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Volumn 167, Issue 1, 2015, Pages 91-102

Molecular and Histopathological Study on the Ameliorative Effects of Curcumin Against Lead Acetate-Induced Hepatotoxicity and Nephrototoxicity in Wistar Rats

Author keywords

Curcumin; Gene expression; Histopathology; Immunoglobulins; Kidney; Lead intoxication; Liver

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALPHA 2 MACROGLOBULIN; ASPARTATE AMINOTRANSFERASE; CATALASE; CREATININE; CURCUMIN; DESMIN; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LEAD ACETATE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OROSOMUCOID; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1; UREA; VIMENTIN; ACUTE PHASE PROTEIN; BIOLOGICAL MARKER; CYTOKINE; INTERMEDIATE FILAMENT PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANOMETALLIC COMPOUND;

EID: 84938989479     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-015-0280-0     Document Type: Article
Times cited : (79)

References (42)
  • 1
    • 0033835501 scopus 로고    scopus 로고
    • The reproductive toxicity and carcinogenicity of lead: a critical review
    • COI: 1:CAS:528:DC%2BD3cXlvFyqtLc%3D, PID: 10940961
    • Landrigan PJ, Boffetta P, Apostoli P (2000) The reproductive toxicity and carcinogenicity of lead: a critical review. Am J Ind Med 38:231–243
    • (2000) Am J Ind Med , vol.38 , pp. 231-243
    • Landrigan, P.J.1    Boffetta, P.2    Apostoli, P.3
  • 2
    • 0035750172 scopus 로고    scopus 로고
    • Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage
    • COI: 1:CAS:528:DC%2BD3MXos1ait7s%3D, PID: 11895129
    • Ercal N, Gurer-Orhan H, Aykin-Burns N (2001) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem 1:529–539. doi:10.2174/1568026013394831
    • (2001) Curr Top Med Chem , vol.1 , pp. 529-539
    • Ercal, N.1    Gurer-Orhan, H.2    Aykin-Burns, N.3
  • 3
    • 0033831298 scopus 로고    scopus 로고
    • Lead as a carcinogen: experimental evidence and mechanisms of action
    • COI: 1:CAS:528:DC%2BD3cXlvFyqurY%3D, PID: 10940970
    • Silbergeld EK, Waalkes M, Rice JM (2000) Lead as a carcinogen: experimental evidence and mechanisms of action. Am J Ind Med 38:316–323
    • (2000) Am J Ind Med , vol.38 , pp. 316-323
    • Silbergeld, E.K.1    Waalkes, M.2    Rice, J.M.3
  • 4
    • 68049088651 scopus 로고    scopus 로고
    • Protective effect of Aquilegia vulgaris (L.) against lead acetate-induced oxidative stress in rats
    • COI: 1:CAS:528:DC%2BD1MXps1eqs78%3D, PID: 19531368
    • El-Nekeety AA, El-Kady AA, Soliman MS, Hassan NS, Abdel-Wahhab MA (2009) Protective effect of Aquilegia vulgaris (L.) against lead acetate-induced oxidative stress in rats. Food Chem Toxicol 47:2209–15. doi:10.1016/j.fct.2009.06.019
    • (2009) Food Chem Toxicol , vol.47 , pp. 2209-2215
    • El-Nekeety, A.A.1    El-Kady, A.A.2    Soliman, M.S.3    Hassan, N.S.4    Abdel-Wahhab, M.A.5
  • 5
    • 61849129297 scopus 로고    scopus 로고
    • Heavy metal induced oxidative stress and its possible reversal by chelation therapy
    • COI: 1:CAS:528:DC%2BD1MXhsFKisr4%3D, PID: 19106443
