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Volumn 4, Issue , 2015, Pages

New Approaches to Radiation Protection

Author keywords

cancer treatment; irradiation; mitigators; radiation protection; radioprotectors

Indexed keywords


EID: 84962971719     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2014.00381     Document Type: Review
Times cited : (117)

References (202)
  • 1
    • 0024411556 scopus 로고
    • Symptomatology of acute radiation effects in humans after exposure to doses of 0.5-30 Gy
    • 2722506
    • Anno GH Baum SJ Withers HR Young RW. Symptomatology of acute radiation effects in humans after exposure to doses of 0.5-30 Gy. Health Phys (1989) 56(6):821–38.10.1097/00004032-198906000-000012722506
    • (1989) Health Phys , vol.56 , Issue.6 , pp. 821-838
    • Anno, G.H.1    Baum, S.J.2    Withers, H.R.3    Young, R.W.4
  • 2
    • 0036286183 scopus 로고    scopus 로고
    • Hematologic consequences of exposure to ionizing radiation
    • 12063018
    • Dainiak N. Hematologic consequences of exposure to ionizing radiation. Exp Hematol (2002) 30(6):513–28.10.1016/S0301-472X(02)00802-012063018
    • (2002) Exp Hematol , vol.30 , Issue.6 , pp. 513-528
    • Dainiak, N.1
  • 3
    • 20244382799 scopus 로고    scopus 로고
    • Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group
    • Waselenko JK MacVittie TJ Blakely WF Pesik N Wiley AL Dickerson WE et al. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med (2004) 140(12):1037–51.10.7326/0003-4819-140-12-200406150-00015
    • (2004) Ann Intern Med , vol.140 , Issue.12 , pp. 1037-1051
    • Waselenko, J.K.1    MacVittie, T.J.2    Blakely, W.F.3    Pesik, N.4    Wiley, A.L.5    Dickerson, W.E.6
  • 5
    • 77955158521 scopus 로고    scopus 로고
    • Radiation victim management and the haematologist in the future: time to revisit therapeutic guidelines?
    • 20597842
    • Drouet M Herodin F. Radiation victim management and the haematologist in the future: time to revisit therapeutic guidelines? Int J Radiat Biol (2010) 86(8):636–48.10.3109/0955300100378960420597842
    • (2010) Int J Radiat Biol , vol.86 , Issue.8 , pp. 636-648
    • Drouet, M.1    Herodin, F.2
  • 6
    • 84866019614 scopus 로고    scopus 로고
    • Acute gastrointestinal syndrome in high-dose irradiated mice
    • 23091876
    • Booth C Tudor G Tudor J Katz BP MacVittie TJ. Acute gastrointestinal syndrome in high-dose irradiated mice. Health Phys (2012) 103(4):383–99.10.1097/HP.0b013e318266ee1323091876
    • (2012) Health Phys , vol.103 , Issue.4 , pp. 383-399
    • Booth, C.1    Tudor, G.2    Tudor, J.3    Katz, B.P.4    MacVittie, T.J.5
  • 7
    • 35148839942 scopus 로고    scopus 로고
    • Trends in the development of radioprotective agents
    • Hosseinimehr SJ. Trends in the development of radioprotective agents. Drug Discov Today (2007) 12(19–20):794–805.10.1016/j.drudis.2007.07.017
    • (2007) Drug Discov Today , vol.12 , Issue.19–20 , pp. 794-805
    • Hosseinimehr, S.J.1
  • 8
    • 0036081059 scopus 로고    scopus 로고
    • Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S
    • 12070305
    • Na Nakorn T Traver D Weissman IL Akashi K. Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S. J Clin Invest (2002) 109(12):1579–85.10.1172/JCI20021527212070305
    • (2002) J Clin Invest , vol.109 , Issue.12 , pp. 1579-1585
    • Na Nakorn, T.1    Traver, D.2    Weissman, I.L.3    Akashi, K.4
  • 10
    • 75149180486 scopus 로고    scopus 로고
    • Correlations of cell surface antigens with individual differences in radiosensitivity in human hematopoietic stem/progenitor cells
    • 20095850
    • Takahashi K Monzen S Hayashi N Kashiwakura I. Correlations of cell surface antigens with individual differences in radiosensitivity in human hematopoietic stem/progenitor cells. Radiat Res (2010) 173(2):184–90.10.1667/RR1839.120095850
    • (2010) Radiat Res , vol.173 , Issue.2 , pp. 184-190
    • Takahashi, K.1    Monzen, S.2    Hayashi, N.3    Kashiwakura, I.4
  • 11
    • 44349122954 scopus 로고    scopus 로고
    • PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome
    • 18522850
    • Qiu W Carson-Walter EB Liu H Epperly M Greenberger JS Zambetti GP et al. PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell (2008) 2(6):576–83.10.1016/j.stem.2008.03.00918522850
    • (2008) Cell Stem Cell , vol.2 , Issue.6 , pp. 576-583
    • Qiu, W.1    Carson-Walter, E.B.2    Liu, H.3    Epperly, M.4    Greenberger, J.S.5    Zambetti, G.P.6
  • 12
    • 77949655884 scopus 로고    scopus 로고
    • Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis
    • 19966853
    • Qiu W Leibowitz B Zhang L Yu J. Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. Oncogene (2010) 29(11):1622–32.10.1038/onc.2009.45119966853
    • (2010) Oncogene , vol.29 , Issue.11 , pp. 1622-1632
    • Qiu, W.1    Leibowitz, B.2    Zhang, L.3    Yu, J.4
  • 13
    • 84856449143 scopus 로고    scopus 로고
    • Alpha-tocopherol succinate protects mice against radiation-induced gastrointestinal injury
    • 22013885
    • Singh PK Wise SY Ducey EJ Fatanmi OO Elliott TB Singh VK. Alpha-tocopherol succinate protects mice against radiation-induced gastrointestinal injury. Radiat Res (2012) 177(2):133–45.10.1667/RR2627.122013885
    • (2012) Radiat Res , vol.177 , Issue.2 , pp. 133-145
    • Singh, P.K.1    Wise, S.Y.2    Ducey, E.J.3    Fatanmi, O.O.4    Elliott, T.B.5    Singh, V.K.6
  • 14
    • 33644839430 scopus 로고    scopus 로고
    • Partial volume rat lung irradiation: temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiation
    • 16524844
    • Calveley VL Khan MA Yeung IW Vandyk J Hill RP. Partial volume rat lung irradiation: temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiation. Int J Radiat Biol (2005) 81(12):887–99.10.1080/0955300060056800216524844
    • (2005) Int J Radiat Biol , vol.81 , Issue.12 , pp. 887-899
    • Calveley, V.L.1    Khan, M.A.2    Yeung, I.W.3    Vandyk, J.4    Hill, R.P.5
  • 16
    • 0022517226 scopus 로고
    • The nature and relevance of late lung pathology following localised irradiation of the thorax in mice and rats
    • Down JD. The nature and relevance of late lung pathology following localised irradiation of the thorax in mice and rats. Br J Cancer Suppl (1986) 7:330–2.
    • (1986) Br J Cancer Suppl , vol.7 , pp. 330-332
    • Down, J.D.1
  • 17
    • 47749090118 scopus 로고    scopus 로고
    • Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation
    • 18434686
    • Day RM Barshishat-Kupper M Mog SR McCart EA Prasanna PG Davis TA et al. Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation. J Radiat Res (2008) 49(4):361–72.10.1269/jrr.0712118434686
    • (2008) J Radiat Res , vol.49 , Issue.4 , pp. 361-372
    • Day, R.M.1    Barshishat-Kupper, M.2    Mog, S.R.3    McCart, E.A.4    Prasanna, P.G.5    Davis, T.A.6
  • 18
    • 0016713652 scopus 로고
    • Normal tissue responses to radiation therapy
    • Bloomer WD Hellman S. Normal tissue responses to radiation therapy. N Engl J Med (1975) 293(2):80–3.10.1056/NEJM197507102930206
    • (1975) N Engl J Med , vol.293 , Issue.2 , pp. 80-83
    • Bloomer, W.D.1    Hellman, S.2
  • 19
    • 0016424848 scopus 로고
    • Cell kinetics, models, and cancer treatment – some principles for the radiation oncologist
    • 1208863
    • Hellman S. Cell kinetics, models, and cancer treatment – some principles for the radiation oncologist. Radiology (1975) 114(1):219–23.10.1148/114.1.2191208863
    • (1975) Radiology , vol.114 , Issue.1 , pp. 219-223
    • Hellman, S.1
  • 20
    • 0032031611 scopus 로고    scopus 로고
    • Clinical radiation pneumonitis and radiographic changes after thoracic radiation therapy for lung carcinoma
    • 9486572
    • Monson JM Stark P Reilly JJ Sugarbaker DJ Strauss GM Swanson SJ et al. Clinical radiation pneumonitis and radiographic changes after thoracic radiation therapy for lung carcinoma. Cancer (1998) 82(5):842–50.10.1002/(SICI)1097-0142(19980301)82:5<842::AID-CNCR7>3.3.CO;2-O9486572
    • (1998) Cancer , vol.82 , Issue.5 , pp. 842-850
    • Monson, J.M.1    Stark, P.2    Reilly, J.J.3    Sugarbaker, D.J.4    Strauss, G.M.5    Swanson, S.J.6
  • 21
    • 0032412758 scopus 로고    scopus 로고
    • Effects of ongoing smoking on the development of radiation-induced pneumonitis in breast cancer and oesophagus cancer patients
    • 9886696
    • Johansson S Bjermer L Franzen L Henriksson R. Effects of ongoing smoking on the development of radiation-induced pneumonitis in breast cancer and oesophagus cancer patients. Radiother Oncol (1998) 49(1):41–7.10.1016/S0167-8140(98)00064-49886696
    • (1998) Radiother Oncol , vol.49 , Issue.1 , pp. 41-47
    • Johansson, S.1    Bjermer, L.2    Franzen, L.3    Henriksson, R.4
  • 22
    • 33644843127 scopus 로고    scopus 로고
    • Radiation pneumonitis and oesophagitis in thoracic irradiation
    • Small W., Woloschak G.E., (eds), New York, NY, Springer Science and Media Business, Inc., In:, editors., :, p
    • Bradley J Movsas B. Radiation pneumonitis and oesophagitis in thoracic irradiation. In: Small W Woloschak GE, editors. Radiation Toxicity: A Practical Guide. New York, NY: Springer Science and Media Business, Inc. (2006). p. 43–52.
    • (2006) Radiation Toxicity: A Practical Guide , pp. 43-52
    • Bradley, J.1    Movsas, B.2
  • 23
    • 33747826874 scopus 로고    scopus 로고
    • Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology
    • 16929324
    • Bentzen SM. Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer (2006) 6(9):702–13.10.1038/nrc195016929324
    • (2006) Nat Rev Cancer , vol.6 , Issue.9 , pp. 702-713
    • Bentzen, S.M.1
  • 24
    • 34347406141 scopus 로고    scopus 로고
    • Toward improving the therapeutic ratio in stereotactic radiosurgery: selective modulation of the radiation responses of both normal tissues and tumor
    • 17639878
    • Hopewell JW Millar WT Ang KK. Toward improving the therapeutic ratio in stereotactic radiosurgery: selective modulation of the radiation responses of both normal tissues and tumor. J Neurosurg (2007) 107(1):84–93.10.3171/JNS-07/07/008417639878
    • (2007) J Neurosurg , vol.107 , Issue.1 , pp. 84-93
    • Hopewell, J.W.1    Millar, W.T.2    Ang, K.K.3
  • 25
    • 77956396683 scopus 로고    scopus 로고
    • Managing the adverse effects of radiation therapy
    • 20704169
    • Berkey FJ. Managing the adverse effects of radiation therapy. Am Fam Physician (2010) 82(4):381–8, 394.20704169
    • (2010) Am Fam Physician , vol.82 , Issue.4 , pp. 381-380
    • Berkey, F.J.1
  • 26
    • 84856824703 scopus 로고    scopus 로고
    • Late toxicity of radiotherapy: a problem or a challenge for the radiation oncologist?
