Mechanism of radioprotection by δ-tocotrienol: Pharmacokinetics, pharmacodynamics and modulation of signalling pathways

British Journal of Radiology

Volumn 85, Issue 1019, 2012, Pages

  Satyamitra, M ^a   Ney, P ^a   Graves III, J ^a   Mullaney, C ^a   Srinivasan, V ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; DELTA TOCOTRIENOL; TOCOPHEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOPHAGY; BONE MARROW; CONTROLLED STUDY; DRUG BLOOD LEVEL; LEUKOCYTE; LYMPHOCYTE; MALE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION PROTECTION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SURVIVAL RATE; SURVIVAL TIME; THROMBOCYTE;

ANIMALS; APOPTOSIS; BONE MARROW; CASPASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROMES C; ERYTHROCYTE COUNT; HEMATOPOIESIS; LEUKOCYTE COUNT; MALE; MICE; PANCYTOPENIA; PLATELET COUNT; RADIATION-PROTECTIVE AGENTS; SIGNAL TRANSDUCTION; VITAMIN E;

EID: 84868010675     PISSN: 00071285     EISSN: None     Source Type: Journal    
DOI: 10.1259/bjr/63355844     Document Type: Article

References (41)

1. Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE, et al. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Internal Med 2004;140:1037-51.
2. Coleman CN, Stone HB, Moulder JE, Pellmar TC. Medicine. Modulation of radiation injury. Science 2004;304:693-4.
3. Moulder JE. Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a review. Int J Radiat Biol 2004;80:3-10. (Pubitemid 38365707)
4. Weiss JF, Landauer MR. History and development of radiation-protective agents. Int J Radiat Biol 2009;85:539-73.
5. Satyamitra MM, Kulkarni S, Ghosh SP, Mullaney CP, Condliffe D, Srinivasan V. Hematopoietic recovery and amelioration of radiation-induced lethality by the vitamin E isoform delta-tocotrienol. Radiat Res 2011;175:736-45.
6. Li XH, Fu D, Latif NH, Mullaney CP, Ney PH, Mog SR, et al. Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. Haematologica 2010;95:1996-2004.
7. Cecconi F, Levine B. The Role of Autophagy in Mammalian development: cell makeover rather than cell death. Dev Cell 2008;15:344-57.
8. Har CH, Keong CK. Effects of tocotrienols on cell viability and apoptosis in normal murine liver cells (BNL CL.2) and liver cancer cells (BNL 1ME A.7R.1), in vitro. Asia Pac J Clin Nutr 2005;14:374-80. (Pubitemid 43219094)
9. Shun MC, Yu W, Gapor A, Parsons R, Atkinson J, Sanders BG, et al. Pro-apoptotic mechanisms of action of a novel vitamin E analog (alpha-TEA) and a naturally occurring form of vitamin E (delta-tocotrienol) in MDA-MB-435 human breast cancer cells. Nutr Cancer 2004;48:95-105. (Pubitemid 38823551)
10. Srivastava JK, Gupta S. Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells. Biochem Biophys Res Commun 2006;346:447-53. (Pubitemid 43902706)
11. Rickmann M, Vaquero EC, Malagelada JR, Molero X. Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway. Gastroenterology 2007;132:2518-32. (Pubitemid 46890868)
12. National Research Council. Guide for the care and use of laboratory animals. 8th edition. Washington DC: The National Academies Press; 2011.
13. Nagy K, Courtet-Compondu MC, Holst B, Kussmann M. Comprehensive analysis of vitamin E constituents in human plasma by liquid chromatography-mass spectrometry. Anal Chem 2007;79:7087-96. (Pubitemid 47438688)
14. Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A. Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacol 2004;47:904-15. (Pubitemid 39440984)
15. Berger ME, Christensen DM, Lowry PC, Jones OW, Wiley AL. Medical management of radiation injuries: current approaches. Occ Med 2006;56:162-72.
16. Casamassima F, Ruggiero C, Caramella D, Tinacci E, Villari N, Ruggiero M. Hematopoietic bone marrow recovery after radiation therapy: MRI evaluation. Blood 1989;73:1677-81. (Pubitemid 19131917)
17. Mauch P, Constine L, Greenberger J, Knospe W, Sullivan J, Liesveld JL, et al. Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy. Int J Radiat Oncol Biol Phys 1995;31:1319-39.
18. Husain K, Francois RA, Yamauchi T, Sebti S, Malafa MP. Delta-tocotrienol is the most bioactive natural tocotrienol in the prevention of pancreatic cancer transformation. Am Assoc Cancer Res 2008;49:3826.
