Oxidative stress, redox regulation and diseases of cellular differentiation

Biochimica et Biophysica Acta - General Subjects

Volumn 1850, Issue 8, 2015, Pages 1607-1621

  Ye, Zhi Wei ^a   Zhang, Jie ^a   Townsend, Danyelle M ^a   Tew, Kenneth D ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Diseases of cellular differentiation; Glutathione; Glutathione S transferase; Reactive oxygen species; Redox; Redox active drugs

Indexed keywords

ACETYLCYSTEINE; ADENANTHIN; AMIFOSTINE; ANTINEOPLASTIC AGENT; ANTIOCIDIN; ARSENIC TRIOXIDE; BUTYLATED HYDROXYANISOLE; CATALASE; EZATIOSTAT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HISTAMINE; INTERLEUKIN 2; LIPOXYGENASE; NITRIC OXIDE SYNTHASE; NORPHENAZONE; NOV 002; PEROXIREDOXIN; PROSTAGLANDIN SYNTHASE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; RETINOIC ACID; SHIKONIN; SUPEROXIDE DISMUTASE; THIOREDOXIN; UNCLASSIFIED DRUG; VORINOSTAT; XANTHINE OXIDASE; SCAVENGER;

ACUTE MYELOBLASTIC LEUKEMIA; ATHEROSCLEROSIS; BONE DISEASE; BRAIN ISCHEMIA; CANCER INHIBITION; CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; DRUG MECHANISM; DRUG SENSITIVITY; DRUG TARGETING; ELECTROPHILIC STRESS; FIBROSIS; HEMATOPOIESIS; HUMAN; LUNG FIBROSIS; MYELODYSPLASTIC SYNDROME; NEUROBLASTOMA; NEUROLOGIC DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOPHILICITY; OBESITY; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; REVIEW; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION; BIOLOGICAL MODEL; DRUG EFFECTS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACETYLCYSTEINE; CELL DIFFERENTIATION; FREE RADICAL SCAVENGERS; HUMANS; MODELS, BIOLOGICAL; OBESITY; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84929379555     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.11.010     Document Type: Review

References (225)

1. Y. Zhang, Y. Du, W. Le, K. Wang, N. Kieffer, and J. Zhang Redox control of the survival of healthy and diseased cells Antioxid. Redox Signal. 15 2011 2867 2908
2. M. Balazy, and S. Nigam Aging, lipid modifications and phospholipases - new concepts Ageing Res. Rev. 2 2003 191 209
3. J. Nordberg, and E.S. Arner Reactive oxygen species, antioxidants, and the mammalian thioredoxin system Free Radic. Biol. Med. 31 2001 1287 1312
4. B. Halliwell Free radicals and metal ions in health and disease Proc. Nutr. Soc. 46 1987 13 26
5. D. Trachootham, W. Lu, M.A. Ogasawara, R.D. Nilsa, and P. Huang Redox regulation of cell survival Antioxid. Redox Signal. 10 2008 1343 1374
6. P. Kuppusamy, and J.L. Zweier Characterization of free radical generation by xanthine oxidase. Evidence for hydroxyl radical generation J. Biol. Chem. 264 1989 9880 9884
7. K.M. Holmstrom, and T. Finkel Cellular mechanisms and physiological consequences of redox-dependent signalling Nat. Rev. Mol. Cell Biol. 15 2014 411 421
8. C. Lee, S.M. Lee, P. Mukhopadhyay, S.J. Kim, S.C. Lee, W.S. Ahn, M.H. Yu, G. Storz, and S.E. Ryu Redox regulation of OxyR requires specific disulfide bond formation involving a rapid kinetic reaction path Nat. Struct. Mol. Biol. 11 2004 1179 1185
9. J.M. McCord, and I. Fridovich Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein) J. Biol. Chem. 244 1969 6049 6055
10. I. Fridovich Superoxide anion radical (O2-.), superoxide dismutases, and related matters J. Biol. Chem. 272 1997 18515 18517
11. F.J. Yost Jr., and I. Fridovich An iron-containing superoxide dismutase from Escherichia coli J. Biol. Chem. 248 1973 4905 4908
12. M. Sundaresan, Z.X. Yu, V.J. Ferrans, K. Irani, and T. Finkel Requirement for generation of H2O2 for platelet-derived growth factor signal transduction Science 270 1995 296 299
13. F. Rossi, P. Bellavite, G. Berton, M. Grzeskowiak, and E. Papini Mechanism of production of toxic oxygen radicals by granulocytes and macrophages and their function in the inflammatory process Pathol. Res. Pract. 180 1985 136 142
14. R.B. Mikkelsen, and P. Wardman Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms Oncogene 22 2003 5734 5754
15. D.S. Bredt Endogenous nitric oxide synthesis: biological functions and pathophysiology Free Radic. Res. 31 1999 577 596
16. K.F. Beck, W. Eberhardt, S. Frank, A. Huwiler, U.K. Messmer, H. Muhl, and J. Pfeilschifter Inducible NO synthase: role in cellular signalling J. Exp. Biol. 202 1999 645 653
17. S. Hussain, W. Slikker Jr., and S.F. Ali Age-related changes in antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase and glutathione in different regions of mouse brain Int. J. Dev. Neurosci. 13 1995 811 817
18. R. Meli, T. Nauser, P. Latal, and W.H. Koppenol Reaction of peroxynitrite with carbon dioxide: intermediates and determination of the yield of CO3∗- and NO2∗ J. Biol. Inorg. Chem. 7 2002 31 36
19. J.R. Harris Release of a macromolecular protein component from human erythrocyte ghosts Biochim. Biophys. Acta 150 1968 534 537
20. M.D. Brand The sites and topology of mitochondrial superoxide production Exp. Gerontol. 45 2010 466 472
21. M.P. Murphy How mitochondria produce reactive oxygen species Biochem. J. 417 2009 1 13
22. Y.R. Chen, and J.L. Zweier Cardiac mitochondria and reactive oxygen species generation Circ. Res. 114 2014 524 537
23. L.A. Sena, and N.S. Chandel Physiological roles of mitochondrial reactive oxygen species Mol. Cell 48 2012 158 167
