메뉴 건너뛰기




Volumn 88, Issue Part B, 2015, Pages 168-178

Roles of Nrf2 in cell proliferation and differentiation

Author keywords

Cell proliferation; Differentiation; Keap1 Nrf2 system; Stem cells

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CCAAT ENHANCER BINDING PROTEIN BETA; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; RETINOID X RECEPTOR ALPHA; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR RUNX2; SIGNAL PEPTIDE;

EID: 84970951874     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.06.030     Document Type: Review
Times cited : (196)

References (152)
  • 1
    • 7244253081 scopus 로고    scopus 로고
    • Nrf2-Keap1 defines a physiologically important stress response mechanism
    • H. Motohashi, and M. Yamamoto Nrf2-Keap1 defines a physiologically important stress response mechanism Trends Mol. Med. 10 2004 549 557
    • (2004) Trends Mol. Med. , vol.10 , pp. 549-557
    • Motohashi, H.1    Yamamoto, M.2
  • 2
    • 0028061444 scopus 로고
    • Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region
    • P. Moi, K. Chan, I. Asunis, and et al. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region Proc. Natl. Acad. Sci. USA 91 1994 9926 9930
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9926-9930
    • Moi, P.1    Chan, K.2    Asunis, I.3
  • 3
    • 0029043995 scopus 로고
    • Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins
    • K. Itoh, K. Igarashi, N. Hayashi, and et al. Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins Mol. Cell. Biol. 15 1995 4184 4193
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4184-4193
    • Itoh, K.1    Igarashi, K.2    Hayashi, N.3
  • 4
    • 0028118492 scopus 로고
    • Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins
    • K. Igarashi, K. Kataoka, K. Itoh, and et al. Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins Nature 367 1994 568 572
    • (1994) Nature , vol.367 , pp. 568-572
    • Igarashi, K.1    Kataoka, K.2    Itoh, K.3
  • 5
    • 0028986047 scopus 로고
    • Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor
    • K. Kataoka, K. Igarashi, K. Itoh, and et al. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor Mol. Cell. Biol. 15 1995 2180 2190
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2180-2190
    • Kataoka, K.1    Igarashi, K.2    Itoh, K.3
  • 6
    • 0033637756 scopus 로고    scopus 로고
    • Positive or negative MARE-dependent transcriptional regulation is determined by the abundance of small Maf proteins
    • H. Motohashi, F. Katsuoka, J.A. Shavit, and et al. Positive or negative MARE-dependent transcriptional regulation is determined by the abundance of small Maf proteins Cell 103 2000 865 875
    • (2000) Cell , vol.103 , pp. 865-875
    • Motohashi, H.1    Katsuoka, F.2    Shavit, J.A.3
  • 7
    • 33745030048 scopus 로고    scopus 로고
    • MafG sumoylation is required for active transcriptional repression
    • H. Motohashi, F. Katsuoka, C. Miyoshi, and et al. MafG sumoylation is required for active transcriptional repression Mol. Cell. Biol. 26 2006 4652 4663
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 4652-4663
    • Motohashi, H.1    Katsuoka, F.2    Miyoshi, C.3
  • 8
    • 78751682729 scopus 로고    scopus 로고
    • Molecular determinants for small Maf protein control of platelet production
    • H. Motohashi, R. Fujita, M. Takayama, and et al. Molecular determinants for small Maf protein control of platelet production Mol. Cell. Biol. 31 2011 151 162
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 151-162
    • Motohashi, H.1    Fujita, R.2    Takayama, M.3
  • 9
    • 33646739904 scopus 로고    scopus 로고
    • Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements
    • T. Yamamoto, M. Kyo, T. Kamiya, and et al. Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements Genes Cells 11 2006 575 591
    • (2006) Genes Cells , vol.11 , pp. 575-591
    • Yamamoto, T.1    Kyo, M.2    Kamiya, T.3
  • 10
    • 36349030396 scopus 로고    scopus 로고
    • Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer
    • M. Kimura, T. Yamamoto, J. Zhang, and et al. Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer J. Biol. Chem. 282 2007 33681 33690
    • (2007) J. Biol. Chem. , vol.282 , pp. 33681-33690
    • Kimura, M.1    Yamamoto, T.2    Zhang, J.3
  • 11
    • 84869076474 scopus 로고    scopus 로고
    • Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks
    • Y. Hirotsu, F. Katsuoka, R. Funayama, and et al. Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks Nucleic Acids Res. 40 2012 10228 10239
    • (2012) Nucleic Acids Res. , vol.40 , pp. 10228-10239
    • Hirotsu, Y.1    Katsuoka, F.2    Funayama, R.3
  • 12
    • 84880682967 scopus 로고    scopus 로고
    • NF-E2 p45 is important for establishing normal function of platelets
    • R. Fujita, M. Takayama-Tsujimoto, H. Satoh, and et al. NF-E2 p45 is important for establishing normal function of platelets Mol. Cell. Biol. 33 2013 2659 2670
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 2659-2670
    • Fujita, R.1    Takayama-Tsujimoto, M.2    Satoh, H.3
  • 13
    • 0025145723 scopus 로고
    • Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element
    • R.S. Frilling, A. Bensimon, Y. Tichauer, and et al. Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element Proc. Natl. Acad. Sci. USA 87 1990 6258 6262
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6258-6262
    • Frilling, R.S.1    Bensimon, A.2    Tichauer, Y.3
  • 14
    • 0024997241 scopus 로고
    • Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants
    • T.H. Rushmore, and C.B. Pickett Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants J. Biol. Chem. 265 1990 14648 14653
    • (1990) J. Biol. Chem. , vol.265 , pp. 14648-14653
    • Rushmore, T.H.1    Pickett, C.B.2
  • 15
    • 0025948113 scopus 로고
    • The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity
    • T.H. Rushmore, M.R. Morton, and C.B. Pickett The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity J. Biol. Chem. 266 1991 11632 11639
    • (1991) J. Biol. Chem. , vol.266 , pp. 11632-11639
    • Rushmore, T.H.1    Morton, M.R.2    Pickett, C.B.3
  • 16
    • 34648813720 scopus 로고    scopus 로고
    • ROS as signaling molecules: Mechanisms that generate specificity in ROS homeostasis
    • B. D'Autréaux, and M.B. Toledano ROS as signaling molecules: mechanisms that generate specificity in ROS homeostasis Nat. Rev. Mol. Cell Biol. 8 2007 813 824
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 813-824
    • D'Autréaux, B.1    Toledano, M.B.2
  • 17
    • 84929379555 scopus 로고    scopus 로고
    • Oxidative stress, redox regulation and diseases of cellular differentiation
    • Z.W. Ye, J. Zhang, D.W. Townsend, and et al. Oxidative stress, redox regulation and diseases of cellular differentiation Biochim. Biophys. Acta 1850 2015 1607 1621
    • (2015) Biochim. Biophys. Acta , vol.1850 , pp. 1607-1621
