-
1
-
-
0033970139
-
The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region
-
doi: 10.1016/S0014-5793(00)01192-3
-
Acquati, F., Accarino, M., Nucci, C., Fumagalli, P., Jovine, L., Ottolenghi, S., et al. (2000). The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region. FEBS Lett. 468, 59-64. doi: 10.1016/S0014-5793(00)01192-3.
-
(2000)
FEBS Lett.
, vol.468
, pp. 59-64
-
-
Acquati, F.1
Accarino, M.2
Nucci, C.3
Fumagalli, P.4
Jovine, L.5
Ottolenghi, S.6
-
2
-
-
66149105111
-
Improved data retrieval from TreeBASE via taxonomic and linguistic data enrichment
-
doi: 10.1186/1471-2148-9-93
-
Anwar, N., and Hunt, E. (2009). Improved data retrieval from TreeBASE via taxonomic and linguistic data enrichment. BMC Evol. Biol. 9:93. doi: 10.1186/1471-2148-9-93.
-
(2009)
BMC Evol. Biol.
, vol.9
, pp. 93
-
-
Anwar, N.1
Hunt, E.2
-
3
-
-
79960464624
-
β-Cell evolution: How the pancreas borrowed from the brain: the shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship
-
doi: 10.1002/bies.201100015
-
Arntfield, M. E., and van der Kooy, D. (2011). β-Cell evolution: How the pancreas borrowed from the brain: the shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship. Bioessays 33, 582-587. doi: 10.1002/bies.201100015.
-
(2011)
Bioessays
, vol.33
, pp. 582-587
-
-
Arntfield, M.E.1
van der Kooy, D.2
-
4
-
-
84862252899
-
The PRINTS database: a fine-grained protein sequence annotation and analysis resource-its status in 2012
-
bas019, doi: 10.1093/database/bas019
-
Attwood, T. K., Coletta, A., Muirhead, G., Pavlopoulou, A., Philippou, P. B., Popov, I., et al. (2012). The PRINTS database: a fine-grained protein sequence annotation and analysis resource-its status in 2012. Database 2012:bas019. doi: 10.1093/database/bas019.
-
(2012)
Database
, vol.2012
-
-
Attwood, T.K.1
Coletta, A.2
Muirhead, G.3
Pavlopoulou, A.4
Philippou, P.B.5
Popov, I.6
-
5
-
-
35848947692
-
Protease research in the era of systems biology
-
doi: 10.1515/BC.2007.146
-
Aufdem Keller, U., Doucet, A., and Overall, C. M. (2007). Protease research in the era of systems biology. Biol. Chem. 388, 1159-1162. doi: 10.1515/BC.2007.146.
-
(2007)
Biol. Chem.
, vol.388
, pp. 1159-1162
-
-
Aufdem Keller, U.1
Doucet, A.2
Overall, C.M.3
-
6
-
-
48249136251
-
Bgee: integrating and comparing heterogeneous transcriptome data among species
-
eds A. Bairoch, S. Cohen-Boulakia, and C. Froidevaux (Berlin: Springer)
-
Bastian, F., Parmentier, G., Roux, J., Moretti, S., Laudet, V., and Robinson-Rechavi, M. (2008). "Bgee: integrating and comparing heterogeneous transcriptome data among species," in Data Integration in the Life Sciences Lecture Notes in Computer Science, Vol. 5109, eds A. Bairoch, S. Cohen-Boulakia, and C. Froidevaux (Berlin: Springer), 124-131.
-
(2008)
Data Integration in the Life Sciences Lecture Notes in Computer Science
, vol.5109
, pp. 124-131
-
-
Bastian, F.1
Parmentier, G.2
Roux, J.3
Moretti, S.4
Laudet, V.5
Robinson-Rechavi, M.6
-
7
-
-
77953806572
-
Animals (Metazoa)
-
eds S. B. Hedges and S. Kumar (Oxford: Oxford University Press)
-
Blair, J. (2009). "Animals (Metazoa)," in The Timetree of Life, eds S. B. Hedges and S. Kumar (Oxford: Oxford University Press), 223-230.
-
(2009)
The Timetree of Life
, pp. 223-230
-
-
Blair, J.1
-
8
-
-
80053083748
-
Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis
-
doi: 10.1073/pnas.1106189108
-
Burkhardt, P., Stegmann, C. M., Cooper, B., Kloepper, T. H., Imig, C., Varoqueaux, F., et al. (2011). Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis. Proc. Natl. Acad. Sci. U.S.A. 108, 15264-15269. doi: 10.1073/pnas.1106189108.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 15264-15269
-
-
Burkhardt, P.1
Stegmann, C.M.2
Cooper, B.3
Kloepper, T.H.4
Imig, C.5
Varoqueaux, F.6
-
9
-
-
58149503769
-
Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function
-
doi: 10.1016/j.nbd.2008.10.014
-
Carmine-Simmen, K., Proctor, T., Tschäpe, J., Poeck, B., Triphan, T., Strauss, R., et al. (2009). Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function. Neurobiol. Dis. 33, 274-281. doi: 10.1016/j.nbd.2008.10.014.
-
(2009)
Neurobiol. Dis.
, vol.33
, pp. 274-281
-
-
Carmine-Simmen, K.1
Proctor, T.2
Tschäpe, J.3
Poeck, B.4
Triphan, T.5
Strauss, R.6
-
10
-
-
2142738304
-
WebLogo: a sequence logo generator
-
doi: 10.1101/gr.849004
-
Crooks, G. E., Hon, G., Chandonia, J.-M., and Brenner, S. E. (2004). WebLogo: a sequence logo generator. Genome Res. 14, 1188-1190. doi: 10.1101/gr.849004.
-
(2004)
Genome Res.