24. J.D. Malhotra, and R.J. Kaufman Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid. Redox Signal. 9 2007 2277 2293
25. B.P. Tu, S.C. Ho-Schleyer, K.J. Travers, and J.S. Weissman Biochemical basis of oxidative protein folding in the endoplasmic reticulum Science 290 2000 1571 1574
26. M.F. Princiotta, D. Finzi, S.B. Qian, J. Gibbs, S. Schuchmann, F. Buttgereit, J.R. Bennink, and J.W. Yewdell Quantitating protein synthesis, degradation, and endogenous antigen processing Immunity 18 2003 343 354
27. D.M. Townsend, Y. Manevich, L. He, Y. Xiong, R.R. Bowers Jr., S. Hutchens, and K.D. Tew Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response Cancer Res. 69 2009 7626 7634
28. G.C. Mills The purification and properties of glutathione peroxidase of erythrocytes J. Biol. Chem. 234 1959 502 506
29. G. Csordas, and G. Hajnoczky SR/ER-mitochondrial local communication: calcium and ROS Biochim. Biophys. Acta 1787 2009 1352 1362
30. S. Coso, I. Harrison, C.B. Harrison, A. Vinh, C.G. Sobey, G.R. Drummond, E.D. Williams, and S. Selemidis NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts Antioxid. Redox Signal. 16 2012 1229 1247
31. D.I. Brown, and K.K. Griendling Nox proteins in signal transduction Free Radic. Biol. Med. 47 2009 1239 1253
32. K. Bedard, and K.H. Krause The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology Physiol. Rev. 87 2007 245 313
33. S. Pendyala, P.V. Usatyuk, I.A. Gorshkova, J.G. Garcia, and V. Natarajan Regulation of NADPH oxidase in vascular endothelium: the role of phospholipases, protein kinases, and cytoskeletal proteins Antioxid. Redox Signal. 11 2009 841 860
34. M. Guida, T. Maraldi, F. Beretti, M.Y. Follo, L. Manzoli, and A. De Pol Nuclear Nox4-derived reactive oxygen species in myelodysplastic syndromes Biomed Res. Int. 2014 2014 456937
35. D. Zhou, L. Shao, and D.R. Spitz Reactive oxygen species in normal and tumor stem cells Adv. Cancer Res. 122 2014 1 67
36. K.M. Brown, and J.R. Arthur Selenium, selenoproteins and human health: a review Public Health Nutr. 4 2001 593 599
37. R.J. Hondal, and E.L. Ruggles Differing views of the role of selenium in thioredoxin reductase Amino Acids 41 2011 73 89
38. J. Limon-Pacheco, and M.E. Gonsebatt The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress Mutat. Res. 674 2009 137 147
39. H. Nightingale, K. Kemp, E. Gray, K. Hares, E. Mallam, N. Scolding, and A. Wilkins Changes in expression of the antioxidant enzyme SOD3 occur upon differentiation of human bone marrow-derived mesenchymal stem cells in vitro Stem Cells Dev. 21 2012 2026 2035
40. K. Kemp, E. Gray, E. Mallam, N. Scolding, and A. Wilkins Inflammatory cytokine induced regulation of superoxide dismutase 3 expression by human mesenchymal stem cells Stem Cell Rev. 6 2010 548 559
41. S.E. Schriner, N.J. Linford, G.M. Martin, P. Treuting, C.E. Ogburn, M. Emond, P.E. Coskun, W. Ladiges, N. Wolf, H. Van Remmen, D.C. Wallace, and P.S. Rabinovitch Extension of murine life span by overexpression of catalase targeted to mitochondria Science 308 2005 1909 1911
42. D.F. Dai, L.F. Santana, M. Vermulst, D.M. Tomazela, M.J. Emond, M.J. MacCoss, K. Gollahon, G.M. Martin, L.A. Loeb, W.C. Ladiges, and P.S. Rabinovitch Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging Circulation 119 2009 2789 2797
43. A.C. Liao, B.M. Craver, B.P. Tseng, K.K. Tran, V.K. Parihar, M.M. Acharya, and C.L. Limoli Mitochondrial-targeted human catalase affords neuroprotection from proton irradiation Radiat. Res. 180 2013 1 6
44. G. Bauer Targeting extracellular ROS signaling of tumor cells Anticancer Res. 34 2014 1467 1482
45. G. Bauer Tumor cell-protective catalase as a novel target for rational therapeutic approaches based on specific intercellular ROS signaling Anticancer Res. 32 2012 2599 2624
46. G. Filomeni, G. Rotilio, and M.R. Ciriolo Cell signalling and the glutathione redox system Biochem. Pharmacol. 64 2002 1057 1064
47. R. Brigelius-Flohe, and M. Maiorino Glutathione peroxidases Biochim. Biophys. Acta 1830 2013 3289 3303
48. E. Lubos, J. Loscalzo, and D.E. Handy Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities Antioxid. Redox Signal. 15 2011 1957 1997
49. S. Herbette, P. Roeckel-Drevet, and J.R. Drevet Seleno-independent glutathione peroxidases FEBS J. 274 2007 2163 2180
50. H. Sztajer, B. Gamain, K.D. Aumann, C. Slomianny, K. Becker, R. Brigelius-Flohe, and L. Flohe The putative glutathione peroxidase gene of Plasmodium falciparum codes for a thioredoxin peroxidase J. Biol. Chem. 276 2001 7397 7403
51. S.G. Rhee, and H.A. Woo Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H(2)O(2), and protein chaperones Antioxid. Redox Signal. 15 2011 781 794
52. S.G. Rhee, H.Z. Chae, and K. Kim Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling Free Radic. Biol. Med. 38 2005 1543 1552
53. A.B. Fisher, C. Dodia, Y. Manevich, J.W. Chen, and S.I. Feinstein Phospholipid hydroperoxides are substrates for non-selenium glutathione peroxidase J. Biol. Chem. 274 1999 21326 21334
54. I.V. Peshenko, and H. Shichi Oxidation of active center cysteine of bovine 1-Cys peroxiredoxin to the cysteine sulfenic acid form by peroxide and peroxynitrite Free Radic. Biol. Med. 31 2001 292 303
55. D.F. Mahmood, A. Abderrazak, K. El Hadri, T. Simmet, and M. Rouis The thioredoxin system as a therapeutic target in human health and disease Antioxid. Redox Signal. 19 2013 1266 1303
