A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection

Current Drug Metabolism

Volumn 4, Issue 1, 2003, Pages 59-72

  Sonoda, J ^a   Rosenfeld, J M ^a   Xu, L ^b   Evans, R M ^a   Xie, W ^b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; ANDROGEN RECEPTOR; BROMETHOL; CALCITRIOL; CYCLOSPORIN; CYTOCHROME P450 2B; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; DEXAMETHASONE; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE; GLUTATHIONE; HYPERICUM PERFORATUM EXTRACT; IMMUNOSUPPRESSIVE AGENT; MIDAZOLAM; MORPHINE; NUCLEAR HORMONE RECEPTOR; ORAL CONTRACEPTIVE AGENT; PHENOBARBITAL; PREGNANE X RECEPTOR; PROTEINASE INHIBITOR; RIFAMPICIN; STEROID RECEPTOR; SULFOTRANSFERASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID; VITAMIN D RECEPTOR; XENOBIOTIC AGENT; ZOXAZOLAMINE;

CELL CULTURE; DRUG ANTAGONISM; DRUG CONJUGATION; DRUG GLUCURONIDATION; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; ENZYME REGULATION; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; GENETIC CODE; GENETIC ENGINEERING; GENOTOXICITY; HORMONE RESPONSIVE ELEMENT; HUMAN; HYPERICUM PERFORATUM; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHARMACOGENETICS; PROMOTER REGION; REVIEW; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION; XENOBIOTIC METABOLISM;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; PHARMACEUTICAL PREPARATIONS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; XENOBIOTICS;

EID: 0037303706     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200033336739     Document Type: Review

References (136)

1. Mangelsdorf, D.J. and Evans, R.M. (1995) Cell, 83, 841-850.
2. Blumberg, B. and Evans, R. M. (1998) Genes Dev., 12, 3149-3155.
3. Savas, U.; Griffin, K. J. and Johnson, E. F. (1999) Mol. Pharmacol., 56, 851-857.
4. Waxman, D. J. (1999) Arch. Biochem. Biophys., 369, 11-23.
5. Xie, W. and Evans, R.M. (2001) J. Biol. Chem., 276(41), 37739-37742.
6. Xie, W. and Evans, R.M. (2002) Drug Discov.Today, 7(9), 509-515.
7. Sueyoshi, T. and Negishi, M. (2001) Annu. Rev. Pharmacol. Toxicol., 41, 123-143.
8. Tzameli I, and Moore D.D. (2001) Trends Endocrinol. Metab., 12(1), 7-10.
9. Goodwin, B.; Redinbo, M.R. and Kliewer, S.A. (2002) Annu. Rev. Pharmacol. Toxicol., 42, 1-23.
10. Liddle, C. and Goodwin, B. (2002) Semin. Liver Dis., 22(2), 115-122.
11. Gonzalez, F. J. (1992) Trends Pharmacol. Sci., 13, 346-352.
12. Denison, M. S. and Whitlock, J. P. Jr. (1995) J. Biol. Chem., 270, 18175-18178.
13. Maurel, P. (1996) Cytochrome P450: Metabolic and Toxicological Aspects (Ioannides, C. Eds), CRC Press, Boca Raton, FL., pp. 241-270.
14. Bocherding, S.M.; Baciewicz, A.M. and Self, T.H. (1992) Arch. Intern. Med., 152, 711-716.
15. Hebert, M.F; Roberts, J.P; Prueksaritanont, T. and Benet, L.Z. (1992) Clin. Pharmacol. Ther., 52, 453-457.
16. Moore, L. B.; Goodwin, B.; Jones, S. A.; Wisely, G. B.; Serabjit-Singh, C. J.; Willson, T. M.; Collins, J. L. and Kliewer, S. A. (2000) Proc. Natl. Acad. Sci. USA, 97, 7500-7502.
17. Fugh-Berman, A. (2000) Lancet, 355, 134-138.
18. Piscitelli, S. C.; Burstein, A. H.; Chaitt, D.; Alfaro, R. M. and Falloon, J. (2000) Lancet, 355, 547-548.
19. Ruschitzka, F.; Meier, P. J.; Turina, M.; Luscher, T. F. and Noll, G. (2000) Lancet, 355, 548-549.
20. Blumberg, B; Sabbagh, Jr., W.; Juguilon, H; Bolado, J. Jr.; van Meter, C. M.; Ong, E. S. and Evans, R. M. (1998) Genes Dev., 12, 3195-3205.
