Resveratrol ameliorates methotrexate-induced hepatotoxicity in rats via inhibition of lipid peroxidation

Human and Experimental Toxicology

Volumn 32, Issue 6, 2013, Pages 662-671

  Dalaklioglu, S ^a   Genc, G E ^a   Aksoy, N H ^b   Akcit, F ^c   Gumuslu, S ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

^b Ataturk Government Hospital   (Turkey)

^c Department of Biochemistry   (Turkey)

Author keywords

hepatotoxicity; lipid peroxidation; methotrexate; Resveratrol

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CATALASE; GLUTATHIONE TRANSFERASE; LIPID; METHOTREXATE; RESVERATROL; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER PROTECTION; LIVER TOXICITY; MALE; MICROSCOPY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

HEPATOTOXICITY; LIPID PEROXIDATION; METHOTREXATE; RESVERATROL;

ANIMALS; CATALASE; DRUG-INDUCED LIVER INJURY; ENZYME INHIBITORS; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; MALE; METHOTREXATE; RATS; RATS, WISTAR; STILBENES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

RATTUS;

EID: 84878302010     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327112468178     Document Type: Article

References (63)

1. Djerassi I. High-dose methotrexate (NSC-740) and citrovorum factor (NSC-3590) rescue: background and rationale. Cancer Chemother Rep. 1975 ; 6: 3-6
2. Te HS, Schiano TD, Kuan SF. Hepatic effects of long term methotrexate use in the treatment of inflammatory bowel disease. Am J Gastroenterol. 2000 ; 5: 3150-3156
3. Widemann BC, Balis FM, Kempf-Bielack B, Bielack S, Pratt CB, Ferrari S, et al. High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma: incidence, treatment, and outcome. Cancer. 2004 ; 100: 2222-2232
4. West SG. Methotrexate hepatoxicity. Rheum Dis Clin North Am. 1997 ; 23: 883-915
5. Johovic N, Cevik H, Sehirli OA, Yegen BC, Sener G. Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. J Pineal Res. 2003 ; 34: 282-287
6. Uraz S, Tahan V, Aygun C, Eren F, Unluguzel G, Yuksel M, et al. Role of ursodeoxycholic acid in prevention of methotrexate-induced liver toxicity. Dig Dis Sci. 2008 ; 53: 1071-1077
7. Bartsch H, Nair J. Ultrasensitive and specific detection methods for exocylic DNA adducts: markers for lipid peroxidation and oxidative stress. Toxicology. 2000 ; 153: 105-114
8. Stohs SJ, Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med. 1995 ; 18: 321-336
9. Padma VV, Baskaran R, Roopesh RS, Poornima P. Quercetin attenuates lindane induced oxidative stress in Wistar rats. Mol Biol Rep. 2012 ; 39: 6895-6905
10. Uz E, Söǧüt S, Sahin S, Var A, Ozyurt H, Güleç M, et al. The protective role of caffeic acid phenethyl ester (CAPE) on testicular tissue after testicular torsion and detorsion. World J Urol. 2002 ; 20: 264-270
11. Uzar E, Koyuncuoglu HR, Uz E, Yilmaz HR, Kutluhan S, Kilbas S, et al. The activities of antioxidant enzymes and the level of malondialdehyde in cerebellum of rats subjected to methotrexate: protective effect of caffeic acid phenethyl ester. Mol Cell Biochem. 2006 ; 291: 63-68
12. Uzar E, Sahin O, Koyuncuoglu HR, Uz E, Bas O, Kilbas S, et al. The activity of adenosine deaminase and the level of nitric oxide in spinal cord of methotrexate administered rats: protective effect of caffeic acid phenethyl ester. Toxicology. 2006 ; 218: 125-133
13. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticanc Res. 2004 ; 24: 2783-2840
14. Upadhyay G, Kumar A, Singh MP. Effect of silymarin on pyrogallol- and rifampicin-induced hepatotoxicity in mouse. Eur J Pharmacol. 2007 ; 565: 190-201
15. Giovannini L, Migliori M, Longoni BM, Das DK, Bertelli AA, Panichi V, et al. Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys. J Cardiovasc Pharmacol. 2001 ; 37: 262-270
16. Das DK, Sato M, Ray PS, Maulik G, Engelman RM, Bertelli AA, et al. Cardioprotection of red wine: role of polyphenolic antioxidants. Drugs Exp Clin Res. 1999 ; 25: 115-120
