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Volumn 2014, Issue , 2014, Pages

Effects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C Virus Infection Patients: A Meta-Analysis of Randomized Controlled Trials

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; PLACEBO; SILIBININ; SILYMARIN; VIRUS RNA;

EID: 84930903372     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/941085     Document Type: Review
Times cited : (28)

References (42)
  • 1
    • 0036735666 scopus 로고    scopus 로고
    • Use of complementary and alternative medicine in patients with liver disease
    • D. B. Strader, B. R. Bacon, K. L. Lindsay et al., "Use of complementary and alternative medicine in patients with liver disease," The American Journal of Gastroenterology, vol. 97, no. 9, pp. 2391-2397, 2002.
    • (2002) The American Journal of Gastroenterology , vol.97 , Issue.9 , pp. 2391-2397
    • Strader, D.B.1    Bacon, B.R.2    Lindsay, K.L.3
  • 2
    • 39549094030 scopus 로고    scopus 로고
    • Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial
    • L. B. Seeff, T. M. Curto, G. Szabo et al., "Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial," Hepatology, vol. 47, no. 2, pp. 605-612, 2008.
    • (2008) Hepatology , vol.47 , Issue.2 , pp. 605-612
    • Seeff, L.B.1    Curto, T.M.2    Szabo, G.3
  • 3
    • 65449136656 scopus 로고    scopus 로고
    • Diagnosis, management, and treatment of hepatitis C: An update
    • M. G. Ghany, D. B. Strader, D. L. Thomas, and L. B. Seeff, "Diagnosis, management, and treatment of hepatitis C: An update," Hepatology, vol. 49, no. 4, pp. 1335-1374, 2009.
    • (2009) Hepatology , vol.49 , Issue.4 , pp. 1335-1374
    • Ghany, M.G.1    Strader, D.B.2    Thomas, D.L.3    Seeff, L.B.4
  • 4
    • 79957833378 scopus 로고    scopus 로고
    • Silybin and the liver: From basic research to clinical practice,"World
    • C. Loguercio and D. Festi, "Silybin and the liver: From basic research to clinical practice,"World Journal of Gastroenterology, vol. 17, no. 18, pp. 2288-2301, 2011.
    • (2011) Journal of Gastroenterology , vol.17 , Issue.18 , pp. 2288-2301
    • Loguercio, C.1    Festi, D.2
  • 5
    • 84878563030 scopus 로고    scopus 로고
    • Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle
    • H. S.Althagafy, T.N. Graf, A. A. Sy-Cordero et al., "Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle," Bioorganic and Medicinal Chemistry, vol. 21, no. 13, pp. 3919-3926, 2013.
    • (2013) Bioorganic and Medicinal Chemistry , vol.21 , Issue.13 , pp. 3919-3926
    • Althagafy, H.S.1    Graf, T.N.2    Sy-Cordero, A.A.3
  • 6
    • 84885429520 scopus 로고    scopus 로고
    • Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrindependent trafficking
    • J. Blaising, P. L. Lévy, C. Gondeau et al., "Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrindependent trafficking," Cellular Microbiology, vol. 15, no. 11, pp. 1866-1882, 2013.
    • (2013) Cellular Microbiology , vol.15 , Issue.11 , pp. 1866-1882
    • Blaising, J.1    Lévy, P.L.2    Gondeau, C.3
  • 7
    • 34249915550 scopus 로고    scopus 로고
    • Advances in the use of milk thistle (Silybum marianum)
    • J. Post-White, E. J. Ladas, and K. M. Kelly, "Advances in the use of milk thistle (Silybum marianum)," Integrative Cancer Therapies, vol. 6, no. 2, pp. 104-109, 2007.
    • (2007) Integrative Cancer Therapies , vol.6 , Issue.2 , pp. 104-109
    • Post-White, J.1    Ladas, E.J.2    Kelly, K.M.3
  • 8
    • 60749103299 scopus 로고    scopus 로고
    • Effects of silymarin supplementation in chronic hepatitis C patients treated with peg-interferon + ribavirin. A placebo-controlled double blind study
    • A. Pár, E. Roth, A. Miseta et al., "Effects of silymarin supplementation in chronic hepatitis C patients treated with peg-interferon + ribavirin. A placebo-controlled double blind study," Orvosi Hetilap, vol. 150, no. 2, pp. 73-79, 2009.