21. Kliewer, S.A.; Moore, J.T.; Wade, L.; Staudinger, J.L.; Watson, M.A.; Jones, S.A.; McKee, D.D.; Oliver, B.B.; Willson, T.M.; Zetterstrom, R.H.; Perlmann, T. and Lehmann, J.M. (1998) Cell, 92, 73-82.
22. Bertilsson, G.; Heidrich, J.; Svensson, K.; Asman, M.; Jendeberg, L.; Sydow-Backman, M.; Ohlsson, R.; Postlind, H.; Blomquist, P.and Berkenstam, A. (1998) Proc. Natl. Acad. Sci. USA, 95, 12208-12213.
23. Lehmann, J.M.; McKee, D.D.; Watson, M.A.; Willson, T.M.; Moore, J.T.and Kliewer, S.A. (1998) J. Clin. Invest., 102, 1016-1023.
24. Xie, W.; Barwick, J. L.; Downes, M.; Blumberg, B.; Simon, C. M.; Nelson, M. C.; Neuschwander-Tetri, B. A.; Brunt, E. M.; Guzelian, P. S. and Evans, R. M. (2000) Nature, 406(6794), 435-439.
25. Staudinger. J.L.; Goodwin, B.; Jones, S.A.; Hawkins-Brown, D.; MacKenzie, K.I.; LaTour, A.; Liu, Y.; Klaassen, C.D.; Brown, K.K.; Reinhard, J.; Willson, T.M.; Koller, B.H. and Kliewer, S.A. (2001) Proc. Natl. Acad. Sci. USA, 98(6), 3369-3374.
26. Quattrochi, L.C. and Guzelian, P.S. (2001) Drug Metab. Dispos., 29(5), 615-622.
27. Gibson, G.G.; Plant, N.J.; Swales, K.E.; Ayrton, A. and El-Sankary, W. (2002) Xenobiotica, 32(3),165-206.
28. Watkins, R..E; Wisely, G.B.; Moore, L.B.; Collins, J.L.; Lambert, M.H.; Williams, S.P.; Willson, T.M.; Kliewer, S.A. and Redinbo, M.R. (2001) Science, 292(5525), 2329-2333.
29. Watkins, R.E.; Noble, S.M. and Redinbo, M.R. (2002) Curr. Opin. Drug Discov. Devel., 5(1), 150-158.
30. Ekins, S. and Schuetz, E. (2002) Trends Pharmacol. Sci., 23(2), 49-50.
31. Barwick, J. L.; Quattrochi, L. C.; Mills, A. S.; Potenza, C.; Tukey, R. H. and Guzelian, P.S. (1996) Mol. Pharmacol., 50, 10-16.
32. Nelson, D.R. (1999) Achiev. Biochem. Biophy., 369, 1-10.
33. Gillam, E.M. (2001) Trends Pharmacol. Sci., 22(9), 448.
34. Moore, J.T. and Kliewer, S.A. (2000) Toxicology, 153(1-3), 1-10.
35. Honkakoski, P.; Zelko, I.; Sueyoshi, T. and Negishi, M. (1998) Mol. Cell. Biol., 18(10), 5652-5658.
36. Trottier, E.; Belzil, A.; Stoltz, C. and Anderson, A. (1995) Gene, 158, 263-268.
37. Park, Y.; Li, H. and Kemper, B. (1996) J. Biol. Chem., 271, 23725-23728.
38. Honkakoski, P. and Negishi, M. (1997) J. Biol. Chem., 272, 14943-14949.
39. Wei, P.; Zhang, J.; Egan-Hafley, M.; Liang, S. and Moore, D. D. (2000) Nature, 407, 920-923.
40. Forman, B. M.; Tzameli, I.; Choi, H.S.; Chen, J.; Simha, D.; Seol, W.; Evans, R. M. and Moore, D.D., (1998) Nature, 395(6702), 612-615.
41. Sueyoshi, T.; Kawamoto, T.; Zelko, I.; Honkakoski, P. and Negishi, M. (1999) J. Biol. Chem., 274, 6043-6046.
42. Kawamoto, T; Sueyoshi, T; Zelko, I;Moore, R; Washburn, K; Negishi, M. (1999) Mol. Cell. Biol., 19(9), 6318-6322.
43. Xie, W.; Barwick, J.L.; Simon C.M.; Pierce A.M.; Safe S.; Blumberg B.; Guzelian P.S.; Evans R.M. (2000) Genes and Dev., 14, 3014-3023.
