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Volumn 4, Issue DEC, 2013, Pages

A tale of two drug targets: The evolutionary history of BACE1 and BACE2

Author keywords

Alzheimer's Disease; BACE1; BACE2; Protein family evolution; Type II diabetes

Indexed keywords


EID: 84892376862     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2013.00293     Document Type: Article
Times cited : (17)

References (88)
  • 1
    • 0033970139 scopus 로고    scopus 로고
    • The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region
    • doi: 10.1016/S0014-5793(00)01192-3
    • Acquati, F., Accarino, M., Nucci, C., Fumagalli, P., Jovine, L., Ottolenghi, S., et al. (2000). The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region. FEBS Lett. 468, 59-64. doi: 10.1016/S0014-5793(00)01192-3.
    • (2000) FEBS Lett. , vol.468 , pp. 59-64
    • Acquati, F.1    Accarino, M.2    Nucci, C.3    Fumagalli, P.4    Jovine, L.5    Ottolenghi, S.6
  • 2
    • 66149105111 scopus 로고    scopus 로고
    • Improved data retrieval from TreeBASE via taxonomic and linguistic data enrichment
    • doi: 10.1186/1471-2148-9-93
    • Anwar, N., and Hunt, E. (2009). Improved data retrieval from TreeBASE via taxonomic and linguistic data enrichment. BMC Evol. Biol. 9:93. doi: 10.1186/1471-2148-9-93.
    • (2009) BMC Evol. Biol. , vol.9 , pp. 93
    • Anwar, N.1    Hunt, E.2
  • 3
    • 79960464624 scopus 로고    scopus 로고
    • β-Cell evolution: How the pancreas borrowed from the brain: the shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship
    • doi: 10.1002/bies.201100015
    • Arntfield, M. E., and van der Kooy, D. (2011). β-Cell evolution: How the pancreas borrowed from the brain: the shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship. Bioessays 33, 582-587. doi: 10.1002/bies.201100015.
    • (2011) Bioessays , vol.33 , pp. 582-587
    • Arntfield, M.E.1    van der Kooy, D.2
  • 4
    • 84862252899 scopus 로고    scopus 로고
    • The PRINTS database: a fine-grained protein sequence annotation and analysis resource-its status in 2012
    • bas019, doi: 10.1093/database/bas019
    • Attwood, T. K., Coletta, A., Muirhead, G., Pavlopoulou, A., Philippou, P. B., Popov, I., et al. (2012). The PRINTS database: a fine-grained protein sequence annotation and analysis resource-its status in 2012. Database 2012:bas019. doi: 10.1093/database/bas019.
    • (2012) Database , vol.2012
    • Attwood, T.K.1    Coletta, A.2    Muirhead, G.3    Pavlopoulou, A.4    Philippou, P.B.5    Popov, I.6
  • 5
    • 35848947692 scopus 로고    scopus 로고
    • Protease research in the era of systems biology
    • doi: 10.1515/BC.2007.146
    • Aufdem Keller, U., Doucet, A., and Overall, C. M. (2007). Protease research in the era of systems biology. Biol. Chem. 388, 1159-1162. doi: 10.1515/BC.2007.146.
    • (2007) Biol. Chem. , vol.388 , pp. 1159-1162
    • Aufdem Keller, U.1    Doucet, A.2    Overall, C.M.3
  • 7
    • 77953806572 scopus 로고    scopus 로고
    • Animals (Metazoa)
    • eds S. B. Hedges and S. Kumar (Oxford: Oxford University Press)
    • Blair, J. (2009). "Animals (Metazoa)," in The Timetree of Life, eds S. B. Hedges and S. Kumar (Oxford: Oxford University Press), 223-230.
    • (2009) The Timetree of Life , pp. 223-230
    • Blair, J.1
  • 8
    • 80053083748 scopus 로고    scopus 로고
    • Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis
    • doi: 10.1073/pnas.1106189108
    • Burkhardt, P., Stegmann, C. M., Cooper, B., Kloepper, T. H., Imig, C., Varoqueaux, F., et al. (2011). Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis. Proc. Natl. Acad. Sci. U.S.A. 108, 15264-15269. doi: 10.1073/pnas.1106189108.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 15264-15269
    • Burkhardt, P.1    Stegmann, C.M.2    Cooper, B.3    Kloepper, T.H.4    Imig, C.5    Varoqueaux, F.6
  • 9
    • 58149503769 scopus 로고    scopus 로고
    • Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function
    • doi: 10.1016/j.nbd.2008.10.014
    • Carmine-Simmen, K., Proctor, T., Tschäpe, J., Poeck, B., Triphan, T., Strauss, R., et al. (2009). Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function. Neurobiol. Dis. 33, 274-281. doi: 10.1016/j.nbd.2008.10.014.
    • (2009) Neurobiol. Dis. , vol.33 , pp. 274-281
    • Carmine-Simmen, K.1    Proctor, T.2    Tschäpe, J.3    Poeck, B.4    Triphan, T.5    Strauss, R.6
  • 10
    • 2142738304 scopus 로고    scopus 로고
    • WebLogo: a sequence logo generator
    • doi: 10.1101/gr.849004
    • Crooks, G. E., Hon, G., Chandonia, J.-M., and Brenner, S. E. (2004). WebLogo: a sequence logo generator. Genome Res. 14, 1188-1190. doi: 10.1101/gr.849004.
    • (2004) Genome Res. , vol.14 , pp. 1188-1190
    • Crooks, G.E.1    Hon, G.2    Chandonia, J.-M.3    Brenner, S.E.4
  • 11
    • 84887212478 scopus 로고    scopus 로고
    • Refining the Ciona intestinalis model of central nervous system regeneration
    • doi: 10.1371/journal.pone.0004458
    • Dahlberg, C., Auger, H., Dupont, S., Sasakura, Y., Thorndyke, M., and Joly, J.-S. (2009). Refining the Ciona intestinalis model of central nervous system regeneration. PLoS ONE 4:e4458. doi: 10.1371/journal.pone.0004458.