, vol.14
, pp. 1188-1190
-
-
Crooks, G.E.1
Hon, G.2
Chandonia, J.-M.3
Brenner, S.E.4
-
11
-
-
84887212478
-
Refining the Ciona intestinalis model of central nervous system regeneration
-
doi: 10.1371/journal.pone.0004458
-
Dahlberg, C., Auger, H., Dupont, S., Sasakura, Y., Thorndyke, M., and Joly, J.-S. (2009). Refining the Ciona intestinalis model of central nervous system regeneration. PLoS ONE 4:e4458. doi: 10.1371/journal.pone.0004458.
-
(2009)
PLoS ONE
, vol.4
-
-
Dahlberg, C.1
Auger, H.2
Dupont, S.3
Sasakura, Y.4
Thorndyke, M.5
Joly, J.-S.6
-
12
-
-
84866291339
-
The membrane-bound aspartyl protease BACE1: molecular and functional properties in Alzheimer's disease and beyond
-
doi: 10.3389/fphys.2012.00008
-
Dislich, B., and Lichtenthaler, S. F. (2012). The membrane-bound aspartyl protease BACE1: molecular and functional properties in Alzheimer's disease and beyond. Front. Physiol. 3:8. doi: 10.3389/fphys.2012.00008.
-
(2012)
Front. Physiol.
, vol.3
, pp. 8
-
-
Dislich, B.1
Lichtenthaler, S.F.2
-
13
-
-
24744449320
-
Phenotypic and biochemical analyses of BACE1-and BACE2-deficient mice
-
doi: 10.1074/jbc.M505249200
-
Dominguez, D., Tournoy, J., Hartmann, D., Huth, T., Cryns, K., Deforce, S., et al. (2005). Phenotypic and biochemical analyses of BACE1-and BACE2-deficient mice. J. Biol. Chem. 280, 30797-30806. doi: 10.1074/jbc.M505249200.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 30797-30806
-
-
Dominguez, D.1
Tournoy, J.2
Hartmann, D.3
Huth, T.4
Cryns, K.5
Deforce, S.6
-
14
-
-
84872559270
-
Data deposition: missing data mean holes in tree of life
-
doi: 10.1038/493305f
-
Drew, B. T. (2013). Data deposition: missing data mean holes in tree of life. Nature 493, 305. doi: 10.1038/493305f.
-
(2013)
Nature
, vol.493
, pp. 305
-
-
Drew, B.T.1
-
15
-
-
33751063056
-
Progress toward the discovery and development of efficacious BACE inhibitors
-
Durham, T. B., and Shepherd, T. A. (2006). Progress toward the discovery and development of efficacious BACE inhibitors. Curr. Opin. Drug Discov. Devel. 9, 776-791.
-
(2006)
Curr. Opin. Drug Discov. Devel.
, vol.9
, pp. 776-791
-
-
Durham, T.B.1
Shepherd, T.A.2
-
16
-
-
80052723784
-
Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass
-
doi: 10.1016/j.cmet.2011.06.018
-
Esterhazy, D., Stutzer, I., Wang, H., Rechsteiner, M. P., Beauchamp, J., Dobeli, H., et al. (2011). Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab. 14, 365-377. doi: 10.1016/j.cmet.2011.06.018.
-
(2011)
Cell Metab.
, vol.14
, pp. 365-377
-
-
Esterhazy, D.1
Stutzer, I.2
Wang, H.3
Rechsteiner, M.P.4
Beauchamp, J.5
Dobeli, H.6
-
17
-
-
0034662929
-
BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
-
doi: 10.1073/pnas.160115697
-
Farzan, M., Schnitzler, C. E., Vasilieva, N., Leung, D., and Choe, H. (2000). BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proc. Natl. Acad. Sci. U.S.A. 97, 9712-9717. doi: 10.1073/pnas.160115697.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 9712-9717
-
-
Farzan, M.1
Schnitzler, C.E.2
Vasilieva, N.3
Leung, D.4
Choe, H.5
-
18
-
-
84857736151
-
BACE1 dependent neuregulin proteolysis
-
doi: 10.2174/156720512799361637
-
Fleck, D., Garratt, A. N., Haass, C., and Willem, M. (2012). BACE1 dependent neuregulin proteolysis. Curr. Alzheimer Res. 9, 178-183. doi: 10.2174/156720512799361637.
-
(2012)
Curr. Alzheimer Res.
, vol.9
, pp. 178-183
-
-
Fleck, D.1
Garratt, A.N.2
Haass, C.3
Willem, M.4
-
19
-
-
0030807655
-
BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data
-
doi: 10.1093/oxfordjournals.molbev.a025808
-
Gascuel, O. (1997). BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. Mol. Biol. Evol. 14, 685-695. doi: 10.1093/oxfordjournals.molbev.a025808.
-
(1997)
Mol. Biol. Evol.
, vol.14
, pp. 685-695
-
-
Gascuel, O.1
-
20
-
-
33750705653
-
A century of Alzheimer's disease
-
doi: 10.1126/science.1132814
-
Goedert, M., and Spillantini, M. G. (2006). A century of Alzheimer's disease. Science 314, 777-781. doi: 10.1126/science.1132814.
-
(2006)
Science
, vol.314
, pp. 777-781
-
-
Goedert, M.1
Spillantini, M.G.2
-
21
-
-
84862729639
-
Surprising results on phylogenetic tree building methods based on molecular sequences
-
doi: 10.1186/1471-2105-13-148
-
Gonnet, G. H. (2012). Surprising results on phylogenetic tree building methods based on molecular sequences. BMC Bioinformatics 13:148. doi: 10.1186/1471-2105-13-148.