56. C.H. Lillig, and A. Holmgren Thioredoxin and related molecules - from biology to health and disease Antioxid. Redox Signal. 9 2007 25 47
57. A. Holmgren Glutathione-dependent enzyme reactions of the phage T4 ribonucleotide reductase system J. Biol. Chem. 253 1978 7424 7430
58. A. Holmgren, and F. Aslund Glutaredoxin Methods Enzymol. 252 1995 283 292
59. K.D. Tew Glutathione-associated enzymes in anticancer drug resistance Cancer Res. 54 1994 4313 4320
60. Y. Manevich, S. Hutchens, K.D. Tew, and D.M. Townsend Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation Free Radic. Biol. Med. 54 2013 62 70
61. V. Adler, Z. Yin, S.Y. Fuchs, M. Benezra, L. Rosario, K.D. Tew, M.R. Pincus, M. Sardana, C.J. Henderson, C.R. Wolf, R.J. Davis, and Z. Ronai Regulation of JNK signaling by GSTp EMBO J. 18 1999 1321 1334
62. Z. Yin, V.N. Ivanov, H. Habelhah, K. Tew, and Z. Ronai Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases Cancer Res. 60 2000 4053 4057
63. J. Zhang, C. Grek, Z.-W. Ye, Y. Manevich, K.D. Tew, and D.M. Townsend Chapter four - pleiotropic functions of glutathione S-transferase P M.T. Danyelle, D.T. Kenneth, Adv Cancer Res volume 122 2014 Academic Press 143 175
64. C.L. Grek, J. Zhang, Y. Manevich, D.M. Townsend, and K.D. Tew Causes and consequences of cysteine S-glutathionylation J. Biol. Chem. 288 2013 26497 26504
65. D.M. Townsend, Y. Manevich, L. He, S. Hutchens, C.J. Pazoles, and K.D. Tew Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress J. Biol. Chem. 284 2009 436 445
66. Y. Manevich, S.I. Feinstein, and A.B. Fisher Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST Proc. Natl. Acad. Sci. U. S. A. 101 2004 3780 3785
67. J.A. Trujillo, N.P. Croft, N.L. Dudek, R. Channappanavar, A. Theodossis, A.I. Webb, M.A. Dunstone, P.T. Illing, N.S. Butler, C. Fett, D.C. Tscharke, J. Rossjohn, S. Perlman, and A.W. Purcell The cellular redox environment alters antigen presentation J. Biol. Chem. 289 2014 27979 27991
68. H.S. Kim, S.L. Ullevig, H.N. Nguyen, D. Vanegas, and R. Asmis Redox regulation of 14-3-3zeta controls monocyte migration Arterioscler. Thromb. Vasc. Biol. 34 2014 1514 1521
69. H. Ghoti, J. Amer, A. Winder, E. Rachmilewitz, and E. Fibach Oxidative stress in red blood cells, platelets and polymorphonuclear leukocytes from patients with myelodysplastic syndrome Eur. J. Haematol. 79 2007 463 467
70. B. Novotna, Y. Bagryantseva, M. Siskova, and R. Neuwirtova Oxidative DNA damage in bone marrow cells of patients with low-risk myelodysplastic syndrome Leuk. Res. 33 2009 340 343
71. F.L. Zhou, W.G. Zhang, Y.C. Wei, S. Meng, G.G. Bai, B.Y. Wang, H.Y. Yang, W. Tian, X. Meng, H. Zhang, and S.P. Chen Involvement of oxidative stress in the relapse of acute myeloid leukemia J. Biol. Chem. 285 2010 15010 15015
72. F. Zhou, Q. Shen, and F.X. Claret Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia J. Leukoc. Biol. 94 2013 423 429
73. P.S. Hole, R.L. Darley, and A. Tonks Do reactive oxygen species play a role in myeloid leukemias? Blood 117 2011 5816 5826
74. A. Jogi, I. Ora, H. Nilsson, A. Lindeheim, Y. Makino, L. Poellinger, H. Axelson, and S. Pahlman Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype Proc. Natl. Acad. Sci. U. S. A. 99 2002 7021 7026
75. B. Marengo, L. Raffaghello, V. Pistoia, D. Cottalasso, M.A. Pronzato, U.M. Marinari, and C. Domenicotti Reactive oxygen species: biological stimuli of neuroblastoma cell response Cancer Lett. 228 2005 111 116
76. S. Tavakoli, and R. Asmis Reactive oxygen species and thiol redox signaling in the macrophage biology of atherosclerosis Antioxid. Redox Signal. 17 2012 1785 1795
77. M. Qiao, Q. Zhao, C.F. Lee, L.R. Tannock, E.J. Smart, R.G. LeBaron, C.F. Phelix, Y. Rangel, and R. Asmis Thiol oxidative stress induced by metabolic disorders amplifies macrophage chemotactic responses and accelerates atherogenesis and kidney injury in LDL receptor-deficient mice Arterioscler. Thromb. Vasc. Biol. 29 2009 1779 1786
78. S. Srinivasan, A. Koenigstein, J. Joseph, L. Sun, B. Kalyanaraman, M. Zaidi, and N.G. Avadhani Role of mitochondrial reactive oxygen species in osteoclast differentiation Ann. N. Y. Acad. Sci. 1192 2010 245 252
79. N.K. Lee, Y.G. Choi, J.Y. Baik, S.Y. Han, D.W. Jeong, Y.S. Bae, N. Kim, and S.Y. Lee A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation Blood 106 2005 852 859
80. H. Ha, H.B. Kwak, S.W. Lee, H.M. Jin, H.M. Kim, H.H. Kim, and Z.H. Lee Reactive oxygen species mediate RANK signaling in osteoclasts Exp. Cell Res. 301 2004 119 127
81. J.M. Lean, C.J. Jagger, B. Kirstein, K. Fuller, and T.J. Chambers Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation Endocrinology 146 2005 728 735
82. H. Kanzaki, F. Shinohara, M. Kajiya, and T. Kodama The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling J. Biol. Chem. 288 2013 23009 23020
83. M. Almeida Unraveling the role of FoxOs in bone - insights from mouse models Bone 49 2011 319 327
84. S.H. Kim, and S.H. Moon Osteoclast differentiation inhibitors: a patent review (2008-2012) Expert Opin. Ther. Pat. 23 2013 1591 1610
85. N. Sampson, P. Berger, and C. Zenzmaier Redox signaling as a therapeutic target to inhibit myofibroblast activation in degenerative fibrotic disease Biomed Res. Int. 2014 2014 131737
