Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation

Journal of Hematology and Oncology

Volumn 7, Issue 1, 2014, Pages

  Gluzman Poltorak, Zoya ^a   Mendonca, Sarita R ^a   Vainstein, Vladimir ^a   Kha, Hue ^a   Basile, Lena A ^a  

^a Neumedicines Inc   (United States)

Author keywords

Hematopoiesis; HSARS; IL 12; Radiation; Syndrome; Total body irradiation

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 18; PLACEBO; RECOMBINANT INTERLEUKIN 12; INTERLEUKIN 12; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTEREMIA; BLEEDING; BONE MARROW SUPPRESSION; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; DECREASED APPETITE; DIARRHEA; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; ERYTHROCYTE; ESCHERICHIA COLI; FEBRILE NEUTROPENIA; FEMALE; HEMATOLOGIC DISEASE; HEMATOPOIESIS; HEMATOPOIETIC SYNDROME OF THE ACUTE RADIATION SYNDROME; HISTOPATHOLOGY; LETHAL DOSE; LYMPHOCYTE; MALE; MEGAKARYOCYTE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PRODROMAL SYMPTOM; PROTEIN BLOOD LEVEL; RADIATION DOSE; RADIATION INJURY; RETICULOCYTE; RHESUS MONKEY; SEPSIS; SEPTICEMIA; SINGLE DRUG DOSE; STAPHYLOCOCCUS AUREUS; SURVIVAL; SURVIVAL RATE; THROMBOCYTE; THROMBOCYTE VOLUME; THROMBOCYTOPENIA; TISSUE REGENERATION; VOMITING; WHOLE BODY RADIATION; ANIMAL; BLOOD; DRUG EFFECTS; HUMAN; RADIATION INJURIES, EXPERIMENTAL; RADIATION RESPONSE; RANDOMIZATION;

ANIMALS; FEMALE; HEMATOPOIESIS; HUMANS; INTERLEUKIN-12; MACACA MULATTA; MALE; RADIATION INJURIES, EXPERIMENTAL; RANDOM ALLOCATION; RECOMBINANT PROTEINS; SURVIVAL RATE; WHOLE-BODY IRRADIATION;

EID: 84898539134     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/1756-8722-7-31     Document Type: Article

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