Toward improving the therapeutic ratio in stereotactic radiosurgery: Selective modulation of the radiation responses of both normal tissues and tumor

Journal of Neurosurgery

Volumn 107, Issue 1, 2007, Pages 84-93

  Hopewell, John W ^a   Millar, William T ^b   Ang, K Kian ^c  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Dose volume latency effect; Modulation of CNS damage; Radiation enhancer; Radiation necrosis

Indexed keywords

DIPYRIDAMOLE; GADOLINIUM TEXAPHYRIN; GAMMA LINOLENIC ACID;

ARTERIOVENOUS MALFORMATION; BRAIN NECROSIS; BRAIN TUMOR; CANCER CONTROL; CANCER RADIOTHERAPY; CENTRAL NERVOUS SYSTEM DISEASE; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; HUMAN; HYPOXIA; OCCLUSIVE CEREBROVASCULAR DISEASE; PATHOGENESIS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIATION INJURY REPAIR; RADIOSURGERY; REVIEW; RISK FACTOR; STEREOTAXIC SURGERY; TREATMENT DURATION; TREATMENT PLANNING;

BRAIN; BRAIN NEOPLASMS; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; INCIDENCE; MODELS, NEUROLOGICAL; NECROSIS; RADIATION INJURIES; RADIOSURGERY; RADIOTHERAPY DOSAGE;

EID: 34347406141     PISSN: 00223085     EISSN: 00223085     Source Type: Journal    
DOI: 10.3171/JNS-07/07/0084     Document Type: Review

References (45)

