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Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 1, 2005, Pages 211-215

Design and synthesis of highly active Alzheimer's β-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability

(10) Kimura, Tooru a Shuto, Daisuke a Hamada, Yoshio a Igawa, Naoto a Kasai, Soko a Liu, Ping a Hidaka, Koushi a Hamada, Takashi a Hayashi, Yoshio a Kiso, Yoshiaki a

a KYOTO PHARMACEUTICAL UNIVERSITY (Japan)

Author keywords

Secretase; Alzheimer's disease; BACE1 inhibitor; Bioisostere

Indexed keywords

BETA SECRETASE; BETA SECRETASE INHIBITOR; CARBOXYLIC ACID; KMI 420; KMI 429; PROPIONIC ACID DERIVATIVE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; DRUG STABILITY; ENDOPEPTIDASES; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEASE INHIBITORS;

EID: 9644266667 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2004.09.090 Document Type: Article

Times cited : (107)

References (30)

1
- 0025753852
- D.J. Selkoe Neuron 6 1991 487
- (1991) Neuron , vol.6 , pp. 487
- Selkoe, D.J.¹

2
- 0033600274
- D.J. Selkoe Nature 399 1999 A23
- (1999) Nature , vol.399
- Selkoe, D.J.¹

3
- 0033613129
- S. Sinha, and I. Lieberburg Proc. Natl. Acad. Sci. U.S.A. 96 1999 11049
- (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 11049
- Sinha, S.¹ Lieberburg, I.²

4
- 0033595706
- R. Vassar, B.D. Bennett, S. Babu-Khan, S. Kahn, E.A. Mendiaz, P. Denis, D.B. Teplow, S. Ross, P. Amarante, R. Loeloff, Y. Luo, S. Fisher, J. Fuller, S. Edenson, J. Lile, M.A. Jarosinski, A.L. Biere, E. Curran, T. Burgess, J.C. Louis, F. Collins, J. Treanor, G. Rogers, and M. Citron Science 286 1999 735
- (1999) Science , vol.286 , pp. 735
- Vassar, R.¹ Bennett, B.D.² Babu-Khan, S.³ Kahn, S.⁴ Mendiaz, E.A.⁵ Denis, P.⁶ Teplow, D.B.⁷ Ross, S.⁸ Amarante, P.⁹ Loeloff, R.¹⁰ Luo, Y.¹¹ Fisher, S.¹² Fuller, J.¹³ Edenson, S.¹⁴ Lile, J.¹⁵ Jarosinski, M.A.¹⁶ Biere, A.L.¹⁷ Curran, E.¹⁸ Burgess, T.¹⁹ Louis, J.C.²⁰ more..

5
- 0033518264
- R. Yan, M.J. Bienkowski, M.E. Shuck, H. Miao, M.C. Tory, A.M. Pauley, J.R. Brashier, N.C. Stratman, W.R. Mathews, A.E. Buhl, D.B. Carter, A.G. Tomasselli, L.A. Parodi, R.L. Heinrikson, and M.E. Gurney Nature 402 1999 533
- (1999) Nature , vol.402 , pp. 533
- Yan, R.¹ Bienkowski, M.J.² Shuck, M.E.³ Miao, H.⁴ Tory, M.C.⁵ Pauley, A.M.⁶ Brashier, J.R.⁷ Stratman, N.C.⁸ Mathews, W.R.⁹ Buhl, A.E.¹⁰ Carter, D.B.¹¹ Tomasselli, A.G.¹² Parodi, L.A.¹³ Heinrikson, R.L.¹⁴ Gurney, M.E.¹⁵

6
- 0033518251
- S. Sinha, J.P. Anderson, R. Barbour, G.S. Basi, R. Caccavello, D. Davis, M. Doan, H.F. Dovey, N. Frigon, J. Hong, K. Jacobson-Croak, N. Jewett, P. Keim, J. Knops, I. Lieberburg, M. Power, H. Tan, G. Tatsuno, J. Tung, D. Schenk, P. Seubert, S.M. Suomensaari, S. Wang, D. Walker, J. Zhao, L. McConlogue, and V. John Nature 402 1999 537
- (1999) Nature , vol.402 , pp. 537
- Sinha, S.¹ Anderson, J.P.² Barbour, R.³ Basi, G.S.⁴ Caccavello, R.⁵ Davis, D.⁶ Doan, M.⁷ Dovey, H.F.⁸ Frigon, N.⁹ Hong, J.¹⁰ Jacobson-Croak, K.¹¹ Jewett, N.¹² Keim, P.¹³ Knops, J.¹⁴ Lieberburg, I.¹⁵ Power, M.¹⁶ Tan, H.¹⁷ Tatsuno, G.¹⁸ Tung, J.¹⁹ Schenk, D.²⁰ more..

