Rapid loss of bone mass and strength in mice after abdominal irradiation

Radiation Research

Volumn 176, Issue 5, 2011, Pages 624-635

  Jia, Dan ^a   Gaddy, Dana ^a   Suvac, Larry J ^a   Corry, Peter M ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

ABDOMINAL RADIOTHERAPY; ANIMAL EXPERIMENT; ARTICLE; BONE DEFECT; BONE DENSITY; BONE MASS; BONE STRENGTH; CELL DIFFERENTIATION; CONTROLLED STUDY; FEMUR; MALE; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL; RADIATION INJURY; SKELETON; TIBIA; TRABECULAR BONE; X RAY;

ABDOMEN; ANIMALS; BODY WEIGHT; BONE AND BONES; BONE DENSITY; DOSE-RESPONSE RELATIONSHIP, RADIATION; MALE; MICE; MICE, INBRED C57BL; ORGAN SPECIFICITY; OSTEOGENESIS; TIME FACTORS;

MUS; TRABECULA;

EID: 80155175720     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR2505.1     Document Type: Article

References (67)

1. Orton CG. Uses of therapeutic x rays in medicine. Health Phys 1995; 69:662-76.
2. Bernier J, Hall EJ, Giaccia A. Radiation oncology: a century of achievements. Nat Rev Cancer 2004; 4:737-47. (Pubitemid 39215072)
3. Cohen L, Schultheiss TE, Hendrickson FR, Mansell J, Saroja KR, Lennox A. Normal tissue reactions and complications following high-energy neutron beam therapy: I. Crude response rates. Int J Radiat Oncol Biol Phys 1989; 16:73-8. (Pubitemid 19045337)
4. Stone HB, Coleman CN, Anscher MS, McBride WH. Effects of radiation on normal tissue: consequences and mechanisms. Lancet Oncol 2003; 4:529-36. (Pubitemid 38351709)
5. Smith RP, Heron DE, Huq MS, Yue NJ. Modern radiation treatment planning and delivery-from Röntgen to real time. Hematol Oncol Clin N Am 2006; 20:45-62.
6. Golis G, Zanaboni F, Vanoli P, Russo A, Franchi M, Scarfone G, et al. The impact of whole-abdomen radiotherapy on survival in advanced ovarian cancer patients with minimal residual disease after chemotherapy. Gynecol Oncol 1990; 39:150-4. (Pubitemid 20372403)
7. Liu L, Glicksman AS, Coachman N, Kuten A. Low acute gastrointestinal and genitourinary toxicities in whole pelvic irradiation of prostate cancer. Int J Radiat Oncol Biol Phys 1997; 38:65-71. (Pubitemid 27270944)
8. Dorr W, Kost S, Keinert K, Glaser FH, Endert G, Herrmann T. Early intestinal changes following abdominal radiotherapy comparison of endpoints. Strahlenther Onkol 2006; 182:1-8. (Pubitemid 43069829)
9. Somosy Z, Horvath G, Telbisz A, Rez G, Palfia Z. Morphological aspects of ionizing radiation response of small intestine. Micron 2002; 33:167-78. (Pubitemid 32997017)
10. Keefe DM, Gibson RJ, Hauer-Jensen M. Gastrointestinal mucositis. Semin Oncol Nurs 2004; 20:38-47. (Pubitemid 38609557)
11. Kwon JW, Huh SJ, Yoon YC, Choi SH, Jung JY, Oh D, et al. Pelvic bone complications after radiation therapy of uterine cervical cancer: evaluation with MRI. AJR Am J Roentgenol 2008; 191:987-94.
12. Igdem S, Alco G, Ercan T, Barlan M, Ganiyusufoglu K, Unalan B, et al. Insufficiency fractures after pelvic radiotherapy in patients with prostate cancer. Int J Radiat Oncol Biol Phys 2010; 77:818
13. Baxter NN, Habermann EB, Tepper JE, Durham SB, Virnig BA. Risk of pelvic fractures in older women following pelvic irradiation. JAMA 2005; 294:2587-93. (Pubitemid 41697248)
14. Ikushima H, Osaki K, Furutani S, Yamashita K, Kishida Y, Kudoh T, et al. Pelvic bone complications following radiation therapy of gynecologic malignancies: clinical evaluation of radiation-induced pelvic insufficiency fractures. Gynecol Oncol 2006; 103:1100-4. (Pubitemid 44821340)