    • Ye, Z.W.1    Zhang, J.2    Townsend, D.W.3
  • 18
    • 84857116578 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
    • P.D. Ray, B.W. Huang, and Y. Tsuji Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling Cell Signal. 24 2012 981 990
    • (2012) Cell Signal. , vol.24 , pp. 981-990
    • Ray, P.D.1    Huang, B.W.2    Tsuji, Y.3
  • 19
    • 75749136883 scopus 로고    scopus 로고
    • Signaling functions of reactive oxygen species
    • H.J. Forman, M. Maiorino, and F. Ursini Signaling functions of reactive oxygen species Biochemistry 49 2010 835 842
    • (2010) Biochemistry , vol.49 , pp. 835-842
    • Forman, H.J.1    Maiorino, M.2    Ursini, F.3
  • 20
    • 79954504166 scopus 로고    scopus 로고
    • Basic principles and emerging concepts in the redox control of transcription factors
    • R. Brigelius-Flohé, and L. Flohé Basic principles and emerging concepts in the redox control of transcription factors Antioxid. Redox Signal. 15 2011 2335 2381
    • (2011) Antioxid. Redox Signal. , vol.15 , pp. 2335-2381
    • Brigelius-Flohé, R.1    Flohé, L.2
  • 21
    • 84897421970 scopus 로고    scopus 로고
    • The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
    • J.D. Hayes, and A.T. Dinkova-Kostova The Nrf2 regulatory network provides an interface between redox and intermediary metabolism Trends Biochem. Sci. 39 2014 199 218
    • (2014) Trends Biochem. Sci. , vol.39 , pp. 199-218
    • Hayes, J.D.1    Dinkova-Kostova, A.T.2
  • 22
    • 34447132814 scopus 로고    scopus 로고
    • Skeletal remodeling in health and disease
    • M. Zaidi Skeletal remodeling in health and disease Nat. Med. 13 2007 791 801
    • (2007) Nat. Med. , vol.13 , pp. 791-801
    • Zaidi, M.1
  • 23
    • 0025236484 scopus 로고
    • Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo
    • I.R. Garrett, B.F. Boyce, R.O. Oreffo, and et al. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo J. Clin. Invest. 85 1990 632 639
    • (1990) J. Clin. Invest. , vol.85 , pp. 632-639
    • Garrett, I.R.1    Boyce, B.F.2    Oreffo, R.O.3
  • 24
    • 0142186681 scopus 로고    scopus 로고
    • A crucial role for thiol antioxidants in estrogen-deficiency bone loss
    • J.M. Lean, J.T. Davies, K. Fuller, and et al. A crucial role for thiol antioxidants in estrogen-deficiency bone loss J. Clin. Invest. 112 2003 915 923
    • (2003) J. Clin. Invest. , vol.112 , pp. 915-923
    • Lean, J.M.1    Davies, J.T.2    Fuller, K.3
  • 25
    • 84883641346 scopus 로고    scopus 로고
    • Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation
    • S. Hyeon, H. Lee, Y. Yang, and et al. Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation Free Radic. Biol. Med. 65 2013 789 799
    • (2013) Free Radic. Biol. Med. , vol.65 , pp. 789-799
    • Hyeon, S.1    Lee, H.2    Yang, Y.3
  • 26
    • 84881399163 scopus 로고    scopus 로고
    • The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling
    • H. Kanzaki, F. Shinohara, M. Kajiya, and et al. The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling J. Biol. Chem. 288 2013 23009 23020
    • (2013) J. Biol. Chem. , vol.288 , pp. 23009-23020
    • Kanzaki, H.1    Shinohara, F.2    Kajiya, M.3
  • 27
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • P. Ducy, R. Zhang, V. Geoffroy, and et al. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation Cell 89 1997 747 754
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3
  • 28
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • T. Komori, H. Yagi, S. Nomura, and et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts Cell 89 1997 755 764
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3
  • 29
    • 33745871571 scopus 로고    scopus 로고
    • Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activation
    • E. Hinoi, S. Fujimori, L. Wang, and et al. Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activation J. Biol. Chem. 281 2006 18015 18024
    • (2006) J. Biol. Chem. , vol.281 , pp. 18015-18024
    • Hinoi, E.1    Fujimori, S.2    Wang, L.3
  • 30
    • 0032949156 scopus 로고    scopus 로고
    • Maturational disturbance of chondrocytes in Cbfa1-deficient mice
    • M. Inada, T. Yasui, S. Nomura, and et al. Maturational disturbance of chondrocytes in Cbfa1-deficient mice Dev. Dyn. 214 1999 279 290
    • (1999) Dev. Dyn. , vol.214 , pp. 279-290
    • Inada, M.1    Yasui, T.2    Nomura, S.3
  • 31
    • 33846003498 scopus 로고    scopus 로고
    • Nuclear factor p45-related factor 2 negatively regulates chondrogenesis
    • E. Hinoi, T. Takarada, S. Fujimori, and et al. Nuclear factor p45-related factor 2 negatively regulates chondrogenesis Bone 40 2007 337 344
    • (2007) Bone , vol.40 , pp. 337-344
    • Hinoi, E.1    Takarada, T.2    Fujimori, S.3
  • 32
    • 84896048226 scopus 로고    scopus 로고
    • Nrf2 is a novel regulator of bone acquisition
    • C.K. Park, Y. Lee, K.H. Kim, and et al. Nrf2 is a novel regulator of bone acquisition Bone 63 2014 36 46
    • (2014) Bone , vol.63 , pp. 36-46
    • Park, C.K.1    Lee, Y.2    Kim, K.H.3
  • 33
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • D.L. Lacey, E. Timms, H.L. Tan, and et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation Cell 93 1998 165 176
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3
  • 34
    • 7344233085 scopus 로고    scopus 로고
    • Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
    • J.G. Emery, P. McDonnell, M.B. Burke, and et al. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL J. Biol. Chem. 273 1998 14363 14367
    • (1998) J. Biol. Chem. , vol.273 , pp. 14363-14367
    • Emery, J.G.1    McDonnell, P.2    Burke, M.B.3
  • 35
    • 80155175720 scopus 로고    scopus 로고
    • Rapid loss of bone mass and strength in mice after abdominal irradiation
    • D. Jia, D. Gaddy, L.J. Suva, and et al. Rapid loss of bone mass and strength in mice after abdominal irradiation Radiat. Res. 176 2011 624 635
    • (2011) Radiat. Res. , vol.176 , pp. 624-635
    • Jia, D.1    Gaddy, D.2    Suva, L.J.3
  • 36
    • 73949122265 scopus 로고    scopus 로고
    • Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse
    • H. Kondo, K. Yumoto, J.S. Alwood, and et al. Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse J. Appl. Physiol. 108 2010 152 161
    • (2010) J. Appl. Physiol. , vol.108 , pp. 152-161
    • Kondo, H.1    Yumoto, K.2    Alwood, J.S.3
  • 37
    • 84870211726 scopus 로고    scopus 로고
    • Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL
    • T. Rana, M.A. Schultz, M.L. Freeman, and et al. Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL Free Radic. Biol. Med. 53 2012 2298 2307
    • (2012) Free Radic. Biol. Med. , vol.53 , pp. 2298-2307
    • Rana, T.1    Schultz, M.A.2    Freeman, M.L.3
  • 38
    • 77950553993 scopus 로고    scopus 로고
    • Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity
