Transforming growth factor β3 attenuates the development of radiation-induced pulmonary fibrosis in mice by decreasing fibrocyte recruitment and regulating IFN-γ/IL-4 balance

Immunology Letters

Volumn 162, Issue 1, 2014, Pages 27-33

  Xu, Long ^a   Xiong, Shanshan ^a   Guo, Renfeng ^b   Yang, Zhihua ^a   Wang, Qianjun ^a   Xiao, Fengjun ^a   Wang, Haibao ^c   Pan, Xiujie ^a   Zhu, Maoxiang ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Cytokine; Fibrocyte; Radiation induced pulmonary fibrosis; Regulatory T cells; Transforming growth factor

Indexed keywords

COLLAGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA3; TRANSFORMING GROWTH FACTOR BETA3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTI FIBROTIC ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL COUNT; CELL INFILTRATION; CELL TYPE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; DRUG MECHANISM; EPITHELIUM HYPERPLASIA; FEMALE; FIBROCYTE; IMMUNE RESPONSE; INHIBITION KINETICS; IRRADIATION; LUNG FIBROSIS; LUNG HOMOGENATE; LUNG LAVAGE; MOUSE; NONHUMAN; RADIATION INDUCED PULMONARY FIBROSIS; RADIATION INJURY; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; TH1 CELL; ANIMAL; CONNECTIVE TISSUE CELL; DISEASE MODEL; EXPERIMENTAL RADIATION INJURY; IMMUNOLOGY; METABOLISM; PATHOLOGY; PULMONARY FIBROSIS;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; COLLAGEN; CONNECTIVE TISSUE CELLS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-4; MICE; PULMONARY FIBROSIS; RADIATION INJURIES, EXPERIMENTAL; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA3;

EID: 84908321410     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2014.06.010     Document Type: Article

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