    • 22619647
    • Petersen C Wurschmidt F. Late toxicity of radiotherapy: a problem or a challenge for the radiation oncologist? Breast Care (Basel) (2011) 6(5):369–74.10.1159/00033422022619647
    • (2011) Breast Care (Basel) , vol.6 , Issue.5 , pp. 369-374
    • Petersen, C.1    Wurschmidt, F.2
  • 27
    • 0034307213 scopus 로고    scopus 로고
    • Predictors of severe esophagitis include use of concurrent chemotherapy, but not the length of irradiated esophagus: a multivariate analysis of patients with lung cancer treated with nonoperative therapy
    • 11020565
    • Werner-Wasik M Pequignot E Leeper D Hauck W Curran W. Predictors of severe esophagitis include use of concurrent chemotherapy, but not the length of irradiated esophagus: a multivariate analysis of patients with lung cancer treated with nonoperative therapy. Int J Radiat Oncol Biol Phys (2000) 48(3):689–96.10.1016/S0360-3016(00)00699-411020565
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , Issue.3 , pp. 689-696
    • Werner-Wasik, M.1    Pequignot, E.2    Leeper, D.3    Hauck, W.4    Curran, W.5
  • 28
    • 0037083350 scopus 로고    scopus 로고
    • Combined chemotherapy and radiation therapy for head and neck malignancies: quality of life issues
    • 11920484
    • Nguyen NP Sallah S Karlsson U Antoine JE. Combined chemotherapy and radiation therapy for head and neck malignancies: quality of life issues. Cancer (2002) 94(4):1131–41.10.1002/cncr.1025711920484
    • (2002) Cancer , vol.94 , Issue.4 , pp. 1131-1141
    • Nguyen, N.P.1    Sallah, S.2    Karlsson, U.3    Antoine, J.E.4
  • 29
    • 36949026694 scopus 로고    scopus 로고
    • Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
    • 18066086
    • Lee JH Paull TT. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene (2007) 26(56):7741–8.10.1038/sj.onc.121087218066086
    • (2007) Oncogene , vol.26 , Issue.56 , pp. 7741-7748
    • Lee, J.H.1    Paull, T.T.2
  • 30
    • 54449087649 scopus 로고    scopus 로고
    • Combined chemo-radiotherapy for locally advanced non-small cell lung cancer: current status and future development
    • 18632283
    • Guida C Maione P Rossi A Bareschino M Schettino C Barzaghi D et al. Combined chemo-radiotherapy for locally advanced non-small cell lung cancer: current status and future development. Crit Rev Oncol Hematol (2008) 68(3):222–32.10.1016/j.critrevonc.2008.05.00718632283
    • (2008) Crit Rev Oncol Hematol , vol.68 , Issue.3 , pp. 222-232
    • Guida, C.1    Maione, P.2    Rossi, A.3    Bareschino, M.4    Schettino, C.5    Barzaghi, D.6
  • 31
    • 77951498823 scopus 로고    scopus 로고
    • Challenges of integrating chemotherapy and targeted therapy with radiation in locally advanced head and neck squamous cell cancer
    • 20216313
    • Marur S Forastiere AA. Challenges of integrating chemotherapy and targeted therapy with radiation in locally advanced head and neck squamous cell cancer. Curr Opin Oncol (2010) 22(3):206–11.10.1097/CCO.0b013e328338475c20216313
    • (2010) Curr Opin Oncol , vol.22 , Issue.3 , pp. 206-211
    • Marur, S.1    Forastiere, A.A.2
  • 32
    • 67649378846 scopus 로고    scopus 로고
    • Extended-field radiation therapy with whole pelvis radiotherapy and cisplatin chemosensitization in the treatment of IB2-IIIB cervical carcinoma: a retrospective review
    • Ring KL Young JL Dunlap NE Andersen WA Schneider BF. Extended-field radiation therapy with whole pelvis radiotherapy and cisplatin chemosensitization in the treatment of IB2-IIIB cervical carcinoma: a retrospective review. Am J Obstet Gynecol (2009) 201(1):109.e1–6.10.1016/j.ajog.2009.03.022
    • (2009) Am J Obstet Gynecol , vol.201 , Issue.1
    • Ring, K.L.1    Young, J.L.2    Dunlap, N.E.3    Andersen, W.A.4    Schneider, B.F.5
  • 33
    • 70549109311 scopus 로고    scopus 로고
    • Brain tumors across the age spectrum: biology, therapy, and late effects
    • 19959032
    • Merchant TE Pollack IF Loeffler JS. Brain tumors across the age spectrum: biology, therapy, and late effects. Semin Radiat Oncol (2010) 20(1):58–66.10.1016/j.semradonc.2009.09.00519959032
    • (2010) Semin Radiat Oncol , vol.20 , Issue.1 , pp. 58-66
    • Merchant, T.E.1    Pollack, I.F.2    Loeffler, J.S.3
  • 34
    • 75349083873 scopus 로고    scopus 로고
    • Risk factors for cognitive decline in children treated for brain tumors
    • 19931477
    • Duffner PK. Risk factors for cognitive decline in children treated for brain tumors. Eur J Paediatr Neurol (2010) 14:106–15.10.1016/j.ejpn.2009.10.00519931477
    • (2010) Eur J Paediatr Neurol , vol.14 , pp. 106-115
    • Duffner, P.K.1
  • 35
    • 79955013110 scopus 로고    scopus 로고
    • Potential targets for intervention in radiation-induced heart disease
    • 20583977
    • Boerma M Hauer-Jensen M. Potential targets for intervention in radiation-induced heart disease. Curr Drug Targets (2010) 11(11):1405–12.10.2174/138945011100901140520583977
    • (2010) Curr Drug Targets , vol.11 , Issue.11 , pp. 1405-1412
    • Boerma, M.1    Hauer-Jensen, M.2
  • 36
    • 80052286168 scopus 로고    scopus 로고
    • Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention
    • 20826032
    • Andratschke N Maurer J Molls M Trott KR. Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention. Radiother Oncol (2011) 100(2):160–6.10.1016/j.radonc.2010.08.01020826032
    • (2011) Radiother Oncol , vol.100 , Issue.2 , pp. 160-166
    • Andratschke, N.1    Maurer, J.2    Molls, M.3    Trott, K.R.4
  • 37
    • 84868159268 scopus 로고    scopus 로고
    • Cranial irradiation increases risk of stroke in pediatric brain tumor survivors
    • 22968468
    • Campen CJ Kranick SM Kasner SE Kessler SK Zimmerman RA Lustig R et al. Cranial irradiation increases risk of stroke in pediatric brain tumor survivors. Stroke (2012) 43(11):3035–40.10.1161/STROKEAHA.112.66156122968468
    • (2012) Stroke , vol.43 , Issue.11 , pp. 3035-3040
    • Campen, C.J.1    Kranick, S.M.2    Kasner, S.E.3    Kessler, S.K.4    Zimmerman, R.A.5    Lustig, R.6
  • 38
    • 0018837308 scopus 로고
    • Time effects in molecular radiation biology
    • Adams GE Jameson DG. Time effects in molecular radiation biology. Radiat Environ Biophys (1980) 17(2):95–113.10.1007/BF02027847
    • (1980) Radiat Environ Biophys , vol.17 , Issue.2 , pp. 95-113
    • Adams, G.E.1    Jameson, D.G.2
  • 39
    • 0021092745 scopus 로고
    • Oxygen effect, hydrogen peroxide yields, and time scale of interaction of potentially damaging species in electron pulse irradiated bacterial spores
    • 11542738
    • Tallentire A. Oxygen effect, hydrogen peroxide yields, and time scale of interaction of potentially damaging species in electron pulse irradiated bacterial spores. Adv Space Res (1983) 3(8):105–12.10.1016/0273-1177(83)90180-111542738
    • (1983) Adv Space Res , vol.3 , Issue.8 , pp. 105-112
    • Tallentire, A.1
  • 40
    • 0026101445 scopus 로고
    • “Radiation chemistry” literature compilations: their wider value in free radical research
    • 1650739
    • Wardman P Ross AB. “Radiation chemistry” literature compilations: their wider value in free radical research. Free Radic Biol Med (1991) 10(3–4):243–7.10.1016/0891-5849(91)90081-D1650739
    • (1991) Free Radic Biol Med , vol.10 , Issue.3–4 , pp. 243-247
    • Wardman, P.1    Ross, A.B.2
  • 41
    • 0034079862 scopus 로고    scopus 로고
    • Free radicals and antioxidants in the year 2000. A historical look to the future
    • 10863535
    • Gutteridge JM Halliwell B. Free radicals and antioxidants in the year 2000. A historical look to the future. Ann N Y Acad Sci (2000) 899:136–47.10.1111/j.1749-6632.2000.tb06182.x10863535
    • (2000) Ann N Y Acad Sci , vol.899 , pp. 136-147
    • Gutteridge, J.M.1    Halliwell, B.2
  • 42
    • 84907107090 scopus 로고
    • Radiation dose dependence of the sensitization by oxygen and oxygen mimic sensitizers
    • 2994369
    • Revesz L Palcic B. Radiation dose dependence of the sensitization by oxygen and oxygen mimic sensitizers. Acta Radiol Oncol (1985) 24(3):209–17.10.3109/028418685091343892994369
    • (1985) Acta Radiol Oncol , vol.24 , Issue.3 , pp. 209-217
    • Revesz, L.1    Palcic, B.2
  • 43
    • 0027030912 scopus 로고
    • Hypoxia as a determinant factor in radiotherapy? Where are we?
    • Guichard M. Hypoxia as a determinant factor in radiotherapy? Where are we? BJR Suppl (1992) 24:142–5.
    • (1992) BJR Suppl , vol.24 , pp. 142-145
    • Guichard, M.1
  • 44
    • 84874607439 scopus 로고    scopus 로고
    • Microenvironment and radiation therapy
    • 23509762
    • Yoshimura M Itasaka S Harada H Hiraoka M. Microenvironment and radiation therapy. Biomed Res Int (2013) 2013:685308.10.1155/2013/68530823509762
    • (2013) Biomed Res Int , vol.2013 , pp. 685308
    • Yoshimura, M.1    Itasaka, S.2    Harada, H.3    Hiraoka, M.4
  • 45
    • 0021160107 scopus 로고
    • The contribution of hydroxyl radical to radiosensitization: a study of DNA damage
    • 6089257
    • Skov KA. The contribution of hydroxyl radical to radiosensitization: a study of DNA damage. Radiat Res (1984) 99(3):502–10.10.2307/35763266089257
    • (1984) Radiat Res , vol.99 , Issue.3 , pp. 502-510
    • Skov, K.A.1
  • 46
    • 0021992831 scopus 로고
    • Characterization of hydroxyl radical-induced damage after sparsely and densely ionizing irradiation
    • 2984128
    • Roots R Chatterjee A Chang P Lommel L Blakely EA. Characterization of hydroxyl radical-induced damage after sparsely and densely ionizing irradiation. Int J Radiat Biol Relat Stud Phys Chem Med (1985) 47(2):157–66.10.1080/095530085145502312984128
    • (1985) Int J Radiat Biol Relat Stud Phys Chem Med , vol.47 , Issue.2 , pp. 157-166
    • Roots, R.1    Chatterjee, A.2    Chang, P.3    Lommel, L.4    Blakely, E.A.5
  • 47
    • 77951979338 scopus 로고    scopus 로고
    • Plasma membrane signaling induced by ionizing radiation
    • 20117234
    • Corre I Niaudet C Paris F. Plasma membrane signaling induced by ionizing radiation. Mutat Res (2010) 704(1–3):61–7.10.1016/j.mrrev.2010.01.01420117234
    • (2010) Mutat Res , vol.704 , Issue.1–3 , pp. 61-67
    • Corre, I.1    Niaudet, C.2    Paris, F.3
  • 48
    • 80054873621 scopus 로고    scopus 로고
    • Radiation-induced reductive modifications of sulfur-containing amino acids within peptides and proteins
    • 21447412
    • Chatgilialoglu C Ferreri C Torreggiani A Salzano AM Renzone G Scaloni A. Radiation-induced reductive modifications of sulfur-containing amino acids within peptides and proteins. J Proteomics (2011) 74(11):2264–73.10.1016/j.jprot.2011.03.01221447412
    • (2011) J Proteomics , vol.74 , Issue.11 , pp. 2264-2273
    • Chatgilialoglu, C.1    Ferreri, C.2    Torreggiani, A.3    Salzano, A.M.4    Renzone, G.5    Scaloni, A.6
  • 49
    • 0028927261 scopus 로고
    • Reactions of oxyl radicals with DNA
    • 7628729
    • Breen AP Murphy JA. Reactions of oxyl radicals with DNA. Free Radic Biol Med (1995) 18(6):1033–77.10.1016/0891-5849(94)00209-37628729
    • (1995) Free Radic Biol Med , vol.18 , Issue.6 , pp. 1033-1077
    • Breen, A.P.1    Murphy, J.A.2
  • 50
    • 0028814266 scopus 로고    scopus 로고
    • DNA damage profiles induced by oxidizing agents
    • Epe B. DNA damage profiles induced by oxidizing agents. Rev Physiol Biochem Pharmacol (1996) 127:223–49.10.1007/BFb0048268
    • (1996) Rev Physiol Biochem Pharmacol , vol.127 , pp. 223-249
    • Epe, B.1
  • 51
    • 0031773901 scopus 로고    scopus 로고
    • Enzymatic processing of radiation-induced free radical damage in DNA
    • 9806610
    • Wallace SS. Enzymatic processing of radiation-induced free radical damage in DNA. Radiat Res (1998) 150(5 Suppl):S60–79.10.2307/35798099806610
    • (1998) Radiat Res , vol.150 , pp. S60-S79
    • Wallace, S.S.1
  • 52
    • 0344585940 scopus 로고    scopus 로고
    • The interacting pathways for prevention and repair of oxidative DNA damage
    • 14637258
    • Slupphaug G Kavli B Krokan HE. The interacting pathways for prevention and repair of oxidative DNA damage. Mutat Res (2003) 531(1–2):231–51.10.1016/j.mrfmmm.2003.06.00214637258
    • (2003) Mutat Res , vol.531 , Issue.1–2 , pp. 231-251
    • Slupphaug, G.1    Kavli, B.2    Krokan, H.E.3
  • 53
    • 17644409069 scopus 로고    scopus 로고
    • ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
    • 15790808
    • Lee JH Paull TT. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science (2005) 308(5721):551–4.10.1126/science.110829715790808
    • (2005) Science , vol.308 , Issue.5721 , pp. 551-554
    • Lee, J.H.1    Paull, T.T.2
  • 54
    • 34247483506 scopus 로고    scopus 로고
    • ATM activation and DNA damage response
    • 17457059
    • Lavin MF Kozlov S. ATM activation and DNA damage response. Cell Cycle (2007) 6(8):931–42.10.4161/cc.6.8.418017457059
    • (2007) Cell Cycle , vol.6 , Issue.8 , pp. 931-942
    • Lavin, M.F.1    Kozlov, S.2
  • 55
    • 77649131406 scopus 로고    scopus 로고
    • Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
    • 20177395
    • Moynahan ME Jasin M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol (2010) 11(3):196–207.10.1038/nrm285120177395
    • (2010) Nat Rev Mol Cell Biol , vol.11 , Issue.3 , pp. 196-207
    • Moynahan, M.E.1    Jasin, M.2
  • 56
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • 20192759
    • Lieber MR. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 79:181–211.10.1146/annurev.biochem.052308.09313120192759
    • (2010) Annu Rev Biochem , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 57
    • 84876174441 scopus 로고    scopus 로고
    • The ATM signaling network in development and disease
    • 23532176
    • Stracker TH Roig I Knobel PA Marjanovic M. The ATM signaling network in development and disease. Front Genet (2013) 4:37.10.3389/fgene.2013.0003723532176
    • (2013) Front Genet , vol.4 , pp. 37
    • Stracker, T.H.1    Roig, I.2    Knobel, P.A.3    Marjanovic, M.4
  • 58
    • 0344305376 scopus 로고    scopus 로고
    • Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress
    • 14651848
    • Huang TT Wuerzberger-Davis SM Wu ZH Miyamoto S. Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell (2003) 115(5):565–76.10.1016/S0092-8674(03)00895-X14651848
    • (2003) Cell , vol.115 , Issue.5 , pp. 565-576
    • Huang, T.T.1    Wuerzberger-Davis, S.M.2    Wu, Z.H.3    Miyamoto, S.4
  • 59
    • 84876141622 scopus 로고    scopus 로고
    • Promotion of DNA repair by nuclear IKKbeta phosphorylation of ATM in response to genotoxic stimuli
    • 22614018
    • Sakamoto K Hikiba Y Nakagawa H Hirata Y Hayakawa Y Kinoshita H et al. Promotion of DNA repair by nuclear IKKbeta phosphorylation of ATM in response to genotoxic stimuli. Oncogene (2013) 32(14):1854–62.10.1038/onc.2012.19222614018
    • (2013) Oncogene , vol.32 , Issue.14 , pp. 1854-1862
    • Sakamoto, K.1    Hikiba, Y.2    Nakagawa, H.3    Hirata, Y.4    Hayakawa, Y.5    Kinoshita, H.6
  • 61
    • 79957532007 scopus 로고    scopus 로고
    • Assessing the risk of second malignancies after modern radiotherapy
    • 21593785
    • Newhauser WD Durante M. Assessing the risk of second malignancies after modern radiotherapy. Nat Rev Cancer (2011) 11(6):438–48.10.1038/nrc306921593785
    • (2011) Nat Rev Cancer , vol.11 , Issue.6 , pp. 438-448
    • Newhauser, W.D.1    Durante, M.2
  • 62
    • 79961096506 scopus 로고    scopus 로고
    • After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndrome (MODS)
    • 21417595
    • Williams JP McBride WH. After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndrome (MODS). Int J Radiat Biol (2011) 87(8):851–68.10.3109/09553002.2011.56099621417595
    • (2011) Int J Radiat Biol , vol.87 , Issue.8 , pp. 851-868
    • Williams, J.P.1    McBride, W.H.2
  • 63
    • 0035479075 scopus 로고    scopus 로고
    • Can short-term administration of dexamethasone abrogate radiation-induced acute cytokine gene response in lung and modify subsequent molecular responses?