44. Tzameli, I.; Pissios, P.; Schuetz, E.G. and Moore, D.D. (2000) Mol. Cell Biol., 20(9), 2951-2958.
45. Goodwin, B.; Moore, L.B.; Stoltz, C.M.; McKee, D.D. and Kliewer, S.A. (2001) Mol. Pharmacol., 60(3), 427-431.
46. Xie, W.; Radominska-Pandya, A.; Shi, Y.; Simon, C.M.; Nelson, M.C.; Ong, E.S.; Waxman, D.J. and Evans, R.M. (2001) Proc. Natl. Acad. Sci. USA, 98(6), 3375-3380.
47. Strom, S. C.; Pisarov, L. A.; Dorko, K.; Thompson, M. T.; Schuetz, J. D. and Schuetz, E. G. (1996) Methods Enzymol., 272, 388-400.
48. Honkakoski, P.; Moore, R.; Gynther, J.; and Negishi, M. (1996) J. Biol. Chem., 271, 9746-9753.
49. Schmiedlin-Ren, P.; Thummel, K.E.; Fisher, J.M.; Paine, M.F.; Lown, K.S. and Watkins, P.B. (1997) Mol. Pharmacol., 51(5),741-754.
50. Schmiedlin-Ren, P.; Thummel, K.E.; Fisher J.M.; Paine, M.F.; Watkins, P.B. (2001) Drug Metab. Dispos., 29(11), 1446-1453.
51. Thummel, K.E.; Brimer, C.; Yasuda, K.; Thottassery, J.; Senn, T.; Lin, Y.; Ishizuka, H.; Kharasch, E.; Schuetz, J. and Schuetz, E. (2001) Mol. Pharmacol., 60(6), 1399-1406.
52. Drocourt, L.; Ourlin, J.C.; Pascussi, J.M.; Maurel, P. and Vilarem, M.J. (2002) J. Biol. Chem., 277(28), 25125-25132.
53. Pence, B.C. and Buddingh, F. (1988) Carcinogenesis, 9(1), 187-190.
54. Kawaura, A.; Tanida, N.; Sawada, K.; Oda, M. and Shimoyama, T. (1989) Carcinogenesis, 10(4), 647-649.
55. Wietholtz, H. ; Marschall, H. U.; Sjovall, J. and S. Matern. (1996) J. Hepatol., 24, 713-718.
56. Pillot, T.; Ouzzine, M.; Fournel-Gigleux, S.; Lafaurie, C.; Radominska, A.; Burchell, B.; Siest, G. and Magdalou, J. (1993) J. Biol. Chem., 268, 25636-25642.
57. Radominska-Pyrek, A.; Zimniak, P.; Irshaid, Y.M.; Lester, R.; Tephly, T.R. and St Pyrek, J. (1987) J. Clin. Invest., 80, 234-241.
58. Makishima, M.; Lu, T.T.; Xie, W.; Whitefield, G.K.; Domoto, H.; Evans, R.M.; Haussler, M.R. and Mangelsdorf, D.J. (2002) Science, 296, 1313-1316.
59. Zhang, J.; Kuehl, P.; Green, E.D.; Touchman, J.W.; Watkins, P.B.; Daly, A.; Hall, S.D.; Maurel, P.; Relling, M.; Brimer, C.; Yasuda, K., Wrighton, S.A.; Hancock, M.; Kim, R.B.; Strom, S.; Thummel, K.; Russell, C.G.; Hudson, J.R. Jr.; Schuetz, E.G. and Boguski, M.S. (2001) Pharmacogenetics, 11(7), 555-572.
60. Hustert. E; Zibat, A.; Presecan-Siedel, E.; Eiselt, R.; Mueller, R.; Fuss, C.; Brehm, I.; Brinkmann, U.; Eichelbaum, M.; Wojnowski, L. and Burk, O. (2001) Drug Metab. Dispos., 29(11),1454-1459.
61. Forman, B.M. (2001) Pharmacogenetics, 11(7), 551-552.
62. Shimada, T.; Yamazaki, H.; Mimura, M.; Wakamiya, N.; Ueng, Y.F.; Guengerich, F.P. and Inui, Y. (1996) Drug Metab. Dispos., 24(5), 515-522.
63. Komori, M.; Nishio, K.; Kitada, M.; Shiramatsu, K.; Muroya, K.; Soma, M.; Nagashima, K; Kamataki, T. (1990) Biochemistry, 29(18), 4430-4433.
