Free radicals and antioxidants in the year 2000. A historical look to the future

Annals of the New York Academy of Sciences

Volumn 899, Issue , 2000, Pages 136-147

  Gutteridge, John M C ^a   Halliwell, Barry ^b  

^a ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; COPPER ZINC SUPEROXIDE DISMUTASE; FERROUS ION; FREE RADICAL; IRON SUPEROXIDE DISMUTASE; MANGANESE SUPEROXIDE DISMUTASE; NITRIC OXIDE; PEROXY RADICAL; POLYMER; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

CELL FUNCTION; CHROMATOGRAPHY; COMBUSTION; CONFERENCE PAPER; DNA SEQUENCE; ELECTROPHORESIS; IONIZING RADIATION; LIPID PEROXIDATION; MOLECULAR CLONING; OXIDATION; OXIDATION REDUCTION REACTION; OXYGEN TOXICITY; POLYMERASE CHAIN REACTION; RADIATION; RECOMBINANT DNA TECHNOLOGY;

EID: 0034079862     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06182.x     Document Type: Conference Paper

References (51)

1. 1. GERSCHMAN, R., D.L. GILBERT, S.W. NYE, P. DWYER & W.O. FENN. 1956. Oxygen poisoning and X-irradiation: a mechanism in common. Science 119: 623-626.
2. 2. MCCORD, J.M. & I. FRIDOVICH. 1969. Superoxide dismutase. An enzymic function for erythrocuprein (haemocuprein). J. Biol. Chem. 244: 6049-6055.
3. 3. MCCORD, J.M. & I. FRIDOVICH. 1969. The utility of superoxide dismutase in studying free radical reactions. I. Radicals generated by the interaction of sulfite, dimethylsulfoxide and oxygen. J. Biol. Chem. 244: 6056-6063.
4. 4. MCCORD, J.M. & I. FRIDOVICH. 1968. The reduction of cytochrome c by milk xanthine oxidase. J. Biol. Chem. 243: 5753-5760.
5. 5. HALLIWELL, B. 1973. Superoxide dismutase: a contaminant of bovine catalase. Biochem. J. 135: 379-381.
6. 6. REIST, M., K.A. MARSHALL, P. JENNER & B. HALLIWELL. 1998. Toxic effects of sulphite in combination with peroxynitrite on neuronal cells. J. Neurochem. 71: 2431-2438.
7. 7. LEHMANN, Y., L. MILE & M. TEUBER. 1996. Rubrerythrin from Clostridium perfringens: cloning of the gene, purification of the protein and characterization of its superoxide dismutase function. J. Bact. 178: 7152-7158.
8. 8. TOUATI, D. 1989. The molecular genetics of superoxide dismutase in E. coli. Free Rad. Res. Commun. 8: 1-9.
9. 9. LEBOVITZ, R. M., H. ZHANG, H. VOGEL et al. 1996. Neurodegeneration, myocardial injury and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc. Natl. Acad. Sci. US 93: 9782-9787.
10. 10. LI, Y., T. T. HUANG, E. J. CARLSON et al. 1995. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese SOD. Nature Genet. 11: 376-381.
11. 11. MATZUK, M. M., L. DIONNE, Q. GUO et al. 1998. Ovarian function in superoxide dismulase 1 and 2 knockout mice. Endocrinology 139: 4008-4011.
12. 2. J. Biol. Chem. 273: 22528-22536.
13. 2. A physiological role for the thioredoxin system. Planta 151: 242-246.
14. 14. NAKAMURA, H., Y. NAKAMURA & J. YODOI. 1997. Redox regulation of cellular activation. Annu. Rev. Immunol. 15: 351-369.
15. 15. HALLIWELL B. & J. M. C. GUTTERIDGE. 1984. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219: 1-14.
16. 16. GUTTERIDGE, J.M.C. 1982. The role of superoxide and hydroxyl radicals in phospholipid peroxidation catalysed by iron salts. FEBS Lett. 150: 454-458.
17. 17. HALLIWELL, B. & J.M.C. GUTTERIDGE. Free Radicals in Biology and Medicine. Oxford University Press. Oxford, UK. First edition 1985, second edition 1989, third edition 1999.
18. 18. PICARD, V., S. EPSZTEJN, P. SANTAMBROGIO et al. 1998. Role of ferritin in the control of the labile iron pool in murine erythroleukemia cells. J. Biol. Chem. 273: 15382-15386.
19. 19. BIEMOND, P., H.G. VAN EIJK, A.J. SWAAK & J.F. KOSTER. 1984. Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. J. Clin. Invest. 73: 1576-1579.
20. ANNALS NEW YORK ACADEMY OF SCIENCES 20. GUTTERIDGE, J.M.C. 1986. Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides. FEBS Lett. 201: 291-295.
21. 21. KEYER, K. & J.A. IMLAY. 1996. Superoxide accelerates DNA damage by elevating free-iron levels. Proc. Natl. Acad. Sci. USA 93: 13635-13640.
22. 22. THEIL, E.G. 1998. The iron responsive element (IRE) family of mRNA regulators. Regulation of iron transport and uptake compared in animals, plants and microorganisms. Metal Ion Biol. Syst. 35: 403-434.