    • (2009) Orvosi Hetilap , vol.150 , Issue.2 , pp. 73-79
    • Pár, A.1    Roth, E.2    Miseta, A.3
  • 9
    • 33645307385 scopus 로고    scopus 로고
    • Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C
    • A. Gordon, D. A. Hobbs, D. S. Bowden et al., "Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C," Journal of Gastroenterology and Hepatology, vol. 21, no. 1, pp. 275-280, 2006.
    • (2006) Journal of Gastroenterology and Hepatology , vol.21 , Issue.1 , pp. 275-280
    • Gordon, A.1    Hobbs, D.A.2    Bowden, D.S.3
  • 10
    • 21644454887 scopus 로고    scopus 로고
    • Rand omised doubleblinded trial evaluating silymarin for chronic hepatitis C in an Egyptian village: Study description and 12-month results
    • M.D. Tanamly, F. Tadros, S. Labeeb et al., "Rand omised doubleblinded trial evaluating silymarin for chronic hepatitis C in an Egyptian village: Study description and 12-month results," Digestive and Liver Disease, vol. 36, no. 11, pp. 752-759, 2004.
    • (2004) Digestive and Liver Disease , vol.36 , Issue.11 , pp. 752-759
    • Tanamly, M.D.1    Tadros, F.2    Labeeb, S.3
  • 11
    • 84863905251 scopus 로고    scopus 로고
    • Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: A rand omized controlled trial,"The
    • M.W. Fried, V. J. Navarro, N. Afdhal et al., "Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: A rand omized controlled trial,"The Journal of the AmericanMedical Association, vol. 308, no. 3, pp. 274-282, 2012.
    • (2012) Journal of the AmericanMedical Association , vol.308 , Issue.3 , pp. 274-282
    • Fried, M.W.1    Navarro, V.J.2    Afdhal, N.3
  • 12
    • 84874112756 scopus 로고    scopus 로고
    • Intravenous silibinin monotherapy shows significant antiviral activity in HCVinfected patients in the peri-transplantation period
    • Z. Mariño, G. Crespo, M. DAmato et al., "Intravenous silibinin monotherapy shows significant antiviral activity in HCVinfected patients in the peri-transplantation period," Journal of Hepatology, vol. 58, no. 3, pp. 415-420, 2013.
    • (2013) Journal of Hepatology , vol.58 , Issue.3 , pp. 415-420
    • Mariño, Z.1    Crespo, G.2    Damato, M.3
  • 13
    • 55249084176 scopus 로고    scopus 로고
    • Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy
    • P. Ferenci, T. Scherzer, H. Kerschner et al., "Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy," Gastroenterology, vol. 135, no. 5, pp. 1561-1567, 2008.
    • (2008) Gastroenterology , vol.135 , Issue.5 , pp. 1561-1567
    • Ferenci, P.1    Scherzer, T.2    Kerschner, H.3
  • 14
    • 83455179381 scopus 로고    scopus 로고
    • Intravenous silibinin as rescue treatment for on-treatment non-responders to pegylated interferon/ribavirin combination therapy
    • K. Rutter, T. Scherzer, S. Beinhardt et al., "Intravenous silibinin as rescue treatment for on-treatment non-responders to pegylated interferon/ribavirin combination therapy," Antiviral Therapy, vol. 16, no. 8, pp. 1327-1333, 2011.
    • (2011) Antiviral Therapy , vol.16 , Issue.8 , pp. 1327-1333
    • Rutter, K.1    Scherzer, T.2    Beinhardt, S.3
  • 15
    • 0034576945 scopus 로고    scopus 로고
    • Milk thistle: Effects on liver disease and cirrhosis and clinical adverse effects
    • C.Mulrow, V. Lawrence, B. Jacobs et al., "Milk thistle: Effects on liver disease and cirrhosis and clinical adverse effects," Evidence Report/Technology Assessment (Summary), no. 21, pp. 1-3, 2000.
    • (2000) Evidence Report/Technology Assessment (Summary) , Issue.21 , pp. 1-3
    • Mulrow, C.1    Lawrence, V.2    Jacobs, B.3
  • 16
    • 0037109597 scopus 로고    scopus 로고
    • Milk thistle for the treatment of liver disease: A systematic review and meta-analysis
    • B. P. Jacobs, C. Dennehy, G. Ramirez, J. Sapp, and V. A. Lawrence, "Milk thistle for the treatment of liver disease: A systematic review and meta-analysis," The American Journal of Medicine, vol. 113, no. 6, pp. 506-515, 2002.
