-
1
-
-
79959424209
-
Metabolic engineering for the production of natural products
-
Pickens L.B., Tang Y., Chooi Y.H. Metabolic engineering for the production of natural products. Annu Rev Chem Biomol Eng 2011, 2:211-236.
-
(2011)
Annu Rev Chem Biomol Eng
, vol.2
, pp. 211-236
-
-
Pickens, L.B.1
Tang, Y.2
Chooi, Y.H.3
-
2
-
-
58149095417
-
Biosynthesis of polyketide synthase extender units
-
Chan Y.A., Podevels A.M., Kevany B.M., Thomas M.G. Biosynthesis of polyketide synthase extender units. Nat Prod Rep 2009, 26:90-114.
-
(2009)
Nat Prod Rep
, vol.26
, pp. 90-114
-
-
Chan, Y.A.1
Podevels, A.M.2
Kevany, B.M.3
Thomas, M.G.4
-
4
-
-
33748631825
-
Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms
-
3468-3496.5
-
Fischbach M.A., Walsh C.T. Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Chem Rev 2006, 106. 3468-3496.5.
-
(2006)
Chem Rev
, vol.106
-
-
Fischbach, M.A.1
Walsh, C.T.2
-
5
-
-
77950127253
-
Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis
-
Olano C., Mendez C., Salas J.A. Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis. Nat Prod Rep 2010, 27:571-616.
-
(2010)
Nat Prod Rep
, vol.27
, pp. 571-616
-
-
Olano, C.1
Mendez, C.2
Salas, J.A.3
-
6
-
-
38949083855
-
The chemical versatility of natural-product assembly lines
-
Walsh C.T. The chemical versatility of natural-product assembly lines. Acc Chem Res 2008, 41:4-10.
-
(2008)
Acc Chem Res
, vol.41
, pp. 4-10
-
-
Walsh, C.T.1
-
7
-
-
69249202590
-
The biosynthetic logic of polyketide diversity
-
Hertweck C. The biosynthetic logic of polyketide diversity. Angew Chem Int Ed Engl 2009, 48:4688-4716.
-
(2009)
Angew Chem Int Ed Engl
, vol.48
, pp. 4688-4716
-
-
Hertweck, C.1
-
8
-
-
83455210375
-
Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity
-
Wilson M.C., Moore B.S. Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. Nat Prod Rep 2012, 29:72-86.
-
(2012)
Nat Prod Rep
, vol.29
, pp. 72-86
-
-
Wilson, M.C.1
Moore, B.S.2
-
9
-
-
34547542453
-
Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway
-
Erb T.J., Berg I.A., Brecht V., Muller M., Fuchs G., Alber B.E. Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway. Proc Natl Acad Sci USA 2007, 104:10631-10636.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 10631-10636
-
-
Erb, T.J.1
Berg, I.A.2
Brecht, V.3
Muller, M.4
Fuchs, G.5
Alber, B.E.6
-
10
-
-
68149134832
-
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine
-
Eustaquio A.S., McGlinchey R.P., Liu Y., Hazzard C., Beer L.L., Florova G., Alhamadsheh M.M., Lechner A., Kale A.J., Kobayashi Y., et al. Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proc Natl Acad Sci USA 2009, 106:12295-12300.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 12295-12300
-
-
Eustaquio, A.S.1
McGlinchey, R.P.2
Liu, Y.3
Hazzard, C.4
Beer, L.L.5
Florova, G.6
Alhamadsheh, M.M.7
Lechner, A.8
Kale, A.J.9
Kobayashi, Y.10
-
11
-
-
79959378209
-
Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation
-
Takahashi S., Toyoda A., Sekiyama Y., Takagi H., Nogawa T., Uramoto M., Suzuki R., Koshino H., Kumano T., Panthee S., et al. Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation. Nat Chem Biol 2011, 7:461-468.
-
(2011)
Nat Chem Biol
, vol.7
, pp. 461-468
-
-
Takahashi, S.1
Toyoda, A.2
Sekiyama, Y.3
Takagi, H.4
Nogawa, T.5
Uramoto, M.6
Suzuki, R.7
Koshino, H.8
Kumano, T.9
Panthee, S.10
-
12
-
-
68049104343
-
Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity
-
Liu Y., Hazzard C., Eustaquio A.S., Reynolds K.A., Moore B.S. Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity. J Am Chem Soc 2009, 131:10376-10377.
-
(2009)
J Am Chem Soc
, vol.131
, pp. 10376-10377
-
-
Liu, Y.1
Hazzard, C.2
Eustaquio, A.S.3
Reynolds, K.A.4
Moore, B.S.5
-
13
-
-
45749125659
-
Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome
-
Eustaquio A.S., Moore B.S. Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angew Chem Int Ed Engl 2008, 47:3936-3938.
-
(2008)
Angew Chem Int Ed Engl
, vol.47
, pp. 3936-3938
-
-
Eustaquio, A.S.1
Moore, B.S.2
-
14
-
-
79851505835
-
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues
-
Mo S., Kim D.H., Lee J.H., Park J.W., Basnet D.B., Ban Y.H., Yoo Y.J., Chen S.W., Park S.R., Choi E.A., et al. Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. J Am Chem Soc 2011, 133:976-985.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 976-985
-
-
Mo, S.1
Kim, D.H.2
Lee, J.H.3
Park, J.W.4
Basnet, D.B.5
Ban, Y.H.6
Yoo, Y.J.7
Chen, S.W.8
Park, S.R.9
Choi, E.A.10
-
15
-
-
79951595684
-
Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor
-
Qu X.D., Jiang N., Xu F., Shao L., Tang G.L., Wilkinson B., Liu W. Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor. Mol Biosyst 2011, 7:852-861.
