Radiation-induced senescence-like phenotype in proliferating and plateau-phase vascular endothelial cells

Experimental Cell Research

Volumn 313, Issue 15, 2007, Pages 3326-3336

  Igarashi, Kaori ^a   Sakimoto, Ippei ^a   Kataoka, Keiko ^a   Ohta, Keisuke ^a,b   Miura, Masahiko ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Angiogenesis; Ionizing radiation; Radiotherapy; Senescence like phenotype; Vascular endothelial cells

Indexed keywords

ANGIOGENESIS; ARTICLE; CELL CYCLE PROGRESSION; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DNA HELIX; DNA REPAIR; DNA STRAND BREAKAGE; ENDOTHELIUM CELL; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; IRRADIATION; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE;

EID: 34548043307     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2007.06.001     Document Type: Article

References (38)

1. Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 29 (2002) 15-18
2. Kerbel R., and Folkman J. Clinical translation of angiogenesis inhibitors. Nat. Rev., Cancer 2 (2002) 727-739
3. Davis G.E., and Senger D.R. Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ. Res. 97 (2005) 1093-1107
4. Mao X.W. A quantitative study of the effects of ionizing radiation on endothelial cells and capillary-like network formation. Technol. Cancer Res. Treat. 5 (2006) 127-134
5. Karnabatidis D., Dimopoulos J.C., Siablis D., Papazafiropouros D., Kalogeropoulou C.P., and Nikiforidis G. Quantification of the ionising radiation effect over angiogenesis in the chick embryo and its chorioallantoic membrane by computerised analysis of angiographic images. Acta Radiol. 42 (2001) 333-338
6. Abdollahi A., Griggs D.W., Zieher H., Roth A., Lipson K.E., Saffrich R., Grone H.J., Hallahan D.E., Reisfeld R.A., Debus J., Niethammer A.G., and Huber P.E. Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy. Clin. Cancer Res. 11 (2005) 6270-6279
7. Sonveaux P., Brouet A., Havaux X., Gregoire V., Dessy C., Balligand J.L., and Feron O. Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy. Cancer Res. 63 (2003) 1012-1019
8. Polytarchou C., Gligoris T., Kardamakis D., Kotsaki E., and Papadimitriou E. X-rays affect the expression of genes involved in angiogenesis. Anticancer Res. 24 (2004) 2941-2945
9. Kermani P., Leclerc G., Martel R., and Fareh R.J. Effect of ionizing radiation on thymidine uptake, differentiation, and VEGFR2 receptor expression in endothelial cells: the role of VEGF(165). Int. J. Radiat. Oncol. Biol. Phys. 50 (2001) 213-220
10. Huber P.E., Bischof M., Jenne J., Heiland S., Peschke P., Saffrich R., Grone H.J., Debus J., Lipson K.E., and Abdollahi A. Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy. Cancer Res. 65 (2005) 3643-3655
11. Gajdusek C., Onoda K., London S., Johnson M., Morrison R., and Mayberg M. Early molecular changes in irradiated aortic endothelium. J. Cell. Physiol. 188 (2001) 8-23
12. Edwards E., Geng L., Tan J., Onishko H., Donnelly E., and Hallahan D.E. Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation. Cancer Res. 62 (2002) 4671-4677
13. Minamino T., Miyauchi H., Yoshida T., Tateno K., Kunieda T., and Komuro I. Vascular cell senescence and vascular aging. J. Mol. Cell. Cardiol. 36 (2004) 175-183
14. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., Peacocke M., and Campisi J. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 9363-9367
15. Burrig K.F. The endothelium of advanced arteriosclerotic plaques in humans. Arterioscler. Thromb. 11 (1991) 1678-1689
16. Sedelnikova O.A., Horikawa I., Zimonjic D.B., Popescu N.C., Bonner W.M., and Barret J.C. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat. Cell Biol. 6 (2004) 168-170
17. Kanaar R., Hoeijmakers J.H., and van Gent D.C. Molecular mechanisms of DNA double strand break repair. Trends Cell Biol. 8 (1998) 483-489