    • Flora SJS, Mittal M, Mehta A (2008) Heavy metal induced oxidative stress and its possible reversal by chelation therapy. Indian J Med Res 128:501–23
    • (2008) Indian J Med Res , vol.128 , pp. 501-523
    • Flora, S.J.S.1    Mittal, M.2    Mehta, A.3
  • 6
    • 38049040853 scopus 로고    scopus 로고
    • Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimental nephrotoxicity
    • COI: 1:CAS:528:DC%2BD2sXhtlSkurjK, PID: 18001039
    • Kuhad A, Pilkhwal S, Sharma S, Tirkey N, Chopra K (2007) Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimental nephrotoxicity. J Agric Food Chem 55:10150–10155. doi:10.1021/jf0723965
    • (2007) J Agric Food Chem , vol.55 , pp. 10150-10155
    • Kuhad, A.1    Pilkhwal, S.2    Sharma, S.3    Tirkey, N.4    Chopra, K.5
  • 7
    • 2142784187 scopus 로고    scopus 로고
    • Biological properties of curcumin-cellular and molecular mechanisms of action
    • COI: 1:CAS:528:DC%2BD2cXjslSmsb0%3D, PID: 15116757
    • Joe B, Vijaykumar M, Lokesh BR (2004) Biological properties of curcumin-cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr 44:97–111. doi:10.1080/10408690490424702
    • (2004) Crit Rev Food Sci Nutr , vol.44 , pp. 97-111
    • Joe, B.1    Vijaykumar, M.2    Lokesh, B.R.3
  • 8
    • 0034905272 scopus 로고    scopus 로고
    • Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice
    • COI: 1:CAS:528:DC%2BD3MXlvFKks7s%3D, PID: 11481399
    • Okada K, Wangpoengtrakul C, Tanaka T, Toyokuni S, Uchida S, Osawa T (2001) Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. J Nutr 131:2090–2095
    • (2001) J Nutr , vol.131 , pp. 2090-2095
    • Okada, K.1    Wangpoengtrakul, C.2    Tanaka, T.3    Toyokuni, S.4    Uchida, S.5    Osawa, T.6
  • 9
    • 34447621810 scopus 로고    scopus 로고
    • Effect of lead acetate on cytosolic thioredoxin reductase activity and oxidative stress parameters in rat kidneys
    • COI: 1:CAS:528:DC%2BD2sXptlylt7c%3D, PID: 17651309
    • Conterato GMM, Augusti PR, Somacal S, Einsfeld L, Sobieski R, Torres JR (2007) Effect of lead acetate on cytosolic thioredoxin reductase activity and oxidative stress parameters in rat kidneys. Basic Clin Pharmacol Toxicol 101:96–100
    • (2007) Basic Clin Pharmacol Toxicol , vol.101 , pp. 96-100
    • Conterato, G.M.M.1    Augusti, P.R.2    Somacal, S.3    Einsfeld, L.4    Sobieski, R.5    Torres, J.R.6
  • 10
    • 84900012228 scopus 로고    scopus 로고
    • Acute exposure to low lead levels and its implications on the activity and expression of cytosolic thioredoxin reductase in the kidney
    • COI: 1:CAS:528:DC%2BC2cXns12ksrY%3D, PID: 24345272
    • Conterato GM, Quatrin A, Somacal S, Ruviaro AR, Vicentini J, Augusti PR et al (2014) Acute exposure to low lead levels and its implications on the activity and expression of cytosolic thioredoxin reductase in the kidney. Basic Clin Pharmacol Toxicol 114:476–84. doi:10.1111/bcpt.12183
    • (2014) Basic Clin Pharmacol Toxicol , vol.114 , pp. 476-484
    • Conterato, G.M.1    Quatrin, A.2    Somacal, S.3    Ruviaro, A.R.4    Vicentini, J.5    Augusti, P.R.6
  • 11
    • 84904170594 scopus 로고    scopus 로고
    • Protective role of omega 3 polyunsaturated fatty acid against lead acetate induced toxicity in liver of female rats
