Bromobenzene-induced hepatotoxicity at the transcriptome level

Toxicological Sciences

Volumn 79, Issue 2, 2004, Pages 411-422

  Heijne, Wilbert H M ^a   Slitt, Angela L ^b   van Bladeren, Peter J ^c   Groten, John P ^a   Klaassen, Curtis D ^b   Stierum, Rob H ^a   van Ommen, Ben ^a  

^a TNO   (Netherlands)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Bromobenzene; cDNA microarray; Hepatotoxicity; Rat; Toxicogenomics; Transcriptomics

Indexed keywords

BROMOBENZENE; CHOLESTEROL; COMPLEMENTARY DNA; CYTOCHROME P450 4A; FATTY ACID; GLUTATHIONE; MESSENGER RNA; METALLOTHIONEIN; PROTEIN; STEROL;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; CHOLESTEROL METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; DNA DETERMINATION; DNA MICROARRAY; DNA RESPONSIVE ELEMENT; DRUG METABOLISM; ELECTRON; FATTY ACID METABOLISM; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE REARRANGEMENT; LIVER TOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN DEPLETION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; BROMOBENZENES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUTATHIONE; HEPATITIS, TOXIC; LIVER; MALE; MICROARRAY ANALYSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED STRAINS; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 2942750426     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh128     Document Type: Article

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