    • (2002) The American Journal of Medicine , vol.113 , Issue.6 , pp. 506-515
    • Jacobs, B.P.1    Dennehy, C.2    Ramirez, G.3    Sapp, J.4    Lawrence, V.A.5
  • 17
    • 0035211762 scopus 로고    scopus 로고
    • The use of silymarin in the treatment of liver diseases
    • R. Saller, R.Meier, and R. Brignoli, "The use of silymarin in the treatment of liver diseases," Drugs, vol. 61,no. 14,pp. 2035-2063, 2001.
    • (2001) Drugs , vol.61 , Issue.14 , pp. 2035-2063
    • Saller, R.1    Meier, R.2    Brignoli, R.3
  • 18
    • 44949121637 scopus 로고    scopus 로고
    • Milk thistle for alcoholic and /or hepatitis B or C virus liver diseases
    • A. Rambaldi, B. P. Jacobs, and C. Gluud, "Milk thistle for alcoholic and /or hepatitis B or C virus liver diseases," Cochrane Database of Systematic Reviews, vol. 17, no. 4, 2007.
    • (2007) Cochrane Database of Systematic Reviews , vol.17 , Issue.4
    • Rambaldi, A.1    Jacobs, B.P.2    Gluud, C.3
  • 21
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in ameta-analysis
    • J. P. T. Higgins and S. G. Thompson, "Quantifying heterogeneity in ameta-analysis," Statistics in Medicine, vol. 21,no. 11,pp. 1539-1558, 2002.
    • (2002) Statistics in Medicine , vol.21 , Issue.11 , pp. 1539-1558
    • Higgins, J.P.T.1    Thompson, S.G.2
  • 22
    • 84878536109 scopus 로고    scopus 로고
    • Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection
    • O. Adeyemo, H. Doi, K. R. Reddy, and D. E. Kaplan, "Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection," Journal of Viral Hepatitis, vol. 20, no. 7, pp. 453-462, 2013.
    • (2013) Journal of Viral Hepatitis , vol.20 , Issue.7 , pp. 453-462
    • Adeyemo, O.1    Doi, H.2    Reddy, K.R.3    Kaplan, D.E.4
  • 23
    • 81855217432 scopus 로고    scopus 로고
    • Differences in the disposition of patients with nonalcoholic fatty liver disease and chronichepatitis
    • S. J. Schrieber, R. L. Hawke, Z. Wen, P. C. Smith, K. R. Reddy, and A. S. Wahed, "Differences in the disposition of patients with nonalcoholic fatty liver disease and chronichepatitis," Drug Metabolism and Disposition, vol. 39, no. 12, pp. 2182-2190, 2011.
    • (2011) Drug Metabolism and Disposition , vol.39 , Issue.12 , pp. 2182-2190
    • Schrieber, S.J.1    Hawke, R.L.2    Wen, Z.3    Smith, P.C.4    Reddy, K.R.5    Wahed, A.S.6
  • 24
    • 22844440901 scopus 로고    scopus 로고
    • Non-interferonbased therapy: An option for amelioration of necroinflammation in hepatitis C patients who cannot afford interferon therapy
    • A. El-Zayadi, M. Attia, H. M. Badran et al., "Non-interferonbased therapy: An option for amelioration of necroinflammation in hepatitis C patients who cannot afford interferon therapy," Liver International, vol. 25, no. 4, pp. 746-751, 2005.
    • (2005) Liver International , vol.25 , Issue.4 , pp. 746-751
    • El-Zayadi, A.1    Attia, M.2    Badran, H.M.3
  • 25
    • 84859632884 scopus 로고    scopus 로고
    • Spirulina platensis versus silymarin in the treatment of chronic hepatitis C virus infection. A pilot rand omized, comparative clinical trial
    • article 32
    • M. Yakoot and A. Salem, "Spirulina platensis versus silymarin in the treatment of chronic hepatitis C virus infection. A pilot rand omized, comparative clinical trial," BMC Gastroenterology, vol. 12, article 32, 2012.
