ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation

Cell Stem Cell

Volumn 12, Issue 6, 2013, Pages 761-773

  Myant, Kevin B ^a   Cammareri, Patrizia ^a   McGhee, Ewan J ^a   Ridgway, Rachel A ^a   Huels, David J ^a   Cordero, Julia B ^a   Schwitalla, Sarah ^b   Kalna, Gabriela ^a   Ogg, Erinn Lee ^a   Athineos, Dimitris ^a   Timpson, Paul ^a   Vidal, Marcos ^a   Murray, Graeme I ^c   Greten, Florian R ^b   Anderson, Kurt I ^a   Sansom, Owen J ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; WNT PROTEIN; NEUROPEPTIDE; RAC1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APC GENE; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER INHIBITION; CANCER STAGING; CARCINOGENESIS; CELL COUNT; CELL POPULATION; CELL PROLIFERATION; CELL TRANSFORMATION; CHROMATIN IMMUNOPRECIPITATION; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; GENE; GENE ACTIVATION; GENE DELETION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTESTINAL STEM CELL; INTESTINE EPITHELIUM CELL; MICROARRAY ANALYSIS; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; UPREGULATION; ANIMAL; C57BL MOUSE; COLORECTAL TUMOR; CYTOLOGY; METABOLISM; PATHOLOGY; SMALL INTESTINE;

ANIMALS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; INTESTINE, SMALL; MICE; MICE, INBRED C57BL; NEUROPEPTIDES; NF-KAPPA B; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STEM CELLS; WNT PROTEINS;

EID: 84878889056     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2013.04.006     Document Type: Article

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