64. Schuetz, J.D.; Beach, D.L. and Guzelian, P.S. (1994) Pharmacogenetics, 4(1), 11-20.
65. Greuet, J.; Pichard, L.; Bonfils, C.; Domergue, J. and Maurel, P. (1996) Biochem. Biophys. Res. Commun., 225(2), 689-694.
66. Burk, O.; Tegude, H.; Koch, I.; Hustert, E.; Wolbold, R.; Glaeser, H.; Klein, K.; Fromm M.F.; Nuessler, A.K.; Neuhaus, P.; Zanger, U.M.; Eichelbaum, M. and Wojnowski, L. (2002) J. Biol. Chem., 277(27), 24280-24288.
67. Pascussi, J.M.; Jounaidi, Y.; Drocourt, L.; Domergue, J.; Balabaud, C.; Maurel, P. and Vilarem, M.J. (1999) Biochem. Biophys. Res. Commun., 260(2), 377-381.
68. Hayes, J.D. and Pulford, D.J. (1995) Crit. Rev. Biochem. Mol. Biol., 30(6), 445-600.
69. Salinas, A.E. and Wong, M.G. (1999) Curr. Med. Chem., 6(4), 279-309.
70. Nagata, K. and Yamazoe, Y. (2000) Annu. Rev. Pharmacol. Toxicol., 40, 159-176.
71. Tukey, R.H. and Strassburg, C.P. (2000) Annu. Rev. Pharmacol. Toxicol., 40, 581-616.
72. Sheweita, S.A. (2000) Curr. Drug Metab., 1(2), 107-32.
73. Guengerich, F.P. (2000) Carcinogenesis, 21(3), 345-351.
74. Christensen C B and Jorgensen L. N. (1987) Pharmacol. Toxicol., 60, 75-76.
75. Kaplowitz, N.; Kuhlekamp, J. and Clifton, G. (1975) Biochem. J., 146(2), 351-356.
76. Adachi, Y.; Nanno, T.; Yamashita, M.; Ueshima, S. and Yamamoto, T. (1985) Gastroenterol. Jpn., 20(2), 104-10.
77. Liu, L. and Klaassen, C.D. (1996) Drug Metab. Dispos., 24(8), 854-858.
78. Runge-Morris, M.; Rose, K.; Falany, C.N. and Kocarek, T.A. (1998) Drug Metab. Dispos., 26(8), 795-801.
79. Garcia-Allan, C.; Lord, P.G.; Loughlin, J.M.; Orton, T.C. and Sidaway, J.E. (2000) J. Biochem. Mol. Toxicol., 14(2), 65-72.
80. Rae, J.M.; Johnson, M.D.; Lippman, M.E. and Flockhart, D.A. (2001) J. Pharmacol. Exp. Ther., 299(3), 849-857.
81. Vansell, N.R. and Klaassen, C.D. (2002) Drug Metab. Dispos., 30(3), 240-246.
82. Mackenzie, P.I; Owens, I.S.; Burchell, B.; Bock, K.W.; Bairoch, A.; Belanger, A.; Fournel-Gigleux, S.; Green, M.; Hum, D.W.; Iyanagi, T.; Lancet, D.; Louisot, P.; Magdalou, J.; Chowdhury, J.R.; Ritter, J.K.; Schachter, H.; Tephly, T.R.; Tipton, K.F.; Nebert, D.W. (1997) Pharmacogenetics, 7(4), 255-69.
83. Harding, D.; Jeremiah, S.J.; Povey, S. and Burchell, B. (1990) Ann. Hum. Genet., 54, 17-21.
84. Hu, Z. and Wells, P.G. (1992) J. Pharmacol. Exp. Ther., 263(1), 334-342.
85. de Morais, S.M. and Wells, P.G. (1988) J. Pharmacol. Exp. Ther., 247(1), 323-31.
86. Raheja, K.L.; Linscheer, W.G. and Cho, C. (1983) J. Toxicol. Environ. Health, 12(1), 143-158.
87. Strassburg, C. P.; Manns, M. P. and Tukey, R. H. (1997) Cancer Res., 57, 2979-2985.
88. Mackenzie, P.I.; Gonzalez, F.J. and Owens, I.S. (1984) J. Biol. Chem., 259(19), 12153-12160.
89. Berk, P.D. (1994) Semin. Liver Dis., 14(4), 321-332.
90. Sugatani, J.; Kojima, H.; Ueda, A.; Kakizaki, S.; Yoshinari, K.; Gong, Q.H.; Owens, I.S.; Negishi, M. and Sueyoshi, T. (2001) Hepatology, 33(5), 1232-1238.