    • (2009) PLoS ONE , vol.4
    • Dahlberg, C.1    Auger, H.2    Dupont, S.3    Sasakura, Y.4    Thorndyke, M.5    Joly, J.-S.6
  • 12
    • 84866291339 scopus 로고    scopus 로고
    • The membrane-bound aspartyl protease BACE1: molecular and functional properties in Alzheimer's disease and beyond
    • doi: 10.3389/fphys.2012.00008
    • Dislich, B., and Lichtenthaler, S. F. (2012). The membrane-bound aspartyl protease BACE1: molecular and functional properties in Alzheimer's disease and beyond. Front. Physiol. 3:8. doi: 10.3389/fphys.2012.00008.
    • (2012) Front. Physiol. , vol.3 , pp. 8
    • Dislich, B.1    Lichtenthaler, S.F.2
  • 13
    • 24744449320 scopus 로고    scopus 로고
    • Phenotypic and biochemical analyses of BACE1-and BACE2-deficient mice
    • doi: 10.1074/jbc.M505249200
    • Dominguez, D., Tournoy, J., Hartmann, D., Huth, T., Cryns, K., Deforce, S., et al. (2005). Phenotypic and biochemical analyses of BACE1-and BACE2-deficient mice. J. Biol. Chem. 280, 30797-30806. doi: 10.1074/jbc.M505249200.
    • (2005) J. Biol. Chem. , vol.280 , pp. 30797-30806
    • Dominguez, D.1    Tournoy, J.2    Hartmann, D.3    Huth, T.4    Cryns, K.5    Deforce, S.6
  • 14
    • 84872559270 scopus 로고    scopus 로고
    • Data deposition: missing data mean holes in tree of life
    • doi: 10.1038/493305f
    • Drew, B. T. (2013). Data deposition: missing data mean holes in tree of life. Nature 493, 305. doi: 10.1038/493305f.
    • (2013) Nature , vol.493 , pp. 305
    • Drew, B.T.1
  • 15
    • 33751063056 scopus 로고    scopus 로고
    • Progress toward the discovery and development of efficacious BACE inhibitors
    • Durham, T. B., and Shepherd, T. A. (2006). Progress toward the discovery and development of efficacious BACE inhibitors. Curr. Opin. Drug Discov. Devel. 9, 776-791.
    • (2006) Curr. Opin. Drug Discov. Devel. , vol.9 , pp. 776-791
    • Durham, T.B.1    Shepherd, T.A.2
  • 16
    • 80052723784 scopus 로고    scopus 로고
    • Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass
    • doi: 10.1016/j.cmet.2011.06.018
    • Esterhazy, D., Stutzer, I., Wang, H., Rechsteiner, M. P., Beauchamp, J., Dobeli, H., et al. (2011). Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab. 14, 365-377. doi: 10.1016/j.cmet.2011.06.018.
    • (2011) Cell Metab. , vol.14 , pp. 365-377
    • Esterhazy, D.1    Stutzer, I.2    Wang, H.3    Rechsteiner, M.P.4    Beauchamp, J.5    Dobeli, H.6
  • 17
    • 0034662929 scopus 로고    scopus 로고
    • BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
    • doi: 10.1073/pnas.160115697
    • Farzan, M., Schnitzler, C. E., Vasilieva, N., Leung, D., and Choe, H. (2000). BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proc. Natl. Acad. Sci. U.S.A. 97, 9712-9717. doi: 10.1073/pnas.160115697.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 9712-9717
    • Farzan, M.1    Schnitzler, C.E.2    Vasilieva, N.3    Leung, D.4    Choe, H.5
  • 18
    • 84857736151 scopus 로고    scopus 로고
    • BACE1 dependent neuregulin proteolysis
    • doi: 10.2174/156720512799361637
    • Fleck, D., Garratt, A. N., Haass, C., and Willem, M. (2012). BACE1 dependent neuregulin proteolysis. Curr. Alzheimer Res. 9, 178-183. doi: 10.2174/156720512799361637.
    • (2012) Curr. Alzheimer Res. , vol.9 , pp. 178-183
    • Fleck, D.1    Garratt, A.N.2    Haass, C.3    Willem, M.4
  • 19
    • 0030807655 scopus 로고    scopus 로고
    • BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data
    • doi: 10.1093/oxfordjournals.molbev.a025808
    • Gascuel, O. (1997). BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. Mol. Biol. Evol. 14, 685-695. doi: 10.1093/oxfordjournals.molbev.a025808.
    • (1997) Mol. Biol. Evol. , vol.14 , pp. 685-695
    • Gascuel, O.1
  • 20
    • 33750705653 scopus 로고    scopus 로고
    • A century of Alzheimer's disease
    • doi: 10.1126/science.1132814
    • Goedert, M., and Spillantini, M. G. (2006). A century of Alzheimer's disease. Science 314, 777-781. doi: 10.1126/science.1132814.
    • (2006) Science , vol.314 , pp. 777-781
    • Goedert, M.1    Spillantini, M.G.2
  • 21
    • 84862729639 scopus 로고    scopus 로고
    • Surprising results on phylogenetic tree building methods based on molecular sequences
    • doi: 10.1186/1471-2105-13-148
    • Gonnet, G. H. (2012). Surprising results on phylogenetic tree building methods based on molecular sequences. BMC Bioinformatics 13:148. doi: 10.1186/1471-2105-13-148.