    • 11567802
    • Hong JH Chiang CS Tsao CY Lin PY Wu CJ McBride WH. Can short-term administration of dexamethasone abrogate radiation-induced acute cytokine gene response in lung and modify subsequent molecular responses? Int J Radiat Oncol Biol Phys (2001) 51(2):296–303.10.1016/S0360-3016(01)01702-311567802
    • (2001) Int J Radiat Oncol Biol Phys , vol.51 , Issue.2 , pp. 296-303
    • Hong, J.H.1    Chiang, C.S.2    Tsao, C.Y.3    Lin, P.Y.4    Wu, C.J.5    McBride, W.H.6
  • 64
    • 0038071781 scopus 로고    scopus 로고
    • Bronchoalveolar lavage and interstitial cells have different roles in radiation-induced lung injury
    • 12745880
    • Hong JH Jung SM Tsao TC Wu CJ Lee CY Chen FH et al. Bronchoalveolar lavage and interstitial cells have different roles in radiation-induced lung injury. Int J Radiat Biol (2003) 79(3):159–67.10.1080/095530003100007689412745880
    • (2003) Int J Radiat Biol , vol.79 , Issue.3 , pp. 159-167
    • Hong, J.H.1    Jung, S.M.2    Tsao, T.C.3    Wu, C.J.4    Lee, C.Y.5    Chen, F.H.6
  • 65
    • 77957884094 scopus 로고    scopus 로고
    • Pathogenetic mechanisms in radiation fibrosis
    • Yarnold J Brotons MC. Pathogenetic mechanisms in radiation fibrosis. Radiother Oncol (2010) 97(1):149–61.10.1016/j.radonc.2010.09.002
    • (2010) Radiother Oncol , vol.97 , Issue.1 , pp. 149-161
    • Yarnold, J.1    Brotons, M.C.2
  • 66
    • 34447116285 scopus 로고    scopus 로고
    • Amifostine: the first selective-target and broad-spectrum radioprotector
    • 17602063
    • Kouvaris JR Kouloulias VE Vlahos LJ. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist (2007) 12(6):738–47.10.1634/theoncologist.12-6-73817602063
    • (2007) Oncologist , vol.12 , Issue.6 , pp. 738-747
    • Kouvaris, J.R.1    Kouloulias, V.E.2    Vlahos, L.J.3
  • 67
    • 0029990864 scopus 로고    scopus 로고
    • Exploration of platinum-based dose-intensive chemotherapy strategies with amifostine (Ethyol)
    • 8976821
    • Schuchter LM. Exploration of platinum-based dose-intensive chemotherapy strategies with amifostine (Ethyol). Eur J Cancer (1996) 32A(Suppl 4):S40–2.10.1016/S0959-8049(96)00316-48976821
    • (1996) Eur J Cancer , vol.32A , pp. S40-S42
    • Schuchter, L.M.1
  • 68
    • 33745206033 scopus 로고    scopus 로고
    • Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research
    • 16530908
    • Ali BH Al Moundhri MS. Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research. Food Chem Toxicol (2006) 44(8):1173–83.10.1016/j.fct.2006.01.01316530908
    • (2006) Food Chem Toxicol , vol.44 , Issue.8 , pp. 1173-1183
    • Ali, B.H.1    Al Moundhri, M.S.2
  • 69
    • 67349112401 scopus 로고    scopus 로고
    • Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity
    • 18986801
    • Chirino YI Pedraza-Chaverri J. Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity. Exp Toxicol Pathol (2009) 61(3):223–42.10.1016/j.etp.2008.09.00318986801
    • (2009) Exp Toxicol Pathol , vol.61 , Issue.3 , pp. 223-242
    • Chirino, Y.I.1    Pedraza-Chaverri, J.2
  • 70
    • 0027942635 scopus 로고
    • Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (Ethyol): preclinical aspects
    • van der Vijgh WJ Peters GJ. Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (Ethyol): preclinical aspects. Semin Oncol (1994) 21(5 Suppl 11):2–7.
    • (1994) Semin Oncol , vol.21 , pp. 2-7
    • van der Vijgh, W.J.1    Peters, G.J.2
  • 71
    • 0036987232 scopus 로고    scopus 로고
    • Radioprotective effect of amifostine in patients with head and neck squamous cell carcinoma
    • 12577247
    • Bourhis J Rosine D. Radioprotective effect of amifostine in patients with head and neck squamous cell carcinoma. Semin Oncol (2002) 29(6 Suppl 19):61–2.10.1053/sonc.2002.3734912577247
    • (2002) Semin Oncol , vol.29 , pp. 61-62
    • Bourhis, J.1    Rosine, D.2
  • 72
    • 2442661630 scopus 로고    scopus 로고
    • A randomized trial of amifostine as radioprotector in the radiotherapy of head and neck cancer
    • 17385823
    • Karacetin D Yucel B Leblebicioglu B Aksakal O Maral O Incekara O. A randomized trial of amifostine as radioprotector in the radiotherapy of head and neck cancer. J BUON (2004) 9(1):23–6.17385823
    • (2004) J BUON , vol.9 , Issue.1 , pp. 23-26
    • Karacetin, D.1    Yucel, B.2    Leblebicioglu, B.3    Aksakal, O.4    Maral, O.5    Incekara, O.6
  • 73
    • 79959311310 scopus 로고    scopus 로고
    • Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient data
    • 21576630
    • Bourhis J Blanchard P Maillard E Brizel DM Movsas B Buentzel J et al. Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient data. J Clin Oncol (2011) 29(18):2590–7.10.1200/JCO.2010.33.145421576630
    • (2011) J Clin Oncol , vol.29 , Issue.18 , pp. 2590-2597
    • Bourhis, J.1    Blanchard, P.2    Maillard, E.3    Brizel, D.M.4    Movsas, B.5    Buentzel, J.6
  • 75
    • 84868231714 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy of amifostine in the prevention of cisplatin ototoxicity
    • 23092832
    • Duval M Daniel SJ. Meta-analysis of the efficacy of amifostine in the prevention of cisplatin ototoxicity. J Otolaryngol Head Neck Surg (2012) 41(5):309–15.23092832
    • (2012) J Otolaryngol Head Neck Surg , vol.41 , Issue.5 , pp. 309-315
    • Duval, M.1    Daniel, S.J.2
  • 76
    • 84871384685 scopus 로고    scopus 로고
    • Postmastectomy hypofractionated and accelerated radiation therapy with (and without) subcutaneous amifostine cytoprotection
    • 23040218
    • Koukourakis MI Panteliadou M Abatzoglou IM Sismanidou K Sivridis E Giatromanolaki A. Postmastectomy hypofractionated and accelerated radiation therapy with (and without) subcutaneous amifostine cytoprotection. Int J Radiat Oncol Biol Phys (2013) 85(1):e7–13.10.1016/j.ijrobp.2012.08.01723040218
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , Issue.1 , pp. e7-e13
    • Koukourakis, M.I.1    Panteliadou, M.2    Abatzoglou, I.M.3    Sismanidou, K.4    Sivridis, E.5    Giatromanolaki, A.6
  • 77
    • 46249094714 scopus 로고    scopus 로고
    • Alternate delivery route for amifostine as a radio-/chemo-protecting agent
    • 18549666
    • Praetorius NP Mandal TK. Alternate delivery route for amifostine as a radio-/chemo-protecting agent. J Pharm Pharmacol (2008) 60(7):809–15.10.1211/jpp.60.7.000118549666
    • (2008) J Pharm Pharmacol , vol.60 , Issue.7 , pp. 809-815
    • Praetorius, N.P.1    Mandal, T.K.2
  • 78
    • 84903728783 scopus 로고    scopus 로고
    • Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis
    • 24597748
    • Seed TM Inal CE Singh VK. Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis. Int J Radiat Biol (2014) 90(7):594–604.10.3109/09553002.2014.89945024597748
    • (2014) Int J Radiat Biol , vol.90 , Issue.7 , pp. 594-604
    • Seed, T.M.1    Inal, C.E.2    Singh, V.K.3
  • 79
    • 84884734549 scopus 로고    scopus 로고
    • Palifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre-clinical models
    • 24151975
    • Finch PW Mark Cross LJ McAuley DF Farrell CL. Palifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre-clinical models. J Cell Mol Med (2013) 17(9):1065–87.10.1111/jcmm.1209124151975
    • (2013) J Cell Mol Med , vol.17 , Issue.9 , pp. 1065-1087
    • Finch, P.W.1    Mark Cross, L.J.2    McAuley, D.F.3    Farrell, C.L.4
  • 80
    • 84891166572 scopus 로고    scopus 로고
    • Clinical applications of palifermin: amelioration of oral mucositis and other potential indications
    • 24251854
    • Vadhan-Raj S Goldberg JD Perales MA Berger DP van den Brink MR. Clinical applications of palifermin: amelioration of oral mucositis and other potential indications. J Cell Mol Med (2013) 17(11):1371–84.10.1111/jcmm.1216924251854
    • (2013) J Cell Mol Med , vol.17 , Issue.11 , pp. 1371-1384
    • Vadhan-Raj, S.1    Goldberg, J.D.2    Perales, M.A.3    Berger, D.P.4    van den Brink, M.R.5
  • 81
    • 84896905005 scopus 로고    scopus 로고
    • Clinical effectiveness of palifermin in prevention and treatment of oral mucositis in children with acute lymphoblastic leukaemia: a case-control study
    • 24357856
    • Lauritano D Petruzzi M Di Stasio D Lucchese A. Clinical effectiveness of palifermin in prevention and treatment of oral mucositis in children with acute lymphoblastic leukaemia: a case-control study. Int J Oral Sci (2014) 6(1):27–30.10.1038/ijos.2013.9324357856
    • (2014) Int J Oral Sci , vol.6 , Issue.1 , pp. 27-30
    • Lauritano, D.1    Petruzzi, M.2    Di Stasio, D.3    Lucchese, A.4
  • 82
    • 0032897928 scopus 로고    scopus 로고
    • Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis
    • 9989524
    • Epperly MW Bray JA Krager S Berry LM Gooding W Engelhardt JF et al. Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis. Int J Radiat Oncol Biol Phys (1999) 43(1):169–81.10.1016/S0360-3016(98)00355-19989524
    • (1999) Int J Radiat Oncol Biol Phys , vol.43 , Issue.1 , pp. 169-181
    • Epperly, M.W.1    Bray, J.A.2    Krager, S.3    Berry, L.M.4    Gooding, W.5    Engelhardt, J.F.6
  • 83
    • 0034131278 scopus 로고    scopus 로고
    • Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation
    • 10871749
    • Epperly MW Defilippi S Sikora C Gretton J Kalend A Greenberger JS. Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation. Gene Ther (2000) 7(12):1011–8.10.1038/sj.gt.330120710871749
    • (2000) Gene Ther , vol.7 , Issue.12 , pp. 1011-1018
    • Epperly, M.W.1    Defilippi, S.2    Sikora, C.3    Gretton, J.4    Kalend, A.5    Greenberger, J.S.6
  • 84
    • 0035144389 scopus 로고    scopus 로고
    • Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy
    • 11121210
    • Epperly MW Gretton JA DeFilippi SJ Greenberger JS Sikora CA Liggitt D et al. Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy. Radiat Res (2001) 155(1 Pt 1):2–14.10.1667/0033-7587(2001)155[0002:MORICE]2.0.CO;211121210
    • (2001) Radiat Res , vol.155 , pp. 2-14
    • Epperly, M.W.1    Gretton, J.A.2    DeFilippi, S.J.3    Greenberger, J.S.4    Sikora, C.A.5    Liggitt, D.6
  • 85
    • 0035921188 scopus 로고    scopus 로고
    • Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation
    • 11474496
    • Epperly MW Kagan VE Sikora CA Gretton JE Defilippi SJ Bar-Sagi D et al. Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation. Int J Cancer (2001) 96(4):221–31.10.1002/ijc.102311474496
    • (2001) Int J Cancer , vol.96 , Issue.4 , pp. 221-231
    • Epperly, M.W.1    Kagan, V.E.2    Sikora, C.A.3    Gretton, J.E.4    Defilippi, S.J.5    Bar-Sagi, D.6
  • 86
    • 0036249831 scopus 로고    scopus 로고
    • Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane
    • 11966323
    • Epperly MW Sikora CA DeFilippi SJ Gretton JA Zhan Q Kufe DW et al. Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane. Radiat Res (2002) 157(5):568–77.10.1667/0033-7587(2002)157[0568:MSDSIR]2.0.CO;211966323
    • (2002) Radiat Res , vol.157 , Issue.5 , pp. 568-577
    • Epperly, M.W.1    Sikora, C.A.2    DeFilippi, S.J.3    Gretton, J.A.4    Zhan, Q.5    Kufe, D.W.6
  • 87
    • 0037338423 scopus 로고    scopus 로고
    • Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene
    • 12600239
    • Guo H Seixas-Silva JA Jr Epperly MW Gretton JE Shin DM Bar-Sagi D et al. Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiat Res (2003) 159(3):361–70.10.1667/0033-7587(2003)159[0361:PORIOC]2.0.CO;212600239