91. Jemnitz, K.; Lengyel, G. and Vereczkey, L. (2002) Biochem. Biophys. Res. Commun., 291(1), 29-33.
92. Cancado, E.L.; Leitao, R.M.; Carrilho, F.J. and Laudanna, A.A. (1998) Am. J. Gastroenterol., 93(9), 1510-1517.
93. Magdalou, J.; Fournel-Gigleux, S.; Pritchard, M. and Siest, G. (1993) Biol. Cell, 77(1), 13-16.
94. Issemann, I. and Green, S. (1990) Nature, 347(6294), 645-650.
95. Lee, S.S.; Pineau, T.; Drago, J.; Lee, E.J.; Owens, J.W.; Kroetz, D.L.; Fernandez-Salguero, P.M.; Westphal, H. and Gonzalez, F.J. (1995) Mol. Cell. Biol., 15(6), 3012-3022.
96. Negishi, M.; Pedersen, L.G.; Petrotchenko, E.; Shevtsov, S.; Gorokhov, A.; Kakuta, Y and Pedersen, L.C. (2001) Arch. Biochem. Biophys., 390(2), 149-157.
97. Morris, M.E. and Pang, K.S. (1987) J. Pharmacokinet. Biopharm., 15(5), 473-496.
98. Qian, Y.M.; Sun, X.J.; Tong, M.H.; Li, X.P.; Richa, J. and Song, W.C. (2001) Endocrinology, 142(12), 5342-5350.
99. Falany, J.L. and Falany, C.N. (1996) Endocrinology, 137(4), 1395-401.
100. Song, C.S.; Jung, M.H.; Kim, S.C.; Hassan, T.; Roy, A.K. and Chatterjee, B. (1998) J. Biol. Chem., 273(34), 21856-21866.
101. Qian, Y.M. and Song, W.C. (1999) Endocrinology, 140(3), 1048-1053.
102. Seth, P.; Lunetta, K.L.; Bell, D.W.; Gray, H.; Nasser, S.M.; Rhei, E.; Kaelin, C.M.; Iglehart, D.J.; Marks, J.R.; Garber, J.E.; Haber, D.A. and Polyak, K. (2000) Cancer Res., 60(24), 6859-6863.
103. Borthwick, E.B.,:Coughtrie, M.W. and Burchell, A. (1995) J. Steroid Biochem. Mol. Biol., 55(2), 255-259.
104. Borthwick, E.B.; Voice, M.W.; Burchell, A. and Coughtrie, M.W. (1995) Biochem. Pharmacol., 49(10), 1381-1386.
105. Klaassen, C.D.; Liu, L. and Dunn, R.T., 2nd (1998) Chem. Biol. Interact., 109(1-3), 299-313.
106. Forman, B. M.; Goode, E.; Chen, J.; Oro, A. E.; Bradley, D. J.; Perlmann, T.; Noonan, D. J.; Burka, L. T.; McMorris, T. and Lamph, W. W. (1995) Cell, 81(5), 687-693.
107. Wang, H.; Chen, J.; Hollister, K.; Sowers, L. C. and Forman, B. M. (1999) Mol. Cell, 3, 543-553.
108. Parks, D. J.; Blanchard, S. G.; Bledsoe, R. K.; Chandra, G.; Consler, T. G.; Kliewer, S. A.; Stimmel, J. B.; Willson, T. M.; Zavacki, A. M.; Moore, D. D. and Lehmann, J. M. (1999) Science, 284, 1365-1368.
109. Makishima, M.; Okamoto, A. Y.; Repa, J. J.; Tu, H.; Learned, R. M.; Luk, A.; Hull, M. V.; Lustig, K. D.; Mangelsdorf, D. J. and Shan, B. (1999) Science, 284, 1362-1365.
110. Lu, T. T.; Makishima, M.; Repa, J. J.; Schoonjans, K.; Kerr, T. A.; Auwerx, J. and Mangelsdorf, D. J. (2000) Mol. Cell, 6, 507-515.
111. Goodwin, B.; Jones, S. A.; Price, R. R.; Watson, M. A.; McKee, D. D.; Moore, L. B.; Galardi, C.; Wilson,. J. G.; Lewis, M. C.; Roth, M. E.; Maloney, P. R.; Willson, T. M. and Kliewer, S. A. (2000) Mol. Cell, 6, 517-526.
