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Volumn 6, Issue JAN, 2016, Pages

Drug-induced liver toxicity and prevention by herbal antioxidants: An Overview

Author keywords

Antioxidant; Hepatoprotection; Hepatotoxicity; Herbal medicine

Indexed keywords

AMIODARONE; AMOXICILLIN; ANTIOXIDANT; CELL NUCLEUS RECEPTOR; CHLORPROMAZINE; CIPROFLOXACIN; CURCUMIN; CYTOCHROME P450; DICLOFENAC; DRUG METABOLIZING ENZYME; ERYTHROMYCIN; GINKGO BILOBA EXTRACT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISONIAZID; ORAL CONTRACEPTIVE AGENT; PARACETAMOL; PYROGALLOL; RESVERATROL; RIFAMPICIN; SILYMARIN; TUBERCULOSTATIC AGENT; VALPROIC ACID;

EID: 84962808952     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2015.00363     Document Type: Review
Times cited : (178)

References (242)
  • 1
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal, B. B., and Shishioda, S. (2006). Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol. 71, 1397-1421. doi: 10.1016/j.bcp.2006.02.009.
    • (2006) Biochem. Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishioda, S.2
  • 2
    • 84870844654 scopus 로고    scopus 로고
    • Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb-and paraquat-induced hepatotoxicity in rats
    • Ahmad, I., Shukla, S., Kumar, A., Singh, B. K., Kumar, V., Chauhan, A. K., et al. (2013). Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb-and paraquat-induced hepatotoxicity in rats. Chem. Biol. Interact. 201, 9-18. doi: 10.1016/j.cbi.2012.10.027.
    • (2013) Chem. Biol. Interact , vol.201 , pp. 9-18
    • Ahmad, I.1    Shukla, S.2    Kumar, A.3    Singh, B.K.4    Kumar, V.5    Chauhan, A.K.6
  • 3
    • 0030912384 scopus 로고    scopus 로고
    • Effect of inducers on hepatic microsomal mixed function oxidase system of male rats during food restriction
    • Ahmed, R. S., and Pawar, S. S. (1997). Effect of inducers on hepatic microsomal mixed function oxidase system of male rats during food restriction. Indian J. Exp. Biol. 35, 46-49.
    • (1997) Indian J. Exp. Biol , vol.35 , pp. 46-49
    • Ahmed, R.S.1    Pawar, S.S.2
  • 4
    • 8844264504 scopus 로고    scopus 로고
    • Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity
    • Aithal, G. P. (2004). Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity. Expert Opin. Drug Saf. 3, 519-523. doi: 10.1517/14740338.3.6.519.
    • (2004) Expert Opin. Drug Saf , vol.3 , pp. 519-523
    • Aithal, G.P.1
  • 5
    • 79952446700 scopus 로고    scopus 로고
    • Hepatotoxicity related to antirheumatic drugs
    • Aithal, G. P. (2011). Hepatotoxicity related to antirheumatic drugs. Nat. Rev. Rheumatol. 7, 139-150. doi: 10.1038/nrrheum.2010.214.
    • (2011) Nat. Rev. Rheumatol , vol.7 , pp. 139-150
    • Aithal, G.P.1
  • 6
    • 4544295749 scopus 로고    scopus 로고
    • Production of hydrogen peroxide by polyphenol and polyphenol-rich beverages under quasi-physiological conditions
    • Akagawa, M., Shigemitsu, T., and Suyama, K. (2003). Production of hydrogen peroxide by polyphenol and polyphenol-rich beverages under quasi-physiological conditions. Biosci. Biotechnol. Biochem. 67, 2632-2640. doi: 10.1271/bbb.67.2632.
    • (2003) Biosci. Biotechnol. Biochem , vol.67 , pp. 2632-2640
    • Akagawa, M.1    Shigemitsu, T.2    Suyama, K.3
  • 7
    • 12344322514 scopus 로고    scopus 로고
    • Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride
    • Aleksunes, L. M., Slitt, A. M., Cherrington, N. J., Thibodeau, M. S., Klaassen, C. D., and Manautou, J. E. (2005). Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride. Toxicol. Sci. 83, 44-52. doi: 10.1093/toxsci/kfi013.
    • (2005) Toxicol. Sci , vol.83 , pp. 44-52
    • Aleksunes, L.M.1    Slitt, A.M.2    Cherrington, N.J.3    Thibodeau, M.S.4    Klaassen, C.D.5    Manautou, J.E.6
  • 9
    • 0037409693 scopus 로고    scopus 로고
    • Comparison of optimised isotherm models for basic dye adsorption by kudzu
    • Allen, S. J., Gan, Q., Matthews, R., and Johnson, P. A. (2003). Comparison of optimised isotherm models for basic dye adsorption by kudzu. Bioresour. Technol. 88, 143-152. doi: 10.1016/S0960-8524(02)00281-X.
    • (2003) Bioresour. Technol , vol.88 , pp. 143-152
    • Allen, S.J.1    Gan, Q.2    Matthews, R.3    Johnson, P.A.4
  • 10
    • 0033598106 scopus 로고    scopus 로고
    • Atorvastatin induced cholestatic hepatitis in a young woman with systemic lupus erythematosus
    • Alonso, J. J., Osorio, J. M., Cabello, F. G., Osa, A. L., Leon, L., and Garcia, J. D. M. (1999). Atorvastatin induced cholestatic hepatitis in a young woman with systemic lupus erythematosus. Arch. Intern. Med. 159, 1811-1812. doi: 10.1001/archinte.159.15.1811-a.
    • (1999) Arch. Intern. Med , vol.159 , pp. 1811-1812
    • Alonso, J.J.1    Osorio, J.M.2    Cabello, F.G.3    Osa, A.L.4    Leon, L.5    Garcia, J.D.M.6
  • 11
    • 0037382718 scopus 로고    scopus 로고
    • Association of Alzheimer's disease onset with ginkgo biloba and other symptomatic cognitive treatments in a population of women aged 75 years and older from the EPIDOS study
    • Andrieu, S., Gillette, S., Amouyal, K., Nourhashemi, F., Reynish, E., Ousset, P. J., et al. (2003). Association of Alzheimer's disease onset with ginkgo biloba and other symptomatic cognitive treatments in a population of women aged 75 years and older from the EPIDOS study. J. Gerontol. 58, 372-377. doi: 10.1093/gerona/58.4.m372.
    • (2003) J. Gerontol , vol.58 , pp. 372-377
    • Andrieu, S.1    Gillette, S.2    Amouyal, K.3    Nourhashemi, F.4    Reynish, E.5    Ousset, P.J.6
  • 12
    • 0027516244 scopus 로고
    • Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studies in isolated periportal and perivenous hepatocytes
    • Anundi, I., Lahteenmaki, T., Rundgren, M., Moldeus, P., and Lindros, K. O. (1993). Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studies in isolated periportal and perivenous hepatocytes. Biochem. Pharmacol. 45, 1251-1259. doi: 10.1016/0006-2952(93)90277-4.
    • (1993) Biochem. Pharmacol , vol.45 , pp. 1251-1259
    • Anundi, I.1    Lahteenmaki, T.2    Rundgren, M.3    Moldeus, P.4    Lindros, K.O.5
  • 13
    • 3042664719 scopus 로고    scopus 로고
    • From blood to bile: recent advances in hepatobiliary transport
    • Arrese, M., and Accatino, L. (2002). From blood to bile: recent advances in hepatobiliary transport. Ann. Hepatol. 1, 64-71.
    • (2002) Ann. Hepatol , vol.1 , pp. 64-71
    • Arrese, M.1    Accatino, L.2
  • 14
    • 84902166593 scopus 로고    scopus 로고
    • Protective effect of resveratrol on sodium fluoride-induced oxidative stress, hepatotoxicity and neurotoxicity in rats
    • Atmaca, N., Atmaca, H. T., Kanici, A., and Anteplioglu, T. (2014). Protective effect of resveratrol on sodium fluoride-induced oxidative stress, hepatotoxicity and neurotoxicity in rats. Food Chem. Toxicol. 70, 191-197. doi: 10.1016/j.fct.2014.05.011.
    • (2014) Food Chem. Toxicol , vol.70 , pp. 191-197
    • Atmaca, N.1    Atmaca, H.T.2    Kanici, A.3    Anteplioglu, T.4
  • 15
    • 0035005193 scopus 로고    scopus 로고
    • Protective effect of N-acetylcysteine in isoniazid induced hepatic injury in growing rats
    • Attri, S., Rana, S. V., Vaiphie, K., Katyal, R., Sodhi, C. P., Kanwar, S., et al. (2001). Protective effect of N-acetylcysteine in isoniazid induced hepatic injury in growing rats. Indian J. Exp. Biol. 39, 436-440.
    • (2001) Indian J. Exp. Biol , vol.39 , pp. 436-440
    • Attri, S.1    Rana, S.V.2    Vaiphie, K.3    Katyal, R.4    Sodhi, C.P.5    Kanwar, S.6
  • 16
    • 0034617986 scopus 로고    scopus 로고
    • Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention
    • Bagchi, D., Bagchi, M., Stohs, S. J., Das, D. K., Ray, S. D., Kuszynski, C. A., et al. (2000). Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148, 187-197. doi: 10.1016/S0300-483X(00)00210-9.
    • (2000) Toxicology , vol.148 , pp. 187-197
    • Bagchi, D.1    Bagchi, M.2    Stohs, S.J.3    Das, D.K.4    Ray, S.D.5    Kuszynski, C.A.6
  • 18
    • 0029129057 scopus 로고
    • Drug safety discontinuations in the United Kingdom, the United States, and Spain from 1974 through 1993, a regulatory perspective
    • Bakke, O. M., Manocchia, M., de Abajo, F., Kaitin, K. I., and Lasagna, L. (1995). Drug safety discontinuations in the United Kingdom, the United States, and Spain from 1974 through 1993: a regulatory perspective. Clin. Pharmacol. Ther. 58, 108-117. doi: 10.1016/0009-9236(95)90078-0.
    • (1995) Clin. Pharmacol. Ther , vol.58 , pp. 108-117
    • Bakke, O.M.1    Manocchia, M.2    de Abajo, F.3    Kaitin, K.I.4    Lasagna, L.5
  • 19
    • 0029090947 scopus 로고
    • Diclofenac-associated hepatotoxicity: analysis of 180 cases reported to the Food and Drug Administration as adverse reactions
    • Banks, A. T., Zimmerman, H. J., Ishak, K. G., and Harter, J. G. (1995). Diclofenac-associated hepatotoxicity: analysis of 180 cases reported to the Food and Drug Administration as adverse reactions. Hepatology 22, 820-827.
    • (1995) Hepatology , vol.22 , pp. 820-827
    • Banks, A.T.1    Zimmerman, H.J.2    Ishak, K.G.3    Harter, J.G.4
  • 20
    • 0036775158 scopus 로고    scopus 로고
    • Heme oxygenase-1: redox regulation and role in the hepatic response to oxidative stress
    • Bauer, M., and Bauer, I. (2002). Heme oxygenase-1: redox regulation and role in the hepatic response to oxidative stress. Antioxid. Redox. Signal. 4, 749-758. doi: 10.1089/152308602760598891.
    • (2002) Antioxid. Redox. Signal , vol.4 , pp. 749-758
    • Bauer, M.1    Bauer, I.2
  • 21
    • 70449113012 scopus 로고    scopus 로고
    • Epidemiology of idiosyncratic drug-induced liver injury
    • Bell, L. N., and Chalasani, N. (2009). Epidemiology of idiosyncratic drug-induced liver injury. Semin. Liver Dis. 29:337. doi: 10.1055/s-0029-1240002.
    • (2009) Semin. Liver Dis , vol.29 , pp. 337
    • Bell, L.N.1    Chalasani, N.2
  • 22
    • 0022364266 scopus 로고
    • Altered thiol and calcium homeostasis in the oxidative hepatocellular injury
    • Bellomo, G., and Orrenius, S. (1985). Altered thiol and calcium homeostasis in the oxidative hepatocellular injury. Hepatology 5, 876-882. doi: 10.1002/hep.1840050529.
    • (1985) Hepatology , vol.5 , pp. 876-882
    • Bellomo, G.1    Orrenius, S.2
  • 23
    • 0031785386 scopus 로고    scopus 로고
    • Effect of natural beta-carotene supplementation in children exposed to radiation from the Chernobyl accident
    • Ben-Amotz, A., Yatziv, S., Sela, M., Greenberg, S., Rachmilevich, B., Shwarzman, M., et al. (1998). Effect of natural beta-carotene supplementation in children exposed to radiation from the Chernobyl accident. Radiat. Environ. Biophys. 37, 87-193. doi: 10.1007/s004110050116.
    • (1998) Radiat. Environ. Biophys , vol.37 , pp. 87-193
    • Ben-Amotz, A.1    Yatziv, S.2    Sela, M.3    Greenberg, S.4    Rachmilevich, B.5    Shwarzman, M.6
  • 24
    • 4844225372 scopus 로고    scopus 로고
    • Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs
    • Biour, M., Ben Salem, C., Chazouillères, O., Grangé, J. D., Serfaty, L., and Poupon, R. (2004). Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs. Gastroenterol. Clin. Biol. 28, 720-759. doi: 10.1016/S0399-8320(04)95062-2.
    • (2004) Gastroenterol. Clin. Biol , vol.28 , pp. 720-759
    • Biour, M.1    Ben Salem, C.2    Chazouillères, O.3    Grangé, J.D.4    Serfaty, L.5    Poupon, R.6
  • 25
    • 70449086055 scopus 로고    scopus 로고
    • The natural history of drug-induced liver injury
    • Björnsson, E. (2009). The natural history of drug-induced liver injury. Semin. Liver Dis. 29, 357-363. doi: 10.1055/s-0029-1240004.
    • (2009) Semin. Liver Dis , vol.29 , pp. 357-363
    • Björnsson, E.1
  • 26
    • 84878325626 scopus 로고    scopus 로고
    • Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland
    • Björnsson, E. S., Bergmann, O. M., Björnsson, H. K., Kvaran, R. B., Olafsson, S., et al. (2013). Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology 144:1419. doi: 10.1053/j.gastro.2013.02.006.
    • (2013) Gastroenterology , vol.144 , pp. 1419
    • Björnsson, E.S.1    Bergmann, O.M.2    Björnsson, H.K.3    Kvaran, R.B.4    Olafsson, S.5
  • 27
    • 67649827488 scopus 로고    scopus 로고
    • Nonprescription use of pain relievers by middle-aged and elderly community-living adults: national survey on drug use and health
    • Blazer, D. G., and Wu, L. T. (2009). Nonprescription use of pain relievers by middle-aged and elderly community-living adults: national survey on drug use and health. J. Am. Geriatr. Soc. 57, 1252-1257. doi: 10.1111/j.1532-5415.2009.02306.x.