    • (2003) Radiat Res , vol.159 , Issue.3 , pp. 361-370
    • Guo, H.1    Seixas-Silva, J.A.2    Epperly, M.W.3    Gretton, J.E.4    Shin, D.M.5    Bar-Sagi, D.6
  • 88
    • 0348226533 scopus 로고    scopus 로고
    • Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage
    • 14565825
    • Epperly MW Gretton JE Sikora CA Jefferson M Bernarding M Nie S et al. Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage. Radiat Res (2003) 160(5):568–78.10.1667/RR308114565825
    • (2003) Radiat Res , vol.160 , Issue.5 , pp. 568-578
    • Epperly, M.W.1    Gretton, J.E.2    Sikora, C.A.3    Jefferson, M.4    Bernarding, M.5    Nie, S.6
  • 89
    • 37749025173 scopus 로고    scopus 로고
    • Gene therapy approaches for stem cell protection
    • 17700708
    • Greenberger JS. Gene therapy approaches for stem cell protection. Gene Ther (2008) 15(2):100–8.10.1038/sj.gt.330300417700708
    • (2008) Gene Ther , vol.15 , Issue.2 , pp. 100-108
    • Greenberger, J.S.1
  • 90
    • 84882279930 scopus 로고    scopus 로고
    • Conditional radioresistance of Tet-inducible manganese superoxide dismutase bone marrow stromal cell lines
    • 23862693
    • Epperly MW Chaillet JR Kalash R Shaffer B Goff J Franicola D et al. Conditional radioresistance of Tet-inducible manganese superoxide dismutase bone marrow stromal cell lines. Radiat Res (2013) 180(2):189–204.10.1667/RR3177.123862693
    • (2013) Radiat Res , vol.180 , Issue.2 , pp. 189-204
    • Epperly, M.W.1    Chaillet, J.R.2    Kalash, R.3    Shaffer, B.4    Goff, J.5    Franicola, D.6
  • 91
    • 79957599423 scopus 로고    scopus 로고
    • Antioxidant-chemoprevention diet ameliorates late effects of total-body irradiation and supplements radioprotection by MnSOD-plasmid liposome administration
    • 21466381
    • Epperly MW Wang H Jones JA Dixon T Montesinos CA Greenberger JS. Antioxidant-chemoprevention diet ameliorates late effects of total-body irradiation and supplements radioprotection by MnSOD-plasmid liposome administration. Radiat Res (2011) 175(6):759–65.10.1667/RR2398.121466381
    • (2011) Radiat Res , vol.175 , Issue.6 , pp. 759-765
    • Epperly, M.W.1    Wang, H.2    Jones, J.A.3    Dixon, T.4    Montesinos, C.A.5    Greenberger, J.S.6
  • 92
    • 79958256118 scopus 로고    scopus 로고
    • Modulation of in utero total body irradiation induced newborn mouse growth retardation by maternal manganese superoxide dismutase-plasmid liposome (MnSOD-PL) gene therapy
    • 21248791
    • Epperly MW Smith T Zhang X Goff JP Franicola D Greenberger B et al. Modulation of in utero total body irradiation induced newborn mouse growth retardation by maternal manganese superoxide dismutase-plasmid liposome (MnSOD-PL) gene therapy. Gene Ther (2011) 18(6):579–83.10.1038/gt.2010.17821248791
    • (2011) Gene Ther , vol.18 , Issue.6 , pp. 579-583
    • Epperly, M.W.1    Smith, T.2    Zhang, X.3    Goff, J.P.4    Franicola, D.5    Greenberger, B.6
  • 93
    • 77649157348 scopus 로고    scopus 로고
    • Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients
    • 20133970
    • Epperly MW Franicola D Shields D Rwigema JC Stone B Zhang X et al. Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients. In vivo (2010) 24(1):9–19.20133970
    • (2010) In vivo , vol.24 , Issue.1 , pp. 9-19
    • Epperly, M.W.1    Franicola, D.2    Shields, D.3    Rwigema, J.C.4    Stone, B.5    Zhang, X.6
  • 94
    • 78650939212 scopus 로고    scopus 로고
    • Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death
    • 21320058
    • Mustata G Li M Zevola N Bakan A Zhang L Epperly M et al. Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death. Curr Top Med Chem (2011) 11(3):281–90.10.2174/15680261179407264121320058
    • (2011) Curr Top Med Chem , vol.11 , Issue.3 , pp. 281-290
    • Mustata, G.1    Li, M.2    Zevola, N.3    Bakan, A.4    Zhang, L.5    Epperly, M.6
  • 95
    • 84880085839 scopus 로고    scopus 로고
    • Strategies for discovery of small molecule radiation protectors and radiation mitigators
    • 22655254
    • Greenberger JS Clump D Kagan V Bayir H Lazo JS Wipf P et al. Strategies for discovery of small molecule radiation protectors and radiation mitigators. Front Oncol (2011) 1:59.10.3389/fonc.2011.0005922655254
    • (2011) Front Oncol , vol.1 , pp. 59
    • Greenberger, J.S.1    Clump, D.2    Kagan, V.3    Bayir, H.4    Lazo, J.S.5    Wipf, P.6
  • 96
    • 80755189473 scopus 로고    scopus 로고
    • Amelioration of radiation esophagitis by orally administered p53/Mdm2/Mdm4 inhibitor (BEB55) or GS-nitroxide
    • 22021675
    • Kim H Bernard ME Epperly MW Shen H Amoscato A Dixon TM et al. Amelioration of radiation esophagitis by orally administered p53/Mdm2/Mdm4 inhibitor (BEB55) or GS-nitroxide. In vivo (2011) 25(6):841–8.22021675
    • (2011) In vivo , vol.25 , Issue.6 , pp. 841-848
    • Kim, H.1    Bernard, M.E.2    Epperly, M.W.3    Shen, H.4    Amoscato, A.5    Dixon, T.M.6
  • 97
    • 17644420314 scopus 로고    scopus 로고
    • Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein
    • 15803505
    • Kruk I Aboul-Enein HY Michalska T Lichszteld K Kladna A. Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein. Luminescence (2005) 20(2):81–9.10.1002/bio.80815803505
    • (2005) Luminescence , vol.20 , Issue.2 , pp. 81-89
    • Kruk, I.1    Aboul-Enein, H.Y.2    Michalska, T.3    Lichszteld, K.4    Kladna, A.5
  • 98
    • 0023664272 scopus 로고
    • Genistein, a specific inhibitor of tyrosine-specific protein kinases
    • 3106339
    • Akiyama T Ishida J Nakagawa S Ogawara H Watanabe S Itoh N et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem (1987) 262(12):5592–5.3106339
    • (1987) J Biol Chem , vol.262 , Issue.12 , pp. 5592-5595
    • Akiyama, T.1    Ishida, J.2    Nakagawa, S.3    Ogawara, H.4    Watanabe, S.5    Itoh, N.6
  • 99
    • 4444331727 scopus 로고    scopus 로고
    • Cellular and physiological effects of soy flavonoids
    • 15544549
    • Valachovicova T Slivova V Sliva D. Cellular and physiological effects of soy flavonoids. Mini Rev Med Chem (2004) 4(8):881–7.10.2174/138955704340338715544549
    • (2004) Mini Rev Med Chem , vol.4 , Issue.8 , pp. 881-887
    • Valachovicova, T.1    Slivova, V.2    Sliva, D.3
  • 100
    • 33947426815 scopus 로고    scopus 로고
    • Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells
    • 17049802
    • Wu HJ Chan WH. Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells. Toxicol In vitro (2007) 21(3):335–42.10.1016/j.tiv.2006.09.00217049802
    • (2007) Toxicol In vitro , vol.21 , Issue.3 , pp. 335-342
    • Wu, H.J.1    Chan, W.H.2
  • 101
    • 33748480894 scopus 로고    scopus 로고
    • Antibacterial activity of the soy isoflavone genistein
    • 16847837
    • Hong H Landauer MR Foriska MA Ledney GD. Antibacterial activity of the soy isoflavone genistein. J Basic Microbiol (2006) 46(4):329–35.10.1002/jobm.20051007316847837
    • (2006) J Basic Microbiol , vol.46 , Issue.4 , pp. 329-335
    • Hong, H.1    Landauer, M.R.2    Foriska, M.A.3    Ledney, G.D.4
  • 102
    • 0041661977 scopus 로고    scopus 로고
    • Genistein as an anti-inflammatory agent
    • 14504672
    • Verdrengh M Jonsson IM Holmdahl R Tarkowski A. Genistein as an anti-inflammatory agent. Inflamm Res (2003) 52(8):341–6.10.1007/s00011-003-1182-814504672
    • (2003) Inflamm Res , vol.52 , Issue.8 , pp. 341-346
    • Verdrengh, M.1    Jonsson, I.M.2    Holmdahl, R.3    Tarkowski, A.4
  • 103
    • 0037114205 scopus 로고    scopus 로고
    • Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide
    • 11751189
    • Kang JL Lee HW Lee HS Pack IS Chong Y Castranova V et al. Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide. Am J Respir Crit Care Med (2001) 164(12):2206–12.10.1164/ajrccm.164.12.210401711751189
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.12 , pp. 2206-2212
    • Kang, J.L.1    Lee, H.W.2    Lee, H.S.3    Pack, I.S.4    Chong, Y.5    Castranova, V.6
  • 104
    • 0032970710 scopus 로고    scopus 로고
    • p53-independent apoptosis induced by genistein in lung cancer cells
    • 10368806
    • Lian F Li Y Bhuiyan M Sarkar FH. p53-independent apoptosis induced by genistein in lung cancer cells. Nutr Cancer (1999) 33(2):125–31.10.1207/S15327914NC33020210368806
    • (1999) Nutr Cancer , vol.33 , Issue.2 , pp. 125-131
    • Lian, F.1    Li, Y.2    Bhuiyan, M.3    Sarkar, F.H.4
  • 105
    • 33748580218 scopus 로고    scopus 로고
    • Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship
    • 16934226
    • Comalada M Ballester I Bailon E Sierra S Xaus J Galvez J et al. Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. Biochem Pharmacol (2006) 72(8):1010–21.10.1016/j.bcp.2006.07.01616934226
    • (2006) Biochem Pharmacol , vol.72 , Issue.8 , pp. 1010-1021
    • Comalada, M.1    Ballester, I.2    Bailon, E.3    Sierra, S.4    Xaus, J.5    Galvez, J.6
  • 106
    • 77957997925 scopus 로고    scopus 로고
    • Soy isoflavones ameliorate the adverse effects of chemotherapy in children
    • 20924976
    • Tacyildiz N Ozyoruk D Yavuz G Unal E Dincaslan H Dogu F et al. Soy isoflavones ameliorate the adverse effects of chemotherapy in children. Nutr Cancer (2010) 62(7):1001–5.10.1080/01635581.2010.50984120924976
    • (2010) Nutr Cancer , vol.62 , Issue.7 , pp. 1001-1005
    • Tacyildiz, N.1    Ozyoruk, D.2    Yavuz, G.3    Unal, E.4    Dincaslan, H.5    Dogu, F.6
  • 107
    • 77958005445 scopus 로고    scopus 로고
    • Soy isoflavones in conjunction with radiation therapy in patients with prostate cancer
    • 20924975
    • Ahmad IU Forman JD Sarkar FH Hillman GG Heath E Vaishampayan U et al. Soy isoflavones in conjunction with radiation therapy in patients with prostate cancer. Nutr Cancer (2010) 62(7):996–1000.10.1080/01635581.2010.50983920924975
    • (2010) Nutr Cancer , vol.62 , Issue.7 , pp. 996-1000
    • Ahmad, I.U.1    Forman, J.D.2    Sarkar, F.H.3    Hillman, G.G.4    Heath, E.5    Vaishampayan, U.6
  • 108
    • 0345328280 scopus 로고    scopus 로고
    • Genistein treatment protects mice from ionizing radiation injury
    • Landauer MR Srinivasan V Seed TM. Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol (2003) 23(6):379–85.10.1002/jat.904
    • (2003) J Appl Toxicol , vol.23 , Issue.6 , pp. 379-385
    • Landauer, M.R.1    Srinivasan, V.2    Seed, T.M.3
  • 109
    • 33847184916 scopus 로고    scopus 로고
    • Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival
    • 17378522
    • Davis TA Clarke TK Mog SR Landauer MR. Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. Int J Radiat Biol (2007) 83(3):141–51.10.1080/0955300060113264217378522
    • (2007) Int J Radiat Biol , vol.83 , Issue.3 , pp. 141-151
    • Davis, T.A.1    Clarke, T.K.2    Mog, S.R.3    Landauer, M.R.4
  • 110
    • 52949137022 scopus 로고    scopus 로고
    • Genistein induces radioprotection by hematopoietic stem cell quiescence
    • 18821385
    • Davis TA Mungunsukh O Zins S Day RM Landauer MR. Genistein induces radioprotection by hematopoietic stem cell quiescence. Int J Radiat Biol (2008) 84(9):713–26.10.1080/0955300080231777818821385
    • (2008) Int J Radiat Biol , vol.84 , Issue.9 , pp. 713-726
    • Davis, T.A.1    Mungunsukh, O.2    Zins, S.3    Day, R.M.4    Landauer, M.R.5
  • 111
    • 69949184058 scopus 로고    scopus 로고
    • Effects of genistein following fractionated lung irradiation in mice