-
(2012)
BMC Bioinformatics
, vol.13
, pp. 148
-
-
Gonnet, G.H.1
-
22
-
-
33751381461
-
TimeTree: a public knowledge-base of divergence times among organisms
-
doi: 10.1093/bioinformatics/btl505
-
Hedges, S. B., Dudley, J., and Kumar, S. (2006). TimeTree: a public knowledge-base of divergence times among organisms. Bioinformatics 22, 2971-2972. doi: 10.1093/bioinformatics/btl505.
-
(2006)
Bioinformatics
, vol.22
, pp. 2971-2972
-
-
Hedges, S.B.1
Dudley, J.2
Kumar, S.3
-
23
-
-
77954051527
-
Identification of beta-secretase (BACE1) substrates using quantitative proteomics
-
doi: 10.1371/journal.pone.0008477
-
Hemming, M. L., Elias, J. E., Gygi, S. P., and Selkoe, D. J. (2009). Identification of beta-secretase (BACE1) substrates using quantitative proteomics. PLoS ONE 4:e8477. doi: 10.1371/journal.pone.0008477.
-
(2009)
PLoS ONE
, vol.4
-
-
Hemming, M.L.1
Elias, J.E.2
Gygi, S.P.3
Selkoe, D.J.4
-
24
-
-
0028825276
-
Automated construction and graphical presentation of protein blocks from unaligned sequences
-
doi: 10.1016/0378-1119(95)00486-P
-
Henikoff, S., Henikoff, J. G., Alford, W. J., and Pietrokovski, S. (1995). Automated construction and graphical presentation of protein blocks from unaligned sequences. Gene 163, GC17-GC26. doi: 10.1016/0378-1119(95)00486-P.
-
(1995)
Gene
, vol.163
-
-
Henikoff, S.1
Henikoff, J.G.2
Alford, W.J.3
Pietrokovski, S.4
-
25
-
-
84878095153
-
β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease
-
doi: 10.1021/jm400225m
-
Hilpert, H., Guba, W., Woltering, T. J., Wostl, W., Pinard, E., Mauser, H., et al. (2013). β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J. Med. Chem. 56, 3980-3995. doi: 10.1021/jm400225m.
-
(2013)
J. Med. Chem.
, vol.56
, pp. 3980-3995
-
-
Hilpert, H.1
Guba, W.2
Woltering, T.J.3
Wostl, W.4
Pinard, E.5
Mauser, H.6
-
26
-
-
79959196089
-
Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase
-
doi: 10.1371/journal.pone.0021337
-
Hogl, S., Kuhn, P. H., Colombo, A., and Lichtenthaler, S. F. (2011). Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase. PLoS ONE 6:e21337. doi: 10.1371/journal.pone.0021337.
-
(2011)
PLoS ONE
, vol.6
-
-
Hogl, S.1
Kuhn, P.H.2
Colombo, A.3
Lichtenthaler, S.F.4
-
27
-
-
84876498884
-
Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains
-
doi: 10.1002/pmic.201200582
-
Hogl, S., van Bebber, F., Dislich, B., Kuhn, P.-H., Haass, C., Schmid, B., et al. (2013). Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics 13, 1519-1527. doi: 10.1002/pmic.201200582.
-
(2013)
Proteomics
, vol.13
, pp. 1519-1527
-
-
Hogl, S.1
van Bebber, F.2
Dislich, B.3
Kuhn, P.-H.4
Haass, C.5
Schmid, B.6
-
28
-
-
0028598861
-
Gene duplications and the origins of vertebrate development
-
Holland, P. W., Garcia-Fernandez, J., Williams, N. A., and Sidow, A. (1994). Gene duplications and the origins of vertebrate development. Dev. Suppl. Gene duplications and the origins of vertebrate development, 125-133.
-
(1994)
Dev. Suppl. Gene duplications and the origins of vertebrate development
, pp. 125-133
-
-
Holland, P.W.1
Garcia-Fernandez, J.2
Williams, N.A.3
Sidow, A.4
-
29
-
-
53549093299
-
Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement
-
doi: 10.1101/gr.080119.108
-
Hufton, A. L., Groth, D., Vingron, M., Lehrach, H., Poustka, A. J., and Panopoulou, G. (2008). Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement. Genome Res. 18, 1582-1591. doi: 10.1101/gr.080119.108.
-
(2008)
Genome Res.
, vol.18
, pp. 1582-1591
-
-
Hufton, A.L.1
Groth, D.2
Vingron, M.3
Lehrach, H.4
Poustka, A.J.5
Panopoulou, G.6
-
30
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as beta-secretase
-
doi: 10.1006/mcne.1999.0811
-
Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., et al. (1999). Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol. Cell. Neurosci. 14, 419-427. doi: 10.1006/mcne.1999.0811.
-
(1999)
Mol. Cell. Neurosci.
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
Chapman, C.6
-
31
-
-
0034533808
-
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site
-
doi: 10.1006/mcne.2000.0884
-
Hussain, I., Powell, D. J., Howlett, D. R., Chapman, G. A., Gilmour, L., Murdock, P. R., et al. (2000). ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site. Mol. Cell. Neurosci. 16, 609-619. doi: 10.1006/mcne.2000.0884.
-
(2000)
Mol. Cell. Neurosci.
, vol.16
, pp. 609-619
-
-
Hussain, I.1
Powell, D.J.2
Howlett, D.R.3
Chapman, G.A.4
Gilmour, L.5
Murdock, P.R.6
-
32
-
-
84864471159
-
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
-
doi: 10.1038/nature11283
-
Jonsson, T., Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., et al. (2012). A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 488, 96-99. doi: 10.1038/nature11283.
-
(2012)
Nature
, vol.488
, pp. 96-99
-
-
Jonsson, T.1
Atwal, J.K.2
Steinberg, S.3
Snaedal, J.4
Jonsson, P.V.5
Bjornsson, S.6
-
33
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
-
doi: 10.1038/nrd3505
-
Karran, E., Mercken, M., and De Strooper, B. (2011). The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat. Rev. Drug Discov. 10, 698-712. doi: 10.1038/nrd3505.