    • (2012) BMC Bioinformatics , vol.13 , pp. 148
    • Gonnet, G.H.1
  • 22
    • 33751381461 scopus 로고    scopus 로고
    • TimeTree: a public knowledge-base of divergence times among organisms
    • doi: 10.1093/bioinformatics/btl505
    • Hedges, S. B., Dudley, J., and Kumar, S. (2006). TimeTree: a public knowledge-base of divergence times among organisms. Bioinformatics 22, 2971-2972. doi: 10.1093/bioinformatics/btl505.
    • (2006) Bioinformatics , vol.22 , pp. 2971-2972
    • Hedges, S.B.1    Dudley, J.2    Kumar, S.3
  • 23
    • 77954051527 scopus 로고    scopus 로고
    • Identification of beta-secretase (BACE1) substrates using quantitative proteomics
    • doi: 10.1371/journal.pone.0008477
    • Hemming, M. L., Elias, J. E., Gygi, S. P., and Selkoe, D. J. (2009). Identification of beta-secretase (BACE1) substrates using quantitative proteomics. PLoS ONE 4:e8477. doi: 10.1371/journal.pone.0008477.
    • (2009) PLoS ONE , vol.4
    • Hemming, M.L.1    Elias, J.E.2    Gygi, S.P.3    Selkoe, D.J.4
  • 24
    • 0028825276 scopus 로고
    • Automated construction and graphical presentation of protein blocks from unaligned sequences
    • doi: 10.1016/0378-1119(95)00486-P
    • Henikoff, S., Henikoff, J. G., Alford, W. J., and Pietrokovski, S. (1995). Automated construction and graphical presentation of protein blocks from unaligned sequences. Gene 163, GC17-GC26. doi: 10.1016/0378-1119(95)00486-P.
    • (1995) Gene , vol.163
    • Henikoff, S.1    Henikoff, J.G.2    Alford, W.J.3    Pietrokovski, S.4
  • 25
    • 84878095153 scopus 로고    scopus 로고
    • β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease
    • doi: 10.1021/jm400225m
    • Hilpert, H., Guba, W., Woltering, T. J., Wostl, W., Pinard, E., Mauser, H., et al. (2013). β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J. Med. Chem. 56, 3980-3995. doi: 10.1021/jm400225m.
    • (2013) J. Med. Chem. , vol.56 , pp. 3980-3995
    • Hilpert, H.1    Guba, W.2    Woltering, T.J.3    Wostl, W.4    Pinard, E.5    Mauser, H.6
  • 26
    • 79959196089 scopus 로고    scopus 로고
    • Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase
    • doi: 10.1371/journal.pone.0021337
    • Hogl, S., Kuhn, P. H., Colombo, A., and Lichtenthaler, S. F. (2011). Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase. PLoS ONE 6:e21337. doi: 10.1371/journal.pone.0021337.
    • (2011) PLoS ONE , vol.6
    • Hogl, S.1    Kuhn, P.H.2    Colombo, A.3    Lichtenthaler, S.F.4
  • 27
    • 84876498884 scopus 로고    scopus 로고
    • Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains
    • doi: 10.1002/pmic.201200582
    • Hogl, S., van Bebber, F., Dislich, B., Kuhn, P.-H., Haass, C., Schmid, B., et al. (2013). Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics 13, 1519-1527. doi: 10.1002/pmic.201200582.
    • (2013) Proteomics , vol.13 , pp. 1519-1527
    • Hogl, S.1    van Bebber, F.2    Dislich, B.3    Kuhn, P.-H.4    Haass, C.5    Schmid, B.6
  • 29
    • 53549093299 scopus 로고    scopus 로고
    • Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement
    • doi: 10.1101/gr.080119.108
    • Hufton, A. L., Groth, D., Vingron, M., Lehrach, H., Poustka, A. J., and Panopoulou, G. (2008). Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement. Genome Res. 18, 1582-1591. doi: 10.1101/gr.080119.108.
    • (2008) Genome Res. , vol.18 , pp. 1582-1591
    • Hufton, A.L.1    Groth, D.2    Vingron, M.3    Lehrach, H.4    Poustka, A.J.5    Panopoulou, G.6
  • 30
    • 0033382226 scopus 로고    scopus 로고
    • Identification of a novel aspartic protease (Asp 2) as beta-secretase
    • doi: 10.1006/mcne.1999.0811
    • Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., et al. (1999). Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol. Cell. Neurosci. 14, 419-427. doi: 10.1006/mcne.1999.0811.
    • (1999) Mol. Cell. Neurosci. , vol.14 , pp. 419-427
    • Hussain, I.1    Powell, D.2    Howlett, D.R.3    Tew, D.G.4    Meek, T.D.5    Chapman, C.6
  • 31
    • 0034533808 scopus 로고    scopus 로고
    • ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site
    • doi: 10.1006/mcne.2000.0884
    • Hussain, I., Powell, D. J., Howlett, D. R., Chapman, G. A., Gilmour, L., Murdock, P. R., et al. (2000). ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site. Mol. Cell. Neurosci. 16, 609-619. doi: 10.1006/mcne.2000.0884.
    • (2000) Mol. Cell. Neurosci. , vol.16 , pp. 609-619
    • Hussain, I.1    Powell, D.J.2    Howlett, D.R.3    Chapman, G.A.4    Gilmour, L.5    Murdock, P.R.6
  • 32
    • 84864471159 scopus 로고    scopus 로고
    • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
    • doi: 10.1038/nature11283
    • Jonsson, T., Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., et al. (2012). A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 488, 96-99. doi: 10.1038/nature11283.