    • (2009) J. Am. Geriatr. Soc , vol.57 , pp. 1252-1257
    • Blazer, D.G.1    Wu, L.T.2
  • 28
    • 33749437211 scopus 로고    scopus 로고
    • Bioactivation and hepatotoxicity of nitroaromatic drugs
    • Boelsterli, U. A., Ho, H. K., Zhou, S., and Leow, K. Y. (2006). Bioactivation and hepatotoxicity of nitroaromatic drugs. Curr. Drug Metab. 7, 715-727. doi: 10.2174/138920006778520606.
    • (2006) Curr. Drug Metab , vol.7 , pp. 715-727
    • Boelsterli, U.A.1    Ho, H.K.2    Zhou, S.3    Leow, K.Y.4
  • 29
    • 85044015651 scopus 로고    scopus 로고
    • Antioxidant properties of a series of extracts from medicinal plants
    • Bol'shakova, I. V., Lozovskaia, E. L., and Sapezhinskii, I. I. (1997). Antioxidant properties of a series of extracts from medicinal plants. Biofizika 42, 480-483.
    • (1997) Biofizika , vol.42 , pp. 480-483
    • Bol'shakova, I.V.1    Lozovskaia, E.L.2    Sapezhinskii, I.I.3
  • 30
    • 0014530707 scopus 로고
    • Mercapturic acid formation during the metabolism of arecoline and arecaidine in the rat
    • Boyland, E., and Nery, R. (1969). Mercapturic acid formation during the metabolism of arecoline and arecaidine in the rat. Biochem. J. 113, 123-130. doi: 10.1042/bj1130123.
    • (1969) Biochem. J , vol.113 , pp. 123-130
    • Boyland, E.1    Nery, R.2
  • 31
    • 0031020195 scopus 로고    scopus 로고
    • Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships
    • Cao, G., Sofic, E., and Prior, R. L. (1997). Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic. Biol. Med. 22, 749-760. doi: 10.1016/S0891-5849(96)00351-6.
    • (1997) Free Radic. Biol. Med , vol.22 , pp. 749-760
    • Cao, G.1    Sofic, E.2    Prior, R.L.3
  • 32
    • 57249086242 scopus 로고    scopus 로고
    • Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States
    • Chalasani, N., Fontana, R. J., Bonkovsky, H. L., Watkins, P. B., Davern, T., Serrano, J., et al. (2008). Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology 135:1924. doi: 10.1053/j.gastro.2008.09.011.
    • (2008) Gastroenterology , vol.135 , pp. 1924
    • Chalasani, N.1    Fontana, R.J.2    Bonkovsky, H.L.3    Watkins, P.B.4    Davern, T.5    Serrano, J.6
  • 33
    • 0035192944 scopus 로고    scopus 로고
    • Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2
    • Chang, T. K., Chen, J., and Lee, W. B. (2001). Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J. Pharmacol. Exp. Ther. 299, 874-882.
    • (2001) J. Pharmacol. Exp. Ther , vol.299 , pp. 874-882
    • Chang, T.K.1    Chen, J.2    Lee, W.B.3
  • 34
    • 5144221545 scopus 로고    scopus 로고
    • Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder
    • Chearwae, W., Anuchapreeda, S., Nandigama, K., Ambudkar, S. V., and Limtrakul, P. (2004). Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder. Biochem. Pharmacol. 68, 2043-2052. doi: 10.1016/j.bcp.2004.07.009.
    • (2004) Biochem. Pharmacol , vol.68 , pp. 2043-2052
    • Chearwae, W.1    Anuchapreeda, S.2    Nandigama, K.3    Ambudkar, S.V.4    Limtrakul, P.5
  • 35
    • 33646049054 scopus 로고    scopus 로고
    • Morphological and genetic characterization of a cultivated Cordyceps sinensis fungus and its polysaccharide component possessing antioxidant property in H22 tumor-bearing mice
    • Chen, J., Zhang, W., Lu, T., Li, J., Zheng, Y., and Kong, L. (2006). Morphological and genetic characterization of a cultivated Cordyceps sinensis fungus and its polysaccharide component possessing antioxidant property in H22 tumor-bearing mice. Life Sci. 78, 2742-2748. doi: 10.1016/j.lfs.2005.10.047.
    • (2006) Life Sci , vol.78 , pp. 2742-2748
    • Chen, J.1    Zhang, W.2    Lu, T.3    Li, J.4    Zheng, Y.5    Kong, L.6
  • 36
    • 0041689955 scopus 로고    scopus 로고
    • Ginkgo biloba extract inhibits tumor necrosis factor-(alpha)-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells
    • Chen, J. W., Chen, Y. H., Lin, F. Y., Chen, Y. L., and Lin, S. J. (2003). Ginkgo biloba extract inhibits tumor necrosis factor-(alpha)-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells. Arterioscler. Thromb. Vasc. Biol. 23, 1559-1566. doi: 10.1161/01.ATV.0000089012.73180.63.
    • (2003) Arterioscler. Thromb. Vasc. Biol , vol.23 , pp. 1559-1566
    • Chen, J.W.1    Chen, Y.H.2    Lin, F.Y.3    Chen, Y.L.4    Lin, S.J.5
  • 37
    • 23944438892 scopus 로고    scopus 로고
    • Regulation of mouse organic anion-transporting polypeptides (oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways
    • Cheng, X., Maher, J., Dieter, M. Z., and Klaassen, C. D. (2005). Regulation of mouse organic anion-transporting polypeptides (oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug Metab. Dispos. 33, 1276-1282. doi: 10.1124/dmd.105.003988.
    • (2005) Drug Metab. Dispos , vol.33 , pp. 1276-1282
    • Cheng, X.1    Maher, J.2    Dieter, M.Z.3    Klaassen, C.D.4
  • 38
    • 0035064593 scopus 로고    scopus 로고
    • Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin
    • Chun, Y. J., Ryu, S. Y., Jeong, T. C., and Kim, M. Y. (2001). Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin. Drug Metab. Dispos. 29, 389-393.
    • (2001) Drug Metab. Dispos , vol.29 , pp. 389-393
    • Chun, Y.J.1    Ryu, S.Y.2    Jeong, T.C.3    Kim, M.Y.4
  • 39
    • 33947241783 scopus 로고    scopus 로고
    • The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta)
    • Coleman, J. D., Prabhu, K. S., Thompson, J. T., Reddy, P. S., Peters, J. M., Peterson, B. R., et al. (2007). The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). Free Radic. Biol. Med. 42, 1155-1164. doi: 10.1016/j.freeradbiomed.2007.01.003.
    • (2007) Free Radic. Biol. Med , vol.42 , pp. 1155-1164
    • Coleman, J.D.1    Prabhu, K.S.2    Thompson, J.T.3    Reddy, P.S.4    Peters, J.M.5    Peterson, B.R.6
  • 40
    • 33947101316 scopus 로고    scopus 로고
    • Drug-related hepatotoxicity in a renal transplant recipient with long-term survival and hepatitis C
    • Contreras, A. M., Monteón, F. J., Flores, M. R., Mendoza-Sánchez, F., and Ruiz, I. (2007). Drug-related hepatotoxicity in a renal transplant recipient with long-term survival and hepatitis C. Ann. Hepatol. 6, 70-73.
    • (2007) Ann. Hepatol , vol.6 , pp. 70-73
    • Contreras, A.M.1    Monteón, F.J.2    Flores, M.R.3    Mendoza-Sánchez, F.4    Ruiz, I.5
  • 41
    • 0002825133 scopus 로고    scopus 로고
    • "Mechanisms of chemically induced liver disease, "
    • eds D. Zakin and T. D. Boyer (Philadelphia: WB Saunders), 3rd Edn
    • Dahm, L. J., and Jones, D. P. (1996). "Mechanisms of chemically induced liver disease, " in Hepatology: A Textbook of Liver Disease, 3rd Edn., eds D. Zakin and T. D. Boyer (Philadelphia: WB Saunders), 875-890.
    • (1996) Hepatology: A Textbook of Liver Disease , pp. 875-890
    • Dahm, L.J.1    Jones, D.P.2
  • 42
    • 84878302010 scopus 로고    scopus 로고
    • Resveratrol ameliorates methotrexate-induced hepatotoxicity in rats via inhibition of lipid peroxidation
    • Dalaklioglu, S., Genc, G. E., Aksoy, N. H., Akcit, F., and Gumuslu, S. (2013). Resveratrol ameliorates methotrexate-induced hepatotoxicity in rats via inhibition of lipid peroxidation. Hum. Exp. Toxicol. 32, 662-671. doi: 10.1177/0960327112468178.
    • (2013) Hum. Exp. Toxicol , vol.32 , pp. 662-671
    • Dalaklioglu, S.1    Genc, G.E.2    Aksoy, N.H.3    Akcit, F.4    Gumuslu, S.5
  • 43
    • 0042169046 scopus 로고    scopus 로고
    • Ginkgo biloba extracts and cancer: a research area in its infancy
    • DeFeudis, F. V., Papadopoulos, V., and Drieu, K. (2003). Ginkgo biloba extracts and cancer: a research area in its infancy. Fundam. Clin. Pharmacol. 17, 405-417. doi: 10.1046/j.1472-8206.2003.00156.x.
    • (2003) Fundam. Clin. Pharmacol , vol.17 , pp. 405-417
    • DeFeudis, F.V.1    Papadopoulos, V.2    Drieu, K.3
  • 44
    • 0020957706 scopus 로고
    • Halothane hepatotoxicity: relation between metabolic activation, hypoxia, covalent binding, lipid peroxidation and liver cell damage
    • De Groot, H., and Noll, T. (1983). Halothane hepatotoxicity: relation between metabolic activation, hypoxia, covalent binding, lipid peroxidation and liver cell damage. Hepatology 3, 601-606. doi: 10.1002/hep.1840030421.
    • (1983) Hepatology , vol.3 , pp. 601-606
    • De Groot, H.1    Noll, T.2
  • 45
    • 0029856415 scopus 로고    scopus 로고
    • Effect of silymarin on different acute inflammation models and on leukocyte migration
    • De la Puerta, R., Martinez, E., Bravo, L., and Ahumada, M. C. (1996). Effect of silymarin on different acute inflammation models and on leukocyte migration. J. Pharm. Pharmacol. 48, 968-970. doi: 10.1111/j.2042-7158.1996.tb06014.x.
    • (1996) J. Pharm. Pharmacol , vol.48 , pp. 968-970
    • De la Puerta, R.1    Martinez, E.2    Bravo, L.3    Ahumada, M.C.4
  • 46
    • 42249107140 scopus 로고    scopus 로고
    • Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats
    • Deng, Y., Bi, H. C., Zhao, L. Z., He, F., Liu, Y. Q., Yu, J. J., et al. (2008). Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats. Xenobiotica 38, 465-481. doi: 10.1080/00498250701883233.
    • (2008) Xenobiotica , vol.38 , pp. 465-481
    • Deng, Y.1    Bi, H.C.2    Zhao, L.Z.3    He, F.4    Liu, Y.Q.5    Yu, J.J.6
  • 47
    • 0038768712 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals
    • Denison, M. S., and Nagy, S. R. (2003). Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu. Rev. Pharmacol. Toxicol. 43, 309-334. doi: 10.1146/annurev.pharmtox.43.100901.135828.
    • (2003) Annu. Rev. Pharmacol. Toxicol , vol.43 , pp. 309-334
    • Denison, M.S.1    Nagy, S.R.2
  • 49
    • 0037137560 scopus 로고    scopus 로고
    • Herbal remedies
    • De Smet, P. A. (2002). Herbal remedies. New Eng. J. Med. 347, 2046-2056. doi: 10.1056/NEJMra020398.
    • (2002) New Eng. J. Med , vol.347 , pp. 2046-2056
    • De Smet, P.A.1
  • 51
  • 53
    • 35649005988 scopus 로고    scopus 로고
    • Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cells
    • Fahey, A. J., Adrian Robins, R., and Constantinescu, C. S. (2007). Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cells. J. Cell Mol. Med. 11, 1129-1137. doi: 10.1111/j.1582-4934.2007.00089.x.
    • (2007) J. Cell Mol. Med , vol.11 , pp. 1129-1137
    • Fahey, A.J.1    Adrian Robins, R.2    Constantinescu, C.S.3
  • 54
    • 0345062363 scopus 로고    scopus 로고
    • Hepatic drug metabolizing enzyme induction and serum triacylglycerol elevation in rats treated with chlordiazepoxide, griseofulvin, rifampicin and phenytoin
    • Farombi, E. O., Akinloye, O., Akinmoladun, C. O., and Emerole, G. O. (1999). Hepatic drug metabolizing enzyme induction and serum triacylglycerol elevation in rats treated with chlordiazepoxide, griseofulvin, rifampicin and phenytoin. Clin. Chim. Acta 289, 1-10. doi: 10.1016/S0009-8981(99)00143-6.
    • (1999) Clin. Chim. Acta , vol.289 , pp. 1-10
    • Farombi, E.O.1    Akinloye, O.2    Akinmoladun, C.O.3    Emerole, G.O.4
  • 55
    • 33750838526 scopus 로고    scopus 로고
    • Heme oxygenase-1 as a potential therapeutic target for hepatoprotection
    • Farombi, E. O., and Surh, Y. J. (2006). Heme oxygenase-1 as a potential therapeutic target for hepatoprotection. J. Biochem. Mol. Biol. 39, 479-491. doi: 10.5483/BMBRep.2006.39.5.479.
    • (2006) J. Biochem. Mol. Biol , vol.39 , pp. 479-491
    • Farombi, E.O.1    Surh, Y.J.2
  • 56
    • 0032008339 scopus 로고    scopus 로고
    • Milk thistle (Silybum marianum) for the therapy of liver disease
    • Flora, K., Hahn, M., Rosen, H., and Brenner, K. (1996). Milk thistle (Silybum marianum) for the therapy of liver disease. Am. J. Gastroenterol. 93, 139-143. doi: 10.1111/j.1572-0241.1998.00139.x.
    • (1996) Am. J. Gastroenterol , vol.93 , pp. 139-143
    • Flora, K.1    Hahn, M.2    Rosen, H.3    Brenner, K.4
  • 57
    • 0034645693 scopus 로고    scopus 로고
    • Biological effects of resveratrol
    • Frémont, L. (2000). Biological effects of resveratrol. Life Sci. 66, 663-673. doi: 10.1016/S0024-3205(99)00410-5.
    • (2000) Life Sci , vol.66 , pp. 663-673
    • Frémont, L.1
  • 58
    • 0031442305 scopus 로고    scopus 로고
    • Effects of silibinin and of a synthetic analogue on isolated rat hepatic stellate cells and myofibroblasts
    • Fuchs, E. C., Weyhenmeyer, R., and Weiner, O. H. (1997). Effects of silibinin and of a synthetic analogue on isolated rat hepatic stellate cells and myofibroblasts. Arzneimittelforschung 47, 1383-1387.
    • (1997) Arzneimittelforschung , vol.47 , pp. 1383-1387
    • Fuchs, E.C.1    Weyhenmeyer, R.2    Weiner, O.H.3
  • 59
    • 0031587041 scopus 로고    scopus 로고
    • Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation
    • García, J. J., Reiter, R. J., Guerrero, J. M., Escames, G., Yu, B. P., Oh, C. S., et al. (1997). Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation. FEBS Lett. 408, 297-300. doi: 10.1016/S0014-5793(97)00447-X.
