Ferrous iron and α-ketoglutarate-dependent dioxygenases in the biosynthesis of microbial natural products

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1864, Issue 5, 2016, Pages 453-470

  Wu, Long Fei ^a   Meng, Song ^a   Tang, Gong Li ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Biosynthesis; C H bond activation; Engineering; Enzymatic reaction; Fe(II) ketoglutarate dependent dioxygenase; Natural product

Indexed keywords

2 OXOGLUTARIC ACID; ALPHA KETOGLUTARATE DIOXYGENASE; DIOXYGENASE; FERROUS ION; NATURAL PRODUCT; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; IRON; OXOGLUTARATE DEHYDROGENASE; OXYGEN;

BINDING SITE; BIOSYNTHESIS; BIOTRANSFORMATION; CATALYSIS; CHLORINATION; CITRIC ACID CYCLE; CRYSTAL STRUCTURE; CYCLIZATION; DECARBOXYLATION; ELIMINATION REACTION; EPOXIDATION; FATTY ACID DESATURATION; GENE INACTIVATION; HALOGENATION; HYDROXYLATION; LIGAND BINDING; NONHUMAN; OSMOLARITY; PRIORITY JOURNAL; PROTEIN DOMAIN; REACTION ANALYSIS; REVIEW; SALT STRESS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; BACTERIUM; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; X RAY CRYSTALLOGRAPHY;

BACTERIA; BIOLOGICAL PRODUCTS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; FERROUS COMPOUNDS; HYDROXYLATION; IRON; KETOGLUTARATE DEHYDROGENASE COMPLEX; OXIDATION-REDUCTION; OXYGEN;

EID: 84958729317     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2016.01.012     Document Type: Review

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