    • (2012) Nature , vol.488 , pp. 96-99
    • Jonsson, T.1    Atwal, J.K.2    Steinberg, S.3    Snaedal, J.4    Jonsson, P.V.5    Bjornsson, S.6
  • 33
    • 80052266213 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
    • doi: 10.1038/nrd3505
    • Karran, E., Mercken, M., and De Strooper, B. (2011). The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat. Rev. Drug Discov. 10, 698-712. doi: 10.1038/nrd3505.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 698-712
    • Karran, E.1    Mercken, M.2    De Strooper, B.3
  • 34
    • 39149110563 scopus 로고    scopus 로고
    • The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
    • doi: 10.1038/nature06617
    • King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., et al. (2008). The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature 451, 783-788. doi: 10.1038/nature06617.
    • (2008) Nature , vol.451 , pp. 783-788
    • King, N.1    Westbrook, M.J.2    Young, S.L.3    Kuo, A.4    Abedin, M.5    Chapman, J.6
  • 35
    • 17744396121 scopus 로고    scopus 로고
    • Not so different after all: a comparison of methods for detecting amino acid sites under selection
    • doi: 10.1093/molbev/msi105
    • Kosakovsky Pond, S. L., and Frost, S. D. W. (2005). Not so different after all: a comparison of methods for detecting amino acid sites under selection. Mol. Biol. Evol. 22, 1208-1222. doi: 10.1093/molbev/msi105.
    • (2005) Mol. Biol. Evol. , vol.22 , pp. 1208-1222
    • Kosakovsky Pond, S.L.1    Frost, S.D.W.2
  • 36
    • 78049403832 scopus 로고    scopus 로고
    • Alzheimer's secretases regulate voltage-gated sodium channels
    • doi: 10.1016/j.neulet.2010.08.048
    • Kovacs, D. M., Gersbacher, M. T., and Kim, D. Y. (2010). Alzheimer's secretases regulate voltage-gated sodium channels. Neurosci. Lett. 486, 68-72. doi: 10.1016/j.neulet.2010.08.048.
    • (2010) Neurosci. Lett. , vol.486 , pp. 68-72
    • Kovacs, D.M.1    Gersbacher, M.T.2    Kim, D.Y.3
  • 37
    • 84864148410 scopus 로고    scopus 로고
    • Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
    • doi: 10.1038/emboj.2012.173
    • Kuhn, P.-H., Koroniak, K., Hogl, S., Colombo, A., Zeitschel, U., Willem, M., et al. (2012). Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J. 31, 3157-3168. doi: 10.1038/emboj.2012.173.
    • (2012) EMBO J. , vol.31 , pp. 3157-3168
    • Kuhn, P.-H.1    Koroniak, K.2    Hogl, S.3    Colombo, A.4    Zeitschel, U.5    Willem, M.6
  • 38
    • 57749184792 scopus 로고    scopus 로고
    • Timing of genome duplications relative to the origin of the vertebrates: did cyclostomes diverge before or after?
    • doi: 10.1093/molbev/msn222
    • Kuraku, S., Meyer, A., and Kuratani, S. (2009). Timing of genome duplications relative to the origin of the vertebrates: did cyclostomes diverge before or after? Mol. Biol. Evol. 26, 47-59. doi: 10.1093/molbev/msn222.
    • (2009) Mol. Biol. Evol. , vol.26 , pp. 47-59
    • Kuraku, S.1    Meyer, A.2    Kuratani, S.3
  • 39
    • 79955061701 scopus 로고    scopus 로고
    • Regulated intramembrane proteolysis: signaling pathways and biological functions
    • doi: 10.1152/physiol.00028.2010
    • Lal, M., and Caplan, M. (2011). Regulated intramembrane proteolysis: signaling pathways and biological functions. Physiology 26, 34-44. doi: 10.1152/physiol.00028.2010.
    • (2011) Physiology , vol.26 , pp. 34-44
    • Lal, M.1    Caplan, M.2
  • 40
    • 58149187898 scopus 로고    scopus 로고
    • PDBsum new things
    • doi: 10.1093/nar/gkn860
    • Laskowski, R. A. (2009). PDBsum new things. Nucleic Acids Res. 37, D355-D359. doi: 10.1093/nar/gkn860.
    • (2009) Nucleic Acids Res. , vol.37
    • Laskowski, R.A.1
  • 41
    • 33748032715 scopus 로고    scopus 로고
    • Taking the first steps towards a standard for reporting on phylogenies: Minimum Information About a Phylogenetic Analysis (MIAPA)
    • doi: 10.1089/omi.2006.10.231
    • Leebens-Mack, J., Vision, T., Brenner, E., Bowers, J. E., Cannon, S., Clement, M. J., et al. (2006). Taking the first steps towards a standard for reporting on phylogenies: Minimum Information About a Phylogenetic Analysis (MIAPA). Omics 10, 231-237. doi: 10.1089/omi.2006.10.231.
    • (2006) Omics , vol.10 , pp. 231-237
    • Leebens-Mack, J.1    Vision, T.2    Brenner, E.3    Bowers, J.E.4    Cannon, S.5    Clement, M.J.6
  • 42
    • 79955663580 scopus 로고    scopus 로고
    • Regulated intramembrane proteolysis-lessons from amyloid precursor protein processing
    • doi: 10.1111/j.1471-4159.2011.07248.x
    • Lichtenthaler, S. F., Haass, C., and Steiner, H. (2011). Regulated intramembrane proteolysis-lessons from amyloid precursor protein processing. J. Neurochem. 117, 779-796. doi: 10.1111/j.1471-4159.2011.07248.x.