    • (1997) FEBS Lett , vol.408 , pp. 297-300
    • García, J.J.1    Reiter, R.J.2    Guerrero, J.M.3    Escames, G.4    Yu, B.P.5    Oh, C.S.6
  • 60
    • 84899865599 scopus 로고    scopus 로고
    • Protective effect of curcumin against heavy metals-induced liver damage
    • García-Niño, W. R., and Pedraza-Chaverrí, J. (2014). Protective effect of curcumin against heavy metals-induced liver damage. Food Chem. Toxicol. 69, 182-201. doi: 10.1016/j.fct.2014.04.016.
    • (2014) Food Chem. Toxicol , vol.69 , pp. 182-201
    • García-Niño, W.R.1    Pedraza-Chaverrí, J.2
  • 61
    • 84934444824 scopus 로고    scopus 로고
    • Immunomodulation by curcumin
    • Gautam, S. C., Gao, X., and Dulchavsky, S. (2007). Immunomodulation by curcumin. Adv. Exp. Med. Biol. 595, 321-341. doi: 10.1007/978-0-387-46401-5_14.
    • (2007) Adv. Exp. Med. Biol , vol.595 , pp. 321-341
    • Gautam, S.C.1    Gao, X.2    Dulchavsky, S.3
  • 62
    • 0024408854 scopus 로고
    • Isolation of piceatannol as the antileukemic principle from the seeds of euphorbia lagascae
    • Geahlen, R. L., and McLaughlin, J. L. (1989). Isolation of piceatannol as the antileukemic principle from the seeds of euphorbia lagascae. Biochem. Biophys. Res. Commun. 165, 241-245. doi: 10.1016/0006-291X(89)91060-7.
    • (1989) Biochem. Biophys. Res. Commun , vol.165 , pp. 241-245
    • Geahlen, R.L.1    McLaughlin, J.L.2
  • 63
    • 0036022841 scopus 로고    scopus 로고
    • Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride
    • Geier, A., Kim, S. K., Gerloff, T., Dietrich, C. G., Lammert, F., Karpen, S. J., et al. (2002). Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride. J. Hepatol. 37, 198-205. doi: 10.1016/S0168-8278(02)00108-3.
    • (2002) J. Hepatol , vol.37 , pp. 198-205
    • Geier, A.1    Kim, S.K.2    Gerloff, T.3    Dietrich, C.G.4    Lammert, F.5    Karpen, S.J.6
  • 64
    • 0142243190 scopus 로고    scopus 로고
    • Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum
    • Gescher, A. J., and Steward, W. P. (2003). Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum. Cancer Epidemiol. Biomark 12, 953-957.
    • (2003) Cancer Epidemiol. Biomark , vol.12 , pp. 953-957
    • Gescher, A.J.1    Steward, W.P.2
  • 65
    • 3242723125 scopus 로고    scopus 로고
    • Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein
    • Ghanem, C. I., Gómez, P. C., Arana, M. C., Perassolo, M., Ruiz, M. L., Villanueva, S. S., et al. (2004). Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem. Pharmacol. 68, 791-798. doi: 10.1016/j.bcp.2004.05.014.
    • (2004) Biochem. Pharmacol , vol.68 , pp. 791-798
    • Ghanem, C.I.1    Gómez, P.C.2    Arana, M.C.3    Perassolo, M.4    Ruiz, M.L.5    Villanueva, S.S.6
  • 67
    • 0032924934 scopus 로고    scopus 로고
    • Cytochrome P-450 3A4: regulation and role in drug metabolism
    • Guengerich, F. P. (1999). Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu. Rev. Pharmacol. Toxicol. 39, 1-17. doi: 10.1146/annurev.pharmtox.39.1.1.
    • (1999) Annu. Rev. Pharmacol. Toxicol , vol.39 , pp. 1-17
    • Guengerich, F.P.1
  • 68
    • 0034602337 scopus 로고    scopus 로고
    • Comparison between Chinese medical herb Peuraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalased drug metabolism
    • Guerra, M. C., Speroni, E., Broccoli, M., Cangini, M., Pasini, P., Mingett, A., et al. (2000). Comparison between Chinese medical herb Peuraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalased drug metabolism. Life Sci. 67, 2997-3006. doi: 10.1016/S0024-3205(00)00885-7.
    • (2000) Life Sci , vol.67 , pp. 2997-3006
    • Guerra, M.C.1    Speroni, E.2    Broccoli, M.3    Cangini, M.4    Pasini, P.5    Mingett, A.6
  • 69
    • 0036815248 scopus 로고    scopus 로고
    • Pyrogallol-induced hepatotoxicity in rats: a model to evaluate antioxidant hepatoprotective agents
    • Gupta, Y. K., Sharma, M., and Chaudhary, G. (2002). Pyrogallol-induced hepatotoxicity in rats: a model to evaluate antioxidant hepatoprotective agents. Methods Find. Exp. Clin. Pharmacol. 24, 497-500. doi: 10.1358/mf.2002.24.8.705070.
    • (2002) Methods Find. Exp. Clin. Pharmacol , vol.24 , pp. 497-500
    • Gupta, Y.K.1    Sharma, M.2    Chaudhary, G.3
  • 70
    • 2942530590 scopus 로고    scopus 로고
    • Hepatoprotective effect of New Livfit, a polyherbal formulation, is mediated through its free radical scavenging activity
    • Gupta, Y. K., Sharma, M., Chaudhary, G., and Katiyar, C. K. (2004). Hepatoprotective effect of New Livfit, a polyherbal formulation, is mediated through its free radical scavenging activity. Phytother. Res. 18, 362-364. doi: 10.1002/ptr.1272.
    • (2004) Phytother. Res , vol.18 , pp. 362-364
    • Gupta, Y.K.1    Sharma, M.2    Chaudhary, G.3    Katiyar, C.K.4
  • 71
    • 84880275072 scopus 로고    scopus 로고
    • Preventive effects of resveratrol against azoxymethane induced damage in rat liver
    • Gurocak, S., Karabulut, E., Karadag, N., Ozgor, D., Ozkeles, N., and Karabulut, A. B. (2013). Preventive effects of resveratrol against azoxymethane induced damage in rat liver. Asian Pac. J. Cancer Prev. 14, 2367-2370. doi: 10.7314/APJCP.2013.14.4.2367.
    • (2013) Asian Pac. J. Cancer Prev , vol.14 , pp. 2367-2370
    • Gurocak, S.1    Karabulut, E.2    Karadag, N.3    Ozgor, D.4    Ozkeles, N.5    Karabulut, A.B.6
  • 72
    • 0142027496 scopus 로고    scopus 로고
    • The effect of kefir on the activities of GSH-Px, G. S. T., CAT, GSH and LPO levels in carbon tetrachloride-induced mice tissues
    • Guven, A., and Gulmez, M. (2003). The effect of kefir on the activities of GSH-Px, G. S. T., CAT, GSH and LPO levels in carbon tetrachloride-induced mice tissues. J. Vet. Med. B 50, 412-416. doi: 10.1046/j.1439-0450.2003.00693.x.
    • (2003) J. Vet. Med. B , vol.50 , pp. 412-416
    • Guven, A.1    Gulmez, M.2
  • 75
    • 0030857629 scopus 로고    scopus 로고
    • DNA cleavage reaction and linoleic acid peroxidation induced by tea catechins in the presence of cupric ion
    • Hayakawa, F., Kimura, T., Maeda, T., Fujita, M., Sohmiya, H., Fujii, M., et al. (1997). DNA cleavage reaction and linoleic acid peroxidation induced by tea catechins in the presence of cupric ion. Biochim. Biophys. Acta 1336, 123-131. doi: 10.1016/S0304-4165(97)00019-6.
    • (1997) Biochim. Biophys. Acta , vol.1336 , pp. 123-131
    • Hayakawa, F.1    Kimura, T.2    Maeda, T.3    Fujita, M.4    Sohmiya, H.5    Fujii, M.6
  • 76
    • 0035965945 scopus 로고    scopus 로고
    • Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
    • Hayes, J. D., and McMahon, M. (2001). Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. Cancer Lett. 174, 103-113. doi: 10.1016/S0304-3835(01)00695-4.
    • (2001) Cancer Lett , vol.174 , pp. 103-113
    • Hayes, J.D.1    McMahon, M.2
  • 78
    • 0035100972 scopus 로고    scopus 로고
    • Polysomnographic effects of adjuvant ginkgo biloba therapy in patients with major depression medicated with trimipramine
    • Hemmeter, U., Annen, B., Bischof, R., Brüderlin, U., Hatzinger, M., Rose, U., et al. (2001). Polysomnographic effects of adjuvant ginkgo biloba therapy in patients with major depression medicated with trimipramine. Pharmacopsychiatry 34, 50-59. doi: 10.1055/s-2001-15182.
    • (2001) Pharmacopsychiatry , vol.34 , pp. 50-59
    • Hemmeter, U.1    Annen, B.2    Bischof, R.3    Brüderlin, U.4    Hatzinger, M.5    Rose, U.6
  • 79
    • 7544222053 scopus 로고    scopus 로고
    • Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition
    • Hinson, J. A., Reid, A. B., McCullough, S. S., and James, L. P. (2004). Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition. Drug Metab. Rev. 36, 805-822. doi: 10.1081/DMR-200033494.
    • (2004) Drug Metab. Rev , vol.36 , pp. 805-822
    • Hinson, J.A.1    Reid, A.B.2    McCullough, S.S.3    James, L.P.4
  • 80
    • 77949331621 scopus 로고    scopus 로고
    • Drug-induced liver injury
    • Holt, M., and Ju, C. (2010). Drug-induced liver injury. Handb. Exp. Pharmacol. 196, 3-27. doi: 10.1007/978-3-642-00663-0_1.
    • (2010) Handb. Exp. Pharmacol , vol.196 , pp. 3-27
    • Holt, M.1    Ju, C.2
  • 81
    • 33846113313 scopus 로고    scopus 로고
    • Effects of fenofibrate and xuezhikang on high-fat diet-induced non-alcoholic fatty liver disease
    • Hong, X. Z., Li, L. D., and Wu, L. M. (2007). Effects of fenofibrate and xuezhikang on high-fat diet-induced non-alcoholic fatty liver disease. Clin. Exp. Pharmacol. Physiol. 34, 27-35. doi: 10.1111/j.1440-1681.2007.04547.x.
    • (2007) Clin. Exp. Pharmacol. Physiol , vol.34 , pp. 27-35
    • Hong, X.Z.1    Li, L.D.2    Wu, L.M.3
  • 82
    • 0034655747 scopus 로고    scopus 로고
    • Regulation of cytochrome P450 (CYP) genes by nuclear receptors
    • Honkakoski, P., and Negishi, M. (2000). Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem. J. 347(Pt 2), 321-337. doi: 10.1042/bj3470321.
    • (2000) Biochem. J , vol.347 , pp. 321-337
    • Honkakoski, P.1    Negishi, M.2
  • 83
    • 0025039064 scopus 로고
    • Biochemical changes and morphological alterations of the liver in guinea-pigs after administration of simvastatin (HMG CoA reductase-inhibitor)
    • Horsmans, Y., Desager, J. P., and Harvengt, C. (1990). Biochemical changes and morphological alterations of the liver in guinea-pigs after administration of simvastatin (HMG CoA reductase-inhibitor). Pharmacol. Toxicol. 67, 336-339. doi: 10.1111/j.1600-0773.1990.tb00840.x.
    • (1990) Pharmacol. Toxicol , vol.67 , pp. 336-339
    • Horsmans, Y.1    Desager, J.P.2    Harvengt, C.3
  • 84
    • 0036202380 scopus 로고    scopus 로고
    • Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis
    • Huang, Y. S., Chern, H. D., Su, W. J., Wu, J. C., Lai, S. L., Yang, S. Y., et al. (2002). Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis. Hepatology 35, 883-889. doi: 10.1053/jhep.2002.32102.
    • (2002) Hepatology , vol.35 , pp. 883-889
    • Huang, Y.S.1    Chern, H.D.2    Su, W.J.3    Wu, J.C.4    Lai, S.L.5    Yang, S.Y.6
  • 85
    • 0037380862 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis
    • Huang, Y. S., Chern, H. D., Su, W. J., Wu, J. C., Chang, S. C., Chiang, C. H., et al. (2003). Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. Hepatology 37, 924-930. doi: 10.1053/jhep.2003.50144.
    • (2003) Hepatology , vol.37 , pp. 924-930
    • Huang, Y.S.1    Chern, H.D.2    Su, W.J.3    Wu, J.C.4    Chang, S.C.5    Chiang, C.H.6
  • 86
    • 14644412937 scopus 로고    scopus 로고
    • Protective effect of baicalin on tert-butyl hydroperoxide-induced rat hepatotoxicity
    • Hwang, J. M., Wang, C. J., Chou, F. P., Tseng, T. H., Hsieh, Y. S., Hsu, J. D., et al. (2005). Protective effect of baicalin on tert-butyl hydroperoxide-induced rat hepatotoxicity. Arch. Toxicol. 79, 102-109. doi: 10.1007/s00204-004-0588-6.
    • (2005) Arch. Toxicol , vol.79 , pp. 102-109
    • Hwang, J.M.1    Wang, C.J.2    Chou, F.P.3    Tseng, T.H.4    Hsieh, Y.S.5    Hsu, J.D.6
  • 87
    • 0035689866 scopus 로고    scopus 로고
    • Resveratrol, a natural chemopreventive agent against degenerative diseases
    • Ignatowicz, E., and Baer-Dubowska, W. (2001). Resveratrol, a natural chemopreventive agent against degenerative diseases. Pol. J. Pharmacol. 53, 557-569.
    • (2001) Pol. J. Pharmacol , vol.53 , pp. 557-569
    • Ignatowicz, E.1    Baer-Dubowska, W.2
  • 88
    • 0034668216 scopus 로고    scopus 로고
    • Gene regulation of heme oxygenase-1 as a therapeutic target
    • Immenschuh, S., and Ramadori, G. (2000). Gene regulation of heme oxygenase-1 as a therapeutic target. Biochem. Pharmacol. 60, 1121-1128. doi: 10.1016/S0006-2952(00)00443-3.
    • (2000) Biochem. Pharmacol , vol.60 , pp. 1121-1128
    • Immenschuh, S.1    Ramadori, G.2
  • 89
    • 38649124882 scopus 로고    scopus 로고
    • Mechanism of the anti-inflammatory effect of curcumin: PPAR-gamma Activation
    • Jacob, A., Wu, R., Zhou, M., and Wang, P. (2007). Mechanism of the anti-inflammatory effect of curcumin: PPAR-gamma Activation. PPAR Res. 2007:89369. doi: 10.1155/2007/89369.
    • (2007) PPAR Res , vol.2007 , pp. 89369
    • Jacob, A.1    Wu, R.2    Zhou, M.3    Wang, P.4
  • 90
    • 33748195617 scopus 로고    scopus 로고
    • The safety of aggressive statin therapy: how much can low-density lipoprotein cholesterol be lowered?
