δ-tocotrienol protects mouse and human hematopoietic progenitors from γ-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling

Haematologica

Volumn 95, Issue 12, 2010, Pages 1996-2004

  Li, Xiang Hong ^a   Fu, Dadin ^a   Latif, Nabil H ^a   Mullaney, Conor P ^a   Ney, Patrick H ^a   Mog, Steven R ^a   Whitnall, Mark H ^a   Srinivasan, Venkataraman ^a   Xiao, Mang ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

tocotrienol; Erk; mTOR; Radioprotection

Indexed keywords

CD34 ANTIGEN; DELTA TOCOTRIENOL; HISTONE H2AX; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN S6; SMALL INTERFERING RNA; TOCOPHEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CELL REGENERATION; CELL SURVIVAL; CLONOGENESIS; CONTROLLED STUDY; DEATH; DNA DAMAGE; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GAMMA IRRADIATION; GENE ACTIVATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; RADIATION INJURY; RADIATION PROTECTION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SURVIVAL RATE; SURVIVAL TIME; UPREGULATION;

ANIMALS; ANTIGENS, CD34; BLOTTING, WESTERN; BONE MARROW CELLS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENZYME ACTIVATION; EUKARYOTIC INITIATION FACTOR-4E; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GAMMA RAYS; HEMATOPOIETIC STEM CELLS; HISTONES; HUMANS; MALE; MICE; MICROSCOPY, FLUORESCENCE; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; TOR SERINE-THREONINE KINASES; VITAMIN E;

EID: 78649900365     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2010.026492     Document Type: Article

References (38)