    • (2011) J. Neurochem. , vol.117 , pp. 779-796
    • Lichtenthaler, S.F.1    Haass, C.2    Steiner, H.3
  • 43
    • 79959328800 scopus 로고    scopus 로고
    • Evolution of sodium channels predates the origin of nervous systems in animals
    • doi: 10.1073/pnas.1106363108
    • Liebeskind, B. J., Hillis, D. M., and Zakon, H. H. (2011). Evolution of sodium channels predates the origin of nervous systems in animals. Proc. Natl. Acad. Sci. U.S.A. 108, 9154-9159. doi: 10.1073/pnas.1106363108.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 9154-9159
    • Liebeskind, B.J.1    Hillis, D.M.2    Zakon, H.H.3
  • 44
    • 78649319201 scopus 로고    scopus 로고
    • webPRANK: a phylogeny-aware multiple sequence aligner with interactive alignment browser
    • doi: 10.1186/1471-2105-11-579
    • Löytynoja, A., and Goldman, N. (2010). webPRANK: a phylogeny-aware multiple sequence aligner with interactive alignment browser. BMC Bioinformatics 11:579. doi: 10.1186/1471-2105-11-579.
    • (2010) BMC Bioinformatics , vol.11 , pp. 579
    • Löytynoja, A.1    Goldman, N.2
  • 45
    • 0034634395 scopus 로고    scopus 로고
    • The evolutionary fate and consequences of duplicate genes
    • doi: 10.1126/science.290.5494.1151
    • Lynch, M., and Conery, J. S. (2000). The evolutionary fate and consequences of duplicate genes. Science 290, 1151-1155. doi: 10.1126/science.290.5494.1151.
    • (2000) Science , vol.290 , pp. 1151-1155
    • Lynch, M.1    Conery, J.S.2
  • 46
    • 0033972072 scopus 로고    scopus 로고
    • The probability of duplicate gene preservation by subfunctionalization
    • Lynch, M., and Force, A. (2000). The probability of duplicate gene preservation by subfunctionalization. Genetics 154, 459-473.
    • (2000) Genetics , vol.154 , pp. 459-473
    • Lynch, M.1    Force, A.2
  • 47
    • 0035697435 scopus 로고    scopus 로고
    • The probability of preservation of a newly arisen gene duplicate
    • Lynch, M., O'Hely, M., Walsh, B., and Force, A. (2001). The probability of preservation of a newly arisen gene duplicate. Genetics 159, 1789-1804.
    • (2001) Genetics , vol.159 , pp. 1789-1804
    • Lynch, M.1    O'Hely, M.2    Walsh, B.3    Force, A.4
  • 48
    • 34249951869 scopus 로고    scopus 로고
    • Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity
    • doi: 10.1073/pnas.0609521104
    • Ma, H., Lesne, S., Kotilinek, L., Steidl-Nichols, J. V., Sherman, M., Younkin, L., et al. (2007). Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proc. Natl. Acad. Sci. U.S.A. 104, 8167-8172. doi: 10.1073/pnas.0609521104.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 8167-8172
    • Ma, H.1    Lesne, S.2    Kotilinek, L.3    Steidl-Nichols, J.V.4    Sherman, M.5    Younkin, L.6
  • 49
    • 81255143061 scopus 로고    scopus 로고
    • Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor
    • doi: 10.1523/JNEUROSCI.3647-11.2011
    • May, P. C., Dean, R. A., Lowe, S. L., Martenyi, F., Sheehan, S. M., Boggs, L. N., et al. (2011). Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor. J. Neurosci. 31, 16507-16516. doi: 10.1523/JNEUROSCI.3647-11.2011.
    • (2011) J. Neurosci. , vol.31 , pp. 16507-16516
    • May, P.C.1    Dean, R.A.2    Lowe, S.L.3    Martenyi, F.4    Sheehan, S.M.5    Boggs, L.N.6
  • 50
    • 0035193659 scopus 로고    scopus 로고
    • Divergence pattern of animal gene families and relationship with the Cambrian explosion
    • doi: 10.1002/bies.1147
    • Miyata, T., and Suga, H. (2001). Divergence pattern of animal gene families and relationship with the Cambrian explosion. Bioessays 23, 1018-1027. doi: 10.1002/bies.1147.
    • (2001) Bioessays , vol.23 , pp. 1018-1027
    • Miyata, T.1    Suga, H.2
  • 51
    • 33744807179 scopus 로고    scopus 로고
    • Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling
    • doi: 10.1101/gr.4871006
    • Morin, R. D., Chang, E., Petrescu, A., Liao, N., Griffith, M., Chow, W., et al. (2006). Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling. Genome Res. 16, 796-803. doi: 10.1101/gr.4871006.
    • (2006) Genome Res. , vol.16 , pp. 796-803
    • Morin, R.D.1    Chang, E.2    Petrescu, A.3    Liao, N.4    Griffith, M.5    Chow, W.6
  • 52
    • 40349100482 scopus 로고    scopus 로고
    • Recent progress in the medicinal chemistry of gamma-secretase inhibitors
    • doi: 10.2174/156802608783334088
    • Olson, R. E., and Albright, C. F. (2008). Recent progress in the medicinal chemistry of gamma-secretase inhibitors. Curr. Top. Med. Chem. 8, 17-33. doi: 10.2174/156802608783334088.
    • (2008) Curr. Top. Med. Chem. , vol.8 , pp. 17-33
    • Olson, R.E.1    Albright, C.F.2
  • 53
    • 84873077107 scopus 로고    scopus 로고
    • Chasing the urmetazoon: striking a blow for quality data?
    • doi: 10.1016/j.ympev.2012.05.028
    • Osigus, H.-J., Eitel, M., and Schierwater, B. (2013). Chasing the urmetazoon: striking a blow for quality data? Mol. Phylogenet. Evol. 66, 551-557. doi: 10.1016/j.ympev.2012.05.028.
    • (2013) Mol. Phylogenet. Evol. , vol.66 , pp. 551-557
    • Osigus, H.-J.1    Eitel, M.2    Schierwater, B.3
  • 54
    • 34249857539 scopus 로고    scopus 로고
    • COBALT: constraint-based alignment tool for multiple protein sequences
    • doi: 10.1093/bioinformatics/btm076
    • Papadopoulos, J. S., and Agarwala, R. (2007). COBALT: constraint-based alignment tool for multiple protein sequences. Bioinformatics 23, 1073-1079. doi: 10.1093/bioinformatics/btm076.