15. Kirstensen B, Ejlertsen B, Mouridsen HT, Andersen KW, Lauritzen JB. Femoral fractures in postmenopausal breast cancer patients treated with adjuvant tamoxifen. Breast Cancer Res Treat 1996; 39:321-6. (Pubitemid 26278947)
16. Chen Z, Maraicic M, Aragaki AK, Mouton C, Arendell L, Lopez AM, et al. Fracture risk increases after diagnosis of breast or other cancers in postmenopausal women: results from the Women's Health Initiative. Osteoporos Int 2009; 20:527-36.
17. Mole RH. Whole body irradiation; radiobiology or medicine? Br J Radiol 1953; 26:234-41.
18. Phillips RD, Kimeldorf DJ. Local and systemic effects of ionizing radiation on bone growth. Am J Physiol 1966; 210:1096-100.
19. Gompertz RH, Man WK, Li SK, Baron JH, Spencer J, Michalowski AS. Gastric histamine in a chronic duodenal ulcer model induced by partial thoracic irradiation. Agents Actions 1989; 27:177-9. (Pubitemid 19108530)
20. Van der Meeren A, Monti P, Vandamme M, Squiban C, Wysocki J, Griffiths N. Abdominal radiation exposure elicits inflammatory responses and abscopal effects in the lungs of mice. Radiat Res 2005; 163:144-52. (Pubitemid 40170763)
21. Robin HI, AuBuchon J, Varanasi VR, Weinstein AB. The abscopal effect: demonstration in lymphomatous involvement of kidneys. Med Pediatr Oncol 1981; 9:473-6. (Pubitemid 12245882)
22. Petrovic N, Perovic J, Karanovic D, Todorovic L, Petrovic V. Abscopal effects of local fractionated X-irradiation of face and jaw region. Strahlentherapie 1982; 158:40-2. (Pubitemid 12223284)
23. Koturbash I, Rugo RE, Hendricks CA, Loree J, Thibault B, Kutanzi K, et al. Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo. Oncogene 2006; 25:4267-75. (Pubitemid 44100497)
24. Yang G, Wu L, Chen L, Pei B, Wang Y, Zhan F, et al. Targeted irradiation of shoot apical meristem of Arabidopsis embryos induces long-distance bystander/abscopal effects. Radiat Res 2007; 167:298-305. (Pubitemid 351292541)
25. Jia D, Koonce NA, Griffin RJ, Jackson C, Corry PM. Prevention and mitigation of acute death of mice after abdominal irradiation by the antioxidant N-acetyl-cysteine (NAC). Radiat Res 2010; 173:579-89.
26. Conget PA, Minguell JJ. Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells. J Cell Physiol 1999; 181:67-73. (Pubitemid 29400373)
27. De Meerleer GO, Vakaet LA, De Gersem WR, De Wagter C, De Naeyer B, De Neve W. Radiotherapy of prostate cancer with or without intensity modulated beams: a planning comparison. Int J Radiat Oncol Biol Phys 2000; 47:639-48. (Pubitemid 30317481)
28. Rzonca SO, Suva LJ, Gaddy D, Montague DC, Lecka-Czernik B. Bone is a target for the antidiabetic compound rosiglitazone. Endocrinology 2004; 145:401-6. (Pubitemid 38094536)
29. Fluckey JC, Dupont-Versteegden EE, Montague DC, Knox M, Tesch P, Peterson CA, et al. A rat resistance exercise regimen attenuates losses of musculoskeletal mass during hindlimb suspension. Acta Physiol Scand 2002; 176:293-300. (Pubitemid 35417383)
30. Nagy TR, Clair AL. Precision and accuracy of dual-energy X-ray absorptiometry for determining in vivo body composition of mice. Obes Res 2000; 8:392-8.
31. Weinstein RS, Jia D, Powers CC, Stewart SA, Jilka RL, Parfitt AM, et al. The skeletal effects of glucocorticoid excess override those of orchidectomy in mice. Endocrinology 2004; 145:1980-7. (Pubitemid 38402407)