17. Bastianetto S, Zheng WH, Qirion W. Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. Br J Pharmacol. 2000 ; 131: 711-720
18. Bujanda L, García-Barcina M, Gutiérrez-de Juan V, Bidaurrazaga J, de Luco MF, Gutiérrez-Stampa M, et al. Effect of resveratrol on alcohol-induced mortality and liver lesions in mice. BMC Gastroenterol. 2006 ; 6: 35
19. Sener G, Toklu HZ, Sehirli AO, Velioǧlu-Oǧünç A, Cetinel S, Gedik N. Protective effects of resveratrol against acetaminophen-induced toxicity in mice. Hepatol Res. 2006 ; 35: 62-68
20. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006 ; 5: 493-506
21. Dong Z. Molecular mechanisms of the chemopreventive effect of resveratrol. Mutat Res. 2003 ; 523: 145-150
22. Abraham P, Kolli VK, Rabi S. Melatonin attenuates methotrexate-induced oxidative stress and renal damage in rats. Cell Biochem Funct. 2010 ; 28: 426-433
23. Göçmen AY, Burgucu D, Gümüşlü S.. Effect of resveratrol on platelet activation in hypercholesterolemic rats: CD40-CD40L system as a potential target. Appl Physiol Nutr Metab. 2011 ; 36: 323-330
24. Kolli VK, Abraham P, Isaac B, Selvakumar D. Neutrophil infiltration and oxidative stress may play a critical role in methotrexate-induced renal damage. Chemotherapy. 2009 ; 55: 83-90
25. Sebai H, Sani M, Yacoubi MT, Aouani E, Ghanem-Boughanmi N, Ben-Attia M. Resveratrol, a red wine polyphenol, attenuates lipopolysaccharide-induced oxidative stress in rat liver. Ecotoxicol Environ Saf. 2010 ; 73: 1078-1083
26. Aebi HE. Catalase. Methods of enzymatic analysis. Bergmeyer HU, ed. Weinheim, Germany: VCH Verlagsggesellschaft ; 1987: 273-285.
27. Wasowicz W, Neve J, Peretz A. Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. Clin Chem. 1993 ; 39: 2522-2526
28. Gümüşlü S, Serteser M, Özben T, Balkan S, Balkan E. Inhibitory role of Nw-nitro-l-arginine methyl ester (l-NAME), a potent nitric oxide synthase inhibitor, on brain malondialdehyde and conjugated diene levels during focal cerebral ischemia in rats. Clin Chim Acta. 1997 ; 267: 213-223
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin-phenol reagent. J Biol Chem. 1951 ; 193: 265-275
30. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem. 1974 ; 249: 7130-7139
31. Uraz S, Tahan V. Role of ursodeoxycholic acid in prevention of methotrexate-induced liver toxicity. Dig Dis Sci. 2008 ; 53: 1071-1077
32. Vardi N, Parlakpinar H, Cetin A, Erdogan A, Ozturk CI. Protective effect of b-carotene on methotrexate-induced oxidative liver damage. Toxicol Pathol. 2010 ; 38: 592-597
33. Bansal AK, Bansal M, Soni G, Bhatnagar D. Protective role of vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver. Chem Biol Interact. 2005 ; 156: 101-111
34. Ozguner F, Oktem F, Armagan A, Yilmaz R, Koyu A, Demirel R, et al. Comparative analysis of the protective effects of melatonin and caffeic acid phenethyl ester (CAPE) on mobile phone-induced renal impairment in rat. Mol Cell Biochem. 2005 ; 276: 31-37
35. Liu J, Wang X, Mori A. Immobilization stress-induced antioxidant defense changes in rat plasma: effect of treatment with reduced glutathione. Int J Biochem. 1994 ; 26: 511-517
36. Sahin E, Gümüşlü S. Stress-dependent induction of protein oxidation, lipid peroxidation and anti-oxidants in peripheral tissues of rats: comparison of three stress models immobilization, cold and immobilization-cold. Clin Exp Pharmacol Physiol. 2007 ; 34: 425-431
37. Wang F, Gao F, Lan M, Yuan H, Huang Y, Liu J. Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells. Toxicol In Vitro. 2009 ; 23: 808-815
38. Singh N, Kamath V, Narasimhamurthy K, Rajini PS. Protective effects of potato peel extract against carbon tetrachloride-induced liver injury in rats. Environ Toxicol Pharmacol. 2008 ; 26: 241-246