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
De Strooper, B.3
-
34
-
-
39149110563
-
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
-
doi: 10.1038/nature06617
-
King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., et al. (2008). The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature 451, 783-788. doi: 10.1038/nature06617.
-
(2008)
Nature
, vol.451
, pp. 783-788
-
-
King, N.1
Westbrook, M.J.2
Young, S.L.3
Kuo, A.4
Abedin, M.5
Chapman, J.6
-
35
-
-
17744396121
-
Not so different after all: a comparison of methods for detecting amino acid sites under selection
-
doi: 10.1093/molbev/msi105
-
Kosakovsky Pond, S. L., and Frost, S. D. W. (2005). Not so different after all: a comparison of methods for detecting amino acid sites under selection. Mol. Biol. Evol. 22, 1208-1222. doi: 10.1093/molbev/msi105.
-
(2005)
Mol. Biol. Evol.
, vol.22
, pp. 1208-1222
-
-
Kosakovsky Pond, S.L.1
Frost, S.D.W.2
-
36
-
-
78049403832
-
Alzheimer's secretases regulate voltage-gated sodium channels
-
doi: 10.1016/j.neulet.2010.08.048
-
Kovacs, D. M., Gersbacher, M. T., and Kim, D. Y. (2010). Alzheimer's secretases regulate voltage-gated sodium channels. Neurosci. Lett. 486, 68-72. doi: 10.1016/j.neulet.2010.08.048.
-
(2010)
Neurosci. Lett.
, vol.486
, pp. 68-72
-
-
Kovacs, D.M.1
Gersbacher, M.T.2
Kim, D.Y.3
-
37
-
-
84864148410
-
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
-
doi: 10.1038/emboj.2012.173
-
Kuhn, P.-H., Koroniak, K., Hogl, S., Colombo, A., Zeitschel, U., Willem, M., et al. (2012). Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J. 31, 3157-3168. doi: 10.1038/emboj.2012.173.
-
(2012)
EMBO J.
, vol.31
, pp. 3157-3168
-
-
Kuhn, P.-H.1
Koroniak, K.2
Hogl, S.3
Colombo, A.4
Zeitschel, U.5
Willem, M.6
-
38
-
-
57749184792
-
Timing of genome duplications relative to the origin of the vertebrates: did cyclostomes diverge before or after?
-
doi: 10.1093/molbev/msn222
-
Kuraku, S., Meyer, A., and Kuratani, S. (2009). Timing of genome duplications relative to the origin of the vertebrates: did cyclostomes diverge before or after? Mol. Biol. Evol. 26, 47-59. doi: 10.1093/molbev/msn222.
-
(2009)
Mol. Biol. Evol.
, vol.26
, pp. 47-59
-
-
Kuraku, S.1
Meyer, A.2
Kuratani, S.3
-
39
-
-
79955061701
-
Regulated intramembrane proteolysis: signaling pathways and biological functions
-
doi: 10.1152/physiol.00028.2010
-
Lal, M., and Caplan, M. (2011). Regulated intramembrane proteolysis: signaling pathways and biological functions. Physiology 26, 34-44. doi: 10.1152/physiol.00028.2010.
-
(2011)
Physiology
, vol.26
, pp. 34-44
-
-
Lal, M.1
Caplan, M.2
-
40
-
-
58149187898
-
PDBsum new things
-
doi: 10.1093/nar/gkn860
-
Laskowski, R. A. (2009). PDBsum new things. Nucleic Acids Res. 37, D355-D359. doi: 10.1093/nar/gkn860.
-
(2009)
Nucleic Acids Res.
, vol.37
-
-
Laskowski, R.A.1
-
41
-
-
33748032715
-
Taking the first steps towards a standard for reporting on phylogenies: Minimum Information About a Phylogenetic Analysis (MIAPA)
-
doi: 10.1089/omi.2006.10.231
-
Leebens-Mack, J., Vision, T., Brenner, E., Bowers, J. E., Cannon, S., Clement, M. J., et al. (2006). Taking the first steps towards a standard for reporting on phylogenies: Minimum Information About a Phylogenetic Analysis (MIAPA). Omics 10, 231-237. doi: 10.1089/omi.2006.10.231.
-
(2006)
Omics
, vol.10
, pp. 231-237
-
-
Leebens-Mack, J.1
Vision, T.2
Brenner, E.3
Bowers, J.E.4
Cannon, S.5
Clement, M.J.6
-
42
-
-
79955663580
-
Regulated intramembrane proteolysis-lessons from amyloid precursor protein processing
-
doi: 10.1111/j.1471-4159.2011.07248.x
-
Lichtenthaler, S. F., Haass, C., and Steiner, H. (2011). Regulated intramembrane proteolysis-lessons from amyloid precursor protein processing. J. Neurochem. 117, 779-796. doi: 10.1111/j.1471-4159.2011.07248.x.
-
(2011)
J. Neurochem.
, vol.117
, pp. 779-796
-
-
Lichtenthaler, S.F.1
Haass, C.2
Steiner, H.3
-
43
-
-
79959328800
-
Evolution of sodium channels predates the origin of nervous systems in animals
-
doi: 10.1073/pnas.1106363108
-
Liebeskind, B. J., Hillis, D. M., and Zakon, H. H. (2011). Evolution of sodium channels predates the origin of nervous systems in animals. Proc. Natl. Acad. Sci. U.S.A. 108, 9154-9159. doi: 10.1073/pnas.1106363108.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 9154-9159
-
-
Liebeskind, B.J.1
Hillis, D.M.2
Zakon, H.H.3
-
44
-
-
78649319201
-
webPRANK: a phylogeny-aware multiple sequence aligner with interactive alignment browser
-
doi: 10.1186/1471-2105-11-579
-
Löytynoja, A., and Goldman, N. (2010). webPRANK: a phylogeny-aware multiple sequence aligner with interactive alignment browser. BMC Bioinformatics 11:579. doi: 10.1186/1471-2105-11-579.