    • 19433340
    • Para AE Bezjak A Yeung IW Van Dyk J Hill RP. Effects of genistein following fractionated lung irradiation in mice. Radiother Oncol (2009) 92(3):500–10.10.1016/j.radonc.2009.04.00519433340
    • (2009) Radiother Oncol , vol.92 , Issue.3 , pp. 500-510
    • Para, A.E.1    Bezjak, A.2    Yeung, I.W.3    Van Dyk, J.4    Hill, R.P.5
  • 112
    • 84873021436 scopus 로고    scopus 로고
    • Enhanced hematopoietic protection from radiation by the combination of genistein and captopril
    • 23328620
    • Day RM Davis TA Barshishat-Kupper M McCart EA Tipton AJ Landauer MR. Enhanced hematopoietic protection from radiation by the combination of genistein and captopril. Int Immunopharmacol (2013) 15(2):348–56.10.1016/j.intimp.2012.12.02923328620
    • (2013) Int Immunopharmacol , vol.15 , Issue.2 , pp. 348-356
    • Day, R.M.1    Davis, T.A.2    Barshishat-Kupper, M.3    McCart, E.A.4    Tipton, A.J.5    Landauer, M.R.6
  • 113
    • 79958154578 scopus 로고    scopus 로고
    • Mitigation of radiation-induced lung injury by genistein and EUK-207
    • 21675818
    • Mahmood J Jelveh S Calveley V Zaidi A Doctrow SR Hill RP. Mitigation of radiation-induced lung injury by genistein and EUK-207. Int J Radiat Biol (2011) 87(8):889–901.10.3109/09553002.2011.58331521675818
    • (2011) Int J Radiat Biol , vol.87 , Issue.8 , pp. 889-901
    • Mahmood, J.1    Jelveh, S.2    Calveley, V.3    Zaidi, A.4    Doctrow, S.R.5    Hill, R.P.6
  • 114
    • 34548790085 scopus 로고    scopus 로고
    • Genistein-induced alterations of radiation-responsive gene expression
    • Grace MB Blakely WF Landauer MR. Genistein-induced alterations of radiation-responsive gene expression. Radiat Meas (2007) 42:1152–7.10.1016/j.radmeas.2007.05.011
    • (2007) Radiat Meas , vol.42 , pp. 1152-1157
    • Grace, M.B.1    Blakely, W.F.2    Landauer, M.R.3
  • 115
    • 7544220543 scopus 로고    scopus 로고
    • Genistein induces Gadd45 gene and G2/M cell cycle arrest in the DU145 human prostate cancer cell line
    • 15527761
    • Oki T Sowa Y Hirose T Takagaki N Horinaka M Nakanishi R et al. Genistein induces Gadd45 gene and G2/M cell cycle arrest in the DU145 human prostate cancer cell line. FEBS Lett (2004) 577(1–2):55–9.10.1016/j.febslet.2004.09.08515527761
    • (2004) FEBS Lett , vol.577 , Issue.1–2 , pp. 55-59
    • Oki, T.1    Sowa, Y.2    Hirose, T.3    Takagaki, N.4    Horinaka, M.5    Nakanishi, R.6
  • 116
    • 33644919138 scopus 로고    scopus 로고
    • Soya phytonutrients act on a panel of genes implicated with BRCA1 and BRCA2 oncosuppressors in human breast cell lines
    • 16469160
    • Caetano B Le Corre L Chalabi N Delort L Bignon YJ Bernard-Gallon DJ. Soya phytonutrients act on a panel of genes implicated with BRCA1 and BRCA2 oncosuppressors in human breast cell lines. Br J Nutr (2006) 95(2):406–13.10.1079/BJN2005164016469160
    • (2006) Br J Nutr , vol.95 , Issue.2 , pp. 406-413
    • Caetano, B.1    Le Corre, L.2    Chalabi, N.3    Delort, L.4    Bignon, Y.J.5    Bernard-Gallon, D.J.6
  • 117
    • 33846230598 scopus 로고    scopus 로고
    • Homology-directed repair is required for the development of radioresistance during S phase: interplay between double-strand break repair and checkpoint response
    • 17214519
    • Tamulevicius P Wang M Iliakis G. Homology-directed repair is required for the development of radioresistance during S phase: interplay between double-strand break repair and checkpoint response. Radiat Res (2007) 167(1):1–11.10.1667/RR0751.117214519
    • (2007) Radiat Res , vol.167 , Issue.1 , pp. 1-11
    • Tamulevicius, P.1    Wang, M.2    Iliakis, G.3
  • 118
    • 84884240277 scopus 로고    scopus 로고
    • Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation
    • 23952576
    • Ha CT Li XH Fu D Xiao M Landauer MR. Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation. Radiat Res (2013) 180(3):316–25.10.1667/RR3326.123952576
    • (2013) Radiat Res , vol.180 , Issue.3 , pp. 316-325
    • Ha, C.T.1    Li, X.H.2    Fu, D.3    Xiao, M.4    Landauer, M.R.5
  • 119
    • 0031741785 scopus 로고    scopus 로고
    • Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor β signaling pathways
    • 9848510
    • Kim H Peterson TG Barnes S. Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor β signaling pathways. Am J Clin Nutr (1998) 68S:1418S–25S.9848510
    • (1998) Am J Clin Nutr , vol.68S , pp. 1418-1425
    • Kim, H.1    Peterson, T.G.2    Barnes, S.3
  • 120
    • 29244450469 scopus 로고    scopus 로고
    • Pathogenic role of the renin-angiotensin system in modulating radiation-induced late effects
    • Robbins ME Diz DI. Pathogenic role of the renin-angiotensin system in modulating radiation-induced late effects. Int J Radiat Oncol Biol Phys (2006) 64(1):6–12.10.1016/j.ijrobp.2005.08.033
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , Issue.1 , pp. 6-12
    • Robbins, M.E.1    Diz, D.I.2
  • 121
    • 0022486482 scopus 로고
    • Physiological factors effecting renal radiation tolerance: a guide to the treatment of late effects
    • Robbins ME Hopewell JW. Physiological factors effecting renal radiation tolerance: a guide to the treatment of late effects. Br J Cancer Suppl (1986) 7:265–7.
    • (1986) Br J Cancer Suppl , vol.7 , pp. 265-267
    • Robbins, M.E.1    Hopewell, J.W.2
  • 122
    • 77950791504 scopus 로고    scopus 로고
    • Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation
    • 20116413
    • Davis TA Landauer MR Mog SR Barshishat-Kupper M Zins SR Amare MF et al. Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation. Exp Hematol (2010) 38(4):270–81.10.1016/j.exphem.2010.01.00420116413
    • (2010) Exp Hematol , vol.38 , Issue.4 , pp. 270-281
    • Davis, T.A.1    Landauer, M.R.2    Mog, S.R.3    Barshishat-Kupper, M.4    Zins, S.R.5    Amare, M.F.6
  • 123
    • 78650629415 scopus 로고    scopus 로고
    • Captopril and losartan for mitigation of renal injury caused by single-dose total-body irradiation
    • 21175344
    • Moulder JE Cohen EP Fish BL. Captopril and losartan for mitigation of renal injury caused by single-dose total-body irradiation. Radiat Res (2011) 175(1):29–36.10.1667/RR2400.121175344
    • (2011) Radiat Res , vol.175 , Issue.1 , pp. 29-36
    • Moulder, J.E.1    Cohen, E.P.2    Fish, B.L.3
  • 124
    • 84857826425 scopus 로고    scopus 로고
    • Angiotensin converting enzyme inhibitors mitigate collagen synthesis induced by a single dose of radiation to the whole thorax
    • 22302041
    • Kma L Gao F Fish BL Moulder JE Jacobs ER Medhora M. Angiotensin converting enzyme inhibitors mitigate collagen synthesis induced by a single dose of radiation to the whole thorax. J Radiat Res (2012) 53(1):10–7.10.1269/jrr.1103522302041
    • (2012) J Radiat Res , vol.53 , Issue.1 , pp. 10-17
    • Kma, L.1    Gao, F.2    Fish, B.L.3    Moulder, J.E.4    Jacobs, E.R.5    Medhora, M.6
  • 125
    • 84255176558 scopus 로고    scopus 로고
    • Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors
    • 22023053
    • Medhora M Gao F Jacobs ER Moulder JE. Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors. Respirology (2012) 17(1):66–71.10.1111/j.1440-1843.2011.02092.x22023053
    • (2012) Respirology , vol.17 , Issue.1 , pp. 66-71
    • Medhora, M.1    Gao, F.2    Jacobs, E.R.3    Moulder, J.E.4
  • 126
    • 71649101555 scopus 로고    scopus 로고
    • Renin-angiotensin system suppression mitigates experimental radiation pneumonitis
    • 19931735
    • Ghosh SN Zhang R Fish BL Semenenko VA Li XA Moulder JE et al. Renin-angiotensin system suppression mitigates experimental radiation pneumonitis. Int J Radiat Oncol Biol Phys (2009) 75(5):1528–36.10.1016/j.ijrobp.2009.07.174319931735
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , Issue.5 , pp. 1528-1536
    • Ghosh, S.N.1    Zhang, R.2    Fish, B.L.3    Semenenko, V.A.4    Li, X.A.5    Moulder, J.E.6
  • 127
    • 33947512453 scopus 로고    scopus 로고
    • Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury
    • 17395044
    • Moulder JE Cohen EP. Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury. Semin Radiat Oncol (2007) 17(2):141–8.10.1016/j.semradonc.2006.11.01017395044
    • (2007) Semin Radiat Oncol , vol.17 , Issue.2 , pp. 141-148
    • Moulder, J.E.1    Cohen, E.P.2
  • 128
    • 0023786380 scopus 로고
    • Radiation-induced pulmonary endothelial dysfunction in rats: modification by an inhibitor of angiotensin converting enzyme
    • 3292488
    • Ward WF Kim YT Molteni A Solliday NH. Radiation-induced pulmonary endothelial dysfunction in rats: modification by an inhibitor of angiotensin converting enzyme. Int J Radiat Oncol Biol Phys (1988) 15(1):135–40.10.1016/0360-3016(88)90357-43292488
    • (1988) Int J Radiat Oncol Biol Phys , vol.15 , Issue.1 , pp. 135-140
    • Ward, W.F.1    Kim, Y.T.2    Molteni, A.3    Solliday, N.H.4
  • 129
    • 0025235028 scopus 로고
    • The effect of captopril on benign and malignant reactions in irradiated rat skin
    • 2198982
    • Ward WF Molteni A Ts’ao C Hinz JM. The effect of captopril on benign and malignant reactions in irradiated rat skin. Br J Radiol (1990) 63(749):349–54.10.1259/0007-1285-63-749-3492198982
    • (1990) Br J Radiol , vol.63 , Issue.749 , pp. 349-354
    • Ward, W.F.1    Molteni, A.2    Ts’ao, C.3    Hinz, J.M.4
  • 130
    • 0027062830 scopus 로고
    • Treatment of radiation nephropathy with captopril
    • 1475357
    • Cohen EP Fish BL Moulder JE. Treatment of radiation nephropathy with captopril. Radiat Res (1992) 132(3):346–50.10.2307/35782431475357
    • (1992) Radiat Res , vol.132 , Issue.3 , pp. 346-350
    • Cohen, E.P.1    Fish, B.L.2    Moulder, J.E.3
  • 131
    • 0027761457 scopus 로고
    • Prophylaxis of bone marrow transplant nephropathy with captopril, an inhibitor of angiotensin-converting enzyme
    • 8278583
    • Moulder JE Cohen EP Fish BL Hill P. Prophylaxis of bone marrow transplant nephropathy with captopril, an inhibitor of angiotensin-converting enzyme. Radiat Res (1993) 136(3):404–7.10.2307/35785548278583
    • (1993) Radiat Res , vol.136 , Issue.3 , pp. 404-407
    • Moulder, J.E.1    Cohen, E.P.2    Fish, B.L.3    Hill, P.4
  • 132
    • 40949138809 scopus 로고    scopus 로고
    • Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial
    • 18029109
    • Cohen EP Irving AA Drobyski WR Klein JP Passweg J Talano JA et al. Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial. Int J Radiat Oncol Biol Phys (2008) 70(5):1546–51.10.1016/j.ijrobp.2007.08.04118029109
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , Issue.5 , pp. 1546-1551
    • Cohen, E.P.1    Irving, A.A.2    Drobyski, W.R.3    Klein, J.P.4    Passweg, J.5    Talano, J.A.6
  • 133
    • 3843151491 scopus 로고    scopus 로고
    • Inhibition of angiotensin I-converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells
    • 15105290
    • Charrier S Michaud A Badaoui S Giroux S Ezan E Sainteny F et al. Inhibition of angiotensin I-converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells. Blood (2004) 104(4):978–85.10.1182/blood-2003-11-382815105290
    • (2004) Blood , vol.104 , Issue.4 , pp. 978-985
    • Charrier, S.1    Michaud, A.2    Badaoui, S.3    Giroux, S.4    Ezan, E.5    Sainteny, F.6
  • 134
    • 0016746813 scopus 로고
    • Prevention of pulmonary vascular changes of chronic alveolar hypoxia by inhibition of angiotensin I-converting enzyme in the rat