    • Jacobson, T. A. (2006). The safety of aggressive statin therapy: how much can low-density lipoprotein cholesterol be lowered? Mayo Clin. Proc. 81, 1225-1231. doi: 10.4065/81.9.1225.
    • (2006) Mayo Clin. Proc , vol.81 , pp. 1225-1231
    • Jacobson, T.A.1
  • 91
    • 33646925337 scopus 로고    scopus 로고
    • Pain control: non-steroidal anti-inflammatory agents
    • Jacqz-Aigrain, E., and Anderson, B. J. (2006). Pain control: non-steroidal anti-inflammatory agents. Semin. Fetal Neonatal Med. 11, 251-259. doi: 10.1016/j.siny.2006.02.009.
    • (2006) Semin. Fetal Neonatal Med , vol.11 , pp. 251-259
    • Jacqz-Aigrain, E.1    Anderson, B.J.2
  • 93
    • 0030826405 scopus 로고    scopus 로고
    • Chemistry and biology of alkylphenols from Ginkgo biloba L
    • Jaggy, H., and Koch, E. (1997). Chemistry and biology of alkylphenols from Ginkgo biloba L. Pharmazie. 52, 735-738.
    • (1997) Pharmazie , vol.52 , pp. 735-738
    • Jaggy, H.1    Koch, E.2
  • 94
    • 0033800922 scopus 로고    scopus 로고
    • Regulation of genes encoding NAD(P)H:quinone oxidoreductases
    • Jaiswal, A. K. (2000). Regulation of genes encoding NAD(P)H:quinone oxidoreductases. Free Radic. Biol. Med. 29, 254-262. doi: 10.1016/S0891-5849(00)00306-3.
    • (2000) Free Radic. Biol. Med , vol.29 , pp. 254-262
    • Jaiswal, A.K.1
  • 95
    • 2142784187 scopus 로고    scopus 로고
    • Biological properties of Curcumin-cellular and molecular mechanisms of action
    • Joe, B., Vijaykumar, M., and Lokesh, B. R. (2004). Biological properties of Curcumin-cellular and molecular mechanisms of action. Crit. Rev. Food Sci. Nutr. 44, 97-111. doi: 10.1080/10408690490424702.
    • (2004) Crit. Rev. Food Sci. Nutr , vol.44 , pp. 97-111
    • Joe, B.1    Vijaykumar, M.2    Lokesh, B.R.3
  • 96
    • 0036303955 scopus 로고    scopus 로고
    • Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways
    • Johnson, D. R., and Klaassen, C. D. (2002). Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways. Toxico. Sci. 69, 317-321. doi: 10.1093/toxsci/67.2.182.
    • (2002) Toxico. Sci , vol.69 , pp. 317-321
    • Johnson, D.R.1    Klaassen, C.D.2
  • 97
    • 0025334151 scopus 로고
    • Tertbutylhydroperoxide-induced injury in isolated rat hepatocytes: a model for studying antihepatotoxic crude drugs
    • Joyeux, M., Rolland, A., Fleurentin, J., Mortier, F., and Dorfman, P. (1990). Tertbutylhydroperoxide-induced injury in isolated rat hepatocytes: a model for studying antihepatotoxic crude drugs. Planta Med. 56, 171-174. doi: 10.1055/s-2006-960918.
    • (1990) Planta Med , vol.56 , pp. 171-174
    • Joyeux, M.1    Rolland, A.2    Fleurentin, J.3    Mortier, F.4    Dorfman, P.5
  • 98
    • 0034950046 scopus 로고    scopus 로고
    • Drug-induced liver disorders: implications for drug development and regulation
    • Kaplowitz, N. (2001). Drug-induced liver disorders: implications for drug development and regulation. Drug Saf. 24, 483-490. doi: 10.2165/00002018-200124070-00001.
    • (2001) Drug Saf , vol.24 , pp. 483-490
    • Kaplowitz, N.1
  • 99
    • 23244437204 scopus 로고    scopus 로고
    • Isoniazid and rifampicin treatment on phospholipids and their subfractions in liver tissue of rabbits
    • Karthikeyan, S. (2005). Isoniazid and rifampicin treatment on phospholipids and their subfractions in liver tissue of rabbits. Drug Chem. Toxicol. 28, 273-280. doi: 10.1081/DCT-200064463.
    • (2005) Drug Chem. Toxicol , vol.28 , pp. 273-280
    • Karthikeyan, S.1
  • 100
    • 0036252838 scopus 로고    scopus 로고
    • Shogaols from Zingiber officinale protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from beta-amyloid (25-35) insult
    • Kim, D. S., Kim, D. S., and Oppel, M. N. (2002). Shogaols from Zingiber officinale protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from beta-amyloid (25-35) insult. Planta Med. 68, 375-376. doi: 10.1055/s-2002-26757.
    • (2002) Planta Med , vol.68 , pp. 375-376
    • Kim, D.S.1    Kim, D.S.2    Oppel, M.N.3
  • 101
    • 32444442720 scopus 로고    scopus 로고
    • "Zinc, "
    • eds M. E. Shils, M. Shike, A. C. Ross, B. Caballero, and R. J. Cousins (Philadelphia, PA: Lipponcott Williams and Wilkins), 10th Edn
    • King, J. C., and Cousins, R. J. (2006). "Zinc, " in Modern Nutrition in Health and Disease, 10th Edn, eds M. E. Shils, M. Shike, A. C. Ross, B. Caballero, and R. J. Cousins (Philadelphia, PA: Lipponcott Williams and Wilkins), 271-285.
    • (2006) Modern Nutrition in Health and Disease , pp. 271-285
    • King, J.C.1    Cousins, R.J.2
  • 102
    • 20444461672 scopus 로고    scopus 로고
    • Glucose and lipid metabolism after liver transplantation in inbred rats: consequences of hepatic denervation
    • Kissler, H. J., Hauffen, J., Hennig, R., Gepp, H., and Schwille, P. O. (2005). Glucose and lipid metabolism after liver transplantation in inbred rats: consequences of hepatic denervation. Metab. Clin. Exp. 54, 881-890. doi: 10.1016/j.metabol.2005.01.036.
    • (2005) Metab. Clin. Exp , vol.54 , pp. 881-890
    • Kissler, H.J.1    Hauffen, J.2    Hennig, R.3    Gepp, H.4    Schwille, P.O.5
  • 103
    • 0038000046 scopus 로고    scopus 로고
    • The nuclear pregnane X receptor regulates xenobiotic detoxification
    • Kliewer, S. A. (2003). The nuclear pregnane X receptor regulates xenobiotic detoxification. J. Nutr. 133, 2444S-2447S.
    • (2003) J. Nutr , vol.133 , pp. 2444S-2447S
    • Kliewer, S.A.1
  • 104
    • 0036497073 scopus 로고    scopus 로고
    • Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat
    • Kobayashi, K., Urashima, K., Shimada, N., and Chiba, K. (2002). Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochem. Pharmacol. 63, 889-896. doi: 10.1016/S0006-2952(01)00843-7.
    • (2002) Biochem. Pharmacol , vol.63 , pp. 889-896
    • Kobayashi, K.1    Urashima, K.2    Shimada, N.3    Chiba, K.4
  • 105
    • 0037057520 scopus 로고    scopus 로고
    • Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male f344 rats
    • Kohno, H., Tanaka, T., Kawabata, K., Hirose, Y., Sugie, S., Tsuda, H., and Mori, H. (2002). Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male f344 rats. Int. J. Cancer 101, 461-468. doi: 10.1002/ijc.10625.
    • (2002) Int. J. Cancer , vol.101 , pp. 461-468
    • Kohno, H.1    Tanaka, T.2    Kawabata, K.3    Hirose, Y.4    Sugie, S.5    Tsuda, H.6    Mori, H.7
  • 106
    • 0019158171 scopus 로고
    • Lipid peroxidation of rat liver microsomes
    • Koster, J. F., and Slee, R. G. (1980). Lipid peroxidation of rat liver microsomes. Biochim. Biophys. Acta 620, 489-499. doi: 10.1016/0005-2760(80)90141-1.
    • (1980) Biochim. Biophys. Acta , vol.620 , pp. 489-499
    • Koster, J.F.1    Slee, R.G.2
  • 109
    • 0034051526 scopus 로고    scopus 로고
    • Drug-induced liver diseases
    • Larrey, D. (2000). Drug-induced liver diseases. J. Hepatol. 32(Suppl. 1), 77-88. doi: 10.1016/S0168-8278(00)80417-1.
    • (2000) J. Hepatol , vol.32 , pp. 77-88
    • Larrey, D.1
  • 110
    • 32644474169 scopus 로고    scopus 로고
    • Acute liver failure study group. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study
    • Larson, A. M., Polson, J., Fontana, R. J., Davern, T. J., Lalani, E., Hynan, L. S., et al. (2005). Acute liver failure study group. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 42, 1364-1372. doi: 10.1002/hep.20948.
    • (2005) Hepatology , vol.42 , pp. 1364-1372
    • Larson, A.M.1    Polson, J.2    Fontana, R.J.3    Davern, T.J.4    Lalani, E.5    Hynan, L.S.6
  • 111
    • 0043038760 scopus 로고    scopus 로고
    • Molecular analysis on the chemopreventive properties of resveratrol a plant polyphenol microcomponent
    • Latruffe, N., Delmas, D., Jannin, B., Cherkaoui-Malki, M., Passilly-Degrace, P., and Berlot, J. P. (2002). Molecular analysis on the chemopreventive properties of resveratrol a plant polyphenol microcomponent. Int. J. Mol. Med. 10, 755-760. doi: 10.3892/ijmm.10.6.755.
    • (2002) Int. J. Mol. Med , vol.10 , pp. 755-760
    • Latruffe, N.1    Delmas, D.2    Jannin, B.3    Cherkaoui-Malki, M.4    Passilly-Degrace, P.5    Berlot, J.P.6
  • 112
    • 84886101376 scopus 로고    scopus 로고
    • Low doses of curcumin protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK
    • Lee, H. I., McGregor, R. A., Choi, M. S., Seo, K. I., Jung, U. J., Yeo, J., et al. (2013). Low doses of curcumin protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci. 93, 693-699. doi: 10.1016/j.lfs.2013.09.014.
    • (2013) Life Sci , vol.93 , pp. 693-699
    • Lee, H.I.1    McGregor, R.A.2    Choi, M.S.3    Seo, K.I.4    Jung, U.J.5    Yeo, J.6
  • 113
    • 19444379739 scopus 로고    scopus 로고
    • Nrf2 as a novel molecular target for chemoprevention
    • Lee, J. S., and Surh, Y. J. (2005). Nrf2 as a novel molecular target for chemoprevention. Cancer Lett. 224, 171-184. doi: 10.1016/j.canlet.2004.09.042.
    • (2005) Cancer Lett , vol.224 , pp. 171-184
    • Lee, J.S.1    Surh, Y.J.2
  • 114
    • 0041342015 scopus 로고    scopus 로고
    • Drug-induced hepatotoxicity
    • Lee, W. M. (2003). Drug-induced hepatotoxicity. N. Engl. J. Med. 349, 474-485. doi: 10.1056/NEJMra021844.
    • (2003) N. Engl. J. Med , vol.349 , pp. 474-485
    • Lee, W.M.1
  • 115
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • Lehmann, J. M., McKee, D. D., Watson, M. A., Willson, T. M., Moore, J. T., and Kliewer, S. A. (1998). The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J. Clin. Invest. 102, 1016-1023. doi: 10.1172/JCI3703.
    • (1998) J. Clin. Invest , vol.102 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3    Willson, T.M.4    Moore, J.T.5    Kliewer, S.A.6
  • 117
    • 0036773007 scopus 로고    scopus 로고
    • Efficient extraction of ginkgolides and bilobalide from Ginkgo biloba leaves
    • Lichtblau, D., Berger, J. M., and Nakanishi, K. (2002). Efficient extraction of ginkgolides and bilobalide from Ginkgo biloba leaves. J. Nat. Prod. 65, 1501-1504. doi: 10.1021/np0201974.
    • (2002) J. Nat. Prod , vol.65 , pp. 1501-1504
    • Lichtblau, D.1    Berger, J.M.2    Nakanishi, K.3
  • 118
    • 33846847849 scopus 로고    scopus 로고
    • Hepatoprotective effects of Chai-Hu-Ching-Kan-Tang on acetaminophen-induced acute liver injury in rats
    • Lin, T. H., Ng, L. T., Yen, F. L., and Lin, C. C. (2007). Hepatoprotective effects of Chai-Hu-Ching-Kan-Tang on acetaminophen-induced acute liver injury in rats. Am. J. Chin. Med. 35, 69-79. doi: 10.1142/S0192415X07004631.
    • (2007) Am. J. Chin. Med , vol.35 , pp. 69-79
    • Lin, T.H.1    Ng, L.T.2    Yen, F.L.3    Lin, C.C.4
  • 119
    • 33750208750 scopus 로고    scopus 로고
    • Antioxidative and in vitro hepatoprotective activity of Bupleurum kaoi leaf infusion
    • Liu, C. T., Chuang, P. T., Wu, C. Y., Weng, Y. M., Chen, W., and Tseng, C. Y. (2006). Antioxidative and in vitro hepatoprotective activity of Bupleurum kaoi leaf infusion. Phytother. Res. 20, 1003-1008. doi: 10.1002/ptr.1946.
    • (2006) Phytother. Res , vol.20 , pp. 1003-1008
    • Liu, C.T.1    Chuang, P.T.2    Wu, C.Y.3    Weng, Y.M.4    Chen, W.5    Tseng, C.Y.6
  • 120
    • 0026722329 scopus 로고
    • Anti-oxidant activity of dibenzocyclooctene lignans isolated from Schisandraceae
    • Lu, H., and Liu, G. T. (1992). Anti-oxidant activity of dibenzocyclooctene lignans isolated from Schisandraceae. Planta Med. 58, 311-313. doi: 10.1055/s-2006-961473.
    • (1992) Planta Med , vol.58 , pp. 311-313
    • Lu, H.1    Liu, G.T.2
  • 123
    • 85026143490 scopus 로고    scopus 로고
    • Ginkgo biloba for the prevention and treatment of cardiovascular disease: a review of the literature
    • Mahady, G. B. (2002). Ginkgo biloba for the prevention and treatment of cardiovascular disease: a review of the literature. J. Cardiovas. Nurs. 16, 21-32. doi: 10.1097/00005082-200207000-00004.
    • (2002) J. Cardiovas. Nurs , vol.16 , pp. 21-32
    • Mahady, G.B.1
  • 124
    • 33644901007 scopus 로고    scopus 로고
    • Multiple biological activities of curcumin: a short review
    • Maheshwari, R. K., Singh, A. K., Gaddipati, J., and Srimal, R. C. (2006). Multiple biological activities of curcumin: a short review. Life Sci. 78, 2081-2087. doi: 10.1016/j.lfs.2005.12.007.