-
(2010)
BMC Bioinformatics
, vol.11
, pp. 579
-
-
Löytynoja, A.1
Goldman, N.2
-
45
-
-
0034634395
-
The evolutionary fate and consequences of duplicate genes
-
doi: 10.1126/science.290.5494.1151
-
Lynch, M., and Conery, J. S. (2000). The evolutionary fate and consequences of duplicate genes. Science 290, 1151-1155. doi: 10.1126/science.290.5494.1151.
-
(2000)
Science
, vol.290
, pp. 1151-1155
-
-
Lynch, M.1
Conery, J.S.2
-
46
-
-
0033972072
-
The probability of duplicate gene preservation by subfunctionalization
-
Lynch, M., and Force, A. (2000). The probability of duplicate gene preservation by subfunctionalization. Genetics 154, 459-473.
-
(2000)
Genetics
, vol.154
, pp. 459-473
-
-
Lynch, M.1
Force, A.2
-
47
-
-
0035697435
-
The probability of preservation of a newly arisen gene duplicate
-
Lynch, M., O'Hely, M., Walsh, B., and Force, A. (2001). The probability of preservation of a newly arisen gene duplicate. Genetics 159, 1789-1804.
-
(2001)
Genetics
, vol.159
, pp. 1789-1804
-
-
Lynch, M.1
O'Hely, M.2
Walsh, B.3
Force, A.4
-
48
-
-
34249951869
-
Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity
-
doi: 10.1073/pnas.0609521104
-
Ma, H., Lesne, S., Kotilinek, L., Steidl-Nichols, J. V., Sherman, M., Younkin, L., et al. (2007). Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proc. Natl. Acad. Sci. U.S.A. 104, 8167-8172. doi: 10.1073/pnas.0609521104.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 8167-8172
-
-
Ma, H.1
Lesne, S.2
Kotilinek, L.3
Steidl-Nichols, J.V.4
Sherman, M.5
Younkin, L.6
-
49
-
-
81255143061
-
Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor
-
doi: 10.1523/JNEUROSCI.3647-11.2011
-
May, P. C., Dean, R. A., Lowe, S. L., Martenyi, F., Sheehan, S. M., Boggs, L. N., et al. (2011). Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor. J. Neurosci. 31, 16507-16516. doi: 10.1523/JNEUROSCI.3647-11.2011.
-
(2011)
J. Neurosci.
, vol.31
, pp. 16507-16516
-
-
May, P.C.1
Dean, R.A.2
Lowe, S.L.3
Martenyi, F.4
Sheehan, S.M.5
Boggs, L.N.6
-
50
-
-
0035193659
-
Divergence pattern of animal gene families and relationship with the Cambrian explosion
-
doi: 10.1002/bies.1147
-
Miyata, T., and Suga, H. (2001). Divergence pattern of animal gene families and relationship with the Cambrian explosion. Bioessays 23, 1018-1027. doi: 10.1002/bies.1147.
-
(2001)
Bioessays
, vol.23
, pp. 1018-1027
-
-
Miyata, T.1
Suga, H.2
-
51
-
-
33744807179
-
Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling
-
doi: 10.1101/gr.4871006
-
Morin, R. D., Chang, E., Petrescu, A., Liao, N., Griffith, M., Chow, W., et al. (2006). Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling. Genome Res. 16, 796-803. doi: 10.1101/gr.4871006.
-
(2006)
Genome Res.
, vol.16
, pp. 796-803
-
-
Morin, R.D.1
Chang, E.2
Petrescu, A.3
Liao, N.4
Griffith, M.5
Chow, W.6
-
52
-
-
40349100482
-
Recent progress in the medicinal chemistry of gamma-secretase inhibitors
-
doi: 10.2174/156802608783334088
-
Olson, R. E., and Albright, C. F. (2008). Recent progress in the medicinal chemistry of gamma-secretase inhibitors. Curr. Top. Med. Chem. 8, 17-33. doi: 10.2174/156802608783334088.
-
(2008)
Curr. Top. Med. Chem.
, vol.8
, pp. 17-33
-
-
Olson, R.E.1
Albright, C.F.2
-
53
-
-
84873077107
-
Chasing the urmetazoon: striking a blow for quality data?
-
doi: 10.1016/j.ympev.2012.05.028
-
Osigus, H.-J., Eitel, M., and Schierwater, B. (2013). Chasing the urmetazoon: striking a blow for quality data? Mol. Phylogenet. Evol. 66, 551-557. doi: 10.1016/j.ympev.2012.05.028.
-
(2013)
Mol. Phylogenet. Evol.
, vol.66
, pp. 551-557
-
-
Osigus, H.-J.1
Eitel, M.2
Schierwater, B.3
-
54
-
-
34249857539
-
COBALT: constraint-based alignment tool for multiple protein sequences
-
doi: 10.1093/bioinformatics/btm076
-
Papadopoulos, J. S., and Agarwala, R. (2007). COBALT: constraint-based alignment tool for multiple protein sequences. Bioinformatics 23, 1073-1079. doi: 10.1093/bioinformatics/btm076.
-
(2007)
Bioinformatics
, vol.23
, pp. 1073-1079
-
-
Papadopoulos, J.S.1
Agarwala, R.2
-
55
-
-
32544436264
-
Forgotten and novel aspects in pancreas development
-
doi: 10.1042/BC20050069
-
Pieler, T., and Chen, Y. (2006). Forgotten and novel aspects in pancreas development. Biol. Cell 98, 79-88. doi: 10.1042/BC20050069.
