p53-Independent apoptosis induced by genistein in lung cancer cells

Nutrition and Cancer

Volumn 33, Issue 2, 1999, Pages 125-131

  Lian, Fangru ^a   Li, Yiwei ^a   Bhuiyan, Mahbubur ^a   Sarkar, Fazlul H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYLINDOLE DERIVATIVE; GENISTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P21; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INCIDENCE; CANCER MORTALITY; CANCER RISK; DNA DAMAGE; EPIDEMIOLOGICAL DATA; FLOW CYTOMETRY; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; LUNG CANCER; POLYACRYLAMIDE GEL ELECTROPHORESIS; RECEPTOR UPREGULATION; SMOKING CESSATION;

EID: 0032970710     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/S15327914NC330202     Document Type: Article

References (27)

1. Blair, SL, Heerdt, P, Sachar, S, Abolhoda, A, Hochwald, S, et al.: Glutathione metabolism in patients with non-small cell lung cancers. Cancer Res 57, 152-155, 1997.
2. 2-M. Cancer Res 53, 1328-1331, 1997.
3. Spinozzi, F, Pagliacci, MC, Migliorati, G, Moraca, R, Grignani, F, et al.: The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Leukemia Res 198, 431-439, 1994.
4. Constantinou, A, Kiguchi, K, and Iuberman, E: Induction of differentiation and strand breakage in human HL-60 and K-562 leukemia cells by genistein. Cancer Res 50, 2618-2624, 1990.
5. Peterson, G: Evaluation of the biochemical targets of genistein in tumor cells. J Nutr 125, 784s-789s, 1995.
6. Akiyama, T, Ishida, J, Nakagawa, S, Ogawara, H, Watanabe, S, et al.: Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262, 5592-5595, 1987.
7. Feller, SM, and Wong, TW: Identification and characterization of a cytosolic protein tyrosine kinase of HeLa cells. Biochemistry 31, 3044-3051, 1992.
8. Burke, TR: Protein-tyrosine kinase inhibitors. Drug Future 17, 119-131, 1992.
9. Hollenberg, MD: Tyrosine kinase-mediated signal transduction pathways and actions of polypeptide growth factors and G-protein-coupled agonists in smooth muscle. Mol Cell Biochem 149, 77-85, 1995.
10. Simon, HI, Yousefi, S, and Blaser, K: Tyrosine phosphorylation regulates activation and inhibition of apoptosis in human eosinophils and neutrophils. Int Arch Allergy Appl Immunol 107, 338-339, 1995.
11. Kyle, E, Neckers, L, Takimoto, C, Curt, G, and Gergan, R: Genistein induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Mol Pharmacol 51, 193-200, 1997.
12. Hoffman, B, and Liebermann, DA: Molecular controls of apoptosis: differentiation/growth arrest primary response genes, proto-oncogenes, and tumor suppressor genes as positive and negative modulators. Oncogene 9, 1807-1812, 1994.
13. Hartwell, LH, and Kastan, MB: Cell cycle control and cancer. Science 266, 1821-1828, 1994.
14. Steinman, RA, Hoffman, B, Iro, A, Guillouf, C, Liebermann, DA, et al.: Induction of p21 (WAF-1/CIP1) during differentiation. Oncogene 9, 3389-3396, 1994.
15. el Diery, WS, Tokino, T, Velculescu, VE, Levy, DB, Parsons, R, et al.: WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825, 1993.
16. 1 arrest. Cell 76, 1013-1023, 1994.
17. Yang, E, Zha, J, Jockel, J, Boise, LH, Thompson, CB, et al.: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80, 285-291, 1995.
18. Boise, LH, Gonzaiz-Garcia, M, Postema, CE, Ding, L, Lindsten, T, et al.: bcl-x, A bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74, 597-608, 1994.
19. Yin, XM, Oltavi, ZN, and Krosmeyer, SJ: BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369, 321-323, 1994.
20. Oltavi, ZN, and Korsmeryer, SJ: Checkpoints of dueling dimers foil death wishes. Cell 79, 189-192, 1994.
21. Knudson, CM, and Korsmeyer, SJ: Bcl-2 and Bax function independently to regulate cell death. Nature Genet 16, 358-363, 1997.
22. Philpott, NJ, Turner, AJ, Scopes, J, Westby, M, Marsh, JC, et al.: The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques. Blood 87, 2244-2251, 1996.
23. Harris, CC: Structure and function of p53 tumor suppressor gene: roles for rational cancer therapeutic strategies. JNCI 88, 1442-1452, 1996.
24. Burger, H, Nooter, K, Boersma, AW, Kortland, CJ, and Stoter, G: Lack of correlation between cisplatin-induced apoptosis, p53 status and expression of Bc12 family protein in testicular germ cell tumor cell lines. Int J Cancer 73, 592-599, 1997.
25. WAF1 upregulalion, and apoptosis in a non-small-cell lung cancer cell line. Nutr Cancer 31, 184-191, 1998.
26. 2-M arrest, and apoptosis. J Cell Biochem 69, 44-54, 1998.
27. Reed, JC, Miyashita, T, Takayama, S, Wang, HG, Sato, T, et al.: Bcl2 family proteins: regulator of cell death involved in the pathogenesis of cancer and resistance therapy. J Cell Biochem 60, 23-32, 1996.