1. Bentzen SM. Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer. 2006;6(9):702-13.
2. Hotz ME, Fliedner TM, Meineke V. Radiation accident preparedness: a European approach to train physicians to manage mass radiation casualties. Health Phys. 2010;98(6):894-7.
3. Xiao M, Whitnall M. Pharmacological countermeasures for the acute radiation syndrome. Curr Mol Pharmacol. 2009;2(1):122-33.
4. Coleman CN, Stone HB, Moulder JE, Pellmar TC. Medicine. Modulation of radiation injury. Science. 2004;304(5671):693-4.
5. Sen CK, Khanna S, Roy S. Tocotrienols: Vitamin E beyond tocopherols. Life Sci. 2006;78(18):2088-98.
6. Nesaretnam K. Multitargeted therapy of cancer by tocotrienols. Cancer Lett. 2008; 269(2):388-95.
7. Kamat JP, Sarma HD, Devasagayam TP, Nesaretnam K, Basiron Y. Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes. Mol Cell Biochem. 1997;170(1-2):131-7.
8. Astsaturov I, Cohen RB, Harari P. Targeting epidermal growth factor receptor signaling in the treatment of head and neck cancer. Expert Rev Anticancer Ther. 2006;6(9): 1179-93.
9. Krishna M, Narang H. The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell Mol Life Sci. 2008;65(22):3525-44.
10. Chambard JC, Lefloch R, Pouyssegur J, Lenormand P. ERK implication in cell cycle regulation. Biochim Biophys Acta. 2007;1773(8):1299-310.
11. Panta GR, Kaur S, Cavin LG, Cortes ML, Mercurio F, Lothstein L, et al. ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage. Mol Cell Biol. 2004;24(5):1823-35.
12. Proud CG. Signalling to translation: how signal transduction pathways control the protein synthetic machinery. Biochem J. 2007;403(2):217-34.
13. Yang X, Yang C, Farberman A, Rideout TC, de Lange CF, France J, et al. The mammalian target of rapamycin-signaling pathway in regulating metabolism and growth. J Anim Sci. 2008;86(14 Suppl):E36-50.
14. Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006;441(7092):424-30.
15. Jiang BH, Liu LZ. Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist Updat. 2008;11(3):63-76.
16. Bhandari BK, Feliers D, Duraisamy S, Stewart JL, Gingras AC, Abboud HE, et al. Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells. Kidney Int. 2001; 59(3):866-75.
17. Berbee M, Fu Q, Boerma M, Wang J, Kumar KS, Hauer-Jensen M. gamma- Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMGCoA reductase-dependent mechanism. Radiat Res. 2009;171(5):596-605.
18. Kessel JM, Hayflick J, Weyrich AS, Hoffman PA, Gallatin M, McIntyre TM, et al. Coengagement of ICAM-3 and Fc receptors induces chemokine secretion and spreading by myeloid leukocytes. J Immunol. 1998;160(11):5579-87.
19. Srinivasan V, Doctrow S, Singh VK, Whitnall MH. Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008; 30(2):271-90.
20. Xiao M, Inal CE, Parekh VI, Chang CM, Whitnall MH. 5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of nuclear factor-kappaB activation and granulocyte colony-stimulating factor expression. Mol Pharmacol. 2007;72(2): 370-9.
21. Davis TA, Clarke TK, Mog SR, Landauer MR. Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. Int J Radiat Biol. 2007;83(3):141-51.
22. Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 2001;15(7):807-26.
23. Bianchini A, Loiarro M, Bielli P, Busa R, Paronetto MP, Loreni F, et al. Phospho - rylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells. Carcinogenesis. 2008;29(12):2279-88.
24. Braunstein S, Badura ML, Xi Q, Formenti SC, Schneider RJ. Regulation of protein synthesis by ionizing radiation. Mol Cell Biol. 2009;29(21):5645-56.
25. Daly MJ, Gaidamakova EK, Matrosova VY, Vasilenko A, Zhai M, Leapman RD, et al. Protein oxidation implicated as the primary determinant of bacterial radioresistance. PLoS Biol. 2007;5(4):e92.
26. Burma S, Chen BP, Chen DJ. Role of nonhomologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amst). 2006;5(9-10):1042-8.
27. Jeggo P, Lobrich M. Radiation-induced DNA damage responses. Radiat Prot Dosimetry. 2006;122(1-4):124-7.
28. Redon CE, Dickey JS, Bonner WM, Sedelnikova OA. gamma-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin. Adv Space Res. 2009;43(8):1171-8.
29. Ricciardi MR, McQueen T, Chism D, Milella M, Estey E, Kaldjian E, et al. Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia. Leukemia. 2005;19(9): 1543-9.
30. +- derived neutrophil progenitors. Blood. 2009;114(16):3402-12.
31. Hayashi AA, Proud CG. The rapid activation of protein synthesis by growth hormone requires signaling through mTOR. Am J Physiol Endocrinol Metab. 2007;292 (6):E1647-55.
32. Shibata A, Nakagawa K, Sookwong P, Tsuzuki T, Oikawa S, Miyazawa T. Tumor anti-angiogenic effect and mechanism of action of delta-tocotrienol. Biochem Pharmacol. 2008;76(3):330-9.
33. Constantinou C, Papas A, Constantinou AI. Vitamin E and cancer: an insight into the anticancer activities of vitamin E isomers and analogs. Int J Cancer. 2008;123(4): 739-52.
34. Miyazawa T, Shibata A, Sookwong P, Kawakami Y, Eitsuka T, Asai A, et al. Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol). J Nutr Biochem. 2009;20(2):79-86.
35. Rubinfeld H, Seger R. The ERK cascade: a prototype of MAPK signaling. Mol Biotechnol. 2005;31(2):151-74.
36. Karin M. Nuclear factor-kappaB in cancer development and progression. Nature. 2006;441(7092):431-6.
37. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S. MAPK pathways in radiation responses. Oncogene. 2003;22(37):5885-96.
38. Valerie K, Yacoub A, Hagan MP, Curiel DT, Fisher PB, Grant S, et al. Radiation-induced cell signaling: inside-out and outside-in. Mol Cancer Ther. 2007;6(3):789-801.