    • PID: 25045676
    • Abdou HM, Hassan MA (2014) Protective role of omega 3 polyunsaturated fatty acid against lead acetate induced toxicity in liver of female rats. Biomed Res Int 2014:435857. doi:10.1155/2014/435857
    • (2014) Biomed Res Int , vol.2014 , pp. 435857
    • Abdou, H.M.1    Hassan, M.A.2
  • 12
    • 38549153486 scopus 로고    scopus 로고
    • Curcumin protects the rat liver from CCl4 caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation
    • COI: 1:CAS:528:DC%2BD1cXht1ymsbs%3D, PID: 18006644
    • Fu Y, Zheng S, Lin J, Ryerse J, Chen A (2008) Curcumin protects the rat liver from CCl4 caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol 73:399–409
    • (2008) Mol Pharmacol , vol.73 , pp. 399-409
    • Fu, Y.1    Zheng, S.2    Lin, J.3    Ryerse, J.4    Chen, A.5
  • 13
    • 84881489444 scopus 로고    scopus 로고
    • Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening
    • Garcia-Nino W, Tapia E, Zazueta C, Barrón Z, Pando R, García C et al (2013) Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening. J Evi Com Med 1-19. doi:10.1155/2013/424692
    • (2013) J Evi Com Med
    • Garcia-Nino, W.1    Tapia, E.2    Zazueta, C.3    Barrón, Z.4    Pando, R.5    García, C.6
  • 14
    • 84924338413 scopus 로고    scopus 로고
    • Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in Wistar rats
    • PID: 25432491
    • Soliman MM, Nassan MA, Ismail TA (2014) Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in Wistar rats. BMC Complement Altern Med 14:457. doi:10.1186/1472-6882-14-457
    • (2014) BMC Complement Altern Med , vol.14 , pp. 457
    • Soliman, M.M.1    Nassan, M.A.2    Ismail, T.A.3
  • 15
    • 84938978846 scopus 로고    scopus 로고
    • Wilson I, Gamble M (2008) The hematoxylins and eosins. In: Bancroft JD, Gamble M (eds) Theory and practice of histological techniques. Elsevier Health Sciences, London, UK; ISBN-10
    • Wilson I, Gamble M (2008) The hematoxylins and eosins. In: Bancroft JD, Gamble M (eds) Theory and practice of histological techniques. Elsevier Health Sciences, London, UK; ISBN-10. www.expertconsultbook.com/expertconsult/…/linkTo
  • 16
    • 84938984253 scopus 로고    scopus 로고
    • Carson F (1990) Histotechnology: a self-instructional text. 3rd edn. ASCP Press, Chicago, ISBN-10: 0891895817. P 400
    • Carson F (1990) Histotechnology: a self-instructional text. 3rd edn. ASCP Press, Chicago, ISBN-10: 0891895817. P 400. www.ascp.org/…/Histotechnology-A-Self-Instructional-Text-3rd-Edition.
  • 17
    • 0041287680 scopus 로고
    • Analytical chemistry of the elements: lead
    • Polyanskiy NG Fillipova NA ed. (1986) Analytical chemistry of the elements: lead. P.22
    • (1986)
  • 18
    • 0033913619 scopus 로고    scopus 로고
    • A role for oxidative stress in suppressing serum immunoglobulin levels in lead exposed Fisher 344 rats
    • COI: 1:CAS:528:DC%2BD3cXmtV2gsLw%3D, PID: 10871428
    • Ercal N, Neal R, Treeratphan P, Lutz PM, Hammond TC, Dennery PA et al (2000) A role for oxidative stress in suppressing serum immunoglobulin levels in lead exposed Fisher 344 rats. Arch Environ Contam Toxicol 39:251–6