    • (2007) Bioinformatics , vol.23 , pp. 1073-1079
    • Papadopoulos, J.S.1    Agarwala, R.2
  • 55
    • 32544436264 scopus 로고    scopus 로고
    • Forgotten and novel aspects in pancreas development
    • doi: 10.1042/BC20050069
    • Pieler, T., and Chen, Y. (2006). Forgotten and novel aspects in pancreas development. Biol. Cell 98, 79-88. doi: 10.1042/BC20050069.
    • (2006) Biol. Cell , vol.98 , pp. 79-88
    • Pieler, T.1    Chen, Y.2
  • 56
    • 84861512510 scopus 로고    scopus 로고
    • Small-molecule BACE1 inhibitors: a patent literature review (2006-2011)
    • doi: 10.1517/13543776.2012.681302
    • Probst, G., and Xu, Y. (2012). Small-molecule BACE1 inhibitors: a patent literature review (2006-2011). Expert Opin. Ther. Pat. 22, 511-540. doi: 10.1517/13543776.2012.681302.
    • (2012) Expert Opin. Ther. Pat. , vol.22 , pp. 511-540
    • Probst, G.1    Xu, Y.2
  • 57
    • 67650064594 scopus 로고    scopus 로고
    • The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes
    • doi: 10.1101/gr.080531.108
    • Pruitt, K. D., Harrow, J., Harte, R. A., Wallin, C., Diekhans, M., Maglott, D. R., et al. (2009). The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes. Genome Res. 19, 1316-1323. doi: 10.1101/gr.080531.108.
    • (2009) Genome Res. , vol.19 , pp. 1316-1323
    • Pruitt, K.D.1    Harrow, J.2    Harte, R.A.3    Wallin, C.4    Diekhans, M.5    Maglott, D.R.6
  • 58
    • 12344328859 scopus 로고    scopus 로고
    • Pigment pattern evolution by differential deployment of neural crest and post-embryonic melanophore lineages in Danio fishes
    • doi: 10.1242/dev.01526
    • Quigley, I. K., Turner, J. M., Nuckels, R. J., Manuel, J. L., Budi, E. H., MacDonald, E. L., et al. (2004). Pigment pattern evolution by differential deployment of neural crest and post-embryonic melanophore lineages in Danio fishes. Development 131, 6053-6069. doi: 10.1242/dev.01526.
    • (2004) Development , vol.131 , pp. 6053-6069
    • Quigley, I.K.1    Turner, J.M.2    Nuckels, R.J.3    Manuel, J.L.4    Budi, E.H.5    MacDonald, E.L.6
  • 60
    • 70350442584 scopus 로고    scopus 로고
    • Pepsin homologues in bacteria
    • doi: 10.1186/1471-2164-10-437
    • Rawlings, N. D., and Bateman, A. (2009). Pepsin homologues in bacteria. BMC Genomics 10:437. doi: 10.1186/1471-2164-10-437.
    • (2009) BMC Genomics , vol.10 , pp. 437
    • Rawlings, N.D.1    Bateman, A.2
  • 62
    • 84879544231 scopus 로고    scopus 로고
    • BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells
    • doi: 10.1073/pnas.1220748110
    • Rochin, L., Hurbain, I., Serneels, L., Fort, C., Watt, B., Leblanc, P., et al. (2013). BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells. Proc. Natl. Acad. Sci. U.S.A. 110, 10658-10663. doi: 10.1073/pnas.1220748110.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 10658-10663
    • Rochin, L.1    Hurbain, I.2    Serneels, L.3    Fort, C.4    Watt, B.5    Leblanc, P.6
  • 64
    • 79958026120 scopus 로고    scopus 로고
    • Cathepsins, S., B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease
    • doi: 10.1515/bc.2011.054
    • Schechter, I., and Ziv, E. (2011). Cathepsins, S., B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease. Biol. Chem. 392, 555-569. doi: 10.1515/bc.2011.054.
    • (2011) Biol. Chem. , vol.392 , pp. 555-569
    • Schechter, I.1    Ziv, E.2
  • 65
    • 35348860241 scopus 로고    scopus 로고
    • Presenilin: running with scissors in the membrane
    • doi: 10.1016/j.cell.2007.10.012
    • Selkoe, D. J., and Wolfe, M. S. (2007). Presenilin: running with scissors in the membrane. Cell 131, 215-221. doi: 10.1016/j.cell.2007.10.012.
    • (2007) Cell , vol.131 , pp. 215-221
    • Selkoe, D.J.1    Wolfe, M.S.2
  • 66
    • 84879020737 scopus 로고    scopus 로고
    • The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage
    • doi: 10.1186/gb-2013-14-3-r28
    • Shaffer, H. B., Minx, P., Warren, D. E., Shedlock, A. M., Thomson, R. C., Valenzuela, N., et al. (2013). The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol. 14:R28. doi: 10.1186/gb-2013-14-3-r28.
    • (2013) Genome Biol. , vol.14
    • Shaffer, H.B.1    Minx, P.2    Warren, D.E.3    Shedlock, A.M.4    Thomson, R.C.5    Valenzuela, N.6
  • 67
    • 84865448747 scopus 로고    scopus 로고
    • FigShare
    • doi: 10.4103/0976-500X.81919
    • Singh, J. (2011). FigShare. J. Pharmacol. Pharmacother. 2, 138-139. doi: 10.4103/0976-500X.81919.