    • (2012) BMC Gastroenterology , vol.12
    • Yakoot, M.1    Salem, A.2
  • 26
    • 77957265017 scopus 로고    scopus 로고
    • Silymarin ascending multiple oral dosing phase i study in noncirrhotic patients with chronic hepatitis C
    • R. L. Hawke, S. J. Schrieber, T. A. Soule et al., "Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C," The Journal of Clinical Pharmacology, vol. 50, no. 4, pp. 434-449, 2010.
    • (2010) The Journal of Clinical Pharmacology , vol.50 , Issue.4 , pp. 434-449
    • Hawke, R.L.1    Schrieber, S.J.2    Soule, T.A.3
  • 27
    • 84857067107 scopus 로고    scopus 로고
    • Rationale, challenges, and participants in a phase II trial of a botanical product for chronic hepatitis C
    • K. R. Reddy, S. H. Belle, M. W. Fried et al., "Rationale, challenges, and participants in a phase II trial of a botanical product for chronic hepatitis C," Clinical Trials, vol. 9, no. 1, pp. 102-112, 2012.
    • (2012) Clinical Trials , vol.9 , Issue.1 , pp. 102-112
    • Reddy, K.R.1    Belle, S.H.2    Fried, M.W.3
  • 28
    • 54549086511 scopus 로고    scopus 로고
    • Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitisC
    • J. M. Bares, J. Berger, J. E. Nelson et al., "Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitisC," Journal of ClinicalGastroenterology, vol. 42, no. 8, pp. 937-944, 2008.
    • (2008) Journal of Clinical Gastroenterology , vol.42 , Issue.8 , pp. 937-944
    • Bares, J.M.1    Berger, J.2    Nelson, J.E.3
  • 29
    • 33644547392 scopus 로고    scopus 로고
    • Antiviral therapy for chronic hepatitis C: Past, present, and future
    • N. Hayashi and T. Takehara, "Antiviral therapy for chronic hepatitis C: Past, present, and future," Journal of Gastroenterology, vol. 41, no. 1, pp. 17-27, 2006.
    • (2006) Journal of Gastroenterology , vol.41 , Issue.1 , pp. 17-27
    • Hayashi, N.1    Takehara, T.2
  • 30
    • 79960453276 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: Management of hepatitis C virus infection
    • European Association for the Study of the Liver, "EASL clinical practice guidelines: Management of hepatitis C virus infection," Journal of Hepatology, vol. 2, pp. 245-264, 2011.
    • (2011) Journal of Hepatology , vol.2 , pp. 245-264
    • European Association for the Study of the Liver1
  • 31
    • 80053339008 scopus 로고    scopus 로고
    • An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases
    • M. G. Ghany,D. R. Nelson, D. B. Strader, D. L. Thomas, and L. B. Seeff, "An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases," Hepatology, vol. 54, no. 4, pp. 1433-1444, 2011.
    • (2011) Hepatology , vol.54 , Issue.4 , pp. 1433-1444
    • Ghany, M.G.1    Nelson, D.R.2    Strader, D.B.3    Thomas, D.L.4    Seeff, L.B.5
  • 33
    • 0037347730 scopus 로고    scopus 로고
    • Synthesis and antihepatotoxic activity of some heterocyclic compounds containing the 1,4-dioxane ring system
    • B. Ahmed, S. A. Khan, and T. Alam, "Synthesis and antihepatotoxic activity of some heterocyclic compounds containing the 1,4-dioxane ring system," Pharmazie, vol. 58, no. 3, pp. 173-176, 2003.
    • (2003) Pharmazie , vol.58 , Issue.3 , pp. 173-176
    • Ahmed, B.1    Khan, S.A.2    Alam, T.3
  • 34
    • 78650028517 scopus 로고    scopus 로고
    • Silymarin use and liver disease progression in the hepatitis C antiviral long-term treatment against cirrhosis trial
    • N. D. Freedman, T. M. Curto, C. Morishima et al., "Silymarin use and liver disease progression in the hepatitis C antiviral long-term treatment against cirrhosis trial," Alimentary Pharmacology and Therapeutics, vol. 33, no. 1, pp. 127-137, 2011.
    • (2011) Alimentary Pharmacology and Therapeutics , vol.33 , Issue.1 , pp. 127-137
    • Freedman, N.D.1    Curto, T.M.2    Morishima, C.3
  • 35
    • 77950530324 scopus 로고    scopus 로고
    • Multiple effects of silymarin on the hepatitis C virus lifecycle
    • J. Wagoner, A. Negash, O. J. Kane et al., "Multiple effects of silymarin on the hepatitis C virus lifecycle," Hepatology, vol. 51, no. 6, pp. 1912-1921, 2010.
