Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis

Oncogene

Volumn 29, Issue 11, 2010, Pages 1622-1632

  Qiu, W ^a   Leibowitz, B ^a   Zhang, L ^a,b   Yu, J ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Growth factors; Intestinal stem cells; P53; PI3K; PUMA

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; PUMA PROTEIN; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STRAIN HCT116; COLON MUCOSA; CONTROLLED STUDY; CRYPT CELL; EPITHELIUM CELL; GASTROINTESTINAL DISEASE; GASTROINTESTINAL TOXICITY; HUMAN; HUMAN CELL; INTESTINE CRYPT; INTESTINE INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION ENTEROPATHY; RADIATION PROTECTION; STEM CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CELL LINE, TUMOR; FEMALE; FIBROBLAST GROWTH FACTOR 2; HCT116 CELLS; HUMANS; IN SITU NICK-END LABELING; INSULIN-LIKE GROWTH FACTOR I; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTESTINES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEM CELLS; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 77949655884     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.451     Document Type: Article

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