3,3′-Diindolymethane ameliorates adriamycin-induced cardiac fibrosis via activation of a BRCA1-dependent anti-oxidant pathway

Pharmacological Research

Volumn 70, Issue 1, 2013, Pages 139-146

  Yao, Zhengwei ^a   Hu, Wei ^a   Yin, Shan ^a   Huang, Zhen ^a   Zhu, Qian ^a   Chen, Jiangning ^a   Zang, Yuhui ^a   Dong, Lei ^a   Zhang, Junfeng ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

3,3 Diindolymethane; Adriamycin; BRCA1; Cardiac fibrosis

Indexed keywords

3,3' DIINDOLYLMETHANE; ALPHA SMOOTH MUSCLE ACTIN; BRCA1 PROTEIN; TRANSCRIPTION FACTOR NRF2; 3,3'-DIINDOLYLMETHANE; ANTINEOPLASTIC ANTIBIOTIC; ANTIOXIDANT; DOXORUBICIN; INDOLE DERIVATIVE; NFE2L2 PROTEIN, MOUSE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FIBROBLAST; HEART MUSCLE FIBROSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT RESPONSE; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; FIBROSIS; HEART FAILURE; HEART MUSCLE; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PATHOLOGY; PRIMARY CELL CULTURE; WESTERN BLOTTING;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; BLOTTING, WESTERN; BRCA1 PROTEIN; CELLS, CULTURED; DOXORUBICIN; FEMALE; FIBROBLASTS; FIBROSIS; HEART FAILURE; INDOLES; MICE; MICE, INBRED ICR; MYOCARDIUM; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PRIMARY CELL CULTURE; REACTIVE OXYGEN SPECIES; UP-REGULATION;

EID: 84875144931     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.01.006     Document Type: Article

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