-
(2006)
Biol. Cell
, vol.98
, pp. 79-88
-
-
Pieler, T.1
Chen, Y.2
-
56
-
-
84861512510
-
Small-molecule BACE1 inhibitors: a patent literature review (2006-2011)
-
doi: 10.1517/13543776.2012.681302
-
Probst, G., and Xu, Y. (2012). Small-molecule BACE1 inhibitors: a patent literature review (2006-2011). Expert Opin. Ther. Pat. 22, 511-540. doi: 10.1517/13543776.2012.681302.
-
(2012)
Expert Opin. Ther. Pat.
, vol.22
, pp. 511-540
-
-
Probst, G.1
Xu, Y.2
-
57
-
-
67650064594
-
The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes
-
doi: 10.1101/gr.080531.108
-
Pruitt, K. D., Harrow, J., Harte, R. A., Wallin, C., Diekhans, M., Maglott, D. R., et al. (2009). The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes. Genome Res. 19, 1316-1323. doi: 10.1101/gr.080531.108.
-
(2009)
Genome Res.
, vol.19
, pp. 1316-1323
-
-
Pruitt, K.D.1
Harrow, J.2
Harte, R.A.3
Wallin, C.4
Diekhans, M.5
Maglott, D.R.6
-
58
-
-
12344328859
-
Pigment pattern evolution by differential deployment of neural crest and post-embryonic melanophore lineages in Danio fishes
-
doi: 10.1242/dev.01526
-
Quigley, I. K., Turner, J. M., Nuckels, R. J., Manuel, J. L., Budi, E. H., MacDonald, E. L., et al. (2004). Pigment pattern evolution by differential deployment of neural crest and post-embryonic melanophore lineages in Danio fishes. Development 131, 6053-6069. doi: 10.1242/dev.01526.
-
(2004)
Development
, vol.131
, pp. 6053-6069
-
-
Quigley, I.K.1
Turner, J.M.2
Nuckels, R.J.3
Manuel, J.L.4
Budi, E.H.5
MacDonald, E.L.6
-
59
-
-
49549106252
-
Segment-based multiple sequence alignment
-
doi: 10.1093/bioinformatics/btn281
-
Rausch, T., Emde, A.-K., Weese, D., Döring, A., Notredame, C., and Reinert, K. (2008). Segment-based multiple sequence alignment. Bioinformatics 24, i187-i192. doi: 10.1093/bioinformatics/btn281.
-
(2008)
Bioinformatics
, vol.24
-
-
Rausch, T.1
Emde, A.-K.2
Weese, D.3
Döring, A.4
Notredame, C.5
Reinert, K.6
-
60
-
-
70350442584
-
Pepsin homologues in bacteria
-
doi: 10.1186/1471-2164-10-437
-
Rawlings, N. D., and Bateman, A. (2009). Pepsin homologues in bacteria. BMC Genomics 10:437. doi: 10.1186/1471-2164-10-437.
-
(2009)
BMC Genomics
, vol.10
, pp. 437
-
-
Rawlings, N.D.1
Bateman, A.2
-
61
-
-
38549096018
-
MEROPS: the peptidase database
-
doi: 10.1093/nar/gkm954
-
Rawlings, N. D., Morton, F. R., Kok, C. Y., Kong, J., and Barrett, A. J. (2008). MEROPS: the peptidase database. Nucleic Acids Res. 36, D320-D325. doi: 10.1093/nar/gkm954.
-
(2008)
Nucleic Acids Res.
, vol.36
-
-
Rawlings, N.D.1
Morton, F.R.2
Kok, C.Y.3
Kong, J.4
Barrett, A.J.5
-
62
-
-
84879544231
-
BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells
-
doi: 10.1073/pnas.1220748110
-
Rochin, L., Hurbain, I., Serneels, L., Fort, C., Watt, B., Leblanc, P., et al. (2013). BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells. Proc. Natl. Acad. Sci. U.S.A. 110, 10658-10663. doi: 10.1073/pnas.1220748110.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 10658-10663
-
-
Rochin, L.1
Hurbain, I.2
Serneels, L.3
Fort, C.4
Watt, B.5
Leblanc, P.6
-
63
-
-
38549163152
-
TreeFam: 2008 Update
-
doi: 10.1093/nar/gkm1005
-
Ruan, J., Li, H., Chen, Z., Coghlan, A., Coin, L. J. M., Guo, Y., et al. (2008). TreeFam: 2008 Update. Nucleic Acids Res. 36, D735-D740. doi: 10.1093/nar/gkm1005.
-
(2008)
Nucleic Acids Res.
, vol.36
-
-
Ruan, J.1
Li, H.2
Chen, Z.3
Coghlan, A.4
Coin, L.J.M.5
Guo, Y.6
-
64
-
-
79958026120
-
Cathepsins, S., B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease
-
doi: 10.1515/bc.2011.054
-
Schechter, I., and Ziv, E. (2011). Cathepsins, S., B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease. Biol. Chem. 392, 555-569. doi: 10.1515/bc.2011.054.
-
(2011)
Biol. Chem.
, vol.392
, pp. 555-569
-
-
Schechter, I.1
Ziv, E.2
-
65
-
-
35348860241
-
Presenilin: running with scissors in the membrane
-
doi: 10.1016/j.cell.2007.10.012
-
Selkoe, D. J., and Wolfe, M. S. (2007). Presenilin: running with scissors in the membrane. Cell 131, 215-221. doi: 10.1016/j.cell.2007.10.012.