    • (2000) Arch Environ Contam Toxicol , vol.39 , pp. 251-256
    • Ercal, N.1    Neal, R.2    Treeratphan, P.3    Lutz, P.M.4    Hammond, T.C.5    Dennery, P.A.6
  • 19
    • 0021053248 scopus 로고
    • Cardiac effects of lead
    • COI: 1:CAS:528:DyaL2cXhsFeq, PID: 6352336
    • Williams BJ, Hejtmancik MR, Abreu M (1983) Cardiac effects of lead. Fed Proc 42:2989–2993
    • (1983) Fed Proc , vol.42 , pp. 2989-2993
    • Williams, B.J.1    Hejtmancik, M.R.2    Abreu, M.3
  • 20
    • 0037837334 scopus 로고    scopus 로고
    • Histological and histochemical alterations in the kidney induced by lead
    • PID: 17146214
    • Jarrar BM (2003) Histological and histochemical alterations in the kidney induced by lead. Ann Saudi Med 23:10–15
    • (2003) Ann Saudi Med , vol.23 , pp. 10-15
    • Jarrar, B.M.1
  • 21
    • 23944478990 scopus 로고    scopus 로고
    • A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress
    • PID: 16054557
    • Del Rio D, Stewart AJ, Pellegrini N (2005) A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316–28. doi:10.1016/j.numecd.2005.05.003
    • (2005) Nutr Metab Cardiovasc Dis , vol.15 , pp. 316-328
    • Del Rio, D.1    Stewart, A.J.2    Pellegrini, N.3
  • 22
    • 0025126555 scopus 로고
    • Role of free radicals and catalytic metal ions in human disease: an overview
    • COI: 1:CAS:528:DyaK3MXksVKrt7Y%3D, PID: 2172697
    • Halliwell B, Gutteridge J (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186:1–85. doi:10.1016/0076-6879(90)86093-B
    • (1990) Methods Enzymol , vol.186
    • Halliwell, B.1    Gutteridge, J.2
  • 23
    • 84859420566 scopus 로고    scopus 로고
    • Ameliorated effects of green tea extract on lead induced liver toxicity in rats
    • COI: 1:CAS:528:DC%2BC38XlsVSjur8%3D, PID: 20889321
    • Mehana EE, Meki AR, Fazili KM (2012) Ameliorated effects of green tea extract on lead induced liver toxicity in rats. Exp Toxicol Pathol 64:291–295. doi:10.1016/j.etp.2010.09.001
    • (2012) Exp Toxicol Pathol , vol.64 , pp. 291-295
    • Mehana, E.E.1    Meki, A.R.2    Fazili, K.M.3
  • 24
    • 84899622061 scopus 로고    scopus 로고
    • Sesamin reduces acute hepatic injury induced by lead coupled with lipopolysaccharide
    • PID: 24726677
    • Chiang H, Chang H, Yao P, Chen Y, Jeng K, Wang J et al (2014) Sesamin reduces acute hepatic injury induced by lead coupled with lipopolysaccharide. J Chin Med Assoc 77:227–233. doi:10.1016/j.jcma.2014.02.010
    • (2014) J Chin Med Assoc , vol.77 , pp. 227-233
    • Chiang, H.1    Chang, H.2    Yao, P.3    Chen, Y.4    Jeng, K.5    Wang, J.6
  • 25
    • 84874569729 scopus 로고    scopus 로고
    • The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model
    • COI: 1:CAS:528:DC%2BC3sXmtV2nsb4%3D, PID: 23391631
    • Ansari MA, Maayah ZH, Bakheet SA, El-Kadi AO, Korashy HM (2013) The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model. Toxicology 306:40–49. doi:10.1016/j.tox.2013.01.024
    • (2013) Toxicology , vol.306 , pp. 40-49
    • Ansari, M.A.1    Maayah, Z.H.2    Bakheet, S.A.3    El-Kadi, A.O.4    Korashy, H.M.5
  • 27