19. Yap SP, Yuen KH, Wong JW. Pharmacokinetics and bioavailability of alpha-, gamma-and delta-tocotrienols under different food status. J Pharm Pharmacol 2001;53:67-71. (Pubitemid 32123701)
20. Gogu SR, Lertora JJ, George WJ, Hyslop NE, Agrawal KC. Protection of zidovudine-induced toxicity against murine erythroid progenitor cells by vitamin E. Exp Hematol 1991;19:649-52.
21. Bartholomew A, Latshaw D, Swayne DE. Changes in blood chemistry, hematology, and histology caused by a selenium/vitamin E deficiency and recovery in chicks. Biol Trace Elem Res 1998;62:7-16. (Pubitemid 28246528)
22. Cherdyntseva N, Shishkina A, Butorin I, Murase H, Gervas P, Kagiya TV. Effect of tocopherol-monoglucoside (TMG), a water-soluble glycosylated derivate of vitamin E, on hematopoietic recovery in irradiated mice. J Radiat Res (Tokyo) 2005;46:37-41. (Pubitemid 40780147)
23. Husain K, Francois RA, Hutchinson SZ, Neuger AM, Lush R, Coppola D, et al. Vitamin E delta-tocotrienol levels in tumor and pancreatic tissue of mice after oral administration. Pharmacology 2009;83:157-63.
24. Trudel G, Payne M, Mädler B, Ramachandran N, Lecompte M, Wade C, et al. Bone marrow fat accumulation after 60 days of bed rest persisted 1 year after activities were resumed along with hemopoietic stimulation: the Women International Space Simulation for Exploration study. J Appl Physiol 2009;107:540-8.
25. Brown JM, Hall EJ, Hirst DG, Kinsella TJ, Kligerman MM, Mitchell JB, et al. Chemical modification of radiation and chemotherapy. Am J Clin Oncol 1988;11:288-303.
26. Ghosh SP, Kulkarni S, Hieber K, Toles R, Romanyukha L, Kao TC, et al. Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. Int J Radiat Biol 2009;85:598-606.
27. Wambi C, Sanzari J, Wan XS, Nuth M, Davis J, Ko YH, et al. Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation. Radiat Res 2008;169:384-96. (Pubitemid 351620037)
28. Hall EJ, Giaccia AJ. Radiobiology for the radiologist. Philadelphia, PA: Lippincott Williams & Wilkins; 2006.
29. Goodman JW, Smith LH. Erythrocyte life span in normal mice and in radiation bone marrow chimeras. Am J Physiol 1961;200:764-70.
30. MacVittie TJ, Farese AM, Herodin F, Grab LB, Baum CM, McKearn JP. Combination therapy for radiationinduced bone marrow aplasia in nonhuman primates using synthokine SC-55494 and recombinant human granulocyte colony-stimulating factor. Blood 1996;87:4129-35.
31. Mac Manus M, Lamborn K, Khan W, Varghese A, Graef L, Knox S. Radiotherapy-associated neutropenia and thrombocytopenia: analysis of risk factors and development of a predictive model. Blood 1997;89:2303-10. (Pubitemid 27143276)
32. Wada S, Satomi Y, Murakoshi M, Noguchi N, Yoshikawa T, Nishino H. Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Lett 2005;229:181-91. (Pubitemid 41429357)
33. McIntyre BS, Briski KP, Tirmenstein MA, Fariss MW, Gapor A, Sylvester PW. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells. Lipids 2000;35:171-80. (Pubitemid 30183648)
34. Agarwal MK, Agarwal ML, Athar M, Gupta S. Tocotrienolrich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. Cell Cycle 2004;3:205-11. (Pubitemid 40268698)
35. Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006;25:4798-811. (Pubitemid 44187627)
36. Jeong HS, Choi HY, Lee ER, Kim JH, Jeon K, Lee HJ, et al. Involvement of caspase-9 in autophagy-mediated cell survival pathway. Biochim Biophys Acta 2011;1813:80-90.
37. Tsujimoto Y, Shimizu S. Another way to die: autophagic programmed cell death. Cell Death Differ 2005;12(Suppl. 2):1528-34. (Pubitemid 41553989)
38. Yorimitsu T, Klionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ 2005;12(Suppl. 2):1542-52. (Pubitemid 41553991)
39. Codogno P, Meijer AJ. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 2005;12(Suppl. 2):1509-18. (Pubitemid 41553987)
40. Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E, et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001;61:439-44. (Pubitemid 32128593)
41. Kim H, Bernard ME, Flickinger J, Epperly MW, Wang H, Dixon TM, et al. The autophagy-inducing drug carbamazepine is a radiation protector and mitigator. Int J Radiat Biol 2011;87:1052-60.