Influence of lipophilicity on the interactions of hydroxy stilbenes with cytochrome P450 3A4

Biochemical and Biophysical Research Communications

Volumn 323, Issue 2, 2004, Pages 668-673

  Regev Shoshani, Gilly ^a   Shoseyov, Oded ^a   Kerem, Zohar ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Cyclosporine; CYP3A4; Kinetics; Piceid; Polyphenols; Resveratrol

Indexed keywords

5,3 DIHYDROXY 4' O METHOXYSTILBENE; 5,4' DIHYDROXY 3 O METHOXYSTILBENE; CYTOCHROME P450 3A4; GLUCOSIDE; HYDROXYL GROUP; PICEID; POLYPHENOL DERIVATIVE; PROTEIN INHIBITOR; RESVERATROL; RESVERATROLOSIDE; STILBENE DERIVATIVE; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; DRUG METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; HORMONE METABOLISM; HYDROXYLATION; IC 50; LIPOPHILICITY; MOLECULAR INTERACTION; PHARMACODYNAMICS; PRIORITY JOURNAL;

CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME STABILITY; HYDROXYL RADICAL; KINETICS; OXIDATION-REDUCTION; PROTEIN BINDING; SOLVENTS; STILBENES; SUBSTRATE SPECIFICITY; TESTOSTERONE;

EID: 4544292829     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.08.141     Document Type: Article

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