7
- 0033382226
- I. Hussain, D. Powell, D.R. Howlett, D.G. Tew, T.D. Meek, C. Chapman, I.S. Gloger, K.E. Murphy, C.D. Southan, D.M. Ryan, T.S. Smith, D.L. Simmons, F.S. Walsh, C. Dingwall, and G. Christie Mol. Cell. Neurosci. 14 1999 419
- (1999) Mol. Cell. Neurosci. , vol.14 , pp. 419
- Hussain, I.¹ Powell, D.² Howlett, D.R.³ Tew, D.G.⁴ Meek, T.D.⁵ Chapman, C.⁶ Gloger, I.S.⁷ Murphy, K.E.⁸ Southan, C.D.⁹ Ryan, D.M.¹⁰ Smith, T.S.¹¹ Simmons, D.L.¹² Walsh, F.S.¹³ Dingwall, C.¹⁴ Christie, G.¹⁵

8
- 0034639925
- A.K. Ghosh, D. Shin, D. Downs, G. Koelsch, X. Lin, J. Ermolieff, and J. Tang J. Am. Chem. Soc. 122 2000 3522
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 3522
- Ghosh, A.K.¹ Shin, D.² Downs, D.³ Koelsch, G.⁴ Lin, X.⁵ Ermolieff, J.⁶ Tang, J.⁷

9
- 0035974650
- A.K. Ghosh, G. Bilcer, C. Harwood, R. Kawahara, D. Shin, K.A. Hussain, L. Hong, J.A. Loy, C. Nguyen, G. Koelsch, J. Ermolieff, and J. Tang J. Med. Chem. 44 2001 2865
- (2001) J. Med. Chem. , vol.44 , pp. 2865
- Ghosh, A.K.¹ Bilcer, G.² Harwood, C.³ Kawahara, R.⁴ Shin, D.⁵ Hussain, K.A.⁶ Hong, L.⁷ Loy, J.A.⁸ Nguyen, C.⁹ Koelsch, G.¹⁰ Ermolieff, J.¹¹ Tang, J.¹²

10
- 0037122704
- J.S. Tung, D.L. Davis, J.P. Anderson, D.E. Walker, S. Mamo, N. Jewett, R.K. Hom, S. Sinha, E.D. Thorsett, and V. John J. Med. Chem. 45 2002 259
- (2002) J. Med. Chem. , vol.45 , pp. 259
- Tung, J.S.¹ Davis, D.L.² Anderson, J.P.³ Walker, D.E.⁴ Mamo, S.⁵ Jewett, N.⁶ Hom, R.K.⁷ Sinha, S.⁸ Thorsett, E.D.⁹ John, V.¹⁰

11
- 0141618463
- H. Tamamura, T. Kato, A. Otaka, and N. Fujii Org. Biomol. Chem. 1 2003 2468
- (2003) Org. Biomol. Chem. , vol.1 , pp. 2468
- Tamamura, H.¹ Kato, T.² Otaka, A.³ Fujii, N.⁴

12
- 0344927114
- D. Shuto, S. Kasai, T. Kimura, P. Liu, K. Hidaka, T. Hamada, S. Shibakawa, Y. Hayashi, C. Hattori, B. Szabo, S. Ishiura, and Y. Kiso Bioorg. Med. Chem. Lett. 13 2003 4273
- (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 4273
- Shuto, D.¹ Kasai, S.² Kimura, T.³ Liu, P.⁴ Hidaka, K.⁵ Hamada, T.⁶ Shibakawa, S.⁷ Hayashi, Y.⁸ Hattori, C.⁹ Szabo, B.¹⁰ Ishiura, S.¹¹ Kiso, Y.¹²

13
- 10744219775
- T. Kimura, D. Shuto, S. Kasai, P. Liu, K. Hidaka, T. Hamada, Y. Hayashi, C. Hattori, M. Asai, S. Kitazume, T.C. Saido, S. Ishiura, and Y. Kiso Bioorg. Med. Chem. Lett. 14 2004 1527
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 1527
- Kimura, T.¹ Shuto, D.² Kasai, S.³ Liu, P.⁴ Hidaka, K.⁵ Hamada, T.⁶ Hayashi, Y.⁷ Hattori, C.⁸ Asai, M.⁹ Kitazume, S.¹⁰ Saido, T.C.¹¹ Ishiura, S.¹² Kiso, Y.¹³

14
- 0025943905
- T. Mimoto, J. Imai, S. Tanaka, N. Hattori, O. Takahashi, S. Kisanuki, Y. Nagano, M. Shintani, H. Hayashi, K. Akaji, and Y. Kiso Chem. Pharm. Bull. 39 1991 2465
- (1991) Chem. Pharm. Bull. , vol.39 , pp. 2465
- Mimoto, T.¹ Imai, J.² Tanaka, S.³ Hattori, N.⁴ Takahashi, O.⁵ Kisanuki, S.⁶ Nagano, Y.⁷ Shintani, M.⁸ Hayashi, H.⁹ Akaji, K.¹⁰ Kiso, Y.¹¹

15
- 0026345730
- T. Mimoto, J. Imai, S. Tanaka, N. Hattori, S. Kisanuki, K. Akaji, and Y. Kiso Chem. Pharm. Bull. 39 1991 3088
- (1991) Chem. Pharm. Bull. , vol.39 , pp. 3088
- Mimoto, T.¹ Imai, J.² Tanaka, S.³ Hattori, N.⁴ Kisanuki, S.⁵ Akaji, K.⁶ Kiso, Y.⁷

