Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival

Food and Chemical Toxicology

Volumn 60, Issue , 2013, Pages 488-496

  Suman, Shubhankar ^a   Datta, Kamal ^a   Chakraborty, Kushal ^b   Kulkarni, Shilpa S ^b   Doiron, Kathryn ^a   Fornace, Albert J ^a,c   Sree Kumar, K ^b   Hauer Jensen, Martin ^d   Ghosh, Sanchita P ^b,c  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE   (United States)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^d UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Apoptosis; Gamma tocotrienol; Gastrointestinal toxicity; Radiation; Radioprotection

Indexed keywords

GAMMA TOCOTRIENOL; POLYSORBATE 80; RADIOPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG POTENCY; GAMMA RADIATION; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; INTESTINE CRYPT; JEJUNUM; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; RADIATION PROTECTION; SINGLE DRUG DOSE; UPREGULATION;

ACUTE RADIATION SYNDROME; APOPTOSIS; ARS; ATAXIA-TELANGIECTASIA-MUTATED; ATM; DNA-DEPENDENT PROTEIN KINASE; DNA-PK; DOSE REDUCTION FACTOR; DRF; GAMMA TOCOTRIENOL; GASTROINTESTINAL; GASTROINTESTINAL TOXICITY; GI; GT3; PARP; POLY-ADP-RIBOSE POLYMERASE; RADIATION; RADIOPROTECTION; REACTIVE OXYGEN SPECIES; ROS; TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE DUTP NICK END LABELING; TUNEL; Γ-TOCOTRIENOL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; CELL SURVIVAL; CHROMANS; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GAMMA RAYS; IN SITU NICK-END LABELING; INTESTINES; MALE; MICE; RADIATION INJURIES; RADIATION-PROTECTIVE AGENTS; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION; VITAMIN E;

EID: 84883405523     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.08.011     Document Type: Article

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