    • (2011) J. Pharmacol. Pharmacother. , vol.2 , pp. 138-139
    • Singh, J.1
  • 68
    • 0033518251 scopus 로고    scopus 로고
    • Purification and cloning of amyloid precursor protein beta-secretase from human brain
    • doi: 10.1038/990114
    • Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., et al. (1999). Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402, 537-540. doi: 10.1038/990114.
    • (1999) Nature , vol.402 , pp. 537-540
    • Sinha, S.1    Anderson, J.P.2    Barbour, R.3    Basi, G.S.4    Caccavello, R.5    Davis, D.6
  • 69
    • 34250815182 scopus 로고    scopus 로고
    • Exploiting new genome data and Internet resources for the phylogenetic analysis of proteases, substrates and inhibitors
    • doi: 10.1042/BST0350599
    • Southan, C. (2007). Exploiting new genome data and Internet resources for the phylogenetic analysis of proteases, substrates and inhibitors. Biochem. Soc. Trans. 35, 599-603. doi: 10.1042/BST0350599.
    • (2007) Biochem. Soc. Trans. , vol.35 , pp. 599-603
    • Southan, C.1
  • 70
    • 84876545164 scopus 로고    scopus 로고
    • BACE2 as a new diabetes target: a patent review (2010-2012)
    • doi: 10.1517/13543776.2013.780032
    • Southan, C. (2013). BACE2 as a new diabetes target: a patent review (2010-2012). Expert Opin. Ther. Pat. 23, 649-663. doi: 10.1517/13543776.2013.780032.
    • (2013) Expert Opin. Ther. Pat. , vol.23 , pp. 649-663
    • Southan, C.1
  • 71
    • 79959444149 scopus 로고    scopus 로고
    • Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: ranking 1654 human protein targets by assayed compounds and molecular scaffolds
    • doi: 10.1186/1758-2946-3-14
    • Southan, C., Boppana, K., Jagarlapudi, S. A., and Muresan, S. (2011). Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: ranking 1654 human protein targets by assayed compounds and molecular scaffolds. J. Cheminform. 3, 14. doi: 10.1186/1758-2946-3-14.
    • (2011) J. Cheminform. , vol.3 , pp. 14
    • Southan, C.1    Boppana, K.2    Jagarlapudi, S.A.3    Muresan, S.4
  • 72
    • 50049092481 scopus 로고    scopus 로고
    • The Trichoplax genome and the nature of placozoans
    • doi: 10.1038/nature07191
    • Srivastava, M., Begovic, E., Chapman, J., Putnam, N. H., Hellsten, U., Kawashima, T., et al. (2008). The Trichoplax genome and the nature of placozoans. Nature 454, 955-960. doi: 10.1038/nature07191.
    • (2008) Nature , vol.454 , pp. 955-960
    • Srivastava, M.1    Begovic, E.2    Chapman, J.3    Putnam, N.H.4    Hellsten, U.5    Kawashima, T.6
  • 73
    • 84868540195 scopus 로고    scopus 로고
    • Discovery of an orally available, brain penetrant BACE1 inhibitor that affords robust CNS Aβ Reduction
    • doi: 10.1021/ml3001165
    • Stamford, A. W., Scott, J. D., Li, S. W., Babu, S., Tadesse, D., Hunter, R., et al. (2012). Discovery of an orally available, brain penetrant BACE1 inhibitor that affords robust CNS Aβ Reduction. ACS Med. Chem. Lett. 3, 897-902. doi: 10.1021/ml3001165.
    • (2012) ACS Med. Chem. Lett. , vol.3 , pp. 897-902
    • Stamford, A.W.1    Scott, J.D.2    Li, S.W.3    Babu, S.4    Tadesse, D.5    Hunter, R.6
  • 74
    • 53849123621 scopus 로고    scopus 로고
    • Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease
    • doi: 10.1007/s00018-008-8271-3
    • Stockley, J. H., and O'Neill, C. (2008). Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease. Cell. Mol. Life Sci. 65, 3265-3289. doi: 10.1007/s00018-008-8271-3.
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 3265-3289
    • Stockley, J.H.1    O'Neill, C.2
  • 75
    • 84867641403 scopus 로고    scopus 로고
    • Sharing and re-use of phylogenetic trees (and associated data) to facilitate synthesis
    • doi: 10.1186/1756-0500-5-574
    • Stoltzfus, A., O'Meara, B., Whitacre, J., Mounce, R., Gillespie, E. L., Kumar, S., et al. (2012). Sharing and re-use of phylogenetic trees (and associated data) to facilitate synthesis. BMC Res. Notes 5:574. doi: 10.1186/1756-0500-5-574.
    • (2012) BMC Res. Notes , vol.5 , pp. 574
    • Stoltzfus, A.1    O'Meara, B.2    Whitacre, J.3    Mounce, R.4    Gillespie, E.L.5    Kumar, S.6
  • 76
    • 84876263985 scopus 로고    scopus 로고
    • Systematic proteomic analysis identifies β-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic β-cells
    • doi: 10.1074/jbc.M112.444703
    • Stützer, I., Selevsek, N., Esterházy, D., Schmidt, A., Aebersold, R., and Stoffel, M. (2013). Systematic proteomic analysis identifies β-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic β-cells. J. Biol. Chem. 288, 10536-10547. doi: 10.1074/jbc.M112.444703.
    • (2013) J. Biol. Chem. , vol.288 , pp. 10536-10547
    • Stützer, I.1    Selevsek, N.2    Esterházy, D.3    Schmidt, A.4    Aebersold, R.5    Stoffel, M.6
  • 77
    • 33746549926 scopus 로고    scopus 로고
    • BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome
    • doi: 10.1096/fj.05-5632com
    • Sun, X., He, G., and Song, W. (2006). BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome. FASEB J. 20, 1369-1376. doi: 10.1096/fj.05-5632com.
