Toll-like receptor 5 agonist protects mice from dermatitis and oral mucositis caused by local radiation: Implications for head-and-neck cancer radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 83, Issue 1, 2012, Pages 228-234

  Burdelya, Lyudmila G ^a   Gleiberman, Anatoli S ^b   Toshkov, Ilia ^b   Aygun Sunar, Semra ^a   Bapardekar, Meghana ^b   Manderscheid Kern, Patricia ^a   Bellnier, David ^a   Krivokrysenko, Vadim I ^b   Feinstein, Elena ^b   Gudkov, Andrei V ^a,b  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b CLEVELAND BIOLABS INC   (United States)

Author keywords

Dermatitis; Flagellin; Inflammation; Mucositis; Radiotherapy

Indexed keywords

ACUTE RADIATION SYNDROME; ANTI-CANCER AGENTS; FLAGELLIN; FRACTIONATED RADIATION; HEAD-AND-NECK CANCER; HUMAN LUNG; INFLAMMATION; INHIBITORY EFFECT; MUCOSITIS; NORMAL TISSUE; ORAL MUCOSITIS; RADIATION-INDUCED; RADIOPROTECTIVE EFFICACY; SIDE EFFECT; SINGLE-DOSE; SQUAMOUS CARCINOMA; TISSUE RECOVERY; TOLL-LIKE RECEPTORS; TOTAL BODY IRRADIATION; WEIGHT LOSS;

DERMATITIS; DISEASES; IRRADIATION; MAMMALS; RADIATION; TUMORS;

RADIOTHERAPY;

CBLB 502; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER RADIOTHERAPY; DERMATITIS; DRUG EFFICACY; EPITHELIUM; FEMALE; HEAD AND NECK CANCER; LUNG ADENOCARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RADIATION PROTECTION; RADIOSENSITIVITY; SQUAMOUS CELL CARCINOMA; STOMATITIS; TUMOR XENOGRAFT; WEIGHT REDUCTION; WOUND HEALING;

ADENOCARCINOMA; ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; LUNG NEOPLASMS; MICE; MOUTH MUCOSA; PEPTIDES; RADIATION INJURIES, EXPERIMENTAL; RADIATION TOLERANCE; RADIATION-PROTECTIVE AGENTS; RADIODERMATITIS; STOMATITIS; TOLL-LIKE RECEPTOR 5; WEIGHT LOSS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84859847723     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.05.055     Document Type: Article

References (16)

1. D.I. Rosenthal, and A. Trotti Strategies for managing radiation-induced mucositis in head and neck cancer Semin Radiat Oncol 19 2009 29 34
2. J.M. Vitolo, A.P. Cotrim, and A.L. Sowers The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse model Clin Cancer Res 10 2004 1807 1812
3. A. Vissink, F.R. Burlage, and F.K. Spijkervet Prevention and treatment of the consequences of head and neck radiotherapy Crit Rev Oral Biol Med 14 2003 213 225
4. R.M. Nagler, and B.J. Baum Prophylactic treatment reduces the severity of xerostomia following radiation therapy for oral cavity cancer Arch Otolaryngol Head Neck Surg 129 2003 247 250
5. G. Russo, R. Haddad, and M. Posner Radiation treatment breaks and ulcerative mucositis in head and neck cancer Oncologist 13 2008 886 898
6. B.A. Murphy, and J. Gilbert Dysphagia in head and neck cancer patients treated with radiation: Assessment, sequelae, and rehabilitation Semin Radiat Oncol 19 2009 35 42
7. M.E. Berger, D.M. Christensen, and P.C. Lowry Medical management of radiation injuries: Current approaches Occup Med (Lond) 56 2006 162 172
8. S.J. Hosseinimehr Trends in the development of radioprotective agents Drug Discov Today 12 2007 794 805
9. J.R. Kouvaris, V.E. Kouloulias, and L.J. Vlahos Amifostine: The first selective-target and broad-spectrum radioprotector Oncologist 12 2007 738 747
10. D.M. Brizel, T.H. Wasserman, and M. Henke Phase III randomized trial of amifostine as a radioprotector in head and neck cancer J Clin Oncol 18 2000 3339 3345
11. D.M. Brizel Pharmacologic approaches to radiation protection J Clin Oncol 25 2007 4084 4089
12. D.J. Grdina, J.S. Murley, and Y. Kataoka Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response Int J Radiat Oncol Biol Phys 73 2009 886 896
13. L.G. Burdelya, V.I. Krivokrysenko, and T.C. Tallant An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models Science 320 2008 226 230
14. R.V. Lalla, S.T. Sonis, and D.E. Peterson Management of oral mucositis in patients who have cancer Dent Clin North Am 52 2008 61 77 viii
15. M. McQuestion Evidence-based skin care management in radiation therapy Semin Oncol Nurs 22 2006 163 173
16. S.H. Rhee, E. Im, and C. Pothoulakis Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer Gastroenterology 135 2008 518 528