    • J. Pi, L. Leung, P. Xue, and et al. Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity J. Biol. Chem. 285 2010 9292 9300
    • (2010) J. Biol. Chem. , vol.285 , pp. 9292-9300
    • Pi, J.1    Leung, L.2    Xue, P.3
  • 39
    • 84855453637 scopus 로고    scopus 로고
    • Nuclear factor erythroid-derived factor2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis
    • Y. Hou, P. Xue, Y. Bai, and et al. Nuclear factor erythroid-derived factor2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis Free Radic. Biol. Med. 52 2012 462 472
    • (2012) Free Radic. Biol. Med. , vol.52 , pp. 462-472
    • Hou, Y.1    Xue, P.2    Bai, Y.3
  • 40
    • 80054911514 scopus 로고    scopus 로고
    • Forming functional fat: A growing understanding of adipocyte differentiation
    • A.G. Cristancho, and M.A. Lazar Forming functional fat: a growing understanding of adipocyte differentiation Nat. Rev. Mol. Cell Biol. 12 2011 722 734
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 722-734
    • Cristancho, A.G.1    Lazar, M.A.2
  • 41
    • 84873336694 scopus 로고    scopus 로고
    • Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome
    • P. Xue, Y. Hou, Y. Chen, and et al. Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome Diabetes 62 2013 845 854
    • (2013) Diabetes , vol.62 , pp. 845-854
    • Xue, P.1    Hou, Y.2    Chen, Y.3
  • 42
    • 84870361939 scopus 로고    scopus 로고
    • Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice
    • J. Xu, S.R. Kulkarni, A.C. Donepudi, and et al. Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice Diabetes 61 2012 3208 3218
    • (2012) Diabetes , vol.61 , pp. 3208-3218
    • Xu, J.1    Kulkarni, S.R.2    Donepudi, A.C.3
  • 43
    • 35148823513 scopus 로고    scopus 로고
    • Nrf2 modulates aryl hydrocarbon receptor signaling: Influence on adipogenesis
    • S. Shin, N. Wakabayashi, V. Misra, and et al. Nrf2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis Mol. Cell. Biol. 27 2007 7188 7197
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 7188-7197
    • Shin, S.1    Wakabayashi, N.2    Misra, V.3
  • 44
    • 84867317004 scopus 로고    scopus 로고
    • Identification of novel Nrf2-regulated genes by ChIP-Seq: Influence on retinoid X receptor alpha
    • B.N. Chorley, M.R. Campbell, X. Wang, and et al. Identification of novel Nrf2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha Nucleic Acids Res. 40 2012 7416 7429
    • (2012) Nucleic Acids Res. , vol.40 , pp. 7416-7429
    • Chorley, B.N.1    Campbell, M.R.2    Wang, X.3
  • 45
    • 77951865861 scopus 로고    scopus 로고
    • Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARγ in obese mice and humans
    • B. Lefebvre, Y. Benomar, A. Guédin, and et al. Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARγ in obese mice and humans J. Clin. Invest. 120 2010 1454 1468
    • (2010) J. Clin. Invest. , vol.120 , pp. 1454-1468
    • Lefebvre, B.1    Benomar, Y.2    Guédin, A.3
  • 46
    • 84880682182 scopus 로고    scopus 로고
    • The Keap1-Nrf2 system prevents onset of diabetes mellitus
    • A. Uruno, Y. Furusawa, Y. Yagishita, and et al. The Keap1-Nrf2 system prevents onset of diabetes mellitus Mol. Cell. Biol. 33 2013 2996 3010
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 2996-3010
    • Uruno, A.1    Furusawa, Y.2    Yagishita, Y.3
  • 47
    • 84893132156 scopus 로고    scopus 로고
    • Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice
    • Y. Yagishita, T. Fukutomi, A. Sugawara, and et al. Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice Diabetes 63 2014 605 618
    • (2014) Diabetes , vol.63 , pp. 605-618
    • Yagishita, Y.1    Fukutomi, T.2    Sugawara, A.3
  • 48
    • 33646193400 scopus 로고    scopus 로고
    • The antioxidant glutathione peroxidase family and spermatozoa: A complex story
    • J.R. Drevet The antioxidant glutathione peroxidase family and spermatozoa: a complex story Mol. Cell. Endocrinol. 250 2006 70 79
    • (2006) Mol. Cell. Endocrinol. , vol.250 , pp. 70-79
    • Drevet, J.R.1
  • 49
    • 84907856420 scopus 로고    scopus 로고
    • Effect of oxidative stress on male reproduction
    • A. Agarwal, G. Virk, C. Ong, and et al. Effect of oxidative stress on male reproduction World J. Mens Health 32 2014 1 17
    • (2014) World J. Mens Health , vol.32 , pp. 1-17
    • Agarwal, A.1    Virk, G.2    Ong, C.3
  • 50
    • 77957233987 scopus 로고    scopus 로고
    • Knockout of the transcription factor Nrf2 disrupts spermatogenesis in an age-dependent manner
    • B.N. Nakamura, G. Lawson, J.Y. Chan, and et al. Knockout of the transcription factor Nrf2 disrupts spermatogenesis in an age-dependent manner Free Radic. Biol. Med. 49 2010 1368 1379
    • (2010) Free Radic. Biol. Med. , vol.49 , pp. 1368-1379
    • Nakamura, B.N.1    Lawson, G.2    Chan, J.Y.3
  • 51
    • 84868103295 scopus 로고    scopus 로고
    • Genetic variation in the Nrf2 promoter associates with defective spermatogenesis in humans
    • B. Yu, H. Lin, L. Yang, and et al. Genetic variation in the Nrf2 promoter associates with defective spermatogenesis in humans J. Mol. Med. 90 2012 1333 1342
    • (2012) J. Mol. Med. , vol.90 , pp. 1333-1342
    • Yu, B.1    Lin, H.2    Yang, L.3
  • 52
    • 84878620505 scopus 로고    scopus 로고
    • Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels
    • T. Suzuki, T. Shibata, K. Takaya, and et al. Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels Mol. Cell. Biol. 33 2013 2402 2412
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 2402-2412
    • Suzuki, T.1    Shibata, T.2    Takaya, K.3
  • 53
    • 84865436984 scopus 로고    scopus 로고
    • Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice
    • H.Y. Cho, B. van Houten, X. Wang, and et al. Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice Antioxid. Redox Signal. 17 2012 1066 1082
    • (2012) Antioxid. Redox Signal. , vol.17 , pp. 1066-1082
    • Cho, H.Y.1    Van Houten, B.2    Wang, X.3
  • 54
    • 84870848726 scopus 로고    scopus 로고
    • Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero
    • A.J. Huebner, D. Dai, M. Morasso, and et al. Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero Dev. Cell 23 2012 1238 1246
    • (2012) Dev. Cell , vol.23 , pp. 1238-1246
    • Huebner, A.J.1    Dai, D.2    Morasso, M.3
  • 55
    • 34250007142 scopus 로고    scopus 로고
    • Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    • D.J. Rossi, D. Bryder, J. Seita, and et al. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age Nature 447 2007 725 730
    • (2007) Nature , vol.447 , pp. 725-730
    • Rossi, D.J.1    Bryder, D.2    Seita, J.3
  • 56
    • 38349132624 scopus 로고    scopus 로고
    • Deconstructing stem cell self-renewal: Genetic insights into cell cycle regulation
    • K.W. Orford, and D.T. Scadden Deconstructing stem cell self-renewal: genetic insights into cell cycle regulation Nat. Rev. Genet. 9 2008 115 128
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 115-128