32. Jia D, O'Brien CA, Stewart SA, Manolagas SC, Weinstein RS. Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density. Endocrinology 2006; 147:5592-9. (Pubitemid 44833476)
33. Aronson J, Hogue WR, Flahiff CM, Gao GG, Shen XC, Skinner RA, et al. Development of tensile strength during distraction osteogenesis in a rat model. J Orthop Res 2001; 19:64-9. (Pubitemid 32288637)
34. Brown EC, Berrien DS, Fletcher TW, Irby DJ, Aronson J, Gao GG, et al. Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition. J Pharmacol Exp Ther 2002; 301:1132-8. (Pubitemid 34595107)
35. Suva LJ, Hartman E, Dilley JD, Russell S, Akel NS, Skinner RA, et al. Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease. Am J Pathol 2008; 172:430-9. (Pubitemid 351282030)
36. Turner CJ, Burr DB. Basic biomechanical measurements of bone: a tutorial. Bone 1993; 14:595-608. (Pubitemid 23198821)
37. Giangregorio L, Blimkie CJ. Skeletal adaptations to alterations in weight-bearing activity: a comparison of models of disuse osteoporosis. Sports Med 2002; 32:459-76. (Pubitemid 34620906)
38. Asknes LH, Bruland OS. Some musculo-skeletal sequelae in cancer survivors. Acta Oncol 2007; 46:490-6. (Pubitemid 46752250)
39. Huh SJ, Kim B, Kang MK, Lee JE, Lim DH, Wark W, et al. Pelvic insufficiency fracture after pelvic irradiation in uterine cervix cancer. Gynecol Oncol 2002; 86:264-8. (Pubitemid 35425520)
40. Wiernik G. Fractionation in radiotherapy. Anticancer Res 1983; 3:283-97.
41. Saunders MI, Dische S. Fractionation in radiotherapy: a view from the clinic. Br J Radiol 1997; 70 Spec No:S17-24. (Pubitemid 27507558)
42. Nishiwaki M, Yasumizu T, Hoshi K, Ushijima. Effect of pregnancy, lactation and weaning on bone mineral density in rats as determined by dual-energy X-ray absorptiometry. Endocr J 1999; 46:711-6.
43. Yasumizu T, Nakamura Y, Hoshi K, Iijima S, Asaka A. Bone metabolism after human parturition and the effect of lactation: longitudinal analysis of serum bone-related proteins and bone mineral content of the lumbar spine. Endocr J 1998; 45:679-86. (Pubitemid 28547656)
44. Alesci S, De Martino MU, Ilas I, Gold PW, Chrousos GP. Glucocorticoid-induced osteoporosis: from basic mechanisms to clinical aspects. Neuroimmunomodulation 2005; 12:1-19. (Pubitemid 40528906)
45. Shaker JL, Lukert BP. Osteoporosis associated with excess glucocorticoids. Endocrinol Metab Clin North Am 2005; 34:341-56. (Pubitemid 40602725)
46. Moschonis G, Manios Y. Skeletal site-dependent response of bone mineral density and quantitative ultrasound parameters following a 12-month dietary intervention using dairy products fortified with calcium and vitamin D: the Postmenopausal Health Study. Br J Nutr 2006; 96:1140-8. (Pubitemid 46470177)
47. Kousteni S, Chen JR, Bellido T, Han L, Ali AA, O'Brien CA, et al. Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science 2002; 298:843-6. (Pubitemid 35231540)
48. Nagashima H. Longitudinal study of in vivo bone mineral changes in rats using dual X-ray absorptiometry-effect of ovariectomy and prednisolone. Nippon Seikeigeka Gakkai Zasshi 1993; 67:1151-61. (Pubitemid 24030043)
49. Hamrick MW, Skedros JG, Pennington C, McNeil PL. Increased osteogenic response to exercise in metaphyseal versus diaphyseal cortical bone. J Musculoskelet Neuronal Interact 2006; 6:258-63. (Pubitemid 44650784)