    • 84899865599 scopus 로고    scopus 로고
    • Protective effect of curcumin against heavy metals-induced liver damage
    • PID: 24751969
    • García-Niño WR, Pedraza-Chaverrí J (2014) Protective effect of curcumin against heavy metals-induced liver damage. Food Chem Toxicol 69:182–201. doi:10.1016/j.fct.2014.04.016
    • (2014) Food Chem Toxicol , vol.69 , pp. 182-201
    • García-Niño, W.R.1    Pedraza-Chaverrí, J.2
  • 28
    • 80455150604 scopus 로고    scopus 로고
    • Effects of environmental lead exposure on T-helper cell-specific cytokines in children
    • COI: 1:CAS:528:DC%2BC3MXhsVagtrfM, PID: 21726182
    • Hsiao CL, Wu KH, Wan KS (2011) Effects of environmental lead exposure on T-helper cell-specific cytokines in children. J Immunotoxicol 8:284–287. doi:10.3109/1547691X.2011.592162
    • (2011) J Immunotoxicol , vol.8 , pp. 284-287
    • Hsiao, C.L.1    Wu, K.H.2    Wan, K.S.3
  • 29
    • 33749240384 scopus 로고    scopus 로고
    • Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation
    • COI: 1:CAS:528:DC%2BD28XhtVWqurvL, PID: 17015049
    • Colombo S, Buclin T, Décosterd LA, Telenti A, Furrer H, Lee BL et al (2006) Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation. Clin Pharmacol Ther 80:307–318
    • (2006) Clin Pharmacol Ther , vol.80 , pp. 307-318
    • Colombo, S.1    Buclin, T.2    Décosterd, L.A.3    Telenti, A.4    Furrer, H.5    Lee, B.L.6
  • 30
    • 0032733651 scopus 로고    scopus 로고
    • Hepatic expression of acute-phase protein genes during carcinogenesis induced by peroxisome proliferators
    • COI: 1:CAS:528:DyaK1MXnvF2mtLs%3D, PID: 10569800
    • Anderson SP, Cattley RC, Corton JC (1999) Hepatic expression of acute-phase protein genes during carcinogenesis induced by peroxisome proliferators. Mol Carcinog 26:226–238
    • (1999) Mol Carcinog , vol.26 , pp. 226-238
    • Anderson, S.P.1    Cattley, R.C.2    Corton, J.C.3
  • 31
    • 14444270882 scopus 로고    scopus 로고
    • Induction and modulation of acute-phase response by protein malnutrition in rats: comparative effect of systemic and localized inflammation on interleukin-6 and acute-phase protein synthesis
    • COI: 1:CAS:528:DyaK1cXhtVekt78%3D, PID: 9446838
    • Lyoumi S, Tamion F, Petit J, Déchelotte P, Dauguet C, Scotté M et al (1998) Induction and modulation of acute-phase response by protein malnutrition in rats: comparative effect of systemic and localized inflammation on interleukin-6 and acute-phase protein synthesis. J Nutr 128:166–174
    • (1998) J Nutr , vol.128 , pp. 166-174
    • Lyoumi, S.1    Tamion, F.2    Petit, J.3    Déchelotte, P.4    Dauguet, C.5    Scotté, M.6
  • 32
    • 0024514345 scopus 로고
    • Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat
    • COI: 1:STN:280:DyaL1M7is1eksg%3D%3D, PID: 2915515
    • Fries JW, Sandstrom DJ, Meyer TW, Rennke HG (1989) Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat. Lab Investig 60:205–218
    • (1989) Lab Investig , vol.60 , pp. 205-218
    • Fries, J.W.1    Sandstrom, D.J.2    Meyer, T.W.3    Rennke, H.G.4
  • 33
    • 0031706336 scopus 로고    scopus 로고
    • Progression of glomerular diseases: is the podocyte the culprit?
