Substrate specificity for rat cytochrome P450 (CYP) isoforms: Screening with cDNA-expressed systems of the rat

Biochemical Pharmacology

Volumn 63, Issue 5, 2002, Pages 889-896

  Kobayashi, Kaoru ^a   Urashima, Kikuko ^a   Shimada, Noriaki ^b   Chiba, Kan ^a  

^a CHIBA UNIVERSITY   (Japan)

^b DAIICHI PURE CHEMICALS CO LTD   (Japan)

Author keywords

cDNA expression system; CYP; Drug metabolism; Probe; Rat; Substrate specificity

Indexed keywords

4 NITROPHENOL; BENZYLOXYRESORUFIN; BUFURALOL; CHLORZOXAZONE; COMPLEMENTARY DNA; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2A2; CYTOCHROME P450 2B1; CYTOCHROME P450 2C11; CYTOCHROME P450 2C12; CYTOCHROME P450 2C13; CYTOCHROME P450 2C6; CYTOCHROME P450 2D1; CYTOCHROME P450 2D2; CYTOCHROME P450 2E1; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; DEXTROMETHORPHAN; DICLOFENAC; ETHOXYRESORUFIN; ISOPROTEIN; MEPHENYTOIN; MIDAZOLAM; PENTOXYRESORUFIN; PHENACETIN; RESORUFIN DERIVATIVE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DEALKYLATION; DEMETHYLATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE EXPRESSION SYSTEM; HUMAN; HUMAN CELL; INCUBATION TIME; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT; SCREENING;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BACULOVIRIDAE; CELLS, CULTURED; CHLORZOXAZONE; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; DEXTROMETHORPHAN; DICLOFENAC; DNA, COMPLEMENTARY; ETHANOLAMINES; GENE EXPRESSION; HUMANS; INSECTS; ISOENZYMES; MEPHENYTOIN; MIDAZOLAM; NITROPHENOLS; PHARMACEUTICAL PREPARATIONS; PHENACETIN; RATS; SUBSTRATE SPECIFICITY; TESTOSTERONE; TUMOR CELLS, CULTURED;

EID: 0036497073     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00843-7     Document Type: Article

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