    • Orford, K.W.1    Scadden, D.T.2
  • 57
    • 84875965163 scopus 로고    scopus 로고
    • Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
    • I. Beerman, C. Bock, B.S. Garrison, and et al. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging Cell Stem Cell 12 2013 413 425
    • (2013) Cell Stem Cell , vol.12 , pp. 413-425
    • Beerman, I.1    Bock, C.2    Garrison, B.S.3
  • 58
    • 84878240136 scopus 로고    scopus 로고
    • Molecular regulation of stem cell quiescence
    • T.H. Cheung, and T.A. Rando Molecular regulation of stem cell quiescence Nat. Rev. Mol. Cell Biol. 14 2013 329 340
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 329-340
    • Cheung, T.H.1    Rando, T.A.2
  • 59
    • 84875902088 scopus 로고    scopus 로고
    • Redox homeostasis: The linchpin in stem cell self-renewal and differentiation
    • K. Wang, T. Zhang, Q. Dong, and et al. Redox homeostasis: the linchpin in stem cell self-renewal and differentiation Cell Death Dis 4 2013 e537
    • (2013) Cell Death Dis , vol.4 , pp. e537
    • Wang, K.1    Zhang, T.2    Dong, Q.3
  • 60
    • 78650968492 scopus 로고    scopus 로고
    • Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner
    • J.E. Le Belle, N.M. Orozco, A.A. Paucar, and et al. Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner Cell Stem Cell 8 2011 59 71
    • (2011) Cell Stem Cell , vol.8 , pp. 59-71
    • Le Belle, J.E.1    Orozco, N.M.2    Paucar, A.A.3
  • 61
    • 84878889056 scopus 로고    scopus 로고
    • ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation
    • K.B. Myant, P. Cammareri, E.J. McGhee, and et al. ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation Cell Stem Cell 12 2013 761 773
    • (2013) Cell Stem Cell , vol.12 , pp. 761-773
    • Myant, K.B.1    Cammareri, P.2    McGhee, E.J.3
  • 62
    • 35548936968 scopus 로고    scopus 로고
    • A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
    • Y.Y. Jang, and S.J. Sharkis A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche Blood 110 2007 3056 3063
    • (2007) Blood , vol.110 , pp. 3056-3063
    • Jang, Y.Y.1    Sharkis, S.J.2
  • 63
    • 34249882777 scopus 로고    scopus 로고
    • Foxo3a is essential for maintenance of the hematopoietic stem cell pool
    • K. Miyamoto, K.Y. Araki, K. Naka, and et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool Cell Stem Cell 1 2007 101 112
    • (2007) Cell Stem Cell , vol.1 , pp. 101-112
    • Miyamoto, K.1    Araki, K.Y.2    Naka, K.3
  • 64
    • 33645730667 scopus 로고    scopus 로고
    • Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
    • K. Ito, A. Hirao, F. Arai, and et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells Nat. Med. 12 2006 446 451
    • (2006) Nat. Med. , vol.12 , pp. 446-451
    • Ito, K.1    Hirao, A.2    Arai, F.3
  • 65
    • 79551610653 scopus 로고    scopus 로고
    • Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila
    • C.E. Hochmuth, B. Biteau, D. Bohmann, and et al. Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila Cell Stem Cell 8 2011 188 199
    • (2011) Cell Stem Cell , vol.8 , pp. 188-199
    • Hochmuth, C.E.1    Biteau, B.2    Bohmann, D.3
  • 66
    • 84919701110 scopus 로고    scopus 로고
    • Even free radicals follow some rules: A guide to free radical research terminology and methodology
    • H.J. Forman, O. Augusto, R. Brigelius-Flohe, and et al. Even free radicals follow some rules: a guide to free radical research terminology and methodology Free Radic. Biol. Med. 78 2015 233 235
    • (2015) Free Radic. Biol. Med. , vol.78 , pp. 233-235
    • Forman, H.J.1    Augusto, O.2    Brigelius-Flohe, R.3
  • 67
    • 84655163961 scopus 로고    scopus 로고
    • Measuring reactive oxygen and nitrogen species with fluorescent probes: Challenges and limitations
    • B. Kalyanaraman, V. Darley-Usmar, K.J. Davies, and et al. Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations Free Radic. Biol. Med. 52 2012 1 6
    • (2012) Free Radic. Biol. Med. , vol.52 , pp. 1-6
    • Kalyanaraman, B.1    Darley-Usmar, V.2    Davies, K.J.3
  • 68
    • 69149106207 scopus 로고    scopus 로고
    • Basal cells as stem cells of the mouse trachea and human airway epithelium
    • J.R. Rock, M.W. Onaitis, E.L. Rawlins, and et al. Basal cells as stem cells of the mouse trachea and human airway epithelium Proc. Natl. Acad. Sci. USA 106 2009 12771 12775
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 12771-12775
    • Rock, J.R.1    Onaitis, M.W.2    Rawlins, E.L.3
  • 69
    • 79960858341 scopus 로고    scopus 로고
    • Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential
    • A.E. Hegab, V.L. Ha, J.L. Gilbert, and et al. Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential Stem Cells 29 2011 1283 1293
    • (2011) Stem Cells , vol.29 , pp. 1283-1293
    • Hegab, A.E.1    Ha, V.L.2    Gilbert, J.L.3
  • 70
    • 84905905334 scopus 로고    scopus 로고
    • Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling
    • M.K. Paul, B. Bisht, D.O. Darmawan, and et al. Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling Cell Stem Cell 15 2014 199 214
    • (2014) Cell Stem Cell , vol.15 , pp. 199-214
    • Paul, M.K.1    Bisht, B.2    Darmawan, D.O.3
  • 71
    • 84908094625 scopus 로고    scopus 로고
    • Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells
    • J. Jang, Y. Wang, H.S. Kim, and et al. Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells Stem Cells 32 2014 2616 2625
    • (2014) Stem Cells , vol.32 , pp. 2616-2625
    • Jang, J.1    Wang, Y.2    Kim, H.S.3
  • 72
    • 0347989458 scopus 로고    scopus 로고
    • Cellular and molecular regulation of muscle regeneration
    • S.B. Chargé, and M.A. Rudnicki Cellular and molecular regulation of muscle regeneration Physiol. Rev. 84 2004 209 238
    • (2004) Physiol. Rev. , vol.84 , pp. 209-238
    • Chargé, S.B.1    Rudnicki, M.A.2
  • 73
    • 37549054341 scopus 로고    scopus 로고
    • The emerging biology of satellite cells and their therapeutic potential
    • S. Kuang, and M.A. Rudnicki The emerging biology of satellite cells and their therapeutic potential Trends Mol. Med. 14 2008 82 91
    • (2008) Trends Mol. Med. , vol.14 , pp. 82-91
    • Kuang, S.1    Rudnicki, M.A.2
  • 74
    • 84910606993 scopus 로고    scopus 로고
    • Nrf2 augments skeletal muscle regeneration after ischaemia-reperfusion injury
    • O. Al-Sawaf, A. Fragoulis, C. Rosen, and et al. Nrf2 augments skeletal muscle regeneration after ischaemia-reperfusion injury J. Pathol. 234 2014 538 547
    • (2014) J. Pathol. , vol.234 , pp. 538-547
    • Al-Sawaf, O.1    Fragoulis, A.2    Rosen, C.3
  • 75
    • 84902578456 scopus 로고    scopus 로고
    • Nrf2 regulates neurogenesis and protects neural progenitor cells against Aβ toxicity
    • V. Kärkkäinen, Y. Pomeshchik, E. Savchenko, and et al. Nrf2 regulates neurogenesis and protects neural progenitor cells against Aβ toxicity Stem Cells 32 2014 1904 1916