    • (2006) Life Sci , vol.78 , pp. 2081-2087
    • Maheshwari, R.K.1    Singh, A.K.2    Gaddipati, J.3    Srimal, R.C.4
  • 125
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • Mangelsdorf, D. J., and Evans, R. M. (1995). The RXR heterodimers and orphan receptors. Cell 83, 841-850. doi: 10.1016/0092-8674(95)90200-7.
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 126
    • 0037281445 scopus 로고    scopus 로고
    • The mis-identification of the major antioxidant flavonoids in young barley (Hordeum vulgare) leaves
    • Markham, K. R., and Mitchell, K. A. (2003). The mis-identification of the major antioxidant flavonoids in young barley (Hordeum vulgare) leaves. Z. Naturforsch. C 58, 53-56. doi: 10.1515/znc-2003-1-209.
    • (2003) Z. Naturforsch. C , vol.58 , pp. 53-56
    • Markham, K.R.1    Mitchell, K.A.2
  • 127
    • 33846885877 scopus 로고    scopus 로고
    • Lymphocyte loss and immunosuppression following acetaminophen-induced hepatotoxicity in mice as a potential mechanism of tolerance
    • Masson, M. J., Peterson, R. A., Chung, C. J., Graf, M. L., Carpenter, L. D., Ambroso, J. L., et al. (2007). Lymphocyte loss and immunosuppression following acetaminophen-induced hepatotoxicity in mice as a potential mechanism of tolerance. Chem. Res. Toxicol. 20, 20-26. doi: 10.1021/tx060190c.
    • (2007) Chem. Res. Toxicol , vol.20 , pp. 20-26
    • Masson, M.J.1    Peterson, R.A.2    Chung, C.J.3    Graf, M.L.4    Carpenter, L.D.5    Ambroso, J.L.6
  • 128
    • 34047275727 scopus 로고    scopus 로고
    • Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans
    • Masubuchi, N., Makino, C., and Murayama, N. (2007). Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans. Chem. Res. Toxicol. 20, 455-464. doi: 10.1021/tx060234h.
    • (2007) Chem. Res. Toxicol , vol.20 , pp. 455-464
    • Masubuchi, N.1    Makino, C.2    Murayama, N.3
  • 129
    • 84859708101 scopus 로고    scopus 로고
    • The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
    • McGill, M. R., Sharpe, M. R., Williams, C. D., Taha, M., Curry, S. C., and Jaeschke, H. (2012). The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J. Clin. Invest. 122, 1574-1583. doi: 10.1172/JCI59755.
    • (2012) J. Clin. Invest , vol.122 , pp. 1574-1583
    • McGill, M.R.1    Sharpe, M.R.2    Williams, C.D.3    Taha, M.4    Curry, S.C.5    Jaeschke, H.6
  • 130
    • 0034840437 scopus 로고    scopus 로고
    • Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications
    • McKenna, D. J., Jones, K., and Hughes, K. (2001). Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications. Altern. Ther. Health Med. 7, 70-86.
    • (2001) Altern. Ther. Health Med , vol.7 , pp. 70-86
    • McKenna, D.J.1    Jones, K.2    Hughes, K.3
  • 131
    • 0027959669 scopus 로고
    • Comparative study of the hepatoprotective effect of silymarin and silybin on isolated rat hepatocytes
    • Miguez, M. P., Anundi, I., Sainz-Pardo, L. A., and Lindros, K. O. (1994). Comparative study of the hepatoprotective effect of silymarin and silybin on isolated rat hepatocytes. Toxicol. In Vitro 8, 581-583. doi: 10.1016/0887-2333(94)90021-3.
    • (1994) Toxicol. In Vitro , vol.8 , pp. 581-583
    • Miguez, M.P.1    Anundi, I.2    Sainz-Pardo, L.A.3    Lindros, K.O.4
  • 132
    • 0038085651 scopus 로고    scopus 로고
    • Effect of natural phenols on the catalytic activity of cytochrome P4502E1
    • Mikstacka, R., Gnojkowski, J., and Baer-Dubowska, W. (2002). Effect of natural phenols on the catalytic activity of cytochrome P4502E1. Acta Biochim. Pol. 49, 917-925.
    • (2002) Acta Biochim. Pol , vol.49 , pp. 917-925
    • Mikstacka, R.1    Gnojkowski, J.2    Baer-Dubowska, W.3
  • 133
    • 0036250045 scopus 로고    scopus 로고
    • Does isoniazid cause more serious hepatotoxicity in hepatitis B virus carriors?
    • Mindie, H. N., and Gabriel, G. (2002). Does isoniazid cause more serious hepatotoxicity in hepatitis B virus carriors? Am. J. Gastroenterol. 97, 1092-1093. doi: 10.1111/j.1572-0241.2002.05700.x.
    • (2002) Am. J. Gastroenterol , vol.97 , pp. 1092-1093
    • Mindie, H.N.1    Gabriel, G.2
  • 134
    • 0027992226 scopus 로고
    • Scavenging of reactive oxygen species by silibinin hemisuccinate
    • Mira, L., Silva, M., and Manso, C. F. (1994). Scavenging of reactive oxygen species by silibinin hemisuccinate. Biochem. Pharmacol. 48, 753-759. doi: 10.1016/0006-2952(94)90053-1.
    • (1994) Biochem. Pharmacol , vol.48 , pp. 753-759
    • Mira, L.1    Silva, M.2    Manso, C.F.3
  • 136
  • 137
    • 84993808216 scopus 로고    scopus 로고
    • Drug-induced liver injury in older adults
    • Mitchell, S. J., and Hilmer, S. N. (2010). Drug-induced liver injury in older adults. Ther. Adv. Drug Saf. 1, 65-77. doi: 10.1177/2042098610386281.
    • (2010) Ther. Adv. Drug Saf , vol.1 , pp. 65-77
    • Mitchell, S.J.1    Hilmer, S.N.2
  • 138
    • 84893671658 scopus 로고    scopus 로고
    • FDA asks physicians to stop prescribing high-dose acetaminophen products
    • Mitka, M. (2014). FDA asks physicians to stop prescribing high-dose acetaminophen products. JAMA 311, 563. doi: 10.1001/jama.2014.716.
    • (2014) JAMA , vol.311 , pp. 563
    • Mitka, M.1
  • 139
    • 0037081807 scopus 로고    scopus 로고
    • Kinetic analysis and mechanistic aspects of autooxidation of catechins
    • Mochizuki, M., Yamazaki, S., Kano, K., and Ikeda, T. (2002). Kinetic analysis and mechanistic aspects of autooxidation of catechins. Biochim. Biophys. Acta 1569, 35-44. doi: 10.1016/S0304-4165(01)00230-6.
    • (2002) Biochim. Biophys. Acta , vol.1569 , pp. 35-44
    • Mochizuki, M.1    Yamazaki, S.2    Kano, K.3    Ikeda, T.4
  • 140
    • 23244458629 scopus 로고    scopus 로고
    • A review of the oral direct thrombin inhibitor ximelagatran: not yet the end of the warfarin era
    • Mohapatra, R., Tran, M., Gore, J. M., and Spencer, F. A. (2005). A review of the oral direct thrombin inhibitor ximelagatran: not yet the end of the warfarin era. Am. Heart J. 150, 19-26. doi: 10.1016/j.ahj.2005.02.012.
    • (2005) Am. Heart J , vol.150 , pp. 19-26
    • Mohapatra, R.1    Tran, M.2    Gore, J.M.3    Spencer, F.A.4
  • 141
    • 30644456411 scopus 로고    scopus 로고
    • Dietary flavonoids: effects on xenobiotic and carcinogen metabolism
    • Moon, Y. J., Wang, X., and Morris, M. E. (2006). Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol. In Vitro 20, 187-210. doi: 10.1016/j.tiv.2005.06.048.
    • (2006) Toxicol. In Vitro , vol.20 , pp. 187-210
    • Moon, Y.J.1    Wang, X.2    Morris, M.E.3
  • 142
    • 7244253081 scopus 로고    scopus 로고
    • Nrf2-Keap1 defines a physiologically important stress response mechanism
    • Motohashi, H., and Yamamoto, M. (2004). Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol. Med. 10, 549-557. doi: 10.1016/j.molmed.2004.09.003.
    • (2004) Trends Mol. Med , vol.10 , pp. 549-557
    • Motohashi, H.1    Yamamoto, M.2
  • 143
    • 0025102171 scopus 로고
    • Prevention by silymarin of membrane alterations in acute CCl4 liver damage
    • Muriel, P., and Mourelle, M. (1990). Prevention by silymarin of membrane alterations in acute CCl4 liver damage. J. Appl. Toxicol. 10, 275-279. doi: 10.1002/jat.2550100408.
    • (1990) J. Appl. Toxicol , vol.10 , pp. 275-279
    • Muriel, P.1    Mourelle, M.2
  • 145
    • 9044254525 scopus 로고    scopus 로고
    • P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature
    • Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., et al. (1996). P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6, 1-42. doi: 10.1097/00008571-199602000-00002.
    • (1996) Pharmacogenetics , vol.6 , pp. 1-42
    • Nelson, D.R.1    Koymans, L.2    Kamataki, T.3    Stegeman, J.J.4    Feyereisen, R.5    Waxman, D.J.6
  • 146
    • 34347377398 scopus 로고    scopus 로고
    • Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers
    • Okada, K., Shoda, J., Kano, M., Suzuki, S., Ohtake, N., Yamamoto, M., et al. (2007). Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers. Am. J. Physiol. Gastrointest. Liver Physiol. 292, G1450-G1463. doi: 10.1152/ajpgi.00302.2006.
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol , vol.292 , pp. G1450-G1463
    • Okada, K.1    Shoda, J.2    Kano, M.3    Suzuki, S.4    Ohtake, N.5    Yamamoto, M.6
  • 147
    • 0031788259 scopus 로고    scopus 로고
    • The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease
    • Oken, B. S., Storzbach, D. M., and Kaye, J. A. (1998). The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch. Neurol. 55, 1409-1415. doi: 10.1001/archneur.55.11.1409.
    • (1998) Arch. Neurol , vol.55 , pp. 1409-1415
    • Oken, B.S.1    Storzbach, D.M.2    Kaye, J.A.3
  • 148
    • 84984580675 scopus 로고    scopus 로고
    • Acetaminophen-induced liver damage in mice: effects of some medicinal plants on the oxidative defense system
    • Olaleye, M. T., and Rocha, B. T. (2008). Acetaminophen-induced liver damage in mice: effects of some medicinal plants on the oxidative defense system. Exp. Toxicol. Pathol. 59, 319-327. doi: 10.1016/j.etp.2007.10.003.
    • (2008) Exp. Toxicol. Pathol , vol.59 , pp. 319-327
    • Olaleye, M.T.1    Rocha, B.T.2
  • 149
    • 0037126649 scopus 로고    scopus 로고
    • Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
    • Ostapowicz, G., Fontana, R. J., Schiødt, F. V., Larson, A., Davern, T. J., Han, S. H., et al. (2002). Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann. Intern. Med. 137, 947-954. doi: 10.7326/0003-4819-137-12-200212170-00007.
    • (2002) Ann. Intern. Med , vol.137 , pp. 947-954
    • Ostapowicz, G.1    Fontana, R.J.2    Schiødt, F.V.3    Larson, A.4    Davern, T.J.5    Han, S.H.6
  • 150
    • 33644925823 scopus 로고    scopus 로고
    • Effect of garlic on isoniazid and rifampicin-induced hepatic injury in rats
    • Pal, R., Vaiphei, K., Sikander, A., Singh, K., and Rana, S. V. (2006). Effect of garlic on isoniazid and rifampicin-induced hepatic injury in rats. World J. Gastroenterol. 12, 636-639.
    • (2006) World J. Gastroenterol , vol.12 , pp. 636-639
    • Pal, R.1    Vaiphei, K.2    Sikander, A.3    Singh, K.4    Rana, S.V.5
  • 151
    • 0032926620 scopus 로고    scopus 로고
    • Biotransformation of curcumin through reduction and glucuronidation in mice
    • Pan, M. H., Huang, T. M., and Lin, J. K. (1999). Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metabol. Dispos. 27, 486-494.
    • (1999) Drug Metabol. Dispos , vol.27 , pp. 486-494
    • Pan, M.H.1    Huang, T.M.2    Lin, J.K.3
  • 152
    • 84875193614 scopus 로고    scopus 로고
    • Drug-induced hepatotoxicity: a review
    • Pandit, A., Sachdeva, T., and Bafna, P. (2012). Drug-induced hepatotoxicity: a review. J. Appl. Pharm. Sci. 02, 233-243. doi: 10.7324/japs.2012.2541.
    • (2012) J. Appl. Pharm. Sci , vol.2 , pp. 233-243
    • Pandit, A.1    Sachdeva, T.2    Bafna, P.3
  • 154
    • 0033613436 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappa B activation via the NIK/IKK signalling complex
    • Plummer, S. M., Holloway, K. A., Manson, M. M., Munks, R. J. L., Kaptein, A., Farrow, S., et al. (1999). Inhibition of cyclooxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappa B activation via the NIK/IKK signalling complex. Oncogene 18, 6013-6020. doi: 10.1038/sj.onc.1202980.
    • (1999) Oncogene , vol.18 , pp. 6013-6020
    • Plummer, S.M.1    Holloway, K.A.2    Manson, M.M.3    Munks, R.J.L.4    Kaptein, A.5    Farrow, S.6
  • 155
    • 34247583381 scopus 로고    scopus 로고
    • Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin
    • Polyak, S. J., Morishima, C., Shuhart, M. C., Wang, C. C., Liu, Y., and Lee, D. Y. (2007). Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin. Gastroenterology 132, 1925-1936. doi: 10.1053/j.gastro.2007.02.038.
    • (2007) Gastroenterology , vol.132 , pp. 1925-1936
    • Polyak, S.J.1    Morishima, C.2    Shuhart, M.C.3    Wang, C.C.4    Liu, Y.5    Lee, D.Y.6
  • 156
    • 0345871329 scopus 로고    scopus 로고
    • Ginkgo biloba extract: review of CNS effects
    • Ponto, L. L., and Schultz, S. K. (2003). Ginkgo biloba extract: review of CNS effects. Ann. Clin. Psychiatry 15, 109-119. doi: 10.3109/10401230309085676.
    • (2003) Ann. Clin. Psychiatry , vol.15 , pp. 109-119
    • Ponto, L.L.1    Schultz, S.K.2
  • 157
    • 84866596506 scopus 로고    scopus 로고
    • Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria
    • Porceddu, M., Buron, N., Roussel, C., Labbe, G., Fromenty, B., and Borgne-Sanchez, A. (2012). Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria. Toxicol. Sci. 129, 332-345. doi: 10.1093/toxsci/KFS197.