    • 167232
    • Zakheim RM Mattioli L Molteni A Mullis KB Bartley J. Prevention of pulmonary vascular changes of chronic alveolar hypoxia by inhibition of angiotensin I-converting enzyme in the rat. Lab Invest (1975) 33(1):57–61.167232
    • (1975) Lab Invest , vol.33 , Issue.1 , pp. 57-61
    • Zakheim, R.M.1    Mattioli, L.2    Molteni, A.3    Mullis, K.B.4    Bartley, J.5
  • 135
    • 0034044261 scopus 로고    scopus 로고
    • Captopril inhibits in vitro and in vivo the proliferation of primitive haematopoietic cells induced into cell cycle by cytotoxic drug administration or irradiation but has no effect on myeloid leukaemia cell proliferation
    • 10886205
    • Chisi JE Briscoe CV Ezan E Genet R Riches AC Wdzieczak-Bakala J. Captopril inhibits in vitro and in vivo the proliferation of primitive haematopoietic cells induced into cell cycle by cytotoxic drug administration or irradiation but has no effect on myeloid leukaemia cell proliferation. Br J Haematol (2000) 109(3):563–70.10.1046/j.1365-2141.2000.02073.x10886205
    • (2000) Br J Haematol , vol.109 , Issue.3 , pp. 563-570
    • Chisi, J.E.1    Briscoe, C.V.2    Ezan, E.3    Genet, R.4    Riches, A.C.5    Wdzieczak-Bakala, J.6
  • 136
    • 25444449603 scopus 로고    scopus 로고
    • Molecular targets and anticancer potential of indole-3-carbinol and its derivatives
    • 16082211
    • Aggarwal BB Ichikawa H. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle (2005) 4(9):1201–15.10.4161/cc.4.9.199316082211
    • (2005) Cell Cycle , vol.4 , Issue.9 , pp. 1201-1215
    • Aggarwal, B.B.1    Ichikawa, H.2
  • 137
    • 33846024022 scopus 로고    scopus 로고
    • Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3’-diindolylmethane
    • 17164373
    • Reed GA Arneson DW Putnam WC Smith HJ Gray JC Sullivan DK et al. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3’-diindolylmethane. Cancer Epidemiol Biomarkers Prev (2006) 15(12):2477–81.10.1158/1055-9965.EPI-06-039617164373
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , Issue.12 , pp. 2477-2481
    • Reed, G.A.1    Arneson, D.W.2    Putnam, W.C.3    Smith, H.J.4    Gray, J.C.5    Sullivan, D.K.6
  • 138
    • 54249098378 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3’-diindolylmethane in healthy subjects
    • 18843002
    • Reed GA Sunega JM Sullivan DK Gray JC Mayo MS Crowell JA et al. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3’-diindolylmethane in healthy subjects. Cancer Epidemiol Biomarkers Prev (2008) 17(10):2619–24.10.1158/1055-9965.EPI-08-052018843002
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , Issue.10 , pp. 2619-2624
    • Reed, G.A.1    Sunega, J.M.2    Sullivan, D.K.3    Gray, J.C.4    Mayo, M.S.5    Crowell, J.A.6
  • 139
    • 77957372039 scopus 로고    scopus 로고
    • A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3’-diindolylmethane) in castrate-resistant, non-metastatic prostate cancer
    • 20733950
    • Heath EI Heilbrun LK Li J Vaishampayan U Harper F Pemberton P et al. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3’-diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am J Transl Res (2010) 2(4):402–11.20733950
    • (2010) Am J Transl Res , vol.2 , Issue.4 , pp. 402-411
    • Heath, E.I.1    Heilbrun, L.K.2    Li, J.3    Vaishampayan, U.4    Harper, F.5    Pemberton, P.6
  • 140
    • 75949106629 scopus 로고    scopus 로고
    • Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia
    • 19939441
    • Del Priore G Gudipudi DK Montemarano N Restivo AM Malanowska-Stega J Arslan AA. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol Oncol (2010) 116(3):464–7.10.1016/j.ygyno.2009.10.06019939441
    • (2010) Gynecol Oncol , vol.116 , Issue.3 , pp. 464-467
    • Del Priore, G.1    Gudipudi, D.K.2    Montemarano, N.3    Restivo, A.M.4    Malanowska-Stega, J.5    Arslan, A.A.6
  • 141
    • 84887501503 scopus 로고    scopus 로고
    • DIM (3,3’-diindolylmethane) confers protection against ionizing radiation by a unique mechanism
    • 24127581
    • Fan S Meng Q Xu J Jiao Y Zhao L Zhang X et al. DIM (3,3’-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. Proc Natl Acad Sci U S A (2013) 110(46):18650–5.10.1073/pnas.130820611024127581
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.46 , pp. 18650-18655
    • Fan, S.1    Meng, Q.2    Xu, J.3    Jiao, Y.4    Zhao, L.5    Zhang, X.6
  • 142
    • 84875144931 scopus 로고    scopus 로고
    • 3,3’-Diindolymethane ameliorates adriamycin-induced cardiac fibrosis via activation of a BRCA1-dependent anti-oxidant pathway
    • 23376355
    • Yao Z Hu W Yin S Huang Z Zhu Q Chen J et al. 3,3’-Diindolymethane ameliorates adriamycin-induced cardiac fibrosis via activation of a BRCA1-dependent anti-oxidant pathway. Pharmacol Res (2013) 70(1):139–46.10.1016/j.phrs.2013.01.00623376355
    • (2013) Pharmacol Res , vol.70 , Issue.1 , pp. 139-146
    • Yao, Z.1    Hu, W.2    Yin, S.3    Huang, Z.4    Zhu, Q.5    Chen, J.6
  • 143
    • 84872224969 scopus 로고    scopus 로고
    • 3,3’-Diindolylmethane protects against cardiac hypertrophy via 5’-adenosine monophosphate-activated protein kinase-alpha2
    • 23326427
    • Zong J Deng W Zhou H Bian ZY Dai J Yuan Y et al. 3,3’-Diindolylmethane protects against cardiac hypertrophy via 5’-adenosine monophosphate-activated protein kinase-alpha2. PLoS One (2013) 8(1):e53427.10.1371/journal.pone.005342723326427
    • (2013) PLoS One , vol.8 , Issue.1 , pp. e53427
    • Zong, J.1    Deng, W.2    Zhou, H.3    Bian, Z.Y.4    Dai, J.5    Yuan, Y.6
  • 144
    • 84881123014 scopus 로고    scopus 로고
    • X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells
    • 22788682
    • Panganiban RA Mungunsukh O Day RM. X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells. Int J Radiat Biol (2012) 89(8):656–67.10.3109/09553002.2012.71150222788682
    • (2012) Int J Radiat Biol , vol.89 , Issue.8 , pp. 656-667
    • Panganiban, R.A.1    Mungunsukh, O.2    Day, R.M.3
  • 145
    • 84866054806 scopus 로고    scopus 로고
    • mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis
    • 22958932
    • Iglesias-Bartolome R Patel V Cotrim A Leelahavanichkul K Molinolo AA Mitchell JB et al. mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell (2012) 11(3):401–14.10.1016/j.stem.2012.06.00722958932
    • (2012) Cell Stem Cell , vol.11 , Issue.3 , pp. 401-414
    • Iglesias-Bartolome, R.1    Patel, V.2    Cotrim, A.3    Leelahavanichkul, K.4    Molinolo, A.A.5    Mitchell, J.B.6
  • 146
    • 34548043307 scopus 로고    scopus 로고
    • Radiation-induced senescence-like phenotype in proliferating and plateau-phase vascular endothelial cells
    • 17662979
    • Igarashi K Sakimoto I Kataoka K Ohta K Miura M. Radiation-induced senescence-like phenotype in proliferating and plateau-phase vascular endothelial cells. Exp Cell Res (2007) 313(15):3326–36.10.1016/j.yexcr.2007.06.00117662979
    • (2007) Exp Cell Res , vol.313 , Issue.15 , pp. 3326-3336
    • Igarashi, K.1    Sakimoto, I.2    Kataoka, K.3    Ohta, K.4    Miura, M.5
  • 147
    • 0034877938 scopus 로고    scopus 로고
    • Induction of a senescence-like phenotype in bovine aortic endothelial cells by ionizing radiation
    • 11500132
    • Oh CW Bump EA Kim JS Janigro D Mayberg MR. Induction of a senescence-like phenotype in bovine aortic endothelial cells by ionizing radiation. Radiat Res (2001) 156(3):232–40.10.1667/0033-7587(2001)156[0232:IOASLP]2.0.CO;211500132
    • (2001) Radiat Res , vol.156 , Issue.3 , pp. 232-240
    • Oh, C.W.1    Bump, E.A.2    Kim, J.S.3    Janigro, D.4    Mayberg, M.R.5
  • 148
    • 55349095456 scopus 로고    scopus 로고
    • Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations
    • 18976161
    • Muller M. Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations. Antioxid Redox Signal (2009) 11(1):59–98.10.1089/ars.2008.210418976161
    • (2009) Antioxid Redox Signal , vol.11 , Issue.1 , pp. 59-98
    • Muller, M.1
  • 149
    • 33646437235 scopus 로고    scopus 로고
    • Premature senescence of endothelial cells: Methusaleh’s dilemma
    • 16603702
    • Chen J Goligorsky MS. Premature senescence of endothelial cells: Methusaleh’s dilemma. Am J Physiol Heart Circ Physiol (2006) 290(5):H1729–39.10.1152/ajpheart.01103.200516603702
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , Issue.5 , pp. H1729-H1739
    • Chen, J.1    Goligorsky, M.S.2
  • 150
    • 84860600742 scopus 로고    scopus 로고
    • Gamma radiation induces senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments
    • 22348537
    • Cmielova J Havelek R Soukup T Jiroutova A Visek B Suchanek J et al. Gamma radiation induces senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments. Int J Radiat Biol (2012) 88(5):393–404.10.3109/09553002.2012.66600122348537
    • (2012) Int J Radiat Biol , vol.88 , Issue.5 , pp. 393-404
    • Cmielova, J.1    Havelek, R.2    Soukup, T.3    Jiroutova, A.4    Visek, B.5    Suchanek, J.6
  • 151
    • 44949201233 scopus 로고    scopus 로고
    • UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53
    • 18216278
    • Lewis DA Yi Q Travers JB Spandau DF. UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53. Mol Biol Cell (2008) 19(4):1346–53.10.1091/mbc.E07-10-104118216278
    • (2008) Mol Biol Cell , vol.19 , Issue.4 , pp. 1346-1353
    • Lewis, D.A.1    Yi, Q.2    Travers, J.B.3    Spandau, D.F.4
  • 152
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • 12483226
    • Holzenberger M Dupont J Ducos B Leneuve P Geloen A Even PC et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature (2003) 421(6919):182–7.10.1038/nature0129812483226
    • (2003) Nature , vol.421 , Issue.6919 , pp. 182-187
    • Holzenberger, M.1    Dupont, J.2    Ducos, B.3    Leneuve, P.4    Geloen, A.5    Even, P.C.6
  • 155
    • 77950188937 scopus 로고    scopus 로고
    • Astrocytes regulate the expression of insulin-like growth factor 1 receptor (IGF1-R) in primary cortical neurons during in vitro senescence
    • 19862643
    • Costantini C Lorenzetto E Cellini B Buffelli M Rossi F Della-Bianca V. Astrocytes regulate the expression of insulin-like growth factor 1 receptor (IGF1-R) in primary cortical neurons during in vitro senescence. J Mol Neurosci (2010) 40(3):342–52.10.1007/s12031-009-9305-519862643
    • (2010) J Mol Neurosci , vol.40 , Issue.3 , pp. 342-352
    • Costantini, C.1    Lorenzetto, E.2    Cellini, B.3    Buffelli, M.4    Rossi, F.5    Della-Bianca, V.6
  • 156
    • 84886258224 scopus 로고    scopus 로고
    • Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence
    • 24205274
    • Panganiban RA Day RM. Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence. PLoS One (2013) 8:e78589.10.1371/journal.pone.007858924205274
    • (2013) PLoS One , vol.8 , pp. e78589
    • Panganiban, R.A.1    Day, R.M.2
  • 157
    • 48549085489 scopus 로고    scopus 로고
    • Flagellin treatment protects against chemicals, bacteria, viruses, and radiation
    • 18523294
    • Vijay-Kumar M Aitken JD Sanders CJ Frias A Sloane VM Xu J et al. Flagellin treatment protects against chemicals, bacteria, viruses, and radiation. J Immunol (2008) 180(12):8280–5.10.4049/jimmunol.180.12.828018523294
    • (2008) J Immunol , vol.180 , Issue.12 , pp. 8280-8285
    • Vijay-Kumar, M.1    Aitken, J.D.2    Sanders, C.J.3    Frias, A.4    Sloane, V.M.5    Xu, J.6
