
-
(2002)
J. Neurosci.
, vol.22
, pp. 515-522
-
-
Bondolfi, L.1
-
48
-
-
0032558784
-
Neuron loss in APP transgenic mice
-
M.E. Calhoun Neuron loss in APP transgenic mice Nature 395 1998 755 756
-
(1998)
Nature
, vol.395
, pp. 755-756
-
-
Calhoun, M.E.1
-
49
-
-
0031740772
-
Neurodegenerative Alzheimer-like pathology in PDAPP 717V→F transgenic mice
-
K.S. Chen Neurodegenerative Alzheimer-like pathology in PDAPP 717V→F transgenic mice Prog. Brain Res. 117 1998 327 334
-
(1998)
Prog. Brain Res.
, vol.117
, pp. 327-334
-
-
Chen, K.S.1
-
50
-
-
0030612033
-
APPSw transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1
-
M.C. Irizarry APPSw transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1 J. Neuropathol. Exp. Neurol. 56 1997 965 973
-
(1997)
J. Neuropathol. Exp. Neurol.
, vol.56
, pp. 965-973
-
-
Irizarry, M.C.1
-
51
-
-
0030611097
-
Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
-
M.C. Irizarry Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse J. Neurosci. 17 1997 7053 7059
-
(1997)
J. Neurosci.
, vol.17
, pp. 7053-7059
-
-
Irizarry, M.C.1
-
52
-
-
0036759157
-
Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways
-
T.D. Stein, and J.A. Johnson Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways J. Neurosci. 22 2002 7380 7388
-
(2002)
J. Neurosci.
, vol.22
, pp. 7380-7388
-
-
Stein, T.D.1
Johnson, J.A.2
-
53
-
-
0028981717
-
The Alzheimer's Aβ peptide induces neurodegeneration and apoptosis in transgenic mice
-
F.M. LaFerla The Alzheimer's Aβ peptide induces neurodegeneration and apoptosis in transgenic mice Nat. Genet. 9 1995 21 30
-
(1995)
Nat. Genet.
, vol.9
, pp. 21-30
-
-
Laferla, F.M.1
-
54
-
-
0041803006
-
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
-
C. Andorfer Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms J. Neurochem. 86 2003 582 590
-
(2003)
J. Neurochem.
, vol.86
, pp. 582-590
-
-
Andorfer, C.1
-
55
-
-
2942598335
-
Nicotine reduces Aβ in the brain and cerebral vessels of APPsw mice
-
E. Hellstrom-Lindahl Nicotine reduces Aβ in the brain and cerebral vessels of APPsw mice Eur. J. Neurosci. 19 2004 2703 2710
-
(2004)
Eur. J. Neurosci.
, vol.19
, pp. 2703-2710
-
-
Hellstrom-Lindahl, E.1
-
56
-
-
1542270719
-
Reduced levels of Aβ 40 and Aβ 42 in brains of smoking controls and Alzheimer's patients
-
E. Hellstrom-Lindahl Reduced levels of Aβ 40 and Aβ 42 in brains of smoking controls and Alzheimer's patients Neurobiol. Dis. 15 2004 351 360
-
(2004)
Neurobiol. Dis.
, vol.15
, pp. 351-360
-
-
Hellstrom-Lindahl, E.1
-
57
-
-
0036316642
-
Chronic nicotine treatment reduces β-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw)
-
A. Nordberg Chronic nicotine treatment reduces β-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw) J. Neurochem. 81 2002 655 658
-
(2002)
J. Neurochem.
, vol.81
, pp. 655-658
-
-
Nordberg, A.1
-
58
-
-
14544304591
-
Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease
-
S. Oddo Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease Proc. Natl. Acad. Sci. U. S. A. 102 2005 3046 3051
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 3046-3051
-
-
Oddo, S.1
|