-
(2007)
Cell
, vol.131
, pp. 215-221
-
-
Selkoe, D.J.1
Wolfe, M.S.2
-
66
-
-
84879020737
-
The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage
-
doi: 10.1186/gb-2013-14-3-r28
-
Shaffer, H. B., Minx, P., Warren, D. E., Shedlock, A. M., Thomson, R. C., Valenzuela, N., et al. (2013). The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol. 14:R28. doi: 10.1186/gb-2013-14-3-r28.
-
(2013)
Genome Biol.
, vol.14
-
-
Shaffer, H.B.1
Minx, P.2
Warren, D.E.3
Shedlock, A.M.4
Thomson, R.C.5
Valenzuela, N.6
-
67
-
-
84865448747
-
FigShare
-
doi: 10.4103/0976-500X.81919
-
Singh, J. (2011). FigShare. J. Pharmacol. Pharmacother. 2, 138-139. doi: 10.4103/0976-500X.81919.
-
(2011)
J. Pharmacol. Pharmacother.
, vol.2
, pp. 138-139
-
-
Singh, J.1
-
68
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
doi: 10.1038/990114
-
Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., et al. (1999). Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402, 537-540. doi: 10.1038/990114.
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
-
69
-
-
34250815182
-
Exploiting new genome data and Internet resources for the phylogenetic analysis of proteases, substrates and inhibitors
-
doi: 10.1042/BST0350599
-
Southan, C. (2007). Exploiting new genome data and Internet resources for the phylogenetic analysis of proteases, substrates and inhibitors. Biochem. Soc. Trans. 35, 599-603. doi: 10.1042/BST0350599.
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 599-603
-
-
Southan, C.1
-
70
-
-
84876545164
-
BACE2 as a new diabetes target: a patent review (2010-2012)
-
doi: 10.1517/13543776.2013.780032
-
Southan, C. (2013). BACE2 as a new diabetes target: a patent review (2010-2012). Expert Opin. Ther. Pat. 23, 649-663. doi: 10.1517/13543776.2013.780032.
-
(2013)
Expert Opin. Ther. Pat.
, vol.23
, pp. 649-663
-
-
Southan, C.1
-
71
-
-
79959444149
-
Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: ranking 1654 human protein targets by assayed compounds and molecular scaffolds
-
doi: 10.1186/1758-2946-3-14
-
Southan, C., Boppana, K., Jagarlapudi, S. A., and Muresan, S. (2011). Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: ranking 1654 human protein targets by assayed compounds and molecular scaffolds. J. Cheminform. 3, 14. doi: 10.1186/1758-2946-3-14.
-
(2011)
J. Cheminform.
, vol.3
, pp. 14
-
-
Southan, C.1
Boppana, K.2
Jagarlapudi, S.A.3
Muresan, S.4
-
72
-
-
50049092481
-
The Trichoplax genome and the nature of placozoans
-
doi: 10.1038/nature07191
-
Srivastava, M., Begovic, E., Chapman, J., Putnam, N. H., Hellsten, U., Kawashima, T., et al. (2008). The Trichoplax genome and the nature of placozoans. Nature 454, 955-960. doi: 10.1038/nature07191.
-
(2008)
Nature
, vol.454
, pp. 955-960
-
-
Srivastava, M.1
Begovic, E.2
Chapman, J.3
Putnam, N.H.4
Hellsten, U.5
Kawashima, T.6
-
73
-
-
84868540195
-
Discovery of an orally available, brain penetrant BACE1 inhibitor that affords robust CNS Aβ Reduction
-
doi: 10.1021/ml3001165
-
Stamford, A. W., Scott, J. D., Li, S. W., Babu, S., Tadesse, D., Hunter, R., et al. (2012). Discovery of an orally available, brain penetrant BACE1 inhibitor that affords robust CNS Aβ Reduction. ACS Med. Chem. Lett. 3, 897-902. doi: 10.1021/ml3001165.
-
(2012)
ACS Med. Chem. Lett.
, vol.3
, pp. 897-902
-
-
Stamford, A.W.1
Scott, J.D.2
Li, S.W.3
Babu, S.4
Tadesse, D.5
Hunter, R.6
-
74
-
-
53849123621
-
Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease
-
doi: 10.1007/s00018-008-8271-3
-
Stockley, J. H., and O'Neill, C. (2008). Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease. Cell. Mol. Life Sci. 65, 3265-3289. doi: 10.1007/s00018-008-8271-3.
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, pp. 3265-3289
-
-
Stockley, J.H.1
O'Neill, C.2
-
75
-
-
84867641403
-
Sharing and re-use of phylogenetic trees (and associated data) to facilitate synthesis
-
doi: 10.1186/1756-0500-5-574
-
Stoltzfus, A., O'Meara, B., Whitacre, J., Mounce, R., Gillespie, E. L., Kumar, S., et al. (2012). Sharing and re-use of phylogenetic trees (and associated data) to facilitate synthesis. BMC Res. Notes 5:574. doi: 10.1186/1756-0500-5-574.
-
(2012)
BMC Res. Notes
, vol.5
, pp. 574
-
-
Stoltzfus, A.1
O'Meara, B.2
Whitacre, J.3
Mounce, R.4
Gillespie, E.L.5
Kumar, S.6
-
76
-
-
84876263985
-
Systematic proteomic analysis identifies β-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic β-cells
-
doi: 10.1074/jbc.M112.444703
-
Stützer, I., Selevsek, N., Esterházy, D., Schmidt, A., Aebersold, R., and Stoffel, M. (2013). Systematic proteomic analysis identifies β-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic β-cells. J. Biol. Chem. 288, 10536-10547. doi: 10.1074/jbc.M112.444703.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 10536-10547
-
-
Stützer, I.1
Selevsek, N.2
Esterházy, D.3
Schmidt, A.4
Aebersold, R.5
Stoffel, M.6
-
77
-
-
33746549926
-
BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome
-
doi: 10.1096/fj.05-5632com
-
Sun, X., He, G., and Song, W. (2006). BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome. FASEB J. 20, 1369-1376. doi: 10.1096/fj.05-5632com.