39. Cetin A, Kaynar L, Kocyigit I, Hacioglu SK, Saraymen R, Ozturk A, et al. Role of grape seed extract on methotrexate induced oxidative stress in rat liver. Am J Chin Med. 2008 ; 36: 861-872
40. Muttigi MS, Prabhu LS, Kedage V, Prakash M, Shetty JK, Virupaksha D, et al. Glutathione S-transferase activity and total thiol status in chronic alcohol abusers before and 30 days after alcohol abstinence. OJHAS. 2009 ; 8: 1-5
41. Uttara B, Singh AV, Zamboni P, Mahajan RT. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol. 2009 ; 7: 65-74
42. Fang YZ, Yang S, Wu G. Free radicals, antioxidant, and nutrition. Nutrition. 2002 ; 18: 872-879
43. Matés JM, Pérez-Gómez C, Núñez de Castro I. Antioxidant enzymes and human diseases. Clin Biochem. 1999 ; 32: 595-603
44. Sengottuvelan M, Senthilkumar R, Nalini N. Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis. Biochim Biophys Acta. 2006 ; 1760: 1175-1183
45. Trakshel GM, Maines MD.. Characterization of glutathione S-transferases in rat kidney. Alteration of composition by cis-platinum. Biochem J. 1988 ; 252: 127-136
46. Loguercio C, de Girolamo V, Cuomo A, Argenzio F, Iannotta C, Disalvo D, et al. Determination of plasma alpha-glutathione-S-transferases in chronic alcohol abusers: relationship with alcohol intake and liver involvement. Alcohol Alcohol. 1998 ; 33: 366-372
47. Galli F, Rovidati S, Benedetti S, Buoncristiani U, Covarelli C, Floridi A, et al. Overexpression of erythrocyte glutathione S-transferase in uremia and dialysis. Clin Chem. 1999 ; 45: 1781-1788
48. Frémont L, Belguendouz L, Delpal S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci. 1999 ; 64: 2511-2521
49. Losa GA. Resveratrol modulates apoptosis and oxidation in human blood mononuclear cells. Eur J Clin Invest. 2003 ; 33: 818-823
50. Martínez J, Moreno JJ. Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochem Pharmacol. 2000 ; 59: 865-870
51. Gusman J, Malonne H, Atassi G. A reappraisal of the potential chemopreventive and chemo therapeutic properties of resveratrol. Carcinogenesis. 2001 ; 22: 1111-1117
52. Leonard S, Xia C, Jiang BH, Stinefelt B, Klandorf H, Harris GK, et al. Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochem Biophys Res Commun. 2003 ; 309: 1017-1026
53. Young JF, Dragsted LO, Daneshvar B, Lauridsen ST, Hanson M, Sandström B. The effect of grape-skin extract on oxidative status. Br J Nutr. 2000 ; 84: 505-513
54. Leung A, Mo Z. Protective effects of Polydatin, an active compound from Polygonum cuspidatum, on cerebral ischemia damage in rats. Chin Pharm Bull. 1996 ; 12: 128-129
55. Upadhyay G, Singh AK, Kumar A, Prakash O, Singh MP. Resveratrol modulates pyrogallol-induced changes in hepatic toxicity markers, xenobiotic metabolizing enzymes and oxidative stress. Eur J Pharmacol. 2008 ; 596: 146-152
56. Cai YJ, Fang JG, Ma LP, Yang L, Liu ZL. Inhibition of free radical-induced peroxidation of rat liver microsomes by resveratrol and its analogues. Biochim Biophys Acta. 2003 ; 1637: 31-38
57. Arivazhagan P, Thilakovathy T, Panneerselvam C. Antioxidant lipoate and tissue antioxidants in aged rats. J Nutr Biochem. 2000 ; 11: 122-127
58. Park CE, Kim MJ, Lee JH, Min BI, Bae H, Choe W, et al. Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Exp Mol Med. 2007 ; 39: 222-229
59. Babiak RM, Campello AP, Carnieri EG, Oliveira MB. Methotrexate: pentose cycle and oxidative stress. Cell Biochem Funct. 1998 ; 16: 283-293
60. Boyer TD, Vessey DA, Holcomb C, Saley N. Studies of the relationship between the catalytic activity and binding of non-substrate ligands by the glutathione S-transferases. Biochem J. 1984 ; 217: 179-185
61. Cao Z, Li Y. Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury. Eur J Pharmacol. 2004 ; 489: 39-48
62. Li Y, Cao Z, Zhu H. Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress. Pharmacol Res. 2006 ; 53: 6-15
63. Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2008 ; 294: L478 - L488