16
- 0001942336
- V.V.S. Murti, T.R. Seshadri, and T.A. Venkitasubramanian Phytochemistry 3 1964 73
- (1964) Phytochemistry , vol.3 , pp. 73
- Murti, V.V.S.¹ Seshadri, T.R.² Venkitasubramanian, T.A.³

17
- 33947487342
- S.L.N. Rao, P.R. Adiga, and P.S. Sarma Biochemistry 3 1964 432
- (1964) Biochemistry , vol.3 , pp. 432
- Rao, S.L.N.¹ Adiga, P.R.² Sarma, P.S.³

18
- 84870332071
- P.S. Spencer, D.N. Roy, A. Ludolph, J. Hugon, M.P. Dwivedi, and H.H. Schaumburg Lancet 11 1986 1066
- (1986) Lancet , vol.11 , pp. 1066
- Spencer, P.S.¹ Roy, D.N.² Ludolph, A.³ Hugon, J.⁴ Dwivedi, M.P.⁵ Schaumburg, H.H.⁶

19
- 0000203502
- E.A. Bell, and J.P. O'Donovan Phytochemistry 5 1966 1211
- (1966) Phytochemistry , vol.5 , pp. 1211
- Bell, E.A.¹ O'Donovan, J.P.²

20
- 0000824984
- B.M. Abegaz, P.B. Nunn, A. De Bruyn, and F. Lambein Phytochemistry 33 1993 1121
- (1993) Phytochemistry , vol.33 , pp. 1121
- Abegaz, B.M.¹ Nunn, P.B.² De Bruyn, A.³ Lambein, F.⁴

21
- 0030480485
- Y. Kohara, K. Kubo, E. Imamiya, T. Wada, Y. Inada, and T. Naka J. Med. Chem. 39 1996 5228
- (1996) J. Med. Chem. , vol.39 , pp. 5228
- Kohara, Y.¹ Kubo, K.² Imamiya, E.³ Wada, T.⁴ Inada, Y.⁵ Naka, T.⁶

22
- 0032873518
- Y. Kiso, H. Matsumoto, S. Yamaguchi, and T. Kimura Lett. Pept. Sci. 6 1999 275
- (1999) Lett. Pept. Sci. , vol.6 , pp. 275
- Kiso, Y.¹ Matsumoto, H.² Yamaguchi, S.³ Kimura, T.⁴

23
- 0036973331
- Y. Hamada, J. Ohtake, Y. Sohma, T. Kimura, Y. Hayashi, and Y. Kiso Bioorg. Med. Chem. 10 2002 4155
- (2002) Bioorg. Med. Chem. , vol.10 , pp. 4155
- Hamada, Y.¹ Ohtake, J.² Sohma, Y.³ Kimura, T.⁴ Hayashi, Y.⁵ Kiso, Y.⁶

24
- 0037811300
- Y. Hamada, H. Matsumoto, T. Kimura, Y. Hayashi, and Y. Kiso Bioorg. Med. Chem. Lett. 13 2003 2727
- (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 2727
- Hamada, Y.¹ Matsumoto, H.² Kimura, T.³ Hayashi, Y.⁴ Kiso, Y.⁵

25
- 0346671290
- Y. Hamada, H. Matsumoto, S. Yamaguchi, T. Kimura, Y. Hayashi, and Y. Kiso Bioorg. Med. Chem. 12 2004 159
- (2004) Bioorg. Med. Chem. , vol.12 , pp. 159
- Hamada, Y.¹ Matsumoto, H.² Yamaguchi, S.³ Kimura, T.⁴ Hayashi, Y.⁵ Kiso, Y.⁶

26
- 0034613320
- L. Hong, G. Koelsch, X. Lin, S. Wu, S. Terzyan, A.K. Ghosh, X.C. Zhang, and J. Tang Science 290 2000 150
- (2000) Science , vol.290 , pp. 150
- Hong, L.¹ Koelsch, G.² Lin, X.³ Wu, S.⁴ Terzyan, S.⁵ Ghosh, A.K.⁶ Zhang, X.C.⁷ Tang, J.⁸

27
- 0026771089
- J.D. Sipe Annu. Rev. Biochem. 61 1992 947
- (1992) Annu. Rev. Biochem. , vol.61 , pp. 947
- Sipe, J.D.¹

28
- 0034516988
- D.J. Selkoe Ann. N.Y. Acad. Sci. 924 2000 17
- (2000) Ann. N.Y. Acad. Sci. , vol.924 , pp. 17
- Selkoe, D.J.¹

29
- 0033452874
- H. Steiner, A. Capell, U. Leimer, and C. Haass Eur. Arch. Psychiatric Clin. Neurosci. 249 1999 266
- (1999) Eur. Arch. Psychiatric Clin. Neurosci. , vol.249 , pp. 266
- Steiner, H.¹ Capell, A.² Leimer, U.³ Haass, C.⁴

30
- 0024410266
- D.J. Selkoe Ann. Med. 21 1989 73
- (1989) Ann. Med. , vol.21 , pp. 73
- Selkoe, D.J.¹

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