Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor

International Journal of Radiation Biology

Volumn 86, Issue 1, 2010, Pages 12-21

  Singh, Vijay K ^a,b   Brown, Darren S ^a   Kao, Tzu Cheg ^a,c  

^a ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c Uniformed Services University of the Health Sciences   (United States)

Author keywords

Cytokines; Gamma irradiation; Granulocyte colony stimulating factor; Mice; Neutralising antibody; Radioprotection; Stem cells; Tocopherol succinate

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; COBALT; CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; NEUTRALIZING ANTIBODY; PLERIXAFOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CELL MOTILITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG FATALITY; FLUORESCENCE ACTIVATED CELL SORTING; HEMATOPOIETIC STEM CELL; IONIZING RADIATION; LETHAL DOSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION PROTECTION; SURVIVAL; TREATMENT DURATION; WHOLE BODY RADIATION;

ALPHA-TOCOPHEROL; ANIMALS; GAMMA RAYS; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL MOBILIZATION; HETEROCYCLIC COMPOUNDS; MALE; MICE; RADIATION-PROTECTIVE AGENTS; WHOLE-BODY IRRADIATION;

MUS;

EID: 75149166590     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553000903264515     Document Type: Article

References (39)

1. Birringer M, EyTina JH, Salvatore BA, Neuzil J. 2003. Vitamin E analogues as inducers of apoptosis: Structure-function relation. British Journal of Cancer 88:1948-1955.
2. Bociek RG, Armitage JO. 1996. Hematopoietic growth factors. CA: A Cancer Journal for Clinicians 46:165-184.
3. Bronchud MH, Scarffe JH, Thatcher N, Crowther D, Souza LM, Alton NK, Testa NG, Dexter TM. 1987. Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. British Journal of Cancer 56:809-813.
4. Broxmeyer HE, Orschell CM, Clapp DW, Hangoc G, Cooper S, Plett PA, Liles WC, Li X, Graham-Evans B, Campbell TB, Calandra G, Bridger G, Dale DC, Srour EF. 2005. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. Journal of Experimental Medicine 201:1307-1318. (Pubitemid 40629073)
5. Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman AS, Gupta D, Kurnasov OV, Fort FL, Osterman AL, Didonato JA, Feinstein E, Gudkov AV. 2008. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 320:226-230.
6. Ciernik IF, Schanz U, Gmur J. 1999. Delaying treatment with granulocyte colony-stimulating factor after allogeneic bone marrow transplantation for hematological malignancies: A prospective randomized trial. Bone Marrow Transplantation 24:147-151.
7. Eggermont E. 2006. Recent advances in vitamin E metabolism and deficiency. European Journal of Pediatrics 165:429-434.
8. Gerber A, Struy H, Weiss G, Lippert H, Ansorge S, Schulz HU. 2000. Effect of granulocyte colony-stimulating factor treatment on ex vivo neutrophil functions in nonneutropenic surgical intensive care patients. Journal of Interferon and Cytokine Research 20:1083-1090.
9. Hanson WR, Houseman KA, Collins PW. 1988. Radiation protection in vivo by prostaglandins and related compounds of the arachidonic acid cascade. Pharmacology and Therapeutics 39:347-356.
10. Herbert KE, Walkley CR, Winkler IG, Hendy J, Olsen GH, Yuan YD, Chandraratna RA, Prince HM, Levesque JP, Purton LE. 2007. Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells. Transplantation 83:375-384.
11. Hermans MH, van de Geijn GJ, Antonissen C, Gits J, van Leeuwen D, Ward AC, Touw IP. 2003. Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells. Blood 101:2584-2590.
12. Herodin F, Drouet M. 2005. Cytokine-based treatment of accidentally irradiated victims and new approaches. Experimental Hematology 33:1071-1080.
13. Herodin F, Grenier N, Drouet M. 2007. Revisiting therapeutic strategies in radiation casualties. Experimental Hematology 35:28-33.
14. Hofer M, PospisilM, Znojil V, Hola J, Vacek A, Streitova D. 2008. Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy. Physiological Research 57:307-310.
15. Hofer M, Pospisil M, Znojil V, Hola J, Vacek A, Weiterova L, Streitova D, Kozubik A. 2006. Meloxicam, a cyclooxygenase 2 inhibitor, supports hematopoietic recovery in gamma-irradiated mice. Radiation Research 166:556-560.
16. Hosseinimehr SJ. 2007. Trends in the development of radioprotective agents. Drug Discovery Today 12:794-805.
17. Kalechman Y, Albeck M, Oron M, Sobelman D, Gurwith M, Seghal SN, Sredni B. 1990. Radioprotective effects of the immunomodulator AS101. Journal of Immunology 145: 1512-1517.