18. Johnson L.K., Longenecker J.P., and Fajardo L.F. Differential radiation response of cultured endothelial cells and smooth myocytes. Anal. Quant. Cytol. 4 (1982) 188-198
19. Oh C.W., Bump E.A., Kim J.S., Janigro D., and Mayberg M.R. Induction of a senescence-like phenotype in bovine aortic endothelial cells by ionizing radiation. Radiat. Res. 156 (2001) 232-240
20. Sakimoto I., Ohta K., Yamazaki T., Ohtani S., Sahara H., Sugawara F., Sakaguchi K., and Miura M. α-Sulfoquinovosylmonoacylglycerol is a novel potent radiosensitizer targeting tumor angiogenesis. Cancer Res. 66 (2006) 2287-2295
21. Minagawa S., Nakabayashi K., Fujii M., Scherer S.W., and Ayusawa D. Early BrdU-responsive genes constitute a novel class of senescence-associated genes in human cells. Exp. Cell Res. 304 (2005) 552-558
22. Kang M.K., Kameta A., Shin K.H., Baluda M.A., Kim H.R., and Park N.H. Senescence-associated genes in normal human oral keratinocytes. Exp. Cell Res. 287 (2003) 272-281
23. Cristofalo V.J., Volker C., Francis M.K., and Tresini M. Age-dependent modifications of gene expression in human fibroblasts. Crit. Rev. Eukaryot. Gene Expr. 8 (1998) 43-80
24. Nguyen M., Arkell J., and Jackson C.J. Human endothelial gelatinases and angiogenesis. Int. J. Biochem. Cell Biol. 33 (2001) 960-970
25. Hahn G.M., and Little J.B. Plateau-phase cultures of mammalian cells: an in vitro model for human cancer. Curr. Top. Radiat. Res. 8 (1972) 39-43
26. Hall E.J., and Giaccia A.J. Repair of radiation damage and the dose-rate effect. In: Hall E.J., and Giaccia A.J. (Eds). Radiobiologogy for the Radiologist (2006), Lippincott Williams and Wilkins, Philadelphia 60-84
27. Foray N., Priestley A., Alsbeih G., Badie C., Capulas E.P., Arlett C.F., and Malaise E.P. Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks. Int. J. Radiat. Biol. 72 (1997) 271-283
28. Jayanth V.R., Belfi C.A., Swick A.R., and Varnes M.E. Insulin and insulin-like growth factor-1 (IGF-1) inhibit repair of potentially lethal radiation damage and chromosome aberrations and alter DNA repair kinetics in plateau-phase A549 cells. Radiat. Res. 143 (1995) 165-174
29. Pilch D.R., Sedelnikova O.A., Redon C., Celeste A., Nussenzweig A., and Bonner W.M. Characteristics of gamma-H2AX foci at DNA double-strand breaks sites. Biochem. Cell. Biol. 81 (2003) 123-129
30. Kobayashi J., Tauchi H., Sakamoto S., Nakamura A., Morishima K., Matsuura S., Kobayashi T., Tamai K., Tanimoto K., and Komatsu K. NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain. Curr. Biol. 12 (2002) 1846-1851
31. Mirzoeva O.K., and Petrini J.H.J. DNA replication-dependent nuclear dynamics of the Mre11 complex. Mol. Cancer Res. 1 (2003) 207-218
32. Shi Y., Dodson G.E., Mukhopadhyay P.S., Shanware N.P., Trinh A.T., and Tibbetts R.S. Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. J. Biol. Chem. 282 (2007) 9236-9243
33. Suzuki K., Okada H., Yamauchi M., Oka Y., Kodama S., and Watanabe M. Qualitative and quantitative analysis of phosphorylated ATM foci induced by low-dose ionizing radiation. Radiat. Res. 165 (2006) 499-504
34. O'Reilly M.S., Holmgren L., Shing Y., Chen C., Rosenthal R.A., Moses M., Lane W.S., Cao Y., Sage E.H., and Folkman J. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79 (1994) 315-328
35. O'Reilly M.S., Boehm T., Shing Y., Fukai N., Vasios G., Lane W.S., Flynn E., Birkhead J.R., Olsen B.R., and Folkman J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88 (1997) 277-285
36. Nenoi M., and Kanai T. Interaction function gamma(x) for Chinese hamster cells treated with hypertonic phosphate-buffered saline after irradiation. Radiat. Res. 116 (1988) 472-481
37. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev., Cancer 3 (2003) 155-168
38. Rafii S., Lyden D., Benezra R., Hattori K., and Heissig B. Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy. Nat. Rev., Cancer 2 (2002) 826-835