50. Lloyd SA, Yuan YY, Simske SJ, Riffle SE, Ferguson VL, Bateman TA. Administration of high-dose macrophage colonystimulating factor increases bone turnover and trabecular volume fraction. J Bone Miner Metab 2009; 27:546-54.
51. McCarthy I, Goodship A, Herzog R, Oganov V, Stussi E, Vahlensieck M. Investigation of bone changes in microgravity during long and short duration space flight: comparison of techniques. Eur J Clin Invest 2000; 30:1044-54. (Pubitemid 32064053)
52. Seeman E, Wahner HW, Offord KP, Kumar R, Johnson WJ, Riggs BL. Differential effects of endocrine dysfunction on the axial and the appendicular skeleton. J Clin Invest 1982; 69:1302-9. (Pubitemid 12081058)
53. Willey JS, Livingston EW, Robbins ME, Bourland JD, Tirado-Lee L, Smith-Sielicki H, et al. Risedronate prevents early radiationinduced osteoporosis in mice at multiple skeletal locations. Bone 2010; 46:101-11.
54. Iida-Klein A, Zhou H, Lu SS, Levine R, Ducayen-Knowles M, Dempster DW, et al. Anabolic action of parathyroid hormone is skeletal site specific at the tissue and cellular levels in mice. J Bone Miner Res 2002; 17:808-16. (Pubitemid 34441897)
55. Soubrier M, Dubost JJ, Boisgard S, Sauvezie B, Gaillard P, Michel JL, et al. Insufficiency fracture. A survey of 60 cases and review of the literature. Joint Bone Spine 2003; 70:209-18.
56. Guggenbuhl P, Meadeb J, Chales G. Osteoporotic fractures of the proximal humerus, pelvis, and ankle: epidemiology and diagnosis. Joint Bone Spine 2005; 72:372-5. (Pubitemid 41415823)
57. Chavassieux P, Seeman E, Delmas PD. Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised by disease. Endocr Rev 2007; 28:151-64. (Pubitemid 46984832)
58. Camphausen K, Moses MA, Menard C, Sproull M, Beecken WD, Folkman J, et al. Radiation abscopal antitumor effect is mediated through p53. Cancer Res 2003; 63:1990-3. (Pubitemid 36460868)
59. Demaria S, Ng B, Devitt ML, Babb JS, Kawashima N, Liebes L, et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys 2004; 58:862-70. (Pubitemid 38221143)
60. Isomura H, Fujie K, Shibata K, Inoue N, Iizuka T, Takebe G, et al. Bone metabolism and oxidative stress in postmenopausal rats with iron overload. Toxicology 2004; 197:93-100. (Pubitemid 38293418)
61. Banf?́ G, Iorio EL, Corsi MM. Oxidative stress, free radicals and bone remodeling. Clin Chem Lab Med 2008; 46:1550-5.
62. Bliziotes M. Update in serotonin and bone. J Clin Endocrinol Metab 2010; 95:4124-32.
63. Ducy P, Karsenty G. The two faces of serotonin in bone biology. J Cell Biol 2010; 191:7-13.
64. Scarantino CW, Ornitz RD, Hoffman LG, Anderson RF Jr. On the mechanism of radiation-induced emesis: the role of serotonin. Int J Radiat Oncol Biol Phys 1994; 30:825-30. (Pubitemid 24355932)
65. Kavanagh BD, Pan CC, Dawson LA, Das SK, Li XA, Ten Haken RK, et al. Radiation dose-volume effects in the stomach and small bowel. Int J Radiat Oncol Biol Phys 2010; 76:S101-7.
66. Fiorino C, Alongi F, Perna L, Broggi S, Cattaneo GM, Cozzarini C, et al. Dose-volume relationships for acute bowel toxicity in patients treated with pelvic nodal irradiation for prostate cancer. Int J Radiat Oncol Biol Phys 2009; 75:27-35.
67. Mameghan H, Fisher R, Mameghan J, Watt WH, Tynan A. Bowel complications after radiotherapy for carcinoma of the prostate: the volume effect. Int J Radiat Oncol Biol Phys 1990; 18:315-20. (Pubitemid 20097525)