86. N. Sampson, P. Berger, and C. Zenzmaier Therapeutic targeting of redox signaling in myofibroblast differentiation and age-related fibrotic disease Oxid. Med. Cell. Longev. 2012 2012 458276
87. O. Lindvall, and Z. Kokaia Stem cells in human neurodegenerative disorders - time for clinical translation? J. Clin. Invest. 120 2010 29 40
88. R. Lemmens, and G.K. Steinberg Stem cell therapy for acute cerebral injury: what do we know and what will the future bring? Curr. Opin. Neurol. 26 2013 617 625
89. M. Sundberg, H. Bogetofte, T. Lawson, J. Jansson, G. Smith, A. Astradsson, M. Moore, T. Osborn, O. Cooper, R. Spealman, P. Hallett, and O. Isacson Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons Stem Cells 31 2013 1548 1562
90. J.P. Magnusson, C. Goritz, J. Tatarishvili, D.O. Dias, E.M. Smith, O. Lindvall, Z. Kokaia, and J. Frisen A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse Science 346 2014 237 241
91. K.A. Kennedy, S.D. Sandiford, I.S. Skerjanc, and S.S. Li Reactive oxygen species and the neuronal fate Cell. Mol. Life Sci. 69 2012 215 221
92. K. Aoyama, and T. Nakaki Impaired glutathione synthesis in neurodegeneration Int. J. Mol. Sci. 14 2013 21021 21044
93. S. Paulsen Bda, M.S. da Silveira, A. Galina, and S.K. Rehen Pluripotent stem cells as a model to study oxygen metabolism in neurogenesis and neurodevelopmental disorders Arch. Biochem. Biophys. 534 2013 3 10
94. E.A. Ostrakhovitch, and O.A. Semenikhin The role of redox environment in neurogenic development Arch. Biochem. Biophys. 534 2013 44 54
95. Y. Manevich, S. Hutchens, P.V. Halushka, K.D. Tew, D.M. Townsend, E.C. Jauch, and K. Borg Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome Free Radic. Biol. Med. 72 2014 210 221
96. J.W. Kim, Q.Q. Tang, X. Li, and M.D. Lane Effect of phosphorylation and S-S bond-induced dimerization on DNA binding and transcriptional activation by C/EBPbeta Proc. Natl. Acad. Sci. U. S. A. 104 2007 1800 1804
97. F.J. Schopfer, M.P. Cole, A.L. Groeger, C.S. Chen, N.K. Khoo, S.R. Woodcock, F. Golin-Bisello, U.N. Motanya, Y. Li, J. Zhang, M.T. Garcia-Barrio, T.K. Rudolph, V. Rudolph, G. Bonacci, P.R. Baker, H.E. Xu, C.I. Batthyany, Y.E. Chen, T.M. Hallis, and B.A. Freeman Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions J. Biol. Chem. 285 2010 12321 12333
98. G.S. Liu, E.C. Chan, M. Higuchi, G.J. Dusting, and F. Jiang Redox mechanisms in regulation of adipocyte differentiation: beyond a general stress response Cells 1 2012 976 993
99. K.S. Schneider, and J.Y. Chan Emerging role of Nrf2 in adipocytes and adipose biology Adv. Nutr. 4 2013 62 66
100. S. Furukawa, T. Fujita, M. Shimabukuro, M. Iwaki, Y. Yamada, Y. Nakajima, O. Nakayama, M. Makishima, M. Matsuda, and I. Shimomura Increased oxidative stress in obesity and its impact on metabolic syndrome J. Clin. Invest. 114 2004 1752 1761
101. H. Lee, Y.J. Lee, H. Choi, E.H. Ko, and J.W. Kim Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion J. Biol. Chem. 284 2009 10601 10609
102. P. Calzadilla, D. Sapochnik, S. Cosentino, V. Diz, L. Dicelio, J.C. Calvo, and L.N. Guerra N-acetylcysteine reduces markers of differentiation in 3 T3-L1 adipocytes Int. J. Mol. Sci. 12 2011 6936 6951
103. Y. Dor, and B. Glaser beta-cell dedifferentiation and type 2 diabetes N. Engl. J. Med. 368 2013 572 573
104. C. Talchai, S. Xuan, H.V. Lin, L. Sussel, and D. Accili Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure Cell 150 2012 1223 1234
105. H. Nakagami The mechanism of white and brown adipocyte differentiation Diabetes Metab. J. 37 2013 85 90
106. Y.H. Son, S. Ka, A.Y. Kim, and J.B. Kim Regulation of adipocyte differentiation via MicroRNAs Endocrinol. Metab. (Seoul) 29 2014 122 135
107. K. Makki, P. Froguel, and I. Wolowczuk Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines ISRN Inflamm. 2013 2013 139239
108. A.W. James Review of signaling pathways governing MSC osteogenic and adipogenic differentiation Scientifica (Cairo) 2013 2013 684736
109. E.D. Rosen, and O.A. MacDougald Adipocyte differentiation from the inside out Nat. Rev. Mol. Cell Biol. 7 2006 885 896
110. J.M. Moreno-Navarrete, and J.M. Fernandez-Real Adipocyte differentiation M.E. Symonds, Adipose tissue biology 2012 Springer Science + BUsiness Media, LLC 17 38
111. E. De Marchi, F. Baldassari, A. Bononi, M.R. Wieckowski, and P. Pinton Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C Oxid. Med. Cell. Longev. 2013 2013 564961
112. B.R. Imhoff, and J.M. Hansen Extracellular redox environments regulate adipocyte differentiation Differentiation 80 2010 31 39
113. S. Mouche, S.B. Mkaddem, W. Wang, M. Katic, Y.H. Tseng, S. Carnesecchi, K. Steger, M. Foti, C.A. Meier, P. Muzzin, C.R. Kahn, E. Ogier-Denis, and I. Szanto Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation Biochim. Biophys. Acta 1773 2007 1015 1027
114. F. Jiang, H.K. Lim, M.J. Morris, L. Prior, E. Velkoska, X. Wu, and G.J. Dusting Systemic upregulation of NADPH oxidase in diet-induced obesity in rats Redox Rep. 16 2011 223 229
115. K. Schroder, K. Wandzioch, I. Helmcke, and R.P. Brandes Nox4 acts as a switch between differentiation and proliferation in preadipocytes Arterioscler. Thromb. Vasc. Biol. 29 2009 239 245
116. Y. Kanda, T. Hinata, S.W. Kang, and Y. Watanabe Reactive oxygen species mediate adipocyte differentiation in mesenchymal stem cells Life Sci. 89 2011 250 258