    • (2014) Stem Cells , vol.32 , pp. 1904-1916
    • Kärkkäinen, V.1    Pomeshchik, Y.2    Savchenko, E.3
  • 76
    • 68349155690 scopus 로고    scopus 로고
    • Nrf2 promotes neuronal cell differentiation
    • F. Zhao, T. Wu, A. Lau, and et al. Nrf2 promotes neuronal cell differentiation Free Radic. Biol. Med. 47 2009 867 879
    • (2009) Free Radic. Biol. Med. , vol.47 , pp. 867-879
    • Zhao, F.1    Wu, T.2    Lau, A.3
  • 77
    • 56549128268 scopus 로고    scopus 로고
    • Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    • A. Wilson, E. Laurenti, G. Oser, and et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair Cell 135 2008 1118 1129
    • (2008) Cell , vol.135 , pp. 1118-1129
    • Wilson, A.1    Laurenti, E.2    Oser, G.3
  • 78
    • 84908125658 scopus 로고    scopus 로고
    • Clonal dynamics of native haematopoiesis
    • J. Sun, A. Ramos, B. Chapman, and et al. Clonal dynamics of native haematopoiesis Nature 514 2014 322 327
    • (2014) Nature , vol.514 , pp. 322-327
    • Sun, J.1    Ramos, A.2    Chapman, B.3
  • 79
    • 66149115277 scopus 로고    scopus 로고
    • IFNα activates dormant haematopoietic stem cell in vivo
    • M.A. Essers, S. Offner, W.E. Blanco-Bose, and et al. IFNα activates dormant haematopoietic stem cell in vivo Nature 458 2009 904 908
    • (2009) Nature , vol.458 , pp. 904-908
    • Essers, M.A.1    Offner, S.2    Blanco-Bose, W.E.3
  • 80
    • 77953462161 scopus 로고    scopus 로고
    • Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection
    • M.T. Baldridge, K.Y. King, N.C. Boles, and et al. Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection Nature 465 2010 793 797
    • (2010) Nature , vol.465 , pp. 793-797
    • Baldridge, M.T.1    King, K.Y.2    Boles, N.C.3
  • 81
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    • Z. Tothova, R. Kollipara, B.J. Huntly, and et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress Cell 128 2007 325 339
    • (2007) Cell , vol.128 , pp. 325-339
    • Tothova, Z.1    Kollipara, R.2    Huntly, B.J.3
  • 82
    • 34248359065 scopus 로고    scopus 로고
    • Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    • K. Parmar, P. Mauch, J.A. Vergilio, and et al. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia Proc. Natl. Acad. Sci. USA 104 2007 5431 5436
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 5431-5436
    • Parmar, K.1    Mauch, P.2    Vergilio, J.A.3
  • 83
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • C. Chen, Y. Liu, R. Liu, and et al. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species J. Exp. Med. 205 2008 2397 2408
    • (2008) J. Exp. Med. , vol.205 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3
  • 84
    • 84055177613 scopus 로고    scopus 로고
    • The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels
    • A.A. Merchant, A. Singh, W. Matsui, and et al. The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels Blood 118 2011 6572 6579
    • (2011) Blood , vol.118 , pp. 6572-6579
    • Merchant, A.A.1    Singh, A.2    Matsui, W.3
  • 85
    • 84874655208 scopus 로고    scopus 로고
    • Nrf2 regulates haematopoietic stem cell function
    • J.J. Tsai, J.A. Dudakov, K. Takahashi, and et al. Nrf2 regulates haematopoietic stem cell function Nat. Cell Biol. 15 2013 309 316
    • (2013) Nat. Cell Biol. , vol.15 , pp. 309-316
    • Tsai, J.J.1    Dudakov, J.A.2    Takahashi, K.3
  • 86
    • 33845445939 scopus 로고    scopus 로고
    • Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    • T. Sugiyama, H. Kohara, M. Noda, and et al. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches Immunity 25 2006 977 988
    • (2006) Immunity , vol.25 , pp. 977-988
    • Sugiyama, T.1    Kohara, H.2    Noda, M.3
  • 87
    • 84893836947 scopus 로고    scopus 로고
    • Nrf2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation
    • J.H. Kim, R.K. Thimmulappa, V. Kumar, and et al. Nrf2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation J. Clin. Invest. 124 2014 730 741
    • (2014) J. Clin. Invest. , vol.124 , pp. 730-741
    • Kim, J.H.1    Thimmulappa, R.K.2    Kumar, V.3
  • 88
    • 84894462190 scopus 로고    scopus 로고
    • Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells
    • S. Murakami, R. Shimizu, P.H. Romeo, and et al. Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells Genes Cells 19 2014 239 253
    • (2014) Genes Cells , vol.19 , pp. 239-253
    • Murakami, S.1    Shimizu, R.2    Romeo, P.H.3
  • 89
    • 79951527854 scopus 로고    scopus 로고
    • The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells
    • I. Bobilev, V. Novik, I. Levi, and et al. The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells Cancer Biol. Ther. 11 2011 317 329
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 317-329
    • Bobilev, I.1    Novik, V.2    Levi, I.3
  • 90
    • 3042716482 scopus 로고    scopus 로고
    • Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia
    • J.M. Lee, K. Chan, Y.W. Kan, and et al. Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia Proc. Nat. Acad. Sci. USA 101 2004 9751 9756
    • (2004) Proc. Nat. Acad. Sci. USA , vol.101 , pp. 9751-9756
    • Lee, J.M.1    Chan, K.2    Kan, Y.W.3
  • 91
    • 78751691722 scopus 로고    scopus 로고
    • Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia
    • Y. Kawatani, T. Suzuki, R. Shimizu, and et al. Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia Blood 117 2011 986 996
    • (2011) Blood , vol.117 , pp. 986-996
    • Kawatani, Y.1    Suzuki, T.2    Shimizu, R.3
  • 92
    • 77449114227 scopus 로고    scopus 로고
    • NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation
    • H. Motohashi, M. Kimura, R. Fujita, and et al. NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation Blood 115 2010 677 686
    • (2010) Blood , vol.115 , pp. 677-686
    • Motohashi, H.1    Kimura, M.2    Fujita, R.3
  • 93
    • 0028061444 scopus 로고
    • Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP-1 repeat of the beta-globin locus control region
    • P. Moi., K. Chan, I. Asunis, and et al. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP-1 repeat of the beta-globin locus control region Proc. Natl. Acad. Sci. USA 91 1994 9926 9930
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9926-9930
    • Moi, P.1    Chan, K.2    Asunis, I.3
  • 94
    • 0030451213 scopus 로고    scopus 로고
    • Nrf2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
    • K. Chan, R. Lu, J.C. Chang, and et al. Nrf2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development Proc. Natl. Acad. Sci. USA 93 1996 13943 13948
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13943-13948
    • Chan, K.1    Lu, R.2    Chang, J.C.3
  • 95
    • 0031577292 scopus 로고    scopus 로고
    • An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