    • (2012) Toxicol. Sci , vol.129 , pp. 332-345
    • Porceddu, M.1    Buron, N.2    Roussel, C.3    Labbe, G.4    Fromenty, B.5    Borgne-Sanchez, A.6
  • 158
    • 18344372908 scopus 로고    scopus 로고
    • The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1
    • Potter, G. A., Patterson, L. H., Wanogho, E., Perry, P. J., Butler, P. C., Ijaz, T., et al. (2002). The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. Br. J. Cancer 86, 774-778. doi: 10.1038/sj.bjc.6600197.
    • (2002) Br. J. Cancer , vol.86 , pp. 774-778
    • Potter, G.A.1    Patterson, L.H.2    Wanogho, E.3    Perry, P.J.4    Butler, P.C.5    Ijaz, T.6
  • 159
    • 0020352208 scopus 로고
    • Effect of isoniazid administration on selected rat and mouse hepatic microsomal mixed-function oxidase and in vitro (C14) acetylhydrazine-derived covalent binding
    • Powell-Jackson, P. R., Tredger, J. M., Smith, H. W., and Williams, R. (1982). Effect of isoniazid administration on selected rat and mouse hepatic microsomal mixed-function oxidase and in vitro (C14) acetylhydrazine-derived covalent binding. Biochem. Pharmacol. 31, 4031-4034. doi: 10.1016/0006-2952(82)90651-7.
    • (1982) Biochem. Pharmacol , vol.31 , pp. 4031-4034
    • Powell-Jackson, P.R.1    Tredger, J.M.2    Smith, H.W.3    Williams, R.4
  • 160
    • 0024411774 scopus 로고
    • Mechanisms of carbon tetrachloride toxicity
    • Racknagel, R. O., Glende, E. J. R., Dolak, J. A., and Waller, R. I. (1989). Mechanisms of carbon tetrachloride toxicity. Pharmacol. Ther. 43, 130-154. doi: 10.1016/0163-7258(89)90050-8.
    • (1989) Pharmacol. Ther , vol.43 , pp. 130-154
    • Racknagel, R.O.1    Glende, E.J.R.2    Dolak, J.A.3    Waller, R.I.4
  • 162
    • 33644780110 scopus 로고    scopus 로고
    • Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats
    • Rana, S. V., Attri, S., Vaiphei, K., Pal, R., Attri, A., and Singh, K. (2006). Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats. World J. Gastroenterol. 12, 287-291. doi: 10.3748/wjg.v12.i2.287.
    • (2006) World J. Gastroenterol , vol.12 , pp. 287-291
    • Rana, S.V.1    Attri, S.2    Vaiphei, K.3    Pal, R.4    Attri, A.5    Singh, K.6
  • 163
    • 0024401849 scopus 로고
    • Acetaminophen ctivation by human liver cytochromes P450IIE1 and P450IA2
    • Raucy, J. L., Lasker, J. M., Lieber, C. S., and Black, M. (1989). Acetaminophen ctivation by human liver cytochromes P450IIE1 and P450IA2. Arch. Biochem. Biophys. 271, 270-283. doi: 10.1016/0003-9861(89)90278-6.
    • (1989) Arch. Biochem. Biophys , vol.271 , pp. 270-283
    • Raucy, J.L.1    Lasker, J.M.2    Lieber, C.S.3    Black, M.4
  • 164
    • 4544292829 scopus 로고    scopus 로고
    • Influence of lipophilicity on the interactions of hydroxy stilbenes with cytochrome P450 3A4
    • Regev-Shoshani, G., Shoseyov, O., and Kerem, Z. (2004). Influence of lipophilicity on the interactions of hydroxy stilbenes with cytochrome P450 3A4. Biochem. Biophys. Res. Commun. 323, 668-673. doi: 10.1016/j.bbrc.2004.08.141.
    • (2004) Biochem. Biophys. Res. Commun , vol.323 , pp. 668-673
    • Regev-Shoshani, G.1    Shoseyov, O.2    Kerem, Z.3
  • 165
    • 13244292321 scopus 로고    scopus 로고
    • Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes
    • Reid, A. B., Kurten, R. C., McCullough, S. S., Brock, R. W., and Hinson, J. A. (2005). Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J. Pharmacol. Exp. Ther. 312, 509-516. doi: 10.1124/jpet.104.075945.
    • (2005) J. Pharmacol. Exp. Ther , vol.312 , pp. 509-516
    • Reid, A.B.1    Kurten, R.C.2    McCullough, S.S.3    Brock, R.W.4    Hinson, J.A.5
  • 166
    • 0036223831 scopus 로고    scopus 로고
    • Summary of information on human CYP enzymes: human P450 metabolism data
    • Rendic, S. (2002). Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabol. Rev. 34, 83-448. doi: 10.1081/DMR-120001392.
    • (2002) Drug Metabol. Rev , vol.34 , pp. 83-448
    • Rendic, S.1
  • 167
    • 0041696926 scopus 로고    scopus 로고
    • Plant derivatives in the treatment of alcohol dependency
    • Rezvani, A. H., Overstreet, D. H., Perfumi, M., and Massi, M. (2003). Plant derivatives in the treatment of alcohol dependency. Pharmacol. Biochem. Behav. 75, 593-606. doi: 10.1016/S0091-3057(03)00124-2.
    • (2003) Pharmacol. Biochem. Behav , vol.75 , pp. 593-606
    • Rezvani, A.H.1    Overstreet, D.H.2    Perfumi, M.3    Massi, M.4
  • 168
    • 0023903374 scopus 로고
    • Glutathione, free radicals and chemotherapeutic agents
    • Ross, D. (1988). Glutathione, free radicals and chemotherapeutic agents. Pharmacol. Ther. 37, 231-249. doi: 10.1016/0163-7258(88)90027-7.
    • (1988) Pharmacol. Ther , vol.37 , pp. 231-249
    • Ross, D.1
  • 169
    • 77953701589 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity
    • Saito, C., Lemasters, J. J., and Jaeschke, H. (2010). c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol. Appl. Pharmacol. 246, 8-17. doi: 10.1016/j.taap.2010.04.015.
    • (2010) Toxicol. Appl. Pharmacol , vol.246 , pp. 8-17
    • Saito, C.1    Lemasters, J.J.2    Jaeschke, H.3
  • 170
    • 34548058841 scopus 로고    scopus 로고
    • Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism
    • Sandur, S. K., Pandey, M. K., Sung, B., Ahn, K. S., Murakami, A., Sethi, G., et al. (2007). Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 28, 1765-1773. doi: 10.1093/carcin/bgm123.
    • (2007) Carcinogenesis , vol.28 , pp. 1765-1773
    • Sandur, S.K.1    Pandey, M.K.2    Sung, B.3    Ahn, K.S.4    Murakami, A.5    Sethi, G.6
  • 171
    • 84929506120 scopus 로고    scopus 로고
    • Effects of nanoparticle-encapsulated curcumin on arsenic-induced liver toxicity in rats
    • Sankar, P., Gopal Telang, A., Kalaivanan, R., Karunakaran, V., Manikam, K., and Sarkar, S. N. (2015). Effects of nanoparticle-encapsulated curcumin on arsenic-induced liver toxicity in rats. Environ. Toxicol. 30, 628-637. doi: 10.1002/tox.21940.
    • (2015) Environ. Toxicol , vol.30 , pp. 628-637
    • Sankar, P.1    Gopal Telang, A.2    Kalaivanan, R.3    Karunakaran, V.4    Manikam, K.5    Sarkar, S.N.6
  • 172
    • 31044431993 scopus 로고    scopus 로고
    • Effect of chitosan supplementation on antitubercular drugs-induced hepatotoxicity in rats
    • Santhosh, S., Sini, T. K., Anandan, R., and Mathew, P. T. (2006). Effect of chitosan supplementation on antitubercular drugs-induced hepatotoxicity in rats. Toxicology 219, 53-59. doi: 10.1016/j.tox.2005.11.001.
    • (2006) Toxicology , vol.219 , pp. 53-59
    • Santhosh, S.1    Sini, T.K.2    Anandan, R.3    Mathew, P.T.4
  • 173
    • 0034801161 scopus 로고    scopus 로고
    • Modulating effect of Liv.100, an ayurvedic formulation on antituberculosis drug-induced alterations in rat liver microsomes
    • Saraswathy, S. D., and Shyamala Devi, C. S. (2001). Modulating effect of Liv.100, an ayurvedic formulation on antituberculosis drug-induced alterations in rat liver microsomes. Phytother. Res. 15, 501-505. doi: 10.1002/ptr.770.
    • (2001) Phytother. Res , vol.15 , pp. 501-505
    • Saraswathy, S.D.1    Shyamala Devi, C.S.2
  • 174
    • 0141755409 scopus 로고    scopus 로고
    • Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice
    • Sass, G., Soares, M. C., Yamashita, K., Seyfried, S., Zimmermann, W. H., Eschenhagen, T., et al. (2003). Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice. Hepatology 38, 909-918. doi: 10.1002/hep.1840380417.
    • (2003) Hepatology , vol.38 , pp. 909-918
    • Sass, G.1    Soares, M.C.2    Yamashita, K.3    Seyfried, S.4    Zimmermann, W.H.5    Eschenhagen, T.6
  • 176
    • 0030005527 scopus 로고    scopus 로고
    • Antiproliferative effect of silybin on gynaecological malignancies: synergism with cisplatin and doxorubicin
    • Scambia, G., De Vincenzo, R., Ranelletti, F. O., Panici, P. B., Ferrandina, G., D'Agostino, G., et al. (1996). Antiproliferative effect of silybin on gynaecological malignancies: synergism with cisplatin and doxorubicin. Eur. J. Cancer 32A, 877-882. doi: 10.1016/0959-8049(96)00011-1.
    • (1996) Eur. J. Cancer , vol.32A , pp. 877-882
    • Scambia, G.1    De Vincenzo, R.2    Ranelletti, F.O.3    Panici, P.B.4    Ferrandina, G.5    D'Agostino, G.6
  • 177
    • 44449147923 scopus 로고    scopus 로고
    • Cardiac ischemia and reperfusion in spontaneously diabetic rats with and without application of EGb 761, I. cardiomyocytes
    • Schneider, R., Welt, K., Aust, W., Löster, H., and Fitzl, G. (2008). Cardiac ischemia and reperfusion in spontaneously diabetic rats with and without application of EGb 761: I. cardiomyocytes. Histol. Histopathol. 23, 807-817.
    • (2008) Histol. Histopathol , vol.23 , pp. 807-817
    • Schneider, R.1    Welt, K.2    Aust, W.3    Löster, H.4    Fitzl, G.5
  • 178
    • 0033384230 scopus 로고    scopus 로고
    • Drug-induced hepatotoxicity: pharmacokinetic perspectives and strategies for risk reduction
    • Shah, R. R. (1999). Drug-induced hepatotoxicity: pharmacokinetic perspectives and strategies for risk reduction. Adv. Drug React. Toxicol. Rev. 18, 181-233.
    • (1999) Adv. Drug React. Toxicol. Rev , vol.18 , pp. 181-233
    • Shah, R.R.1
  • 179
    • 34548124521 scopus 로고    scopus 로고
    • Causality assessment of drug-induced hepatotoxicity: promises and pitfalls
    • Shapiro, M. A., and Lewis, J. H. (2007). Causality assessment of drug-induced hepatotoxicity: promises and pitfalls. Clin. Liver Dis. 11, 477. doi: 10.1016/j.cld.2007.06.003.
    • (2007) Clin. Liver Dis , vol.11 , pp. 477
    • Shapiro, M.A.1    Lewis, J.H.2
  • 180
    • 0031947695 scopus 로고    scopus 로고
    • Inhibition of xanthine oxidase by purpurogallin and silymarin group
    • Sheu, S. Y., Lai, C. H., and Chiang, H. C. (1998). Inhibition of xanthine oxidase by purpurogallin and silymarin group. Anticancer Res. 18, 263-268.
    • (1998) Anticancer Res , vol.18 , pp. 263-268
    • Sheu, S.Y.1    Lai, C.H.2    Chiang, H.C.3
  • 181
    • 0035428028 scopus 로고    scopus 로고
    • Antifibrogenic therapies in chronic HCV infection
    • Shimizu, I. (2001). Antifibrogenic therapies in chronic HCV infection. Curr. Drug Targets Infect. Disord. 1, 227-240. doi: 10.2174/1568005014606053.
    • (2001) Curr. Drug Targets Infect. Disord , vol.1 , pp. 227-240
    • Shimizu, I.1
  • 182
    • 0028288452 scopus 로고
    • Prooxident antioxident properties of iron-hydroquinone and iron-1, 2, 4-benzenetriol complex
    • Singh, V., Ahmad, S., and Rao, G. S. (1994). Prooxident antioxident properties of iron-hydroquinone and iron-1, 2, 4-benzenetriol complex. Implications for benzene toxicity. Toxicology 89, 25-33. doi: 10.1016/0300-483X(94)90130-9.
    • (1994) Implications for benzene toxicity. Toxicology , vol.89 , pp. 25-33
    • Singh, V.1    Ahmad, S.2    Rao, G.S.3
  • 183
    • 0023223973 scopus 로고
    • Activation of hydrazine derivatives of free radicals in the per fused rat liver: a spin trapping study
    • Sinha, B. K. (1987). Activation of hydrazine derivatives of free radicals in the per fused rat liver: a spin trapping study. Biochim. Biophys. Acta 924, 261-269. doi: 10.1016/0304-4165(87)90021-3.
    • (1987) Biochim. Biophys. Acta , vol.924 , pp. 261-269
    • Sinha, B.K.1
  • 184
    • 0028015606 scopus 로고
    • Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity
    • Snawder, J. E., Roe, A. L., Benson, R. W., and Roberts, D. W. (1994). Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity. Biochem. Biophys. Res. Commun. 203, 532-539. doi: 10.1006/bbrc.1994.2215.
    • (1994) Biochem. Biophys. Res. Commun , vol.203 , pp. 532-539
    • Snawder, J.E.1    Roe, A.L.2    Benson, R.W.3    Roberts, D.W.4
  • 185
    • 0031855646 scopus 로고    scopus 로고
    • Oxidative hepatic injury of isoniazid-rifampicin in young rats subjected to protein energy malnutrition
    • Sodhi, C. P., Rana, S. F., Attari, S., Metha, S., Vaiphei, K., and Metha, S. K. (1998). Oxidative hepatic injury of isoniazid-rifampicin in young rats subjected to protein energy malnutrition. Drug Chem. Toxicol. 21, 305-317. doi: 10.3109/01480549809002207.
    • (1998) Drug Chem. Toxicol , vol.21 , pp. 305-317
    • Sodhi, C.P.1    Rana, S.F.2    Attari, S.3    Metha, S.4    Vaiphei, K.5    Metha, S.K.6
  • 186
    • 0030330675 scopus 로고    scopus 로고
    • Study of oxidative stress in isoniazid-induced hepatic injury in young rats with and without protein-energy malnutrition
    • Sodhi, C. P., Rana, S. V., Mehta, S. K., Vaiphei, K., Attri, S., Thakur, S., et al. (1996). Study of oxidative stress in isoniazid-induced hepatic injury in young rats with and without protein-energy malnutrition. J. Biochem. Toxicol. 11, 139-146.
