Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 33, 2014, Pages

  Eustáquio, Alessandra S ^a   Janso, Jeffrey E ^a   Ratnayake, Anokha S ^a   O'Donnell, Christopher J ^a   Koehn, Frank E ^a  

^a PFIZER INC   (United States)

Author keywords

Bacteria; Natural product; Secondary metabolite; Thailanstatin

Indexed keywords

2 OXOGLUTARIC ACID; BETA HYDROXYACID; CARBENE; CARBOXYLIC ACID; CYTOCHROME P450; DIOXYGENASE; EPOXIDE; IRON; POLYKETIDE SYNTHASE; SPLICEOSTATIN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BIOSYNTHESIS; BURKHOLDERIA; CATALYSIS; CELL MEMBRANE PERMEABILITY; DECARBOXYLATION; EPOXIDATION; GENE CLUSTER; GENE INACTIVATION; GENETIC ANALYSIS; HYDROXYLATION; MUTANT; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SPLICEOSOME;

BACTERIA; NATURAL PRODUCT; SECONDARY METABOLITE; THAILANSTATIN;

BIOCATALYSIS; BURKHOLDERIA; DIOXYGENASES; IRON; MOLECULAR SEQUENCE DATA;

EID: 84906302992     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1408300111     Document Type: Article

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