117. K. Mahadev, H. Motoshima, X. Wu, J.M. Ruddy, R.S. Arnold, G. Cheng, J.D. Lambeth, and B.J. Goldstein The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction Mol. Cell. Biol. 24 2004 1844 1854
118. Y. Li, S. Mouche, T. Sajic, C. Veyrat-Durebex, R. Supale, D. Pierroz, S. Ferrari, F. Negro, U. Hasler, E. Feraille, S. Moll, P. Meda, C. Deffert, X. Montet, K.H. Krause, and I. Szanto Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity Int. J. Obes. (Lond.) 36 2012 1503 1513
119. A. De Pauw, S. Tejerina, M. Raes, J. Keijer, and T. Arnould Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations Am. J. Pathol. 175 2009 927 939
120. K.V. Tormos, E. Anso, R.B. Hamanaka, J. Eisenbart, J. Joseph, B. Kalyanaraman, and N.S. Chandel Mitochondrial complex III ROS regulate adipocyte differentiation Cell Metab. 14 2011 537 544
121. J.H. Kim, S.H. Kim, S.Y. Song, W.S. Kim, S.U. Song, T. Yi, M.S. Jeon, H.M. Chung, Y. Xia, and J.H. Sung Hypoxia induces adipocyte differentiation of adipose-derived stem cells by triggering reactive oxygen species generation Cell Biol. Int. 38 2014 32 40
122. U. Ozcan, Q. Cao, E. Yilmaz, A.H. Lee, N.N. Iwakoshi, E. Ozdelen, G. Tuncman, C. Gorgun, L.H. Glimcher, and G.S. Hotamisligil Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306 2004 457 461
123. N. Chaudhari, P. Talwar, A. Parimisetty, C. Lefebvre d'Hellencourt, and P. Ravanan A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress Front. Cell. Neurosci. 8 2014 213
124. P. Jiao, J. Ma, B. Feng, H. Zhang, J.A. Diehl, Y.E. Chin, W. Yan, and H. Xu FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKbeta pathways Obesity (Silver Spring) 19 2011 483 491
125. J.M. Maris Recent advances in neuroblastoma N. Engl. J. Med. 362 2010 2202 2211
126. A.M. Davidoff Neuroblastoma Semin. Pediatr. Surg. 21 2012 2 14
127. D.T. Lau, and L.J. Ashton Genetic factors influencing the risk and clinical outcome of neuroblastoma H. Shimada, Neuroblastoma - present and future 2012 InTech 3 28
128. A. Tee, P.Y. Liu, G.M. Marshall, and T. Liu Neuroblastoma: a malignancy Due to cell differentiation block H. Shimada, Neuroblastoma - present and future 2012 InTech 79 84
129. G. Leondaritis, X. Koliou, S. Johnson, C. Li, A. Florakis, K. Dimas, N. Sakellaridis, and D. Mangoura Interplay between protein kinase C isoforms alpha and epsilon, neurofibromin, and the Ras/MAPK pathway in neuroblastoma differentiation H. Shimada, Neuroblastoma - present and future 2012 InTech
130. H.L. Vieira, P.M. Alves, and A. Vercelli Modulation of neuronal stem cell differentiation by hypoxia and reactive oxygen species Prog. Neurobiol. 93 2011 444 455
131. G. Santilli, G. Lamorte, L. Carlessi, D. Ferrari, L. Rota Nodari, E. Binda, D. Delia, A.L. Vescovi, and L. De Filippis Mild hypoxia enhances proliferation and multipotency of human neural stem cells PLoS One 5 2010 e8575
132. D.M. Panchision The role of oxygen in regulating neural stem cells in development and disease J. Cell. Physiol. 220 2009 562 568
133. J.E. Le Belle, N.M. Orozco, A.A. Paucar, J.P. Saxe, J. Mottahedeh, A.D. Pyle, H. Wu, and H.I. Kornblum Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner Cell Stem Cell 8 2011 59 71
134. J. Chang, and J. Erler Hypoxia-mediated metastasis Adv. Exp. Med. Biol. 772 2014 55 81
135. Z. Yun, and Q. Lin Hypoxia and regulation of cancer cell stemness Adv. Exp. Med. Biol. 772 2014 41 53
136. T. Lofstedt, A. Jogi, M. Sigvardsson, K. Gradin, L. Poellinger, S. Pahlman, and H. Axelson Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells J. Biol. Chem. 279 2004 39223 39231
137. A. Pietras, L.M. Hansford, A.S. Johnsson, E. Bridges, J. Sjolund, D. Gisselsson, M. Rehn, S. Beckman, R. Noguera, S. Navarro, J. Cammenga, E. Fredlund, D.R. Kaplan, and S. Pahlman HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells Proc. Natl. Acad. Sci. U. S. A. 106 2009 16805 16810
138. A. Jogi, J. Vallon-Christersson, L. Holmquist, H. Axelson, A. Borg, and S. Pahlman Human neuroblastoma cells exposed to hypoxia: induction of genes associated with growth, survival, and aggressive behavior Exp. Cell Res. 295 2004 469 487
139. D.G. Tenen Disruption of differentiation in human cancer: AML shows the way Nat. Rev. Cancer 3 2003 89 101
140. A. Mijovic, and G.J. Mufti The myelodysplastic syndromes: towards a functional classification Blood Rev. 12 1998 73 83
141. L. Sachs Cell differentiation and bypassing of genetic defects in the suppression of malignancy Cancer Res. 47 1987 1981 1986
142. A. Marchwicka, M. Cebrat, P. Sampath, L. Sniezewski, and E. Marcinkowska Perspectives of differentiation therapies of acute myeloid leukemia: the search for the molecular basis of patients' variable responses to 1,25-dihydroxyvitamin d and vitamin d analogs Front. Oncol. 4 2014 125
143. M.E. Huang, Y.C. Ye, S.R. Chen, J.R. Chai, J.X. Lu, L. Zhoa, L.J. Gu, and Z.Y. Wang Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia Blood 72 1988 567 572
144. C.X. Liu, Q.Q. Yin, H.C. Zhou, Y.L. Wu, J.X. Pu, L. Xia, W. Liu, X. Huang, T. Jiang, M.X. Wu, L.C. He, Y.X. Zhao, X.L. Wang, W.L. Xiao, H.Z. Chen, Q. Zhao, A.W. Zhou, L.S. Wang, H.D. Sun, and G.Q. Chen Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells Nat. Chem. Biol. 8 2012 486 493