  • 158
    • 42049095095 scopus 로고    scopus 로고
    • An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
    • 18403709
    • Burdelya LG Krivokrysenko VI Tallant TC Strom E Gleiberman AS Gupta D et al. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science (2008) 320(5873):226–30.10.1126/science.115498618403709
    • (2008) Science , vol.320 , Issue.5873 , pp. 226-230
    • Burdelya, L.G.1    Krivokrysenko, V.I.2    Tallant, T.C.3    Strom, E.4    Gleiberman, A.S.5    Gupta, D.6
  • 159
    • 84867594290 scopus 로고    scopus 로고
    • Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure
    • 22837010
    • Krivokrysenko VI Shakhov AN Singh VK Bone F Kononov Y Shyshynova I et al. Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure. J Pharmacol Exp Ther (2012) 343(2):497–508.10.1124/jpet.112.19607122837010
    • (2012) J Pharmacol Exp Ther , vol.343 , Issue.2 , pp. 497-508
    • Krivokrysenko, V.I.1    Shakhov, A.N.2    Singh, V.K.3    Bone, F.4    Kononov, Y.5    Shyshynova, I.6
  • 160
    • 84859847723 scopus 로고    scopus 로고
    • Toll-like receptor 5 agonist protects mice from dermatitis and oral mucositis caused by local radiation: implications for head-and-neck cancer radiotherapy
    • 22000579
    • Burdelya LG Gleiberman AS Toshkov I Aygun-Sunar S Bapardekar M Manderscheid-Kern P et al. Toll-like receptor 5 agonist protects mice from dermatitis and oral mucositis caused by local radiation: implications for head-and-neck cancer radiotherapy. Int J Radiat Oncol Biol Phys (2012) 83(1):228–34.10.1016/j.ijrobp.2011.05.05522000579
    • (2012) Int J Radiat Oncol Biol Phys , vol.83 , Issue.1 , pp. 228-234
    • Burdelya, L.G.1    Gleiberman, A.S.2    Toshkov, I.3    Aygun-Sunar, S.4    Bapardekar, M.5    Manderscheid-Kern, P.6
  • 161
    • 59649092946 scopus 로고    scopus 로고
    • Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms
    • 19267542
    • Ghosh SP Perkins MW Hieber K Kulkarni S Kao TC Reddy EP et al. Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms. Radiat Res (2009) 171(2):173–9.10.1667/RR1367.119267542
    • (2009) Radiat Res , vol.171 , Issue.2 , pp. 173-179
    • Ghosh, S.P.1    Perkins, M.W.2    Hieber, K.3    Kulkarni, S.4    Kao, T.C.5    Reddy, E.P.6
  • 162
    • 84863461654 scopus 로고    scopus 로고
    • Radioprotective effects of ON 01210.Na upon oral administration
    • 22739006
    • Suman S Datta K Doiron K Ren C Kumar R Taft DR et al. Radioprotective effects of ON 01210.Na upon oral administration. J Radiat Res (2012) 53(3):368–76.22739006
    • (2012) J Radiat Res , vol.53 , Issue.3 , pp. 368-376
    • Suman, S.1    Datta, K.2    Doiron, K.3    Ren, C.4    Kumar, R.5    Taft, D.R.6
  • 163
    • 84872112432 scopus 로고    scopus 로고
    • Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD(R) in mice
    • 22843617
    • Ghosh SP Kulkarni S Perkins MW Hieber K Pessu RL Gambles K et al. Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD(R) in mice. J Radiat Res (2012) 53(4):526–36.10.1093/jrr/rrs00122843617
    • (2012) J Radiat Res , vol.53 , Issue.4 , pp. 526-536
    • Ghosh, S.P.1    Kulkarni, S.2    Perkins, M.W.3    Hieber, K.4    Pessu, R.L.5    Gambles, K.6
  • 164
    • 84855992593 scopus 로고    scopus 로고
    • Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response
    • 22264334
    • Suman S Maniar M Fornace AJ Jr Datta K. Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response. Radiat Oncol (2012) 7:6.10.1186/1748-717X-7-622264334
    • (2012) Radiat Oncol , vol.7 , pp. 6
    • Suman, S.1    Maniar, M.2    Fornace, A.J.3    Datta, K.4
  • 165
    • 84874731713 scopus 로고    scopus 로고
    • ON01210.Na (Ex-RAD(R)) mitigates radiation damage through activation of the AKT pathway
    • 23505494
    • Kang AD Cosenza SC Bonagura M Manair M Reddy MV Reddy EP. ON01210.Na (Ex-RAD(R)) mitigates radiation damage through activation of the AKT pathway. PLoS One (2013) 8(3):e58355.10.1371/journal.pone.005835523505494
    • (2013) PLoS One , vol.8 , Issue.3 , pp. e58355
    • Kang, A.D.1    Cosenza, S.C.2    Bonagura, M.3    Manair, M.4    Reddy, M.V.5    Reddy, E.P.6
  • 166
    • 84911492495 scopus 로고    scopus 로고
    • Radiation countermeasure agents: an update (2011-2014)
    • 25315070
    • Singh VK Newman VL Romaine PL Wise SY Seed TM. Radiation countermeasure agents: an update (2011-2014). Expert Opin Ther Pat (2014) 24(11):1229–55.10.1517/13543776.2014.96468425315070
    • (2014) Expert Opin Ther Pat , vol.24 , Issue.11 , pp. 1229-1255
    • Singh, V.K.1    Newman, V.L.2    Romaine, P.L.3    Wise, S.Y.4    Seed, T.M.5
  • 167
    • 67651162024 scopus 로고    scopus 로고
    • Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector
    • 19557601
    • Ghosh SP Kulkarni S Hieber K Toles R Romanyukha L Kao TC et al. Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. Int J Radiat Biol (2009) 85(7):598–606.10.1080/0955300090298512819557601
    • (2009) Int J Radiat Biol , vol.85 , Issue.7 , pp. 598-606
    • Ghosh, S.P.1    Kulkarni, S.2    Hieber, K.3    Toles, R.4    Romanyukha, L.5    Kao, T.C.6
  • 168
    • 77953174306 scopus 로고    scopus 로고
    • Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation
    • 20518653
    • Kulkarni S Ghosh SP Satyamitra M Mog S Hieber K Romanyukha L et al. Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation. Radiat Res (2010) 173(6):738–47.10.1667/RR1824.120518653
    • (2010) Radiat Res , vol.173 , Issue.6 , pp. 738-747
    • Kulkarni, S.1    Ghosh, S.P.2    Satyamitra, M.3    Mog, S.4    Hieber, K.5    Romanyukha, L.6
  • 169
    • 84883405523 scopus 로고    scopus 로고
    • Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival
    • 23941772
    • Suman S Datta K Chakraborty K Kulkarni SS Doiron K Fornace AJ Jr et al. Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival. Food Chem Toxicol (2013) 60:488–96.10.1016/j.fct.2013.08.01123941772
    • (2013) Food Chem Toxicol , vol.60 , pp. 488-496
    • Suman, S.1    Datta, K.2    Chakraborty, K.3    Kulkarni, S.S.4    Doiron, K.5    Fornace, A.J.6
  • 170
    • 84876801589 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure
    • 23561424
    • Kulkarni S Singh PK Ghosh SP Posarac A Singh VK. Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure. Cytokine (2013) 62(2):278–85.10.1016/j.cyto.2013.03.00923561424
    • (2013) Cytokine , vol.62 , Issue.2 , pp. 278-285
    • Kulkarni, S.1    Singh, P.K.2    Ghosh, S.P.3    Posarac, A.4    Singh, V.K.5
  • 171
    • 79957593159 scopus 로고    scopus 로고
    • Hematopoietic recovey and amelioration of radiation-induced lethality by the vitamin E isoform, delta-tocotrienol
    • 21434782
    • Satyamitra M Kulkarni S Ghosh SP Mullaney C Condliffe D Srinivasan V. Hematopoietic recovey and amelioration of radiation-induced lethality by the vitamin E isoform, delta-tocotrienol. Radiat Res (2011) 175:736–45.10.1667/RR2460.121434782
    • (2011) Radiat Res , vol.175 , pp. 736-745
    • Satyamitra, M.1    Kulkarni, S.2    Ghosh, S.P.3    Mullaney, C.4    Condliffe, D.5    Srinivasan, V.6
  • 172
    • 78649900365 scopus 로고    scopus 로고
    • Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling
    • 20823133
    • Li XH Fu D Latif NH Mullaney CP Ney PH Mog SR et al. Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. Haematologica (2010) 95(12):1996–2004.10.3324/haematol.2010.02649220823133
    • (2010) Haematologica , vol.95 , Issue.12 , pp. 1996-2004
    • Li, X.H.1    Fu, D.2    Latif, N.H.3    Mullaney, C.P.4    Ney, P.H.5    Mog, S.R.6
  • 173
    • 84894489825 scopus 로고    scopus 로고
    • Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor
    • 24486300
    • Singh VK Wise SY Scott JR Romaine LP Newman VL Fatanmi OO. Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor. Life Sci (2014) 98:113–22.10.1016/j.lfs.2014.01.06524486300
    • (2014) Life Sci , vol.98 , pp. 113-122
    • Singh, V.K.1    Wise, S.Y.2    Scott, J.R.3    Romaine, L.P.4    Newman, V.L.5    Fatanmi, O.O.6
  • 174
    • 84912558967 scopus 로고    scopus 로고
    • Tocols induce G-CSF and mobilise progenitors that mitigate radiation injury
    • 24993008
    • Singh VK Romaine PL Newman VL Seed TM. Tocols induce G-CSF and mobilise progenitors that mitigate radiation injury. Radiat Prot Dosimetry (2014) 162(1–2):83–7.10.1093/rpd/ncu22324993008
    • (2014) Radiat Prot Dosimetry , vol.162 , Issue.1–2 , pp. 83-87
    • Singh, V.K.1    Romaine, P.L.2    Newman, V.L.3    Seed, T.M.4
  • 175
    • 84868010675 scopus 로고    scopus 로고
    • Mechanism of radioprotection by delta-tocotrienol: pharmacokinetics, pharmacodynamics and modulation of signalling pathways
    • 22674714
    • Satyamitra M Ney P Graves J III Mullaney C Srinivasan V. Mechanism of radioprotection by delta-tocotrienol: pharmacokinetics, pharmacodynamics and modulation of signalling pathways. Br J Radiol (2012) 85(1019):e1093–103.10.1259/bjr/6335584422674714
    • (2012) Br J Radiol , vol.85 , Issue.1019 , pp. e1093-e1103
    • Satyamitra, M.1    Ney, P.2    Graves, J.3    Mullaney, C.4    Srinivasan, V.5
  • 176
    • 71049163875 scopus 로고    scopus 로고
    • Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice
    • 19956666
    • Bhanja P Saha S Kabarriti R Liu L Roy-Chowdhury N Roy-Chowdhury J et al. Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice. PLoS One (2009) 4(11):e8014.10.1371/journal.pone.000801419956666
    • (2009) PLoS One , vol.4 , Issue.11 , pp. e8014
    • Bhanja, P.1    Saha, S.2    Kabarriti, R.3    Liu, L.4    Roy-Chowdhury, N.5    Roy-Chowdhury, J.6
  • 177
    • 84908321410 scopus 로고    scopus 로고
    • Transforming growth factor beta3 attenuates the development of radiation-induced pulmonary fibrosis in mice by decreasing fibrocyte recruitment and regulating IFN-gamma/IL-4 balance
    • 24996042
    • Xu L Xiong S Guo R Yang Z Wang Q Xiao F et al. Transforming growth factor beta3 attenuates the development of radiation-induced pulmonary fibrosis in mice by decreasing fibrocyte recruitment and regulating IFN-gamma/IL-4 balance. Immunol Lett (2014) 162(1 Pt A):27–33.10.1016/j.imlet.2014.06.01024996042
    • (2014) Immunol Lett , vol.162 , pp. 27-33
    • Xu, L.1    Xiong, S.2    Guo, R.3    Yang, Z.4    Wang, Q.5    Xiao, F.6
  • 178
    • 84878598773 scopus 로고    scopus 로고
    • Further proof for an unpopular concept: a single cell from bone marrow can serve as a stem cell for both hematopoiesis and osteogenesis
    • Prockop DJ. Further proof for an unpopular concept: a single cell from bone marrow can serve as a stem cell for both hematopoiesis and osteogenesis. Mol Ther (2013) 21(6):1116–7.10.1038/mt.2013.103
    • (2013) Mol Ther , vol.21 , Issue.6 , pp. 1116-1117
    • Prockop, D.J.1
  • 179
    • 0141483047 scopus 로고    scopus 로고
    • One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues
    • 13679583
    • Prockop DJ Gregory CA Spees JL. One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues. Proc Natl Acad Sci U S A (2003) 100(Suppl 1):11917–23.10.1073/pnas.183413810013679583
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11917-11923
    • Prockop, D.J.1    Gregory, C.A.2    Spees, J.L.3
  • 180
    • 84934437928 scopus 로고    scopus 로고
    • Mesenchymal stem cells increase self-renewal of small intestinal epithelium and accelerate structural recovery after radiation injury
