IGF-I enhances cellular senescence via the reactive oxygen species-p53 pathway

Biochemical and Biophysical Research Communications

Volumn 425, Issue 2, 2012, Pages 478-484

  Handayaningsih, Anastasia Evi ^a   Takahashi, Michiko ^a   Fukuoka, Hidenori ^a   Iguchi, Genzo ^a   Nishizawa, Hitoshi ^a   Yamamoto, Masaaki ^a   Suda, Kentaro ^a   Takahashi, Yutaka ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cellular senescence; IGF I; Longevity; P53; ROS

Indexed keywords

ACETYLCYSTEINE; BETA GALACTOSIDASE; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

AGING; ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL AGING; CELL PROLIFERATION; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL AGING; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HISTONES; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MICE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

RATTUS;

EID: 84865354347     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.07.140     Document Type: Article

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