    • (1996) J. Biochem. Toxicol , vol.11 , pp. 139-146
    • Sodhi, C.P.1    Rana, S.V.2    Mehta, S.K.3    Vaiphei, K.4    Attri, S.5    Thakur, S.6
  • 187
    • 84924338413 scopus 로고    scopus 로고
    • Immunohistochemical and molecular study on the protective effect of curcumin against hepatictoxicity induced by paracetamol in wistar rats
    • Soliman, M. M., Abdo Nassan, M., and Ismail, T. A. (2014). Immunohistochemical and molecular study on the protective effect of curcumin against hepatictoxicity induced by paracetamol in wistar rats. BMC Complement. Altern. Med. 29, 14:457. doi: 10.1186/1472-6882-14-457.
    • (2014) BMC Complement. Altern. Med , vol.29 , Issue.14 , pp. 457
    • Soliman, M.M.1    Abdo Nassan, M.2    Ismail, T.A.3
  • 188
    • 84938989479 scopus 로고    scopus 로고
    • Molecular and histopathological study on the ameliorative effects of curcumin against lead acetate-induced hepatotoxicity and nephrototoxicity in wistar rats
    • Soliman, M. M., Baiomy, A. A., and Yassin, M. H. (2015). Molecular and histopathological study on the ameliorative effects of curcumin against lead acetate-induced hepatotoxicity and nephrototoxicity in wistar rats. Biol. Trace Elem. Res. 167, 91-102. doi: 10.1007/s12011-015-0280-0.
    • (2015) Biol. Trace Elem. Res , vol.167 , pp. 91-102
    • Soliman, M.M.1    Baiomy, A.A.2    Yassin, M.H.3
  • 189
    • 0037377921 scopus 로고    scopus 로고
    • Multiple alterations of canalicular membrane transport activities in rats with CCl(4)-induced hepatic injury
    • Song, I. S., Lee, Y. M., Chung, S. J., and Shim, C. K. (2003). Multiple alterations of canalicular membrane transport activities in rats with CCl(4)-induced hepatic injury. Drug Metab. Dispos. 31, 482-490. doi: 10.1124/dmd.31.4.482.
    • (2003) Drug Metab. Dispos , vol.31 , pp. 482-490
    • Song, I.S.1    Lee, Y.M.2    Chung, S.J.3    Shim, C.K.4
  • 190
    • 0032797573 scopus 로고    scopus 로고
    • Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells
    • Sonnenbichler, J., Scalera, F., Sonnenbichler, I., and Weyhenmeyer, R. (1999). Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells. J. Pharmacol. Exp. Ther. 290, 1375-1383.
    • (1999) J. Pharmacol. Exp. Ther , vol.290 , pp. 1375-1383
    • Sonnenbichler, J.1    Scalera, F.2    Sonnenbichler, I.3    Weyhenmeyer, R.4
  • 191
    • 0022583887 scopus 로고
    • Biochemical effects of the flavolignane silibinin on RNA, protein and DNA synthesis in rat liver
    • Sonnenbichler, J., and Zetl, I. (1986). Biochemical effects of the flavolignane silibinin on RNA, protein and DNA synthesis in rat liver. Progr. Clin. Biol. Res. 213, 319-331.
    • (1986) Progr. Clin. Biol. Res , vol.213 , pp. 319-331
    • Sonnenbichler, J.1    Zetl, I.2
  • 192
    • 0037303706 scopus 로고    scopus 로고
    • A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection
    • Sonoda, J., Rosenfeld, J. M., Xu, L., Evans, R. M., and Xie, W. (2003). A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection. Curr. Drug Metab. 4, 59-72. doi: 10.2174/1389200033336739.
    • (2003) Curr. Drug Metab , vol.4 , pp. 59-72
    • Sonoda, J.1    Rosenfeld, J.M.2    Xu, L.3    Evans, R.M.4    Xie, W.5
  • 194
    • 33845491066 scopus 로고    scopus 로고
    • Pregnane X receptor and natural products: beyond drug-drug interactions
    • Staudinger, J. L., Ding, X., and Lichti, K. (2006). Pregnane X receptor and natural products: beyond drug-drug interactions. Expert Opin. Drug Metab. Toxicol. 2, 847-857. doi: 10.1517/17425255.2.6.847.
    • (2006) Expert Opin. Drug Metab. Toxicol , vol.2 , pp. 847-857
    • Staudinger, J.L.1    Ding, X.2    Lichti, K.3
  • 195
    • 0025228499 scopus 로고
    • Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents
    • Steele, V. E., Kelloff, G. J., Wilkinson, B. P., and Arnold, J. T. (1990). Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents. Cancer Res. 50, 2068-2074.
    • (1990) Cancer Res , vol.50 , pp. 2068-2074
    • Steele, V.E.1    Kelloff, G.J.2    Wilkinson, B.P.3    Arnold, J.T.4
  • 196
    • 84939990825 scopus 로고    scopus 로고
    • Hepatotoxicity of herbal and dietary supplements: an update
    • Stickel, F., and Shouval, D. (2015). Hepatotoxicity of herbal and dietary supplements: an update. Arch. Toxicol. 89, 851-865. doi: 10.1007/s00204-015-1471-3.
    • (2015) Arch. Toxicol , vol.89 , pp. 851-865
    • Stickel, F.1    Shouval, D.2
  • 197
    • 0032813348 scopus 로고    scopus 로고
    • Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances
    • Surh, Y.-J. (1999). Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat. Res. 428, 305-327. doi: 10.1016/S1383-5742(99)00057-5.
    • (1999) Mutat. Res , vol.428 , pp. 305-327
    • Surh, Y.-J.1
  • 198
    • 20044374177 scopus 로고    scopus 로고
    • Effects of aged garlic extract (AGE) on colorectal adenomas: a double-blinded study
    • Tanaka, S., Haruma, K., Kunihiro, M., Nagata, S., Kitadai, Y., Manabe, N., et al. (2004). Effects of aged garlic extract (AGE) on colorectal adenomas: a double-blinded study. Hiroshima J. Med. Sci. 53, 39-45.
    • (2004) Hiroshima J. Med. Sci , vol.53 , pp. 39-45
    • Tanaka, S.1    Haruma, K.2    Kunihiro, M.3    Nagata, S.4    Kitadai, Y.5    Manabe, N.6
  • 199
    • 0035861338 scopus 로고    scopus 로고
    • Coumaroyl flavonol glycosides from the leaves of Ginkgo biloba
    • Tang, Y., Lou, F., Wang, J., Li, Y., and Zhuang, S. (2001). Coumaroyl flavonol glycosides from the leaves of Ginkgo biloba. Phytochemistry 58, 1251-1256. doi: 10.1016/S0031-9422(01)00320-X.
    • (2001) Phytochemistry , vol.58 , pp. 1251-1256
    • Tang, Y.1    Lou, F.2    Wang, J.3    Li, Y.4    Zhuang, S.5
  • 200
    • 17444371694 scopus 로고    scopus 로고
    • Biochemical manifestations of anti-tuberculosis drugs induced hepatotoxicity and the effect of silymarin
    • Tasduq, S. A., Peerzada, K., Koul, S., Bhat, R., and Johri, R. K. (2005). Biochemical manifestations of anti-tuberculosis drugs induced hepatotoxicity and the effect of silymarin. Hepatol. Res. 31, 132-135. doi: 10.1016/j.hepres.2005.01.005.
    • (2005) Hepatol. Res , vol.31 , pp. 132-135
    • Tasduq, S.A.1    Peerzada, K.2    Koul, S.3    Bhat, R.4    Johri, R.K.5
  • 201
    • 0018834480 scopus 로고
    • The mechanism of bromobenzene-induced cytotoxicity studied with isolated hepatocytes
    • Thor, H., and Orrenius, S. (1980). The mechanism of bromobenzene-induced cytotoxicity studied with isolated hepatocytes. Arch. Toxicol. 44, 31-43. doi: 10.1007/BF00303181.
    • (1980) Arch. Toxicol , vol.44 , pp. 31-43
    • Thor, H.1    Orrenius, S.2
  • 202
    • 0023894655 scopus 로고
    • Characterization of glutathione S-transferase in rat kidney
    • Trackshel, G. M., and Maines, M. D. (1988). Characterization of glutathione S-transferase in rat kidney. Biochem. J. 252, 127-136. doi: 10.1042/bj2520127.
    • (1988) Biochem. J , vol.252 , pp. 127-136
    • Trackshel, G.M.1    Maines, M.D.2
  • 203
    • 34047099418 scopus 로고    scopus 로고
    • Prevention of hepatic oxidative injury by Xiao-Chen-Chi-Tang in mice
    • Tseng, S. H., Chien, T. Y., Tzeng, C. F., Lin, Y. H., Wu, C. H., and Wang, C. C. (2007). Prevention of hepatic oxidative injury by Xiao-Chen-Chi-Tang in mice. J. Ethnopharmacol. 111, 232-239. doi: 10.1016/j.jep.2006.11.030.
    • (2007) J. Ethnopharmacol , vol.111 , pp. 232-239
    • Tseng, S.H.1    Chien, T.Y.2    Tzeng, C.F.3    Lin, Y.H.4    Wu, C.H.5    Wang, C.C.6
  • 204
    • 0028892819 scopus 로고
    • Crocetin protects against oxidative damage in rat primary hepatocytes
    • Tseng, T. H., Chu, C. Y., Huang, J. M., Shiow, S. J., and Wang, C. J. (1995). Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett. 97, 61-67. doi: 10.1016/0304-3835(95)03964-X.
    • (1995) Cancer Lett , vol.97 , pp. 61-67
    • Tseng, T.H.1    Chu, C.Y.2    Huang, J.M.3    Shiow, S.J.4    Wang, C.J.5
  • 205
    • 74149084352 scopus 로고    scopus 로고
    • Pyrogallol-mediated toxicity and natural antioxidants: triumphs and pitfalls of preclinical findings and their translational limitations
    • Upadhyay, G., Gupta, S. P., Prakash, O., and Singh, M. P. (2010a). Pyrogallol-mediated toxicity and natural antioxidants: triumphs and pitfalls of preclinical findings and their translational limitations. Chem. Biol. Interact. 183, 333-340. doi: 10.1016/j.cbi.2009.11.028.
    • (2010) Chem. Biol. Interact , vol.183 , pp. 333-340
    • Upadhyay, G.1    Gupta, S.P.2    Prakash, O.3    Singh, M.P.4
  • 206
    • 34249088609 scopus 로고    scopus 로고
    • Effect of silymarin on pyrogallol-and rifampicin-induced hepatotoxicity in mouse
    • Upadhyay, G., Kumar, A., and Singh, M. P. (2007). Effect of silymarin on pyrogallol-and rifampicin-induced hepatotoxicity in mouse. Eur. J. Pharmacol. 565, 190-201. doi: 10.1016/j.ejphar.2007.03.004.
    • (2007) Eur. J. Pharmacol , vol.565 , pp. 190-201
    • Upadhyay, G.1    Kumar, A.2    Singh, M.P.3
  • 207
    • 53049083034 scopus 로고    scopus 로고
    • Resveratrol modulates pyrogallol-induced changes in hepatic toxicity markers, xenobiotic metabolizing enzymes and oxidative stress
    • Upadhyay, G., Singh, A. K., Kumar, A., Prakash, O., and Singh, M. P. (2008). Resveratrol modulates pyrogallol-induced changes in hepatic toxicity markers, xenobiotic metabolizing enzymes and oxidative stress. Eur. J. Pharmacol. 596, 146-152. doi: 10.1016/j.ejphar.2008.08.019.
    • (2008) Eur. J. Pharmacol , vol.596 , pp. 146-152
    • Upadhyay, G.1    Singh, A.K.2    Kumar, A.3    Prakash, O.4    Singh, M.P.5
  • 208
    • 77952878550 scopus 로고    scopus 로고
    • Involvement of multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated protection: evidence from gene expression profiles
    • Upadhyay, G., Tiwari, M. N., Prakash, O., Jyoti, A., Shanker, R., and Singh, M. P. (2010b). Involvement of multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated protection: evidence from gene expression profiles. Food Chem. Toxicol. 48, 1660-1670. doi: 10.1016/j.fct.2010.03.041.
    • (2010) Food Chem. Toxicol , vol.48 , pp. 1660-1670
    • Upadhyay, G.1    Tiwari, M.N.2    Prakash, O.3    Jyoti, A.4    Shanker, R.5    Singh, M.P.6
  • 209
    • 34247349605 scopus 로고    scopus 로고
    • Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs
    • Urquhart, B. L., Tirona, R. G., and Kim, R. B. (2007). Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs. J. Clin. Pharmacol. 47, 566-578. doi: 10.1177/0091270007299930.
    • (2007) J. Clin. Pharmacol , vol.47 , pp. 566-578
    • Urquhart, B.L.1    Tirona, R.G.2    Kim, R.B.3
  • 210
    • 0029433017 scopus 로고
    • Evaluating of blood lipid peroxidation parameters in carbon tetrachloride (CCl4) toxicity in sheep
    • Vajdovich, P., Szilagyi, A., and Gall, T. (1995). Evaluating of blood lipid peroxidation parameters in carbon tetrachloride (CCl4) toxicity in sheep. Acta Vet. Hung. 43, 423-429.
    • (1995) Acta Vet. Hung , vol.43 , pp. 423-429
    • Vajdovich, P.1    Szilagyi, A.2    Gall, T.3
  • 211
    • 0023275278 scopus 로고
    • Silybin dihemisuccinate protects rat erythrocytes against phenylhydrazine-induced lipoperoxidation and hemolysis
    • Valenzuela, A., Guerra, R., and Garrido, A. (1987). Silybin dihemisuccinate protects rat erythrocytes against phenylhydrazine-induced lipoperoxidation and hemolysis. Planta Med. 53, 402-405. doi: 10.1055/s-2006-962757.
    • (1987) Planta Med , vol.53 , pp. 402-405
    • Valenzuela, A.1    Guerra, R.2    Garrido, A.3
  • 212
    • 0037118913 scopus 로고    scopus 로고
    • Chemical analysis of Ginkgo biloba leaves and extracts
    • Van Beek, T. A. (2002). Chemical analysis of Ginkgo biloba leaves and extracts. J. Chromatogr. 967, 21-55. doi: 10.1016/S0021-9673(02)00172-3.
    • (2002) J. Chromatogr , vol.967 , pp. 21-55
    • Van Beek, T.A.1
  • 213
    • 0006229140 scopus 로고    scopus 로고
    • "Metabolism of xenobiotics by the human liver, "
    • eds D. Zakin and T. D. Boyer (Philadelphia: WB Saunders), 3rd Edn
    • Vessey, D. A. (1996). "Metabolism of xenobiotics by the human liver, " in Hepatology: A Textbook of Liver Disease, 3rd Edn., eds D. Zakin and T. D. Boyer (Philadelphia: WB Saunders), 257-305.