    • COI: 1:STN:280:DyaK1cvgtlKlsQ%3D%3D, PID: 9734594
    • Kriz W, Gretz N, Lemley KV (1998) Progression of glomerular diseases: is the podocyte the culprit? Kidney Int 54:687–697
    • (1998) Kidney Int , vol.54 , pp. 687-697
    • Kriz, W.1    Gretz, N.2    Lemley, K.V.3
  • 34
    • 6344278488 scopus 로고    scopus 로고
    • Intermediate filaments and tissue repair
    • COI: 1:CAS:528:DC%2BD2cXovVKlu70%3D, PID: 15501447
    • DePianto D, Coulombe PA (2004) Intermediate filaments and tissue repair. Exp Cell Res 301:68–76
    • (2004) Exp Cell Res , vol.301 , pp. 68-76
    • DePianto, D.1    Coulombe, P.A.2
  • 35
    • 6344273968 scopus 로고    scopus 로고
    • Intermediate filament proteins and their associated diseases
    • COI: 1:CAS:528:DC%2BD2cXpslegs7g%3D, PID: 15537907
    • Omary MB, Coulombe PA, McLean WH (2004) Intermediate filament proteins and their associated diseases. N Engl J Med 351:2087–2100
    • (2004) N Engl J Med , vol.351 , pp. 2087-2100
    • Omary, M.B.1    Coulombe, P.A.2    McLean, W.H.3
  • 37
    • 0033568674 scopus 로고    scopus 로고
    • Curcumin blocks cytokine-mediated NF-κB activation and proinflammatory gene expression by inhibiting inhibitory factor I-κB kinase activity
    • COI: 1:CAS:528:DyaK1MXlvV2lt7o%3D, PID: 10477620
    • Jobin C, Braham C, Russo MP, Juma B, Narula AS, Brenner DA et al (1999) Curcumin blocks cytokine-mediated NF-κB activation and proinflammatory gene expression by inhibiting inhibitory factor I-κB kinase activity. J Immunol 163:3474–3483
    • (1999) J Immunol , vol.163 , pp. 3474-3483
    • Jobin, C.1    Braham, C.2    Russo, M.P.3    Juma, B.4    Narula, A.S.5    Brenner, D.A.6
  • 38
    • 39049193704 scopus 로고    scopus 로고
    • Expression of renal nuclear factor-kappa B, transforming growth factor-beta and fibronectin of rats exposed to lead
    • Qiao YF, Jiang YS, Pang DZ (2006) Expression of renal nuclear factor-kappa B, transforming growth factor-beta and fibronectin of rats exposed to lead. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 3:139–42
    • (2006) Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi , vol.3 , pp. 139-142
    • Qiao, Y.F.1    Jiang, Y.S.2    Pang, D.Z.3
  • 39
    • 0035991077 scopus 로고    scopus 로고
    • Expression of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor in normal and inflamed rat testis
    • COI: 1:CAS:528:DC%2BD38Xlt1Crsbc%3D, PID: 12029068
    • Gerdprasert O, O’Bryan MK, Nikolic-Paterson DJ, Sebire K, de Kretser DM, Hedger MP (2002) Expression of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor in normal and inflamed rat testis. Mol Hum Reprod 8:518–24
    • (2002) Mol Hum Reprod , vol.8 , pp. 518-524
    • Gerdprasert, O.1    O’Bryan, M.K.2    Nikolic-Paterson, D.J.3    Sebire, K.4    de Kretser, D.M.5    Hedger, M.P.6
  • 40
    • 84938987949 scopus 로고    scopus 로고
    • Ghoniem M, El-Sharkawy N, Hussein M, Moustafa G (2012) Efficacy of Curcumin on Lead Induced Nephrotoxicity in Female Albino Rats. Am Sci J 8:502-510
    • Ghoniem M, El-Sharkawy N, Hussein M, Moustafa G (2012) Efficacy of Curcumin on Lead Induced Nephrotoxicity in Female Albino Rats. Am Sci J 8:502-510. www.jofamericanscience.org/journals/…/064_8969am0806_502_510.pdf
  • 41
    • 77955348524 scopus 로고    scopus 로고
    • Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury
    • COI: 1:CAS:528:DC%2BC3cXpt12gu70%3D, PID: 20229497
    • Agarwal R, Goel SK, Behari JR (2010) Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury. J Appl Toxicol 30:457–468. doi:10.1002/jat.1517
    • (2010) J Appl Toxicol , vol.30 , pp. 457-468
    • Agarwal, R.1    Goel, S.K.2    Behari, J.R.3
  • 42
    • 84873957737 scopus 로고    scopus 로고
    • Toxicity of lead: a review with recent updates
    • COI: 1:CAS:528:DC%2BC38XhvVKqs7jM, PID: 23118587
    • Flora G, Gupta D, Tiwari A (2012) Toxicity of lead: a review with recent updates. Interdiscip Toxicol 5:47–58. doi:10.2478/v10102-012-0009-2
    • (2012) Interdiscip Toxicol , vol.5 , pp. 47-58
    • Flora, G.1    Gupta, D.2    Tiwari, A.3


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