145. C.X. Liu, H.C. Zhou, Q.Q. Yin, Y.L. Wu, and G.Q. Chen Targeting peroxiredoxins against leukemia Exp. Cell Res. 319 2013 170 176
146. G.P. Tuszynski, and V.L. Rothman Angiocidin induces differentiation of acute myeloid leukemia cells Exp. Mol. Pathol. 95 2013 249 254
147. B. Zhang, N. Chen, H. Chen, Z. Wang, and Q. Zheng The critical role of redox homeostasis in shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE pathway Oxid. Med. Cell. Longev. 2012 2012 781516
148. J. Liu, L. Cao, J. Chen, S. Song, I.H. Lee, C. Quijano, H. Liu, K. Keyvanfar, H. Chen, L.Y. Cao, B.H. Ahn, N.G. Kumar, I.I. Rovira, X.L. Xu, M. van Lohuizen, N. Motoyama, C.X. Deng, and T. Finkel Bmi1 regulates mitochondrial function and the DNA damage response pathway Nature 459 2009 387 392
149. C. Chen, Y. Liu, R. Liu, T. Ikenoue, K.L. Guan, Y. Liu, and P. Zheng TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species J. Exp. Med. 205 2008 2397 2408
150. C. Piccoli, A. D'Aprile, M. Ripoli, R. Scrima, L. Lecce, D. Boffoli, A. Tabilio, and N. Capitanio Bone-marrow derived hematopoietic stem/progenitor cells express multiple isoforms of NADPH oxidase and produce constitutively reactive oxygen species Biochem. Biophys. Res. Commun. 353 2007 965 972
151. C. Piccoli, R. Ria, R. Scrima, O. Cela, A. D'Aprile, D. Boffoli, F. Falzetti, A. Tabilio, and N. Capitanio Characterization of mitochondrial and extra-mitochondrial oxygen consuming reactions in human hematopoietic stem cells. Novel evidence of the occurrence of NAD(P)H oxidase activity J. Biol. Chem. 280 2005 26467 26476
152. Z. Tothova, R. Kollipara, B.J. Huntly, B.H. Lee, D.H. Castrillon, D.E. Cullen, E.P. McDowell, S. Lazo-Kallanian, I.R. Williams, C. Sears, S.A. Armstrong, E. Passegue, R.A. DePinho, and D.G. Gilliland FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress Cell 128 2007 325 339
153. K. Miyamoto, K.Y. Araki, K. Naka, F. Arai, K. Takubo, S. Yamazaki, S. Matsuoka, T. Miyamoto, K. Ito, M. Ohmura, C. Chen, K. Hosokawa, H. Nakauchi, K. Nakayama, K.I. Nakayama, M. Harada, N. Motoyama, T. Suda, and A. Hirao Foxo3a is essential for maintenance of the hematopoietic stem cell pool Cell Stem Cell 1 2007 101 112
154. M. Baldini, and C. Sacchetti Effect of cystine and cysteine on human bone marrow cultured in medium deficient in amino acids Rev. Hematol. 8 1953 3 19
155. A. Wilson, E. Laurenti, G. Oser, R.C. van der Wath, W. Blanco-Bose, M. Jaworski, S. Offner, C.F. Dunant, L. Eshkind, E. Bockamp, P. Lio, H.R. Macdonald, and A. Trumpp Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair Cell 135 2008 1118 1129
156. L.M. Calvi, G.B. Adams, K.W. Weibrecht, J.M. Weber, D.P. Olson, M.C. Knight, R.P. Martin, E. Schipani, P. Divieti, F.R. Bringhurst, L.A. Milner, H.M. Kronenberg, and D.T. Scadden Osteoblastic cells regulate the haematopoietic stem cell niche Nature 425 2003 841 846
157. S.K. Nilsson, H.M. Johnston, and J.A. Coverdale Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches Blood 97 2001 2293 2299
158. T. Sugiyama, H. Kohara, M. Noda, and T. Nagasawa Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches Immunity 25 2006 977 988
159. G.B. Adams, K.T. Chabner, I.R. Alley, D.P. Olson, Z.M. Szczepiorkowski, M.C. Poznansky, C.H. Kos, M.R. Pollak, E.M. Brown, and D.T. Scadden Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor Nature 439 2006 599 603
160. M.G. Cipolleschi, P. Dello Sbarba, and M. Olivotto The role of hypoxia in the maintenance of hematopoietic stem cells Blood 82 1993 2031 2037
161. H. Iwasaki, and T. Suda Cancer stem cells and their niche Cancer Sci. 100 2009 1166 1172
162. A. Kohler, V. Schmithorst, M.D. Filippi, M.A. Ryan, D. Daria, M. Gunzer, and H. Geiger Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones Blood 114 2009 290 298
163. P.S. Hole, J. Zabkiewicz, C. Munje, Z. Newton, L. Pearn, P. White, N. Marquez, R.K. Hills, A.K. Burnett, A. Tonks, and R.L. Darley Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling Blood 122 2013 3322 3330
164. A. Martner, F.B. Thoren, J. Aurelius, J. Soderholm, M. Brune, and K. Hellstrand Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia Expert. Rev. Hematol. 3 2010 381 391
165. Q. Xu, S.E. Simpson, T.J. Scialla, A. Bagg, and M. Carroll Survival of acute myeloid leukemia cells requires PI3 kinase activation Blood 102 2003 972 980
166. Z. Tothova, and D.G. Gilliland FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system Cell Stem Cell 1 2007 140 152
167. J. Lu, E.H. Chew, and A. Holmgren Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide Proc. Natl. Acad. Sci. U. S. A. 104 2007 12288 12293
168. H. Pelicano, L. Feng, Y. Zhou, J.S. Carew, E.O. Hileman, W. Plunkett, M.J. Keating, and P. Huang Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism J. Biol. Chem. 278 2003 37832 37839
169. J. Wang, L. Li, H. Cang, G. Shi, and J. Yi NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells Leuk. Res. 32 2008 429 436
170. D.M. Townsend, V.L. Findlay, and K.D. Tew Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets Methods Enzymol. 401 2005 287 307
171. J.E. Ruscoe, L.A. Rosario, T. Wang, L. Gate, P. Arifoglu, C.R. Wolf, C.J. Henderson, Z. Ronai, and K.D. Tew Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways J. Pharmacol. Exp. Ther. 298 2001 339 345