    • 17120774
    • Semont A Francois S Mouiseddine M Francois A Sache A Frick J et al. Mesenchymal stem cells increase self-renewal of small intestinal epithelium and accelerate structural recovery after radiation injury. Adv Exp Med Biol (2006) 585:19–30.10.1007/978-0-387-34133-0_217120774
    • (2006) Adv Exp Med Biol , vol.585 , pp. 19-30
    • Semont, A.1    Francois, S.2    Mouiseddine, M.3    Francois, A.4    Sache, A.5    Frick, J.6
  • 182
    • 84865178135 scopus 로고    scopus 로고
    • Thrombotic complications associated with stem cell transplantation
    • Nadir Y Brenner B. Thrombotic complications associated with stem cell transplantation. Blood Rev (2012) 26(5):183–7.10.1016/j.blre.2012.05.001
    • (2012) Blood Rev , vol.26 , Issue.5 , pp. 183-187
    • Nadir, Y.1    Brenner, B.2
  • 183
    • 60849112830 scopus 로고    scopus 로고
    • Intravenous administration of mesenchymal stem cells genetically modified with extracellular superoxide dismutase improves survival in irradiated mice
    • Abdel-Mageed AS Senagore AJ Pietryga DW Connors RH Giambernardi TA Hay RV et al. Intravenous administration of mesenchymal stem cells genetically modified with extracellular superoxide dismutase improves survival in irradiated mice. Blood (2009) 113(5):1201–3.10.1182/blood-2008-07-170936
    • (2009) Blood , vol.113 , Issue.5 , pp. 1201-1203
    • Abdel-Mageed, A.S.1    Senagore, A.J.2    Pietryga, D.W.3    Connors, R.H.4    Giambernardi, T.A.5    Hay, R.V.6
  • 184
    • 80052867757 scopus 로고    scopus 로고
    • Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice
    • 21935373
    • Saha S Bhanja P Kabarriti R Liu L Alfieri AA Guha C. Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice. PLoS One (2011) 6(9):e24072.10.1371/journal.pone.002407221935373
    • (2011) PLoS One , vol.6 , Issue.9 , pp. e24072
    • Saha, S.1    Bhanja, P.2    Kabarriti, R.3    Liu, L.4    Alfieri, A.A.5    Guha, C.6
  • 185
    • 84863220077 scopus 로고    scopus 로고
    • Myeloid progenitors: a radiation countermeasure that is effective when initiated days after irradiation
    • 22559205
    • Singh VK Christensen J Fatanmi OO Gille D Ducey EJ Wise SY et al. Myeloid progenitors: a radiation countermeasure that is effective when initiated days after irradiation. Radiat Res (2012) 177:781–91.10.1667/RR2894.122559205
    • (2012) Radiat Res , vol.177 , pp. 781-791
    • Singh, V.K.1    Christensen, J.2    Fatanmi, O.O.3    Gille, D.4    Ducey, E.J.5    Wise, S.Y.6
  • 186
    • 75149166590 scopus 로고    scopus 로고
    • Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor
    • 20070211
    • Singh VK Brown DS Kao TC. Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor. Int J Radiat Biol (2010) 86(1):12–21.10.3109/0955300090326451520070211
    • (2010) Int J Radiat Biol , vol.86 , Issue.1 , pp. 12-21
    • Singh, V.K.1    Brown, D.S.2    Kao, T.C.3
  • 187
    • 71249088476 scopus 로고    scopus 로고
    • Preclinical development of a bridging therapy for radiation casualties
    • 19853015
    • Singh VK Brown DS Kao TC Seed TM. Preclinical development of a bridging therapy for radiation casualties. Exp Hematol (2010) 38(1):61–70.10.1016/j.exphem.2009.10.00819853015
    • (2010) Exp Hematol , vol.38 , Issue.1 , pp. 61-70
    • Singh, V.K.1    Brown, D.S.2    Kao, T.C.3    Seed, T.M.4
  • 188
    • 84859724011 scopus 로고    scopus 로고
    • Alpha-tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation-induced gastrointestinal injury in mice
    • 22240608
    • Singh VK Wise SY Singh PK Ducey EJ Fatanmi OO Seed TM. Alpha-tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation-induced gastrointestinal injury in mice. Exp Hematol (2012) 40(5):407–17.10.1016/j.exphem.2012.01.00522240608
    • (2012) Exp Hematol , vol.40 , Issue.5 , pp. 407-417
    • Singh, V.K.1    Wise, S.Y.2    Singh, P.K.3    Ducey, E.J.4    Fatanmi, O.O.5    Seed, T.M.6
  • 189
    • 84877276951 scopus 로고    scopus 로고
    • Alpha-tocopherol succinate-mobilized progenitors improve intestinal integrity after whole body irradiation
    • 23270472
    • Singh VK Wise SY Singh PK Posarac A Fatanmi OO Ducey EJ et al. Alpha-tocopherol succinate-mobilized progenitors improve intestinal integrity after whole body irradiation. Int J Radiat Biol (2013) 89(5):334–45.10.3109/09553002.2013.76213723270472
    • (2013) Int J Radiat Biol , vol.89 , Issue.5 , pp. 334-345
    • Singh, V.K.1    Wise, S.Y.2    Singh, P.K.3    Posarac, A.4    Fatanmi, O.O.5    Ducey, E.J.6
  • 190
    • 84892741250 scopus 로고    scopus 로고
    • Alpha-tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation combined injury in mice
    • 23814114
    • Singh VK Wise SY Fatanmi OO Beattie LA Ducey EJ Seed TM. Alpha-tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation combined injury in mice. J Radiat Res (2014) 55(1):41–53.10.1093/jrr/rrt08823814114
    • (2014) J Radiat Res , vol.55 , Issue.1 , pp. 41-53
    • Singh, V.K.1    Wise, S.Y.2    Fatanmi, O.O.3    Beattie, L.A.4    Ducey, E.J.5    Seed, T.M.6
  • 191
    • 84861368159 scopus 로고    scopus 로고
    • CBLB613: a TLR 2/6 agonist, natural lipopeptide of Mycoplasma arginini, as a novel radiation countermeasure
    • 22175300
    • Singh VK Ducey EJ Fatanmi OO Singh PK Brown DS Purmal A et al. CBLB613: a TLR 2/6 agonist, natural lipopeptide of Mycoplasma arginini, as a novel radiation countermeasure. Radiat Res (2012) 177(5):628–42.10.1667/RR2657.122175300
    • (2012) Radiat Res , vol.177 , Issue.5 , pp. 628-642
    • Singh, V.K.1    Ducey, E.J.2    Fatanmi, O.O.3    Singh, P.K.4    Brown, D.S.5    Purmal, A.6
  • 192
    • 84858976312 scopus 로고    scopus 로고
    • Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of toll-like receptor 2 (TLR2)
    • 22479357
    • Shakhov AN Singh VK Bone F Cheney A Kononov Y Krasnov P et al. Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of toll-like receptor 2 (TLR2). PLoS One (2012) 7(3):e33044.10.1371/journal.pone.003304422479357
    • (2012) PLoS One , vol.7 , Issue.3 , pp. e33044
    • Shakhov, A.N.1    Singh, V.K.2    Bone, F.3    Cheney, A.4    Kononov, Y.5    Krasnov, P.6
  • 193
    • 84898539134 scopus 로고    scopus 로고
    • Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation
    • 24708888
    • Gluzman-Poltorak Z Mendonca SR Vainstein V Kha H Basile LA. Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation. J Hematol Oncol (2014) 7:31.10.1186/1756-8722-7-3124708888
    • (2014) J Hematol Oncol , vol.7 , pp. 31
    • Gluzman-Poltorak, Z.1    Mendonca, S.R.2    Vainstein, V.3    Kha, H.4    Basile, L.A.5
  • 194
    • 84875228640 scopus 로고    scopus 로고
    • Epidermal growth factor regulates hematopoietic regeneration after radiation injury
    • 23377280
    • Doan PL Himburg HA Helms K Russell JL Fixsen E Quarmyne M et al. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med (2013) 19(3):295–304.10.1038/nm.307023377280
    • (2013) Nat Med , vol.19 , Issue.3 , pp. 295-304
    • Doan, P.L.1    Himburg, H.A.2    Helms, K.3    Russell, J.L.4    Fixsen, E.5    Quarmyne, M.6
  • 195
    • 77950563923 scopus 로고    scopus 로고
    • Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiation
    • 20394858
    • Zhang L Sun W Wang J Zhang M Yang S Tian Y et al. Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiation. Int J Radiat Oncol Biol Phys (2010) 77(1):261–8.10.1016/j.ijrobp.2009.11.02620394858
    • (2010) Int J Radiat Oncol Biol Phys , vol.77 , Issue.1 , pp. 261-268
    • Zhang, L.1    Sun, W.2    Wang, J.3    Zhang, M.4    Yang, S.5    Tian, Y.6
  • 196
    • 84867568889 scopus 로고    scopus 로고
    • Fibroblast growth factor-peptide promotes bone marrow recovery after irradiation
    • 22879028
    • Ma J Hou Y Han D Zhang M Chen C Zhang B et al. Fibroblast growth factor-peptide promotes bone marrow recovery after irradiation. Adv Exp Med Biol (2013) 765:155–61.10.1007/978-1-4614-4989-8_2222879028
    • (2013) Adv Exp Med Biol , vol.765 , pp. 155-161
    • Ma, J.1    Hou, Y.2    Han, D.3    Zhang, M.4    Chen, C.5    Zhang, B.6
  • 197
    • 84875225107 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation
    • 23021438
    • Zhou D Deoliveira D Kang Y Choi SS Li Z Chao NJ et al. Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation. Int J Radiat Oncol Biol Phys (2013) 85(4):1141–8.10.1016/j.ijrobp.2012.08.01423021438
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , Issue.4 , pp. 1141-1148
    • Zhou, D.1    Deoliveira, D.2    Kang, Y.3    Choi, S.S.4    Li, Z.5    Chao, N.J.6
  • 198
    • 84866375872 scopus 로고    scopus 로고
    • The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation
    • 22805306
    • Mitchell JB Anver MR Sowers AL Rosenberg PS Figueroa M Thetford A et al. The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation. Cancer Res (2012) 72(18):4846–55.10.1158/0008-5472.CAN-12-187922805306
    • (2012) Cancer Res , vol.72 , Issue.18 , pp. 4846-4855
    • Mitchell, J.B.1    Anver, M.R.2    Sowers, A.L.3    Rosenberg, P.S.4    Figueroa, M.5    Thetford, A.6
  • 199
    • 79957586529 scopus 로고    scopus 로고
    • A TPO receptor agonist, ALXN4100TPO, mitigates radiation-induced lethality and stimulates hematopoiesis in CD2F1 mice
    • 21476857
    • Satyamitra M Lombardini E Graves IIIJ Mullaney C Ney P Hunter A et al. A TPO receptor agonist, ALXN4100TPO, mitigates radiation-induced lethality and stimulates hematopoiesis in CD2F1 mice. Radiat Res (2011) 175(6):746–58.10.1667/RR2462.121476857
    • (2011) Radiat Res , vol.175 , Issue.6 , pp. 746-758
    • Satyamitra, M.1    Lombardini, E.2    Graves, I.I.I.J.3    Mullaney, C.4    Ney, P.5    Hunter, A.6
  • 200
    • 84859359102 scopus 로고    scopus 로고
    • A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute
    • 22191567
    • Singh VK Ducey EJ Brown DS Whitnall MH. A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute. Int J Radiat Biol (2012) 88(4):296–310.10.3109/09553002.2012.65272622191567
    • (2012) Int J Radiat Biol , vol.88 , Issue.4 , pp. 296-310
    • Singh, V.K.1    Ducey, E.J.2    Brown, D.S.3    Whitnall, M.H.4
  • 201
    • 84889570788 scopus 로고    scopus 로고
    • A pilot study in rhesus macaques to assess the treatment efficacy of a small molecular weight catalytic metalloporphyrin antioxidant (AEOL 10150) in mitigating radiation-induced lung damage
    • Garofalo MC Ward AA Farese AM Bennett A Taylor-Howell C Cui W et al. A pilot study in rhesus macaques to assess the treatment efficacy of a small molecular weight catalytic metalloporphyrin antioxidant (AEOL 10150) in mitigating radiation-induced lung damage. Health Phys (2014) 106(1):73–83.10.1097/HP.0b013e3182a4d967
    • (2014) Health Phys , vol.106 , Issue.1 , pp. 73-83
    • Garofalo, M.C.1    Ward, A.A.2    Farese, A.M.3    Bennett, A.4    Taylor-Howell, C.5    Cui, W.6
  • 202
    • 84907557797 scopus 로고    scopus 로고
    • Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): a review
    • 25215458
    • Singh VK Newman VL Seed TM. Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): a review. Cytokine (2015) 71(1):22–37.10.1016/j.cyto.2014.08.00325215458
    • (2015) Cytokine , vol.71 , Issue.1 , pp. 22-37
    • Singh, V.K.1    Newman, V.L.2    Seed, T.M.3


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