18. Kalechman Y, Zuloff A, Albeck M, Strassmann G, Sredni B. 1995. Role of endogenous cytokines secretion in radioprotection conferred by the immunomodulator ammonium trichloro( dioxyethylene-0-00)tellurate. Blood 85:1555-1561.
19. Kumar KS, Srinivasan V, Toles R, Jobe L, Seed TM. 2002. Nutritional approaches to radioprotection: Vitamin E. Military Medicine 167:57-59.
20. Kumar KS, Vaishnav YN, Weiss JF. 1988. Radioprotection by antioxidant enzymes and enzyme mimetics. Pharmacology and Therapeutics 39:301-309.
21. Larochelle A, Krouse A, Metzger M, Orlic D, Donahue RE, Fricker S, Bridger G, Dunbar CE, Hematti P. 2006. AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates. Blood 107: 3772-3778.
22. Mehrotra S, Mishra KP, Maurya R, Srimal RC, Singh VK. 2002. Immunomodulation by ethanolic extract of Boerhaavia diffusa roots. International Immunopharmacology 2:987-996. (Pubitemid 34756389)
23. Neta R, Oppenheim JJ, Douches SD. 1988. Interdependence of the radioprotective effects of human recombinant interleukin 1 alpha, tumor necrosis factor alpha, granulocyte colonystimulating factor, and murine recombinant granulocytemacrophage colony-stimulating factor. Journal of Immunology 140:108-111.
24. Neta R, Oppenheim JJ, Schreiber RD, Chizzonite R, Ledney GD, MacVittie TJ. 1991. Role of cytokines (interleukin 1, tumor necrosis factor, and transforming growth factor beta) in natural and lipopolysaccharide-enhanced radioresistance. Journal of Experimental Medicine 173:1177-1182.
25. Neta R, Perlstein R, Vogel SN, Ledney GD, Abrams J. 1992. Role of interleukin 6 (IL-6) in protection from lethal irradiation and in endocrine responses to IL-1 and tumor necrosis factor. Journal of Experimental Medicine 175:689-694.
26. Nicola NA, Metcalf D, Johnson GR, Burgess AW. 1979. Separation of functionally distinct human granulocytemacrophage colony-stimulating factors. Blood 54:614-627.
27. Pulliam AC, Hobson MJ, Ciccone SL, Li Y, Chen S, Srour EF, Yang FC, Broxmeyer HE, Clapp DW. 2008. AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice. Experimental Hematology 36:1084-1090.
28. Rahu M. 2003. Health effects of the Chernobyl accident: Fears, rumours and the truth. European Journal of Cancer 39: 295-299.
29. Singh VK, Shafran RL, Inal CE, Jackson WE III, Whitnall MH. 2005. Effects of whole-body gamma irradiation and 5- androstenediol administration on serum G-CSF. Immunopharmacology and Immunotoxicology 27:521-534.
30. Singh VK, Shafran RL, Jackson WE III, Seed TM, Kumar KS. 2006. Induction of cytokines by radioprotective tocopherol analogs. Experimental and Molecular Pathology 81:55-61.
31. Srinivasan V, Weiss JF. 1992. Radioprotection by vitamin E: Injectable vitamin E administered alone or with WR-3689 enhances survival of irradiated mice. International Journal of Radiation Oncology, Biology, Physics 23:841-845.
32. Uckun FM, Souza L, Waddick KG, Wick M, Song CW. 1990. In vivo radioprotective effects of recombinant human granulocyte colony-stimulating factor in lethally irradiated mice. Blood 75:638-645.
33. Vos O. 1992. Role of endogenous thiols in protection. Advances in Space Research 12:201-207.
34. Waddick KG, Song CW, Souza L, Uckun FM. 1991. Comparative analysis of the in vivo radioprotective effects of recombinant granulocyte colony-stimulating factor (G-CSF), recombinant granulocyte-macrophage CSF, and their combination. Blood 77:2364-2371.
35. Weaver CH, Schulman KA, Buckner CD. 2001. Mobilization of peripheral blood stem cells following myelosuppressive chemotherapy: A randomized comparison of filgrastim, sargramostim, or sequential sargramostim and filgrastim. Bone Marrow Transplantation 27(Suppl. 2):S23-29.
36. Weiss JF, Srinivasan V, Kumar KS, Landauer MR. 1992. Radioprotection by metals: Selenium. Advances in Space Research 12:223-231.
37. Wenisch C, Werkgartner T, Sailer H, Patruta S, Krause R, Daxboeck F, Parschalk B. 2000. Effect of preoperative prophylaxis with filgrastim in cancer neck dissection. European Journal of Clinical Investigation 30:460-466.
38. Whitnall MH, Elliott TB, Landauer MR, Wilhelmsen CL, McKinney L, Kumar KS, Srinivasan V, Ledney GD, Seed TM. 2002. Protection against gamma-irradiation with 5-androstenediol. Military Medicine 167:64-65.
39. Whitnall MH, Inal CE, Jackson WE III, Miner VL, Villa V, Seed TM. 2001. In vivo radioprotection by 5-androstenediol: Stimulation of the innate immune system. Radiation Research 156:283-293.