    • K. Itoh, T. Chiba, S. Takahashi, and et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements Biochem. Biophys. Res. Commun. 236 1997 313 322
    • (1997) Biochem. Biophys. Res. Commun. , vol.236 , pp. 313-322
    • Itoh, K.1    Chiba, T.2    Takahashi, S.3
  • 96
    • 0031914328 scopus 로고    scopus 로고
    • Ablation of Nrf2 function does not increase the erythroid or megakaryocytic cell lineage dysfunction caused by p45 NF-E2 gene disruption
    • T. Kuroha, S. Takahashi, T. Komeno, and et al. Ablation of Nrf2 function does not increase the erythroid or megakaryocytic cell lineage dysfunction caused by p45 NF-E2 gene disruption J. Biochem. 123 1998 376 379
    • (1998) J. Biochem. , vol.123 , pp. 376-379
    • Kuroha, T.1    Takahashi, S.2    Komeno, T.3
  • 97
    • 0029051295 scopus 로고
    • Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development
    • R.A. Shivdasani, M.F. Rosenblatt, D. Zucker-Fanklin, and et al. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development Cell 81 1995 695 704
    • (1995) Cell , vol.81 , pp. 695-704
    • Shivdasani, R.A.1    Rosenblatt, M.F.2    Zucker-Fanklin, D.3
  • 98
    • 77952607108 scopus 로고    scopus 로고
    • Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis
    • M. Takayama, R. Fujita, M. Suzuki, and et al. Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis Mol. Cell. Biol. 30 2010 2668 2680
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 2668-2680
    • Takayama, M.1    Fujita, R.2    Suzuki, M.3
  • 99
    • 0027243681 scopus 로고
    • Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein
    • N.C. Andrews, H. Erdjument-Bromage, M.B. Davidson, and et al. Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein Nature 362 1993 722 728
    • (1993) Nature , vol.362 , pp. 722-728
    • Andrews, N.C.1    Erdjument-Bromage, H.2    Davidson, M.B.3
  • 100
    • 69849107771 scopus 로고    scopus 로고
    • Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy
    • D.J. McCrann, A. Eliades, M. Makitalo, and et al. Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy Blood 114 2009 1243 1249
    • (2009) Blood , vol.114 , pp. 1243-1249
    • McCrann, D.J.1    Eliades, A.2    Makitalo, M.3
  • 101
    • 0028247214 scopus 로고
    • Cloning and functional characterization of LCR-F1: A bZIP transcription factor that activates erythroid-specific, human globin gene expression
    • J.J. Caterina, D. Donze, C.W. Sun, and et al. Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression Nucleic Acids Res. 22 1994 2383 2391
    • (1994) Nucleic Acids Res. , vol.22 , pp. 2383-2391
    • Caterina, J.J.1    Donze, D.2    Sun, C.W.3
  • 102
    • 0033525730 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3
    • A. Kobayashi, E. Ito, T. Toki, and et al. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3 J. Biol. Chem. 274 1999 6443 6452
    • (1999) J. Biol. Chem. , vol.274 , pp. 6443-6452
    • Kobayashi, A.1    Ito, E.2    Toki, T.3
  • 103
    • 0029805130 scopus 로고    scopus 로고
    • Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site
    • T. Oyake, K. Itoh, H. Motohashi, and et al. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site Mol. Cell. Biol. 16 1996 6083 6095
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 6083-6095
    • Oyake, T.1    Itoh, K.2    Motohashi, H.3
  • 104
    • 18644378321 scopus 로고    scopus 로고
    • Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene
    • J. Sun, H. Hoshino, K. Takaku, and et al. Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene EMBO J. 21 2002 5216 5224
    • (2002) EMBO J. , vol.21 , pp. 5216-5224
    • Sun, J.1    Hoshino, H.2    Takaku, K.3
  • 105
    • 0037313210 scopus 로고    scopus 로고
    • Small Maf compound mutants display central nervous system neuronal degeneration, aberrant transcription, and Bach protein mislocalization coincident with myoclonus and abnormal startle response
    • F. Katsuoka, H. Motohashi, Y. Tamagawa, and et al. Small Maf compound mutants display central nervous system neuronal degeneration, aberrant transcription, and Bach protein mislocalization coincident with myoclonus and abnormal startle response Mol. Cell. Biol. 23 2003 1163 1174
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 1163-1174
    • Katsuoka, F.1    Motohashi, H.2    Tamagawa, Y.3
  • 106
    • 84907149982 scopus 로고    scopus 로고
    • Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes
    • T. Tsujita, V. Peirce, L. Baird, and et al. Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes Mol. Cell. Biol. 34 2014 3800 3816
    • (2014) Mol. Cell. Biol. , vol.34 , pp. 3800-3816
    • Tsujita, T.1    Peirce, V.2    Baird, L.3
  • 107
    • 84911200778 scopus 로고    scopus 로고
    • The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program
    • A. Itoh-Nakadai, R. Hikota, A. Muto, and et al. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program Nat. Immunol. 15 2014 1171 1180
    • (2014) Nat. Immunol. , vol.15 , pp. 1171-1180
    • Itoh-Nakadai, A.1    Hikota, R.2    Muto, A.3
  • 108
    • 0032189224 scopus 로고    scopus 로고
    • Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer
    • A. Muto, H. Hoshino, L. Madisen, and et al. Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer EMBO J. 17 1998 5734 5743
    • (1998) EMBO J. , vol.17 , pp. 5734-5743
    • Muto, A.1    Hoshino, H.2    Madisen, L.3
  • 109
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • A. Singh, and J. Settleman EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer Oncogene 29 2010 4741 4751
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 110
    • 84884558125 scopus 로고    scopus 로고
    • Unravelling cancer stem potential
    • B. Beck, and C. Blanpain Unravelling cancer stem potential Nat. Rev. Cancer 13 2013 727 738
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 727-738
    • Beck, B.1    Blanpain, C.2
  • 111
    • 84866894408 scopus 로고    scopus 로고
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers Nature 489 2012 519 525
    • (2012) Nature , vol.489 , pp. 519-525
  • 112
    • 84885735554 scopus 로고    scopus 로고
    • Mutational landscape and significance across 12 major cancer types
    • C. Kandoth, M.D. McLellan, F. Vandin, and et al. Mutational landscape and significance across 12 major cancer types Nature 502 2013 333 339
    • (2013) Nature , vol.502 , pp. 333-339
    • Kandoth, C.1    McLellan, M.D.2    Vandin, F.3
  • 113
    • 84905029258 scopus 로고    scopus 로고
    • Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma
    • Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma Nature 511 2014 543 550
    • (2014) Nature , vol.511 , pp. 543-550
  • 114
    • 33344456501 scopus 로고    scopus 로고
    • Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
    • B. Padmanabhan, K.I. Tong, T. Ohta, and et al. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer Mol. Cell 21 2006 689 700
    • (2006) Mol. Cell , vol.21 , pp. 689-700