172. R.M. Lyons, S.T. Wilks, S. Young, and G.L. Brown Oral ezatiostat HCl (Telintra(R), TLK199) and idiopathic chronic neutropenia (ICN): a case report of complete response of a patient with G-CSF resistant ICN following treatment with ezatiostat, a glutathione S-transferase P1-1 (GSTP1-1) inhibitor J. Hematol. Oncol. 4 2011 43
173. A. Raza, N. Galili, N. Callander, L. Ochoa, L. Piro, P. Emanuel, S. Williams, H. Burris III, S. Faderl, Z. Estrov, P. Curtin, R.A. Larson, J.G. Keck, M. Jones, L. Meng, and G.L. Brown Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome J. Hematol. Oncol. 2 2009 20
174. L. Gate, R.S. Majumdar, A. Lunk, and K.D. Tew Increased myeloproliferation in glutathione S-transferase pi-deficient mice is associated with a deregulation of JNK and Janus kinase/STAT pathways J. Biol. Chem. 279 2004 8608 8616
175. J. Zhang, Z.W. Ye, P. Gao, L. Reyes, E.E. Jones, M. Branham-O'Connor, J.B. Blumer, R.R. Drake, Y. Manevich, D.M. Townsend, and K.D. Tew Glutathione S-Transferase P Influences Redox and Migration Pathways in Bone Marrow PLoS One 9 2014 e107478
176. R. Ait-Belkacem, C. Berenguer, C. Villard, L. Ouafik, D. Figarella-Branger, O. Chinot, and D. Lafitte MALDI imaging and in-source decay for top-down characterization of glioblastoma Proteomics 14 2014 1290 1301
177. T.W. Powers, E.E. Jones, L.R. Betesh, P.R. Romano, P. Gao, J.A. Copland, A.S. Mehta, and R.R. Drake Matrix assisted laser desorption ionization imaging mass spectrometry workflow for spatial profiling analysis of N-linked glycan expression in tissues Anal. Chem. 85 2013 9799 9806
178. B. Enthaler, J.K. Pruns, S. Wessel, C. Rapp, M. Fischer, and K.P. Wittern Improved sample preparation for MALDI-MSI of endogenous compounds in skin tissue sections and mapping of exogenous active compounds subsequent to ex-vivo skin penetration Anal. Bioanal. Chem. 402 2012 1159 1167
179. E.H. Seeley, and R.M. Caprioli Molecular imaging of proteins in tissues by mass spectrometry Proc. Natl. Acad. Sci. U. S. A. 105 2008 18126 18131
180. L.A. McDonnell, and R.M. Heeren Imaging mass spectrometry Mass Spectrom. Rev. 26 2007 606 643
181. D.R. Soprano, B.W. Teets, and K.J. Soprano Role of retinoic acid in the differentiation of embryonal carcinoma and embryonic stem cells Vitam. Horm. 75 2007 69 95
182. N. Shinjyo, and K. Kita Relationship between reactive oxygen species and heme metabolism during the differentiation of Neuro2a cells Biochem. Biophys. Res. Commun. 358 2007 130 135
183. E. Duprez A new role for C/EBPbeta in acute promyelocytic leukemia Cell Cycle 3 2004 389 390
184. A.F. List, R. Heaton, B. Glinsmann-Gibson, and R.L. Capizzi Amifostine protects primitive hematopoietic progenitors against chemotherapy cytotoxicity Semin. Oncol. 23 1996 58 63
185. A.F. List, R. Heaton, B. Glinsmann-Gibson, and R.L. Capizzi Amifostine stimulates formation of multipotent and erythroid bone marrow progenitors Leukemia 12 1998 1596 1602
186. M.F. Romano, A. Lamberti, R. Bisogni, C. Garbi, A.M. Pagnano, P. Auletta, P. Tassone, M.C. Turco, and S. Venuta Amifostine inhibits hematopoietic progenitor cell apoptosis by activating NF-kappaB/Rel transcription factors Blood 94 1999 4060 4066
187. A.A. Erikci, A. Ozturk, B. Karagoz, O. Bilgi, O. Turken, C. Top, and E.G. Kandemir Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia Hematology 13 2008 289 292
188. J. Schanz, H. Jung, B. Wormann, W. Gassmann, T. Petersen, A. Hinke, and D. Haase Amifostine has the potential to induce haematologic responses and decelerate disease progression in individual patients with low- and intermediate-1-risk myelodysplastic syndromes Leuk. Res. 33 2009 1183 1188
189. B. Drolet, C. Simard, and D.M. Roden Unusual effects of a QT-prolonging drug, arsenic trioxide, on cardiac potassium currents Circulation 109 2004 26 29
190. J.L. Mumford, K. Wu, Y. Xia, R. Kwok, Z. Yang, J. Foster, and W.E. Sanders Chronic arsenic exposure and cardiac repolarization abnormalities with QT interval prolongation in a population-based study Environ. Health Perspect. 115 2007 690 694
191. H. Liang, X. Li, L. Wang, S. Yu, Z. Xu, Y. Gu, Z. Pan, T. Li, M. Hu, H. Cui, X. Liu, Y. Zhang, C. Xu, R. Guo, Y. Lu, B. Yang, and H. Shan MicroRNAs contribute to promyelocyte apoptosis in As2O3-treated APL cells Cell. Physiol. Biochem. 32 2013 1818 1829
192. Y. Fan, M. Chen, J. Meng, L. Yu, Y. Tu, L. Wan, K. Fang, and W. Zhu Arsenic trioxide and resveratrol show synergistic anti-leukemia activity and neutralized cardiotoxicity PLoS One 9 2014 e105890
193. F. Luo, Y. Zhuang, M.D. Sides, C.G. Sanchez, B. Shan, E.S. White, and J.A. Lasky Arsenic trioxide inhibits transforming growth factor-beta1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo Respir. Res. 15 2014 51
194. A. Sarria, and K.N. Prasad dl-alpha-Tocopheryl succinate enhances the effect of gamma-irradiation on neuroblastoma cells in culture Proc. Soc. Exp. Biol. Med. 175 1984 88 92
195. J.H. Lee, A.V. Budanov, and M. Karin Sestrins orchestrate cellular metabolism to attenuate aging Cell Metab. 18 2013 792 801
196. S.H. Ro, M. Nam, I. Jang, H.W. Park, H. Park, I.A. Semple, M. Kim, J.S. Kim, H. Park, P. Einat, G. Damari, M. Golikov, E. Feinstein, and J.H. Lee Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species Proc. Natl. Acad. Sci. U. S. A. 111 2014 7849 7854