23. 23. SIMPSON, R.J., C.E. COOPER, K.B. RAJA et al. 1992. Non-transferrin-bound iron species in the serum of hypotransferrinaemic mice. Biochim. Biophys. Acta 1156: 19-26.
24. 24. SYMONS, M.C.R. & J.M.C. GUTTERIDGE. 1998. Free Radicals and Iron Chemistry, Biology and Medicine. Oxford University Press. Oxford, UK.
25. 25. WALLING, C. 1975. Fenton's reagent revisited. Acc. Chem. Res. 8: 125.
26. 26. BECKMAN, J.S. & W.H. KOPPENOL. 1996. Nitric oxide, superoxide and peroxynitrite: the good, the bad and the ugly. Am. J. Physiol. 271: C1424-C1437.
27. 27. RUBBO, H., R. RADI., M. TRUJILLO et al. 1994. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. J. Biol. Chem. 269: 26066-26075.
28. 28. HALLIWELL, B. 1989. Superoxide, iron, vascular endothelium and reperfusion injury. Free Rad. Res. Commun. 5: 315-318.
29. 2 radicals. Chem. Res. Toxicol. 11: 712-713.
30. 30. KAUR, H., M. WHITEMAN & B. HALLIWELL. 1997. Peroxynitrite-dependent aromatic hydroxylation and nitration of salicylate and phenylalanine. Is hydroxyl radical involved? Free Rad. Res. 26: 71-82.
31. 31. RICHESON, C.E., P. MULDER, V.W. BOWRY & K.U. INGOLD. 1998. The complex chemistry of peroxnitrite decomposition: new insights. J. Am. Chem. Soc. 120: 7211-7219.
32. 32. SLATER, T.F. 1984. Free-radical mechanisms of tissue injury. Biochem. J. 222: 1-15.
33. 33. VON SONNTAG, C. 1987. The Chemical Basis of Radiation Biology. Taylor and Francis. London.
34. 34. DAVIES, M.J. & R.T. DEAN. 1997. Radical-Mediated Protein Oxidation. From Chemistry to Medicine. Oxford University Press. Oxford, UK.
35. 35. DIZDAROGLU, M. 1991. Chemical determination of free radical-induced damage to DNA. Free Rad. Biol. Med. 10: 225-242.
36. 36. HALLIWELL, B. & J.M.C. GUTTERIDGE. 1984. Lipid peroxidation, oxygen radicals, cell damage and anti-oxidant therapy. Lancet i: 1396-1398.
37. 37. JACOBSON, M.D. 1996. Reactive oxygen species and programmed cell death. Trends Biochem. Sci. 21: 83-86.
38. 38. HALLIWELL, B., C.E. CROSS & J.M.C. GUTTERIDGE. 1992. Free radicals, antioxidants, and human disease. Where are we now? J. Lab. Clin. Med. 119: 598-620.
39. 39. DIPLOCK, A.T. 1997. Will the "good fairies" please prove to us that vitamin E lessens human degenerative disease? Free Rad. Res. 27: 511-532.
40. 40. GUTTERIDGE, J.M.C. & B. HALLIWELL. 1995. Antioxidants in Nutrition, Health, and Disease. Oxford University Press. Oxford, UK.
41. 41. HALLIWELL, B. 1999. Establishing the significance and optimal intake of dietary antioxidants. The biomarker concept. Nutr. Rev. 57: 104-113.
42. 42. SEN, C.K. 1998. Redox signalling and the emerging therapeutic potential of thiol antioxidants. Biochem. Pharmacol. 55: 1747-1758.
43. 43. JONESON, T. & D. BAR-SAGI. 1998. A Rac I effector site controlling mitogenesis through superoxide production. J. Biol. Chem. 213: 17991-17994.
44. 2 in relation to mammalian cell proliferation. Free Rad. Biol. Med. 18: 775-794.
45. 45. SARAN, M. & W. BORS. 1989. Oxygen radicals acting as chemical messengers: a hypothesis. Free Rad. Res. Commun. 7: 213-220.
46. 46. HALLIWELL, B. 1996. Free radicals, proteins and DNA: oxidative damage versus redox regulation. Biochem. Soc. Trans. 24: 1023-1027.
47. 47. HALLIWELL, B. & J.M.C. GUTTERIDGE. 1986. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch. Biochem. Biophys. 246: 501-514.
48. 2: implications for apoptosis. FEBS Lett. 414: 552-556.
49. 49. CLEMENT, M.V. & S. PERVAIZ. 1999. Reactive oxygen species regulate cellular response to apoptotic stimuli: an hypothesis. Free Rad. Res. 30: 247-252.
50. 50. KONDO, T., F.R. SHARP, J. HONKANIEMI et al. 1997. DNA fragmentation and prolonged expression of c-fos, c-jun and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human Cu,Zn-superoxide dismutase. J. Cereb. Blood Flow Metab. 17: 241-256.
51. 51. MIROCHNITCHENKO, O., U. PALNITKAR, M. PHILBERT & M. INOUYE. 1995. Thermosensitive phenotype of transgenic mice overproducing human glutathione peroxidases. Proc. Natl. Acad. Sci. USA 92: 8120-8124.