    • Padmanabhan, B.1    Tong, K.I.2    Ohta, T.3
  • 115
    • 40449107193 scopus 로고    scopus 로고
    • Loos of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
    • T. Ohta, K. Iijima, M. Miyamoto, and et al. Loos of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth Cancer Res. 68 2008 1303 1309
    • (2008) Cancer Res. , vol.68 , pp. 1303-1309
    • Ohta, T.1    Iijima, K.2    Miyamoto, M.3
  • 116
    • 51649130168 scopus 로고    scopus 로고
    • Cancer related mutations in Nrf2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
    • T. Shibata, T. Ohta, T.I. Tong, and et al. Cancer related mutations in Nrf2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy Proc. Natl. Acad. Sci. USA 105 2008 13568 13573
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 13568-13573
    • Shibata, T.1    Ohta, T.2    Tong, T.I.3
  • 117
    • 77954695549 scopus 로고    scopus 로고
    • Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
    • L.M. Solis, C. Behrens, M. Suraokar, and et al. Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features Clin. Cancer Res. 16 2010 3743 3753
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3743-3753
    • Solis, L.M.1    Behrens, C.2    Suraokar, M.3
  • 118
    • 84862811895 scopus 로고    scopus 로고
    • Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma
    • D. Inoue, T. Suzuki, Y. Mitsuishi, and et al. Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma Cancer Sci. 103 2012 760 766
    • (2012) Cancer Sci. , vol.103 , pp. 760-766
    • Inoue, D.1    Suzuki, T.2    Mitsuishi, Y.3
  • 119
    • 84899865579 scopus 로고    scopus 로고
    • Nrf2 immunolocalization in human breast cancer patients as a prognostic factor
    • Y. Onodera, H. Motohashi, K. Takagi, and et al. Nrf2 immunolocalization in human breast cancer patients as a prognostic factor Endocr. Relat. Cancer 21 2014 241 252
    • (2014) Endocr. Relat. Cancer , vol.21 , pp. 241-252
    • Onodera, Y.1    Motohashi, H.2    Takagi, K.3
  • 120
    • 84938700155 scopus 로고    scopus 로고
    • Activation of the Nrf2 pathway and its impact on the prognosis of anaplastic glioma patients
    • M. Kanamori, T. Higa, Y. Sonoda, and et al. Activation of the Nrf2 pathway and its impact on the prognosis of anaplastic glioma patients Nrueo-oncol. 17 2015 555 565
    • (2015) Nrueo-oncol. , vol.17 , pp. 555-565
    • Kanamori, M.1    Higa, T.2    Sonoda, Y.3
  • 122
    • 84873410837 scopus 로고    scopus 로고
    • Glioblastoma cancer stem cells: Role of the microenvironment and therapeutic targeting
    • L. Persano, E. Rampazzo, G. Basso, and et al. Glioblastoma cancer stem cells: role of the microenvironment and therapeutic targeting Biochem. Pharmacol. 85 2013 612 622
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 612-622
    • Persano, L.1    Rampazzo, E.2    Basso, G.3
  • 123
    • 84881121768 scopus 로고    scopus 로고
    • Nrf2 is required to maintain the self-renewal of glioma stem cells
    • J. Zhu, H. Wang, Q. Sun, and et al. Nrf2 is required to maintain the self-renewal of glioma stem cells BMC Cancer 13 2013 380
    • (2013) BMC Cancer , vol.13 , pp. 380
    • Zhu, J.1    Wang, H.2    Sun, Q.3
  • 124
    • 84892970411 scopus 로고    scopus 로고
    • Differential Nrf2 expression between glioma stem cells and non-stem-like cells in glioblastoma
    • J. Zhu, H. Wang, X. Ji, and et al. Differential Nrf2 expression between glioma stem cells and non-stem-like cells in glioblastoma Oncol. Lett 7 2014 693 698
    • (2014) Oncol. Lett , vol.7 , pp. 693-698
    • Zhu, J.1    Wang, H.2    Ji, X.3
  • 125
    • 84925593582 scopus 로고    scopus 로고
    • Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma
    • E. Singer, J. Judkins, N. Salomonis, and et al. Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma Cell Death Dis 6 2015 e1601
    • (2015) Cell Death Dis , vol.6 , pp. e1601
    • Singer, E.1    Judkins, J.2    Salomonis, N.3
  • 126
    • 84920464700 scopus 로고    scopus 로고
    • De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling
    • C.A. Del Vecchio, Y. Feng, E.S. Sokol, and et al. De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling PLoS Biol. 12 2014 e1001945
    • (2014) PLoS Biol. , vol.12 , pp. e1001945
    • Del Vecchio, C.A.1    Feng, Y.2    Sokol, E.S.3
  • 127
    • 38049055294 scopus 로고    scopus 로고
    • Impaired liver regeneration in Nrf2 knockout mice: Role of ROS-mediated insulin/IGF-1 resistance
    • T.A. Beyer, W. Xu, D. Teupser, and et al. Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance EMBO J. 27 2008 212 223
    • (2008) EMBO J. , vol.27 , pp. 212-223
    • Beyer, T.A.1    Xu, W.2    Teupser, D.3
  • 128
    • 33645799492 scopus 로고    scopus 로고
    • Mechanisms of liver injury. I. TNF-α-induced liver injury: Role of IKK, JNK, and ROS pathways
    • R.F. Schwabe, and D.A. Brenner Mechanisms of liver injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathways Am. J. Physiol. Gastrointest. Liver Physiol. 290 2006 G583 G589
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.290 , pp. G583-G589
    • Schwabe, R.F.1    Brenner, D.A.2
  • 129
    • 77956640097 scopus 로고    scopus 로고
    • Regulation of notch1 signaling by nrf2: Implications for tissue regeneration
    • N. Wakabayashi, S. Shin, S.L. Slocum, and et al. Regulation of notch1 signaling by nrf2: implications for tissue regeneration Sci. Signal. 3 2010 ra52
    • (2010) Sci. Signal. , vol.3 , pp. ra52
    • Wakabayashi, N.1    Shin, S.2    Slocum, S.L.3
  • 130
    • 84901603042 scopus 로고    scopus 로고
    • NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice
    • K. Shirasaki, K. Taguchi, M. Unno, and et al. NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice Hepatology 59 2014 2371 2382
    • (2014) Hepatology , vol.59 , pp. 2371-2382
    • Shirasaki, K.1    Taguchi, K.2    Unno, M.3
  • 131
    • 84863764614 scopus 로고    scopus 로고
    • Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
    • Y. Mitsuishi, K. Taguchi, Y. Kawatani, and et al. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming Cancer Cell 22 2012 66 79
    • (2012) Cancer Cell , vol.22 , pp. 66-79
    • Mitsuishi, Y.1    Taguchi, K.2    Kawatani, Y.3
  • 132
    • 84893822502 scopus 로고    scopus 로고
    • Nrf2 enhances cholangiocyte expansion in Pten-deficient livers
    • K. Taguchi, I. Hirano, T. Itoh, and et al. Nrf2 enhances cholangiocyte expansion in Pten-deficient livers Mol. Cell. Biol. 34 2014 900 913
    • (2014) Mol. Cell. Biol. , vol.34 , pp. 900-913
    • Taguchi, K.1    Hirano, I.2    Itoh, T.3
  • 133
    • 79952256187 scopus 로고    scopus 로고
    • SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
    • P. Rada, A.I. Rojo, S. Chowdhry, and et al. SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner Mol. Cell. Biol. 31 2011 1121 1133
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 1121-1133
    • Rada, P.1    Rojo, A.I.2    Chowdhry, S.3