1. Andratschke NH, Nieder C, Price RE, Rivera B, Tucker SL, Ang KK: Modulation of rodent spinal cord radiation tolerance by administration of platelet-derived growth factor. Int J Radiat Oncol Biol Phys 60:1257-1263, 2004
2. Ang KK, Jiang GL, Guttenberger R, Thames HD, Stephens LC, Smith CD, et al: Impact of spinal cord repair kinetics on the practice of altered fractionation schedules. Radiother Oncol 25:287-294, 1992
3. Benczik J, Tenhunen M, Snellman M, Joensuu H, Farkkila M, Joensuu R, et al: Late radiation effects in the dog brain: correlation of MRI and histological changes. Radiother Oncol 63:107-120, 2002
4. Bijl HP, van Luijk P, Coppes RP, Schippers JM, Konings AW, van der Kogel AJ: Dose-volume effects in the rat cervical spinal cord after proton irradiation. Int J Radiat Oncol Biol Phys 52:205-211, 2002
5. Bijl HP, van Luijk P, Coppes RP, Schippers JM, Konings AW, van der Kogel AJ: Influence of adjacent low-dose fields on tolerance to high doses of protons in rat cervical spinal cord. Int J Radiat Oncol Biol Phys 64:1204-1210, 2006
6. Bijl HP, van Luijk P, Coppes RP, Schippers JM, Konings AW, van der Kogel AJ: Unexpected changes of rat cervical spinal cord tolerance caused by inhomogeneous dose distributions. Int J Radiat Oncol Biol Phys 57:274-281, 2003
7. Calvo W, Hopewell JW, Reinhold HS, Yeung TK: Time- and dose-related changes in the white matter of the rat brain after single doses of X rays. Br J Radiol 61:1043-1052, 1988
8. Coderre JA, Morris GM, Micca, PL, Hopewell JW, Verhagen I, Kleiboer BJ, et al: Late effects of radiation on the central nervous system: role of vascular endothelial damage and glial stem cell survival. Radiat Res 166:495-503, 2006
9. Flickinger JC, Kondziolka D, Lunsford LD, Kassam A, Phuong LK, Liscak R, et al: Development of a model to predict permanent symptomatic postradiosurgery injury for arteriovenous malformation patients. Arteriovenous Malformation Radiosurgery Study Group. Int J Radiat Oncol Biol Phys 46:1143-1148, 2000
10. Fowler JF: The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol 62:679-694, 1989
11. Hopewell JW, Calvo W, Jaenke R, Reinhold HS, Robbins MEC, Whitehouse EM: Microvasculature and radiation damage. Rec Results Can Res 130:1-16, 1993
12. Hopewell JW, Calvo W, Reinhold HS: Radiation effects on blood vessels: role in normal tissue damage, in Steel GG, Adams G, Horwich A (eds): Biological Basis of Radiotherapy, ed 2. Amsterdam: Elsevier, 1989, pp 101-113
13. Hopewell JW, Morris AD, Dixon-Brown A: The influence of field size on the late tolerance of the rat spinal cord to single doses of X rays. Br J Radiol 60:1099-1108, 1987
14. Hopewell JW, van den Aardweg GJMJ, Morris GM, Rezvani M, Robbins MEC, Ross GA, et al: Unsaturated lipids as modulators of radiation damage in normal tissues, in Horrobin DF (ed): New Approaches to Cancer Therapy: Unsaturated Lipids and Photodynamic Therapy. London: Churchill Communications, 1994, pp 88-108
15. Hopewell JW, van der Kogel AJ: Pathophysiological mechanisms leading to the development of late radiation-induced damage to the central nervous system. Front Radiat Ther Oncol 33:265-275, 1999
16. Hornsey S, Myers R, Jenkinson T: The reduction of radiation damage to the spinal cord by post-irradiation administration of vasoactive drugs. Int J Radiat Oncol Biol Phys 18:1437-1442, 1990
17. Kallman P, Agren A, Brahme A: Tumour and normal tissue responses to fractionated non-uniform dose delivery. Int J Radiat Biol 62:249-262, 1992
18. Korytko T, Radivoyevitch T, Colussi V, Wessels BW, Pillai K, Maciunas RJ, et al: 12 Gy gamma knife radiosurgical volume is a predictor for radiation necrosis in non-AVM intracranial tumors. Int J Radiat Oncol Biol Phys 64:419-424, 2006
19. Leibel SA, Sheline GE: Radiation therapy for neoplasms of the brain. J Neurosurg 66:1-22, 1987
20. Ljubimova NV, Levitman MK, Plotnikova ED, Eidus LKh: Endothelial cell population dynamics in rat brain after local irradiation. Br J Radiol 64:934-940, 1991
21. Marks JE, Baglan RJ, Prassad SC, Blank WF: Cerebral radionecrosis: incidence and risk in relation to dose, time, fractionation and volume. Int J Radiat Oncol Biol Phys 7:243-252, 1981
22. Mehta MP, Rodrigus P, Terhaard CH, Rao A, Suh J, Roa W, et al: Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases. J Clin Oncol 21:2529-2536, 2003
23. Mehta MP, Suh JH: Novel radiosensitizers for tumors of the central nervous system. Curr Opin Investig Drugs 5:1284-1291, 2004
24. Millar WT, Canney PA: Derivation and application of equations describing the effects of fractionated protracted irradiation, based on multiple and incomplete repair processes. Part I. Derivation of equations. Int J Radiat Biol 64:275-291, 1993
25. Millar WT, Hendry JH, Canney PA: The influence of the number of fractions and bi-exponential repair kinetics on biological equivalence in pulsed brachytherapy. Br J Radiol 69:457-468, 1996
26. Miller RA, Woodburn K, Fan Q, Renschler MF, Sessler JL, Koutcher JA: In vivo animal studies with gadolinium (III) texaphyrin as a radiation enhancer. Int J Radiat Oncol Biol Phys 45:981-989, 1999
27. Paddick I, Lippitz B: A simple gradient measurement tool to complement the conformity index. J Neurosurg 105 (Suppl):194-201, 2006
28. Pena LA, Fuks Z, Kolesnick RN: Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency. Cancer Res 60:321-327, 2000
29. Pezner RD, Archambeau JO: Brain tolerance unit: a method to estimate risk of radiation brain injury for various dose schedules. Int J Radiat Oncol Biol Phys 7:397-402, 1981
30. Philippens ME, Pop LA, Visser AG, Schellekens SA, van der Kogel AJ: Dose-volume effects in rat thoracolumbar spinal cord: an evaluation of NTCP models. Int J Radiat Oncol Biol Phys 60:578-590, 2004
31. Pop LA, Millar WT, van der Plas M, van der Kogel AJ: Radiation tolerance of rat spinal cord to pulsed dose rate (PDR-) brachytherapy: the impact of differences in temporal dose distribution. Radiother Oncol 55:301-315, 2000
32. Rezvani M, Birds DA, Hodges H, Hopewell JW, Milledew K, Wilkinson JH: Modification of radiation myelopathy by the transplantation of neural stem cells in the rat. Radiat Res 156:408-412, 2001
33. Rosenthal DI, Nurenberg P, Becerra CR, Frenkel EP, Carbone DP, Lum BL, et al: A phase I single-dose trial of gadolinium texaphyrin (Gd-Tex), a tumor selective radiation sensitizer detectable by magnetic resonance imaging. Clin Cancer Res 5:739-745, 1999
34. Ross RM: Cellular and Molecular Studies on the Mechanistic Basis of Clinical Radioresistance in Human Gliomas. Ph.D. Thesis. University of Glasgow, 1992
35. Schultheiss TE, Higgins EM, El-Mahdi AM: The latent period in clinical radiation myelopathy. Int J Radiat Oncol Biol Phys 10: 1109-1115, 1984
36. Schultheiss TE, Kun LE, Ang KK, Stephens LC: Radiation response of the central nervous system. Int J Radiat Oncol Biol Phys 31:1093-1112, 1995
37. Schultheiss TE, Orton CG, Peck RA: Models in radiotherapy: volume effects. Med Phys 10:410-415, 1983
38. Schultheiss TE, Stephens LC, Ang KK, Price RE, Peters LJ: Volume effects in rhesus monkey spinal cord. Int J Radiat Oncol Biol Phys 29:67-72, 1994
39. Sheline GE, Wara WM, Smith V: Therapeutic irradiation and brain injury. Int J Radiat Oncol Biol Phys 6:1215-1228, 1980
40. Siegal T, Pfeffer MR: Radiation-induced changes in the profile of spinal cord serotonin, prostaglandin synthesis, and vascular permeability. Int J Radiat Oncol Biol Phys 31:57-64, 1995
41. Sims EC, Plowman PN: Stereotactic radiosurgery XII. Large AVM and the failure of the radiation response modifier gamma linolenic acid to improve the therapeutic ratio. Br J Neurosurg 15:28-34, 2001
42. Thames HD: An 'incomplete-repair' model for survival after fractionated and continuous irradiations. Int J Radiat Biol Relat Stud Phys Chem Med 47:319-339, 1985
43. van den Aardweg GJMJ, Hopewell JW, Whitehouse EM: The radiation response of the cervical spinal cord of the pig: effects of changing the irradiated volume. Int J Radiat Oncol Biol Phys 31:51-55, 1995
44. van der Kogel AJ: Effects of volume and localisation on rat spinal cord tolerance, in Fielden EM, Fowler JF, Hendry JH, Scott D (eds): Radiation Research: Proceedings of the 8th International Congress of Radiation Research. Edinburgh, July 1987. London, Taylor & Francis, 1987, Vol 1, pp 352 (Abstract E22-25P)
45. van Luijk P, Bijl HP, Konings AW, van der Kogel AJ, Schippers JM: Data on dose-volume effects in the rat spinal cord do not support existing NTCP models. Int J Radiat Oncol Biol Phys 61:892-900, 2005