    • (1996) Hepatology: A Textbook of Liver Disease , pp. 257-305
    • Vessey, D.A.1
  • 214
    • 34250902910 scopus 로고    scopus 로고
    • A survey of Chinese herbal ingredients with liver protection activities
    • Wang, R., Kong, J., Wang, D., Lin-min Lien, L., and Lien, E. J. (2007). A survey of Chinese herbal ingredients with liver protection activities. Chin. Med. 2:5. doi: 10.1186/1749-8546-2-5.
    • (2007) Chin. Med , vol.2 , pp. 5
    • Wang, R.1    Kong, J.2    Wang, D.3    Lin-min Lien, L.4    Lien, E.J.5
  • 215
    • 84929151344 scopus 로고    scopus 로고
    • Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways
    • Wang, Y., Jiang, Y., Fan, X., Tan, H., Zeng, H., Wang, Y., et al. (2015). Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways. Toxicol. Lett. 236, 82-89. doi: 10.1016/j.toxlet.2015.05.001.
    • (2015) Toxicol. Lett , vol.236 , pp. 82-89
    • Wang, Y.1    Jiang, Y.2    Fan, X.3    Tan, H.4    Zeng, H.5    Wang, Y.6
  • 216
    • 84908067485 scopus 로고    scopus 로고
    • Ameliorative action of curcumin in cisplatin-mediated hepatotoxicity: an in vivo study in Wistar rats
    • Waseem, M., Pandey, P., Tomar, B., Raisuddin, S., and Parvez, S. (2014). Ameliorative action of curcumin in cisplatin-mediated hepatotoxicity: an in vivo study in Wistar rats. Arch. Med. Res. 45, 462-468. doi: 10.1016/j.arcmed.2014.07.006.
    • (2014) Arch. Med. Res , vol.45 , pp. 462-468
    • Waseem, M.1    Pandey, P.2    Tomar, B.3    Raisuddin, S.4    Parvez, S.5
  • 218
    • 0033199499 scopus 로고    scopus 로고
    • P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR
    • Waxman, D. J. (1999). P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch. Biochem. Biophys. 369, 11-23. doi: 10.1006/abbi.1999.1351.
    • (1999) Arch. Biochem. Biophys , vol.369 , pp. 11-23
    • Waxman, D.J.1
  • 219
    • 0034859659 scopus 로고    scopus 로고
    • Silymarin: a review of its clinical properties in the management of hepatic disorders
    • Wellington, K., and Jarvis, B. (2001). Silymarin: a review of its clinical properties in the management of hepatic disorders. BioDrugs 15, 465-489. doi: 10.2165/00063030-200115070-00005.
    • (2001) BioDrugs , vol.15 , pp. 465-489
    • Wellington, K.1    Jarvis, B.2
  • 220
    • 0033662614 scopus 로고    scopus 로고
    • The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers
    • Wesnes, K. A., Ward, T., McGinty, A., and Petrini, O. (2000). The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers. Psychopharmacology 152, 353-361. doi: 10.1007/s002130000533.
    • (2000) Psychopharmacology , vol.152 , pp. 353-361
    • Wesnes, K.A.1    Ward, T.2    McGinty, A.3    Petrini, O.4
  • 221
    • 34250785095 scopus 로고    scopus 로고
    • Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice
    • Wolf, K. K., Wood, S. G., Allard, J. L., Hunt, J. A., Gorman, N., Walton-Strong, B. W., et al. (2007). Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice. Drug Metab. Dispos. 35, 1223-1231. doi: 10.1124/dmd.107.014738.
    • (2007) Drug Metab. Dispos , vol.35 , pp. 1223-1231
    • Wolf, K.K.1    Wood, S.G.2    Allard, J.L.3    Hunt, J.A.4    Gorman, N.5    Walton-Strong, B.W.6
  • 222
    • 34250341208 scopus 로고    scopus 로고
    • Genomic profiling in nuclear receptor-mediated toxicity
    • Woods, C. G., Vanden Heuvel, J. P., and Rusyn, I. (2007). Genomic profiling in nuclear receptor-mediated toxicity. Toxicol. Pathol. 35, 474-494. doi: 10.1080/01926230701311351.
    • (2007) Toxicol. Pathol , vol.35 , pp. 474-494
    • Woods, C.G.1    Vanden Heuvel, J.P.2    Rusyn, I.3
  • 223
    • 18544405782 scopus 로고
    • Effects of dietary protein deficiency on the conjugation of foreign compounds in rat liver
    • Wood, G. C., and Woodcock, B. G. (1970). Effects of dietary protein deficiency on the conjugation of foreign compounds in rat liver. J. Pharm. Pharmacol. Suppl:60S+. doi: 10.1111/j.2042-7158.1970.tb08581.x.
    • (1970) J. Pharm. Pharmacol
    • Wood, G.C.1    Woodcock, B.G.2
  • 224
    • 0034988218 scopus 로고    scopus 로고
    • Evaluation of hepatoprotective activity of legumes
    • Wu, S. J., Wang, J. S., Lin, C. C., and Chang, C. H. (2001). Evaluation of hepatoprotective activity of legumes. Phytomedicine 8, 213-219. doi: 10.1078/0944-7113-00033.
    • (2001) Phytomedicine , vol.8 , pp. 213-219
    • Wu, S.J.1    Wang, J.S.2    Lin, C.C.3    Chang, C.H.4
  • 225
    • 34250303950 scopus 로고    scopus 로고
    • Prevention of early liver injury by breviscapine in streptozotocin-induced diabetic rats
    • Wu, Y. G., Xia, L. L., Lin, H., Zhou, D., Qian, H., and Lin, S. T. (2007b). Prevention of early liver injury by breviscapine in streptozotocin-induced diabetic rats. Planta Med. 73, 433-438. doi: 10.1055/s-2007-967182.
    • (2007) Planta Med , vol.73 , pp. 433-438
    • Wu, Y.G.1    Xia, L.L.2    Lin, H.3    Zhou, D.4    Qian, H.5    Lin, S.T.6
  • 226
    • 33847100476 scopus 로고    scopus 로고
    • Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats
    • Wu, Y., Li, L., Wen, T., and Li, Y. Q. (2007a). Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats. Toxicology 232, 50-56. doi: 10.1016/j.tox.2006.12.013.
    • (2007) Toxicology , vol.232 , pp. 50-56
    • Wu, Y.1    Li, L.2    Wen, T.3    Li, Y.Q.4
  • 227
    • 33748929885 scopus 로고    scopus 로고
    • Protective effect of tanshinones against liver injury in mice loaded with restraint stress
    • Xu, J. K., Hiroshi, K., Zheng, J. J., Jiang, T., and Yao, X. S. (2006). Protective effect of tanshinones against liver injury in mice loaded with restraint stress. Yao Xue Xue Bao 41, 631-635.
    • (2006) Yao Xue Xue Bao , vol.41 , pp. 631-635
    • Xu, J.K.1    Hiroshi, K.2    Zheng, J.J.3    Jiang, T.4    Yao, X.S.5
  • 228
    • 28644447262 scopus 로고    scopus 로고
    • Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity
    • Yamazaki, Y., Kakizaki, S., Horiguchi, N., Takagi, H., Mori, M., and Negishi, M. (2005). Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity. World J. Gastroenterol. 11, 5966-5972. doi: 10.3748/wjg.v11.i38.5966.
    • (2005) World J. Gastroenterol , vol.11 , pp. 5966-5972
    • Yamazaki, Y.1    Kakizaki, S.2    Horiguchi, N.3    Takagi, H.4    Mori, M.5    Negishi, M.6
  • 229
    • 79960108778 scopus 로고    scopus 로고
    • Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats
    • Yang, L., Wang, C. Z., Ye, J. Z., and Li, H. T. (2011). Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats. Fitoterapia 82, 834-840. doi: 10.1016/j.fitote.2011.04.009.
    • (2011) Fitoterapia , vol.82 , pp. 834-840
    • Yang, L.1    Wang, C.Z.2    Ye, J.Z.3    Li, H.T.4
  • 230
    • 84901803469 scopus 로고    scopus 로고
    • A systematic review on natural medicines for the prevention and treatment of Alzheimer's disease with meta-analyses of intervention effect of ginkgo
    • Yang, M., Xu, D. D., Zhang, Y., Liu, X., Hoeven, R., and Cho, W. C. (2014a). A systematic review on natural medicines for the prevention and treatment of Alzheimer's disease with meta-analyses of intervention effect of ginkgo. Am. J. Chin. Med. 42, 505-521. doi: 10.1142/S0192415X14500335.
    • (2014) Am. J. Chin. Med , vol.42 , pp. 505-521
    • Yang, M.1    Xu, D.D.2    Zhang, Y.3    Liu, X.4    Hoeven, R.5    Cho, W.C.6
  • 231
    • 84930903372 scopus 로고    scopus 로고
    • Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials
    • Yang, Z., Zhuang, L., Lu, Y., Xu, Q., and Chen, X. (2014b). Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. Biomed Res Int. 2014:941085. doi: 10.1155/2014/941085.
    • (2014) Biomed Res Int , vol.2014
    • Yang, Z.1    Zhuang, L.2    Lu, Y.3    Xu, Q.4    Chen, X.5
  • 232
    • 35948958234 scopus 로고    scopus 로고
    • Interaction of herbal constituents with cytochrome P450 Enz
    • Yarnell, E., and Abascal, K. (2007). Interaction of herbal constituents with cytochrome P450 Enz. Alternat. Complement. Ther. 13, 239-247. doi: 10.1089/act.2007.13508.
    • (2007) Alternat. Complement. Ther , vol.13 , pp. 239-247
    • Yarnell, E.1    Abascal, K.2
  • 233
    • 79951581293 scopus 로고    scopus 로고
    • Silibinin: a novel inhibitor of Aβ aggregation
    • Yin, F., Liu, J., Ji, X., Wang, Y., Zidichouski, J., and Zhang, J. (2011). Silibinin: a novel inhibitor of Aβ aggregation. Neurochem. Int. 58, 399-403. doi: 10.1016/j.neuint.2010.12.017.
    • (2011) Neurochem. Int , vol.58 , pp. 399-403
    • Yin, F.1    Liu, J.2    Ji, X.3    Wang, Y.4    Zidichouski, J.5    Zhang, J.6
  • 235
    • 33846274151 scopus 로고    scopus 로고
    • Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats
    • Young, S. C., Wang, C. J., Lin, J. J., Peng, P. L., Hsu, J. L., and Chou, F. P. (2007). Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats. Arch. Toxicol. 81, 45-55. doi: 10.1007/s00204-006-0106-0.
    • (2007) Arch. Toxicol , vol.81 , pp. 45-55
    • Young, S.C.1    Wang, C.J.2    Lin, J.J.3    Peng, P.L.4    Hsu, J.L.5    Chou, F.P.6
  • 236
    • 0037376253 scopus 로고    scopus 로고
    • Intraspecific relationship analysis by DNA markers and in vitro cytotoxic and antioxidant activity in Eleutherococcus senticosus
    • Yu, C. Y., Kim, S. H., Lim, J. D., Kim, M. J., and Chung, I. M. (2003). Intraspecific relationship analysis by DNA markers and in vitro cytotoxic and antioxidant activity in Eleutherococcus senticosus. Toxicol. In Vitro 17, 229-236. doi: 10.1016/S0887-2333(03)00008-0.
    • (2003) Toxicol. In Vitro , vol.17 , pp. 229-236
    • Yu, C.Y.1    Kim, S.H.2    Lim, J.D.3    Kim, M.J.4    Chung, I.M.5
  • 237
    • 84928965113 scopus 로고    scopus 로고
    • Resveratrol, a natural antioxidant, has a protective effect on liver injury induced by inorganic arsenic exposure
    • Zhang, Z., Gao, L., Cheng, Y., Jiang, J., Chen, Y., Jiang, H., et al. (2014). Resveratrol, a natural antioxidant, has a protective effect on liver injury induced by inorganic arsenic exposure. Biomed. Res. Int. 2014:617202. doi: 10.1155/2014/617202.
    • (2014) Biomed. Res. Int , vol.2014
    • Zhang, Z.1    Gao, L.2    Cheng, Y.3    Jiang, J.4    Chen, Y.5    Jiang, H.6
  • 238
    • 34447326702 scopus 로고    scopus 로고
    • Protective effect of total flavonoids from Bidens bipinnata L. against carbon tetrachloride-induced liver injury in mice
    • Zhong, M. M., Chen, F. H., Yuan, L. P., Wang, X. H., Wu, F. R., Yuan, F. L., et al. (2007). Protective effect of total flavonoids from Bidens bipinnata L. against carbon tetrachloride-induced liver injury in mice. J. Pharm. Pharmacol. 59, 1017-1025. doi: 10.1211/jpp.59.7.0015.
    • (2007) J. Pharm. Pharmacol , vol.59 , pp. 1017-1025
    • Zhong, M.M.1    Chen, F.H.2    Yuan, L.P.3    Wang, X.H.4    Wu, F.R.5    Yuan, F.L.6
  • 239
    • 0033594891 scopus 로고    scopus 로고
    • Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention
    • Zi, X., and Agarwal, R. (1999). Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention. Proc. Natl. Acad. Sci. U.S.A. 96, 7490-7495. doi: 10.1073/pnas.96.13.7490.
    • (1999) Proc. Natl. Acad. Sci. U.S.A , vol.96 , pp. 7490-7495
    • Zi, X.1    Agarwal, R.2
  • 240
    • 0032080609 scopus 로고    scopus 로고
    • A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclindependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells
    • Zi, X., Grasso, A. W., Kung, H.-J., and Agarwal, R. (1998). A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclindependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells. Cancer Res. 58, 1920-1929.
    • (1998) Cancer Res , vol.58 , pp. 1920-1929
    • Zi, X.1    Grasso, A.W.2    Kung, H.-J.3    Agarwal, R.4
  • 241
    • 0031561420 scopus 로고    scopus 로고
    • Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of m RNA expression of an endogenous tumor promoter TNF-a
    • Zi, X., Mukhtar, H., and Agarwal, R. (1997). Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of m RNA expression of an endogenous tumor promoter TNF-a. Biochem. Biophys. Res. Commun. 239, 334-339. doi: 10.1006/bbrc.1997.7375.
    • (1997) Biochem. Biophys. Res. Commun , vol.239 , pp. 334-339
    • Zi, X.1    Mukhtar, H.2    Agarwal, R.3
  • 242
    • 33748426177 scopus 로고    scopus 로고
    • Prevention of hepatic injury by a traditional Chinese formulation, BJ-JN, in mice treated with Bacille-Calmette-Guérin and lipopolysaccharide
    • Zou, Y., Yang, Y., Li, J., Li, W., and Wu, Q. (2006). Prevention of hepatic injury by a traditional Chinese formulation, BJ-JN, in mice treated with Bacille-Calmette-Guérin and lipopolysaccharide. J. Ethnopharmacol. 107, 442-448. doi: 10.1016/j.jep.2006.04.006.
    • (2006) J. Ethnopharmacol , vol.107 , pp. 442-448
    • Zou, Y.1    Yang, Y.2    Li, J.3    Li, W.4    Wu, Q.5


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