-
(2006)
FASEB J.
, vol.20
, pp. 1369-1376
-
-
Sun, X.1
He, G.2
Song, W.3
-
78
-
-
20944444583
-
Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes
-
doi: 10.1096/fj.04-3426com
-
Sun, X., Wang, Y., Qing, H., Christensen, M. A., Liu, Y., Zhou, W., et al. (2005). Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes. FASEB J. 19, 739-749. doi: 10.1096/fj.04-3426com.
-
(2005)
FASEB J.
, vol.19
, pp. 739-749
-
-
Sun, X.1
Wang, Y.2
Qing, H.3
Christensen, M.A.4
Liu, Y.5
Zhou, W.6
-
79
-
-
78049386104
-
Viable mouse gene ablations that robustly alter brain Aβ levels are rare
-
doi: 10.1186/1471-2202-11-143
-
Toyn, J. H., Lin, X.-A., Thompson, M. W., Guss, V., Meredith, J. E., Sankaranarayanan, S., et al. (2010). Viable mouse gene ablations that robustly alter brain Aβ levels are rare. BMC Neurosci. 11:143. doi: 10.1186/1471-2202-11-143.
-
(2010)
BMC Neurosci.
, vol.11
, pp. 143
-
-
Toyn, J.H.1
Lin, X.-A.2
Thompson, M.W.3
Guss, V.4
Meredith, J.E.5
Sankaranarayanan, S.6
-
80
-
-
84887031752
-
Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes
-
doi: 10.1111/jnc.12198
-
Van Bebber, F., Hruscha, A., Willem, M., Schmid, B., and Haass, C. (2013). Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes. J. Neurochem. 127, 471-481. doi: 10.1111/jnc.12198.
-
(2013)
J. Neurochem.
, vol.127
, pp. 471-481
-
-
Van Bebber, F.1
Hruscha, A.2
Willem, M.3
Schmid, B.4
Haass, C.5
-
81
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
doi: 10.1126/science.286.5440.735
-
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., et al. (1999). Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741. doi: 10.1126/science.286.5440.735.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
-
82
-
-
34247342594
-
Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome
-
doi: 10.1371/journal.pbio.0050101
-
Venkatesh, B., Kirkness, E. F., Loh, Y. H., Halpern, A. L., Lee, A. P., Johnson, J., et al. (2007). Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome. PLoS Biol. 5:e101. doi: 10.1371/journal.pbio.0050101.
-
(2007)
PLoS Biol.
, vol.5
-
-
Venkatesh, B.1
Kirkness, E.F.2
Loh, Y.H.3
Halpern, A.L.4
Lee, A.P.5
Johnson, J.6
-
83
-
-
48249093460
-
Beta-secretase: structure, function, and evolution
-
doi: 10.2174/187152708784936626
-
Venugopal, C., Demos, C. M., Rao, K. S., Pappolla, M. A., and Sambamurti, K. (2008). Beta-secretase: structure, function, and evolution. CNS Neurol. Disord. Drug Targets 7, 278-294. doi: 10.2174/187152708784936626.
-
(2008)
CNS Neurol. Disord. Drug Targets
, vol.7
, pp. 278-294
-
-
Venugopal, C.1
Demos, C.M.2
Rao, K.S.3
Pappolla, M.A.4
Sambamurti, K.5
-
84
-
-
62149091579
-
Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts
-
doi: 10.1074/jbc.M808920200
-
Vetrivel, K. S., Meckler, X., Chen, Y., Nguyen, P. D., Seidah, N. G., Vassar, R., et al. (2009). Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J. Biol. Chem. 284, 3793-3803. doi: 10.1074/jbc.M808920200.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 3793-3803
-
-
Vetrivel, K.S.1
Meckler, X.2
Chen, Y.3
Nguyen, P.D.4
Seidah, N.G.5
Vassar, R.6
-
85
-
-
84867516398
-
Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid
-
doi: 10.1021/jm300119p
-
Weiss, M. M., Williamson, T., Babu-Khan, S., Bartberger, M. D., Brown, J., Chen, K., et al. (2012). Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid. J. Med. Chem. 55, 9009-9024. doi: 10.1021/jm300119p.
-
(2012)
J. Med. Chem.
, vol.55
, pp. 9009-9024
-
-
Weiss, M.M.1
Williamson, T.2
Babu-Khan, S.3
Bartberger, M.D.4
Brown, J.5
Chen, K.6
-
86
-
-
84866322498
-
γ-Secretase modulator in Alzheimer's disease: shifting the end
-
doi: 10.3233/Jad-2012-120751
-
Xia, W., Wong, S. T., Hanlon, E., and Morin, P. (2012). γ-Secretase modulator in Alzheimer's disease: shifting the end. J. Alzheimer's Dis. 31, 685-696. doi: 10.3233/Jad-2012-120751.
-
(2012)
J. Alzheimer's Dis.
, vol.31
, pp. 685-696
-
-
Xia, W.1
Wong, S.T.2
Hanlon, E.3
Morin, P.4
-
87
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
doi: 10.1038/990107
-
Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., et al. (1999). Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402, 533-537. doi: 10.1038/990107.
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.4
Tory, M.C.5
Pauley, A.M.6
-
88
-
-
84866152524
-
Adaptive evolution of voltage-gated sodium channels: the first 800 million years
-
doi: 10.1073/pnas.1201884109
-
Zakon, H. H. (2012). Adaptive evolution of voltage-gated sodium channels: the first 800 million years. Proc. Natl. Acad. Sci. U.S.A. 109(Suppl.), 10619-10625. doi: 10.1073/pnas.1201884109.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, Issue.SUPPL.
, pp. 10619-10625
-
-
Zakon, H.H.1
|