    • (2010) Hepatology , vol.51 , Issue.6 , pp. 1912-1921
    • Wagoner, J.1    Negash, A.2    Kane, O.J.3
  • 36
    • 79551572739 scopus 로고    scopus 로고
    • Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation
    • Article ID e16464
    • J. Wagoner, C. Morishima, T. N. Graf et al., "Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation," PLoS ONE, vol. 6, no. 1, Article ID e16464, 2011.
    • (2011) PLoS ONE , vol.6 , Issue.1
    • Wagoner, J.1    Morishima, C.2    Graf, T.N.3
  • 37
    • 77449092252 scopus 로고    scopus 로고
    • Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase
    • A. Ahmed-Belkacem, N. Ahnou, L. Barbotte et al., "Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase," Gastroenterology, vol. 138, no. 3, pp. 1112-1122, 2010.
    • (2010) Gastroenterology , vol.138 , Issue.3 , pp. 1112-1122
    • Ahmed-Belkacem, A.1    Ahnou, N.2    Barbotte, L.3
  • 38
    • 84859716196 scopus 로고    scopus 로고
    • Understand ing silibinins modes of action against HCV using viral kinetic modeling
    • J. Guedj, H. Dahari, R. T. Pohl, P. Ferenci, and A. S. Perelson, "Understand ing silibinins modes of action against HCV using viral kinetic modeling," Journal of Hepatology, vol. 56, no. 5, pp. 1019-1024, 2012.
    • (2012) Journal of Hepatology , vol.56 , Issue.5 , pp. 1019-1024
    • Guedj, J.1    Dahari, H.2    Pohl, R.T.3    Ferenci, P.4    Perelson, A.S.5
  • 39
    • 3142540615 scopus 로고    scopus 로고
    • Investigations on the binding and antioxidant properties of the plant flavonoid fisetin in model biomembranes
    • B. Sengupta, A. Banerjee, and P. K. Sengupta, "Investigations on the binding and antioxidant properties of the plant flavonoid fisetin in model biomembranes," FEBS Letters, vol. 570, no. 1-3, pp. 77-81, 2004.
    • (2004) FEBS Letters , vol.570 , Issue.1-3 , pp. 77-81
    • Sengupta, B.1    Banerjee, A.2    Sengupta, P.K.3
  • 40
    • 0030848422 scopus 로고    scopus 로고
    • Correlation of biochemical response to interferon alfa with histological improvement in hepatitis C: A metaanalysis of diagnostic test characteristics
    • P. A. L. Bonis, J. P. A. Ioannidis, J. C. Cappelleri, M. M. Kaplan, and J. Lau, "Correlation of biochemical response to interferon alfa with histological improvement in hepatitis C: A metaanalysis of diagnostic test characteristics," Hepatology, vol. 26, no. 4, pp. 1035-1044, 1997.
    • (1997) Hepatology , vol.26 , Issue.4 , pp. 1035-1044
    • Bonis, P.A.L.1    Ioannidis, J.P.A.2    Cappelleri, J.C.3    Kaplan, M.M.4    Lau, J.5
  • 41
    • 12644299637 scopus 로고    scopus 로고
    • Relationship between biochemical, virological, and histological response during interferon treatment of chronic hepatitis C
    • M. L. Shiffman, C. M. Hofmann, E. B. Thompson et al., "Relationship between biochemical, virological, and histological response during interferon treatment of chronic hepatitis C," Hepatology, vol. 26, no. 3, pp. 780-785, 1997.
    • (1997) Hepatology , vol.26 , Issue.3 , pp. 780-785
    • Shiffman, M.L.1    Hofmann, C.M.2    Thompson, E.B.3
  • 42
    • 19244377701 scopus 로고    scopus 로고
    • Characteristics of patients with dual infection by hepatitis B and C viruses
    • J. Zarski, B. Bohn, A. Bastie et al., "Characteristics of patients with dual infection by hepatitis B and C viruses," Journal of Hepatology, vol. 28, no. 1, pp. 27-33, 1998.
    • (1998) Journal of Hepatology , vol.28 , Issue.1 , pp. 27-33
    • Zarski, J.1    Bohn, B.2    Bastie, A.3


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