  • 134
    • 84855458875 scopus 로고    scopus 로고
    • Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3
    • A.I. Rojo, O.N. Medina-Campos, P. Rada, and et al. Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3 Free Radic. Biol. Med. 52 2012 473 487
    • (2012) Free Radic. Biol. Med. , vol.52 , pp. 473-487
    • Rojo, A.I.1    Medina-Campos, O.N.2    Rada, P.3
  • 135
    • 77957237159 scopus 로고    scopus 로고
    • Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
    • D. Malhotra, E. Portales-Casamar, A. Singh, and et al. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis Nucleic Acids Res. 38 2010 5718 5734
    • (2010) Nucleic Acids Res. , vol.38 , pp. 5718-5734
    • Malhotra, D.1    Portales-Casamar, E.2    Singh, A.3
  • 136
    • 84922935931 scopus 로고    scopus 로고
    • Nrf2 is essential for timely M-phase entry of replicating hepatocytes during liver regeneration
    • Y. Zou, M. Hu, J. Lee, and et al. Nrf2 is essential for timely M-phase entry of replicating hepatocytes during liver regeneration Am. J. Physiol. Gastrointest. Liver Physiol. 308 2015 G262 G268
    • (2015) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.308 , pp. G262-G268
    • Zou, Y.1    Hu, M.2    Lee, J.3
  • 137
    • 53249154670 scopus 로고    scopus 로고
    • Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling
    • N.M. Reddy, S.R. Kleeberger, J.H. Bream, and et al. Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling Oncogene 27 2008 5821 5832
    • (2008) Oncogene , vol.27 , pp. 5821-5832
    • Reddy, N.M.1    Kleeberger, S.R.2    Bream, J.H.3
  • 138
    • 0346882614 scopus 로고    scopus 로고
    • Wee1-dependent mechanisms required for coordination of cell growth and cell division
    • D.R. Kellogg Wee1-dependent mechanisms required for coordination of cell growth and cell division J. Cell Sci. 116 2003 4883 4890
    • (2003) J. Cell Sci. , vol.116 , pp. 4883-4890
    • Kellogg, D.R.1
  • 139
    • 84872184195 scopus 로고    scopus 로고
    • Phosphorylation network dynamics in the control of cell cycle transitions
    • D. Fisher, L. Krasinska, D. Coudreuse, and et al. Phosphorylation network dynamics in the control of cell cycle transitions J. Cell Sci. 125 2012 4703 4711
    • (2012) J. Cell Sci. , vol.125 , pp. 4703-4711
    • Fisher, D.1    Krasinska, L.2    Coudreuse, D.3
  • 140
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • G.M. DeNicola, F.A. Karreth, T.J. Humpton, and et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis Nature 475 2011 106 109
    • (2011) Nature , vol.475 , pp. 106-109
    • DeNicola, G.M.1    Karreth, F.A.2    Humpton, T.J.3
  • 141
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • R.J. DeBerardinis, J.J. Lum, G. Hatzivassiliou, and et al. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation Cell Metab. 7 2008 11 20
    • (2008) Cell Metab. , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3
  • 142
    • 84879661552 scopus 로고    scopus 로고
    • Transcription factor Nrf2 regulates miR-1 and miR-206 to drive tumorigenesis
    • A. Singh, C. Happel, S.K. Manna, and et al. Transcription factor Nrf2 regulates miR-1 and miR-206 to drive tumorigenesis J. Clin. Invest. 123 2013 2921 2934
    • (2013) J. Clin. Invest. , vol.123 , pp. 2921-2934
    • Singh, A.1    Happel, C.2    Manna, S.K.3
  • 143
    • 84964999321 scopus 로고    scopus 로고
    • Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
    • K.M. Holmström, L. Baird, Y. Zhang, and et al. Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration Biol. Open 2 2013 761 770
    • (2013) Biol. Open , vol.2 , pp. 761-770
    • Holmström, K.M.1    Baird, L.2    Zhang, Y.3
  • 144
    • 84924943241 scopus 로고    scopus 로고
    • Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria
    • K. Itoh, P. Ye, T. Matsumiya, and et al. Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria J. Clin. Biochem. Nutr. 56 2015 91 97
    • (2015) J. Clin. Biochem. Nutr. , vol.56 , pp. 91-97
    • Itoh, K.1    Ye, P.2    Matsumiya, T.3
  • 145
    • 84867040616 scopus 로고    scopus 로고
    • Mitochondrial SKN-1/Nrf mediates a conserved starvation response
    • J. Paek, J.Y. Lo, S.D. Narasimhan, and et al. Mitochondrial SKN-1/Nrf mediates a conserved starvation response Cell Metab. 16 2012 526 537
    • (2012) Cell Metab. , vol.16 , pp. 526-537
    • Paek, J.1    Lo, J.Y.2    Narasimhan, S.D.3
  • 146
    • 0042626242 scopus 로고    scopus 로고
    • SKN-1 links C. Elegans mesendodermal specification to a conserved oxidative stress response
    • J.H. An, and T.K. Blackwell SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response Genes Dev. 17 2003 1882 1893
    • (2003) Genes Dev. , vol.17 , pp. 1882-1893
    • An, J.H.1    Blackwell, T.K.2
  • 147
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C. Elegans
    • A.N. Bishop, and L. Guarente Two neurons mediate diet-restriction-induced longevity in C. elegans Nature 447 2007 545 549
    • (2007) Nature , vol.447 , pp. 545-549
    • Bishop, A.N.1    Guarente, L.2
  • 148
    • 40849118472 scopus 로고    scopus 로고
    • Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. Elegans
    • J.M. Tullet, M. Hertweck, J.H. An, and et al. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans Cell 132 2008 1025 1038
    • (2008) Cell , vol.132 , pp. 1025-1038
    • Tullet, J.M.1    Hertweck, M.2    An, J.H.3
  • 149
    • 84925488579 scopus 로고    scopus 로고
    • Dauer-independent insulin/IGF-1-signalling implicates collagen remodeling in longevity
    • C.Y. Ewald, J.N. Landis, J.P. Abate, and et al. Dauer-independent insulin/IGF-1-signalling implicates collagen remodeling in longevity Nature 519 2015 97 101
    • (2015) Nature , vol.519 , pp. 97-101
    • Ewald, C.Y.1    Landis, J.N.2    Abate, J.P.3
  • 150
    • 84925422896 scopus 로고    scopus 로고
    • Regulation of Nrf2 signaling and longevity in naturally long-lived rodents
    • K.N. Lewis, E. Wason, Y.H. Edrey, and et al. Regulation of Nrf2 signaling and longevity in naturally long-lived rodents Proc. Natl. Acad. Sci. USA 112 2015 3722 3737
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 3722-3737
    • Lewis, K.N.1    Wason, E.2    Edrey, Y.H.3
  • 151
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • V. Tremaroli, and F. Bäckhed Functional interactions between the gut microbiota and host metabolism Nature 489 2012 242 249
    • (2012) Nature , vol.489 , pp. 242-249
    • Tremaroli, V.1    Bäckhed, F.2
  • 152
    • 84866167497 scopus 로고    scopus 로고
    • Reciprocal interactions of the intestinal microbiota and immune system
    • C.L. Maynard, C.O. Elson, R.D. Hatton, and et al. Reciprocal interactions of the intestinal microbiota and immune system Nature 489 2012 231 241
    • (2012) Nature , vol.489 , pp. 231-241
    • Maynard, C.L.1    Elson, C.O.2    Hatton, R.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.