112. Chawla, A.; Saez, E. and Evans, R. M. (2000) Cell, 103, 1-4.
113. Radominska, A.; Treat, S. and Little, J. (1993) Sem. in Liver Disease, 13, 219-234.
114. Iqbal, S.; Vickers, C. and Elias, E. (1990) J. Hepatol., 11(1), 37-42.
115. Fischer, S.; Beuers, U.; Spengler, U.; Zwiebel, F.M. and Koebe, H.G. (1996) Clin. Chim. Acta, 251(2), 173-186.
116. Elekima, O.T.; Mills, C.O.; Ahmad, A.; Skinner, G.R.; Ramsden, D.B.; Bown, J.; Young, T.W. and Elias, E. (2000) Liver 20(1), 45-50.
117. Schuetz, E.G.; Strom, S.; Yasuda, K.; Lecureur, V.; Assem, M.; Brimer, C.; Lamba, J.; Kim, R.B.; Ramachandran, V.; Komoroski, B.J.; Venkataramanan, R.; Cai, H.; Sinal, C.J.; Gonzalez, F.J. and Schuetz, J.D. (2001) J. Biol. Chem., 276(42), 39411-39418.
118. Zhong, S.; Howie, A.F.; Ketterer, B.; Taylor, J.; Hayes, J.D.; Beckett, G.J.; Wathen, C.G.; Wolf, C.R. and Spurr, N.K. (1991) Carcinogenesis, 12(9), 1533-1537.
119. Ueda, A.; Hamadeh, H.K.; Webb, H.K.; Yamamoto, Y.; Sueyoshi, T.; Afshari, C.A.; Lehmann, J.M. and Negishi, M. (2002) Mol. Pharmacol., 61(1), 1-6.
120. Falkner, K.C.; Pinaire, J.A.; Xiao, G.H.; Geoghegan, T.E. and Prough, R.A. (2001) Mol. Pharmacol., 60(3), 611-619.
121. Schuetz, E.G.; Schinkel, A.H.; Relling, M.V. and Schuetz, J.D. (1996) Proc. Natl. Acad. Sci. USA, 93(9), 4001-4005.
122. Kim, R.B.; Wandel, C.; Leake, B.; Cvetkovic, M.; Fromm, M.F.; Dempsey, P.J.; Roden, M.M.; Belas, F.; Chaudhary, A.K.; Roden, D.M.; Wood, A.J. and Wilkinson, G.R. (1999) Pharm. Res., 16(3), 408-414.
123. Lan, L.B.; Dalton, J.T. and Schuetz, E.G. (2000) Mol. Pharmacol., 58(4), 863-869.
124. Synold, T. W.; Dussault, I. and Forman, B. M. (2001) Nat. Med., 7, 584-590
125. Geick, A.; Eichelbaum, M. and Burk, O. (2001) J. Biol. Chem., 276(18),14581-14587.
126. Guo, G.L.; Staudinger, J.; Ogura, K.; Klaassen, C.D. (2002) Mol. Pharmacol., 61(4), 832-839.
127. Guo, G.L.; Johnson, D.R. and Klaassen, C.D. (2002) Drug Metab. Dispos., 30(3), 283-288.
128. Dussault, I.; Lin, M.; Hollister, K.; Wang, E. H.; Synold, T. W. and Forman, B. M. (2001) J. Biol. Chem., 276, 33309-33312.
129. Kast, H.R.; Goodwin, B.; Tarr, P.T.; Jones, S.A.; Anisfeld, A.M.; Stoltz, C.M.; Tontonoz, P.; Kliewer, S.; Willson, T.M. and Edwards, P.A. (2002) J. Biol. Chem., 277(4), 2908-2915.
130. Kauffmann, H.M.; Pfannschmidt, S.; Zoller, H.; Benz, A.; Vorderstemann, B.; Webster, J.I. and Schrenk, D. (2002) Toxicology, 171(2-3), 137-146.
131. Araya, Z. and Wikvall, K. (1999) Biochim. Biophys. Acta, 1438(1), 47-54.
132. Bachs, L.; Pares, A.; Elena, M.; Piera, C. and Rodes, J. 1989) Lancet, 1(8638), 574-576.
133. Bachs, L.; Pares, A.; Elena, M.; Piera, C. and Rodes, J. (1992) Gastroenterology, 102(6), 2077-2080.
134. Gillespie, D.A. and Vickers, C.R. (1993) J. Gastroenterol. Hepatol., 8(2), 168-173.
135. Rushmore, T.H. and Pickett, C.B. (1990) J. Biol. Chem., 265(24), 14648-14653.
136. Ma, Q. (2001) Curr. Drug Metab., 2(2), 149-164.