    • (2006) FASEB J. , vol.20 , pp. 1369-1376
    • Sun, X.1    He, G.2    Song, W.3
  • 78
    • 20944444583 scopus 로고    scopus 로고
    • Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes
    • doi: 10.1096/fj.04-3426com
    • Sun, X., Wang, Y., Qing, H., Christensen, M. A., Liu, Y., Zhou, W., et al. (2005). Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes. FASEB J. 19, 739-749. doi: 10.1096/fj.04-3426com.
    • (2005) FASEB J. , vol.19 , pp. 739-749
    • Sun, X.1    Wang, Y.2    Qing, H.3    Christensen, M.A.4    Liu, Y.5    Zhou, W.6
  • 79
    • 78049386104 scopus 로고    scopus 로고
    • Viable mouse gene ablations that robustly alter brain Aβ levels are rare
    • doi: 10.1186/1471-2202-11-143
    • Toyn, J. H., Lin, X.-A., Thompson, M. W., Guss, V., Meredith, J. E., Sankaranarayanan, S., et al. (2010). Viable mouse gene ablations that robustly alter brain Aβ levels are rare. BMC Neurosci. 11:143. doi: 10.1186/1471-2202-11-143.
    • (2010) BMC Neurosci. , vol.11 , pp. 143
    • Toyn, J.H.1    Lin, X.-A.2    Thompson, M.W.3    Guss, V.4    Meredith, J.E.5    Sankaranarayanan, S.6
  • 80
    • 84887031752 scopus 로고    scopus 로고
    • Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes
    • doi: 10.1111/jnc.12198
    • Van Bebber, F., Hruscha, A., Willem, M., Schmid, B., and Haass, C. (2013). Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes. J. Neurochem. 127, 471-481. doi: 10.1111/jnc.12198.
    • (2013) J. Neurochem. , vol.127 , pp. 471-481
    • Van Bebber, F.1    Hruscha, A.2    Willem, M.3    Schmid, B.4    Haass, C.5
  • 81
    • 0033595706 scopus 로고    scopus 로고
    • Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
    • doi: 10.1126/science.286.5440.735
    • Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., et al. (1999). Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741. doi: 10.1126/science.286.5440.735.
    • (1999) Science , vol.286 , pp. 735-741
    • Vassar, R.1    Bennett, B.D.2    Babu-Khan, S.3    Kahn, S.4    Mendiaz, E.A.5    Denis, P.6
  • 82
    • 34247342594 scopus 로고    scopus 로고
    • Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome
    • doi: 10.1371/journal.pbio.0050101
    • Venkatesh, B., Kirkness, E. F., Loh, Y. H., Halpern, A. L., Lee, A. P., Johnson, J., et al. (2007). Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome. PLoS Biol. 5:e101. doi: 10.1371/journal.pbio.0050101.
    • (2007) PLoS Biol. , vol.5
    • Venkatesh, B.1    Kirkness, E.F.2    Loh, Y.H.3    Halpern, A.L.4    Lee, A.P.5    Johnson, J.6
  • 84
    • 62149091579 scopus 로고    scopus 로고
    • Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts
    • doi: 10.1074/jbc.M808920200
    • Vetrivel, K. S., Meckler, X., Chen, Y., Nguyen, P. D., Seidah, N. G., Vassar, R., et al. (2009). Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J. Biol. Chem. 284, 3793-3803. doi: 10.1074/jbc.M808920200.
    • (2009) J. Biol. Chem. , vol.284 , pp. 3793-3803
    • Vetrivel, K.S.1    Meckler, X.2    Chen, Y.3    Nguyen, P.D.4    Seidah, N.G.5    Vassar, R.6
  • 85
    • 84867516398 scopus 로고    scopus 로고
    • Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid
    • doi: 10.1021/jm300119p
    • Weiss, M. M., Williamson, T., Babu-Khan, S., Bartberger, M. D., Brown, J., Chen, K., et al. (2012). Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid. J. Med. Chem. 55, 9009-9024. doi: 10.1021/jm300119p.
    • (2012) J. Med. Chem. , vol.55 , pp. 9009-9024
    • Weiss, M.M.1    Williamson, T.2    Babu-Khan, S.3    Bartberger, M.D.4    Brown, J.5    Chen, K.6
  • 86
    • 84866322498 scopus 로고    scopus 로고
    • γ-Secretase modulator in Alzheimer's disease: shifting the end
    • doi: 10.3233/Jad-2012-120751
    • Xia, W., Wong, S. T., Hanlon, E., and Morin, P. (2012). γ-Secretase modulator in Alzheimer's disease: shifting the end. J. Alzheimer's Dis. 31, 685-696. doi: 10.3233/Jad-2012-120751.
    • (2012) J. Alzheimer's Dis. , vol.31 , pp. 685-696
    • Xia, W.1    Wong, S.T.2    Hanlon, E.3    Morin, P.4
  • 87
    • 0033518264 scopus 로고    scopus 로고
    • Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
    • doi: 10.1038/990107
    • Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., et al. (1999). Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402, 533-537. doi: 10.1038/990107.
    • (1999) Nature , vol.402 , pp. 533-537
    • Yan, R.1    Bienkowski, M.J.2    Shuck, M.E.3    Miao, H.4    Tory, M.C.5    Pauley, A.M.6
  • 88
    • 84866152524 scopus 로고    scopus 로고
    • Adaptive evolution of voltage-gated sodium channels: the first 800 million years
    • doi: 10.1073/pnas.1201884109
    • Zakon, H. H. (2012). Adaptive evolution of voltage-gated sodium channels: the first 800 million years. Proc. Natl. Acad. Sci. U.S.A. 109(Suppl.), 10619-10625. doi: 10.1073/pnas.1201884109.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , Issue.SUPPL. , pp. 10619-10625
    • Zakon, H.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.