197. Y. Higashi, D. Jitsuiki, K. Chayama, and M. Yoshizumi Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases Recent Pat. Cardiovasc. Drug Discov. 1 2006 85 93
198. H. Yoshida, H. Yanai, Y. Namiki, K. Fukatsu-Sasaki, N. Furutani, and N. Tada Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury CNS Drug Rev. 12 2006 9 20
199. J.R. Chen, O.P. Lazarenko, K. Shankar, M.L. Blackburn, C.K. Lumpkin, T.M. Badger, and M.J. Ronis Inhibition of NADPH oxidases prevents chronic ethanol-induced bone loss in female rats J. Pharmacol. Exp. Ther. 336 2011 734 742
200. J.D. Lambeth Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy Free Radic. Biol. Med. 43 2007 332 347
201. B. Crestani, V. Besnard, and J. Boczkowski Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis Int. J. Biochem. Cell Biol. 43 2011 1086 1089
202. R. Samarakoon, A.D. Dobberfuhl, C. Cooley, J.M. Overstreet, S. Patel, R. Goldschmeding, K.K. Meldrum, and P.J. Higgins Induction of renal fibrotic genes by TGF-beta1 requires EGFR activation, p53 and reactive oxygen species Cell. Signal. 25 2013 2198 2209
203. R. Samarakoon, J.M. Overstreet, and P.J. Higgins TGF-beta signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities Cell. Signal. 25 2013 264 268
204. E.R. Jarman, V.S. Khambata, C. Cope, P. Jones, J. Roger, L.Y. Ye, N. Duggan, D. Head, A. Pearce, N.J. Press, B. Bellenie, B. Sohal, and G. Jarai An inhibitor of NADPH oxidase-4 attenuates established pulmonary fibrosis in a rodent disease model Am. J. Respir. Cell Mol. Biol. 50 2014 158 169
205. Y.H. Paik, J. Kim, T. Aoyama, S. De Minicis, R. Bataller, and D.A. Brenner Role of NADPH oxidases in liver fibrosis Antioxid. Redox Signal. 20 2014 2854 2872
206. H.R. Qian, and Y. Yang Neuron differentiation and neuritogenesis stimulated by N-acetylcysteine (NAC) Acta Pharmacol. Sin. 30 2009 907 912
207. D.M. Townsend, L. He, S. Hutchens, T.E. Garrett, C.J. Pazoles, and K.D. Tew NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance Cancer Res. 68 2008 2870 2877
208. D.M. Townsend, C.J. Pazoles, and K.D. Tew NOV-002, a mimetic of glutathione disulfide Expert Opin. Investig. Drugs 17 2008 1075 1083
209. S. Salama, and S. Montaser Possible modulating impact of glutathione disulfide mimetic on physiological changes in irradiated rats Hum. Exp. Toxicol. 2014 10.1177/0960327114529452
210. N. Galili, P. Tamayo, O.B. Botvinnik, J.P. Mesirov, M.R. Brooks, G. Brown, and A. Raza Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome J. Hematol. Oncol. 5 2012 20
211. A. Raza, N. Galili, S.E. Smith, J. Godwin, R.V. Boccia, H. Myint, D. Mahadevan, D. Mulford, M. Rarick, G.L. Brown, D. Schaar, S. Faderl, R.S. Komrokji, A.F. List, and M. Sekeres A phase 2 randomized multicenter study of 2 extended dosing schedules of oral ezatiostat in low to intermediate-1 risk myelodysplastic syndrome Cancer 118 2012 2138 2147
212. L.N. Pan, J. Lu, and B. Huang HDAC inhibitors: a potential new category of anti-tumor agents Cell. Mol. Immunol. 4 2007 337 343
213. G. Eot-Houllier, G. Fulcrand, L. Magnaghi-Jaulin, and C. Jaulin Histone deacetylase inhibitors and genomic instability Cancer Lett. 274 2009 169 176
214. G. Silva, B.A. Cardoso, H. Belo, and A.M. Almeida Vorinostat induces apoptosis and differentiation in myeloid malignancies: genetic and molecular mechanisms PLoS One 8 2013 e53766
215. C.R. Culy, and C.M. Spencer Amifostine: an update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome Drugs 61 2001 641 684
216. J.M. Yuhas Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid Cancer Res. 40 1980 1519 1524
217. L.M. Shaw, A.T. Turrisi, D.J. Glover, H.S. Bonner, A.L. Norfleet, C. Weiler, and M.M. Kligerman Human pharmacokinetics of WR-2721 Int. J. Radiat. Oncol. Biol. Phys. 12 1986 1501 1504
218. G.T. Wondrak Redox-directed cancer therapeutics: molecular mechanisms and opportunities Antioxid. Redox Signal. 11 2009 3013 3069
219. Z.Y. Wang, and Z. Chen Acute promyelocytic leukemia: from highly fatal to highly curable Blood 111 2008 2505 2515
220. T. Miura, A. Taketomi, T. Nishinaka, and T. Terada Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2 Chem. Biol. Interact. 202 2013 126 135
221. M. Zafarullah, W.Q. Li, J. Sylvester, and M. Ahmad Molecular mechanisms of N-acetylcysteine actions Cell. Mol. Life Sci. 60 2003 6 20
222. P. Calzadilla, M. Gomez-Serrano, E. Garcia-Santos, A. Schiappacasse, Y. Abalde, J.C. Calvo, B. Peral, and L.N. Guerra N-Acetylcysteine affects obesity-related protein expression in 3 T3-L1 adipocytes Redox Rep. 18 2013 210 218
223. K. Gumireddy, A. Li, L. Cao, J. Yan, L. Liu, X. Xu, C. Pazoles, and Q. Huang NOV-002, a glutathione disulfide mimetic, suppresses tumor cell invasion and metastasis J. Carcinog. Mutagen. 2013 2013
224. A.J. Montero, C.M. Diaz-Montero, Y.E. Deutsch, J. Hurley, L.G. Koniaris, T. Rumboldt, S. Yasir, M. Jorda, E. Garret-Mayer, E. Avisar, J. Slingerland, O. Silva, C. Welsh, K. Schuhwerk, P. Seo, M.D. Pegram, and S. Gluck Phase 2 study of neoadjuvant treatment with NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II-IIIc breast cancer Breast Cancer Res. Treat. 132 2012 215 223
225. T.J. Gaymes, R.A. Padua, M. Pla, S. Orr, N. Omidvar, C. Chomienne, G.J. Mufti, and F.V. Rassool Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: a mechanism for leukemia-specific HDI-dependent apoptosis? Mol. Cancer Res. 4 2006 563 573