-
(2011)
Mol Biosyst
, vol.7
, pp. 852-861
-
-
Qu, X.D.1
Jiang, N.2
Xu, F.3
Shao, L.4
Tang, G.L.5
Wilkinson, B.6
Liu, W.7
-
16
-
-
79955668971
-
A branched extender unit shared between two orthogonal polyketide pathways in an endophyte
-
Xu Z.L., Ding L., Hertweck C. A branched extender unit shared between two orthogonal polyketide pathways in an endophyte. Angew Chem Int Ed Engl 2011, 50:4667-4670.
-
(2011)
Angew Chem Int Ed Engl
, vol.50
, pp. 4667-4670
-
-
Xu, Z.L.1
Ding, L.2
Hertweck, C.3
-
17
-
-
79951531655
-
Structure and biosynthesis of the marine streptomycete ansamycin ansalactam a and its distinctive branched chain polyketide extender unit
-
Wilson M.C., Nam S.J., Gulder T.A.M., Kauffman C.A., Jensen P.R., Fenical W., Moore B.S. Structure and biosynthesis of the marine streptomycete ansamycin ansalactam a and its distinctive branched chain polyketide extender unit. J Am Chem Soc 2011, 133:1971-1977.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 1971-1977
-
-
Wilson, M.C.1
Nam, S.J.2
Gulder, T.A.M.3
Kauffman, C.A.4
Jensen, P.R.5
Fenical, W.6
Moore, B.S.7
-
18
-
-
67049132524
-
Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase
-
Erb T.J., Brecht V., Fuchs G., Muller M., Alber B.E. Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase. Proc Natl Acad Sci USA 2009, 106:8871-8876.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 8871-8876
-
-
Erb, T.J.1
Brecht, V.2
Fuchs, G.3
Muller, M.4
Alber, B.E.5
-
19
-
-
83655163980
-
Unusual carbon fixation gives rise to diverse polyketide extender units
-
Quade N., Huo L.J., Rachid S., Heinz D.W., Muller R. Unusual carbon fixation gives rise to diverse polyketide extender units. Nat Chem Biol 2012, 8:117-124.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 117-124
-
-
Quade, N.1
Huo, L.J.2
Rachid, S.3
Heinz, D.W.4
Muller, R.5
-
20
-
-
67849104143
-
Cleavage of four carbon-carbon bonds during biosynthesis of the griseorhodin a spiroketal pharmacophore
-
Yunt Z., Reinhardt K., Li A., Engeser M., Dahse H.M., Gutschow M., Bruhn T., Bringmann G., Piel J. Cleavage of four carbon-carbon bonds during biosynthesis of the griseorhodin a spiroketal pharmacophore. J Am Chem Soc 2009, 131:2297-2305.
-
(2009)
J Am Chem Soc
, vol.131
, pp. 2297-2305
-
-
Yunt, Z.1
Reinhardt, K.2
Li, A.3
Engeser, M.4
Dahse, H.M.5
Gutschow, M.6
Bruhn, T.7
Bringmann, G.8
Piel, J.9
-
21
-
-
84855990581
-
Angucyclines: biosynthesis, mode-of-action, new natural products, and synthesis
-
Kharel M.K., Pahari P., Shepherd M.D., Tibrewal N., Nybo S.E., Shaaban K.A., Rohr J. Angucyclines: biosynthesis, mode-of-action, new natural products, and synthesis. Nat Prod Rep 2012, 29:264-325.
-
(2012)
Nat Prod Rep
, vol.29
, pp. 264-325
-
-
Kharel, M.K.1
Pahari, P.2
Shepherd, M.D.3
Tibrewal, N.4
Nybo, S.E.5
Shaaban, K.A.6
Rohr, J.7
-
22
-
-
84856179567
-
Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis
-
Pahari P., Kharel M.K., Shepherd M.D., van Lanen S.G., Rohr J. Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis. Angew Chem Int Ed Engl 2012, 51:1216-1220.
-
(2012)
Angew Chem Int Ed Engl
, vol.51
, pp. 1216-1220
-
-
Pahari, P.1
Kharel, M.K.2
Shepherd, M.D.3
van Lanen, S.G.4
Rohr, J.5
-
23
-
-
67651173021
-
GilR, an unusual lactone-forming enzyme involved in gilvocarcin biosynthesis
-
Kharel M.K., Pahari P., Lian H., Rohr J. GilR, an unusual lactone-forming enzyme involved in gilvocarcin biosynthesis. Chembiochem 2009, 10:1305-1308.
-
(2009)
Chembiochem
, vol.10
, pp. 1305-1308
-
-
Kharel, M.K.1
Pahari, P.2
Lian, H.3
Rohr, J.4
-
24
-
-
79959540983
-
The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis
-
Noinaj N., Bosserman M.A., Schickli M.A., Piszczek G., Kharel M.K., Pahari P., Buchanan S.K., Rohr J. The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis. J Biol Chem 2011, 286:23533-23543.
-
(2011)
J Biol Chem
, vol.286
, pp. 23533-23543
-
-
Noinaj, N.1
Bosserman, M.A.2
Schickli, M.A.3
Piszczek, G.4
Kharel, M.K.5
Pahari, P.6
Buchanan, S.K.7
Rohr, J.8
-
26
-
-
43049113173
-
Delta-amino group hydroxylation of l-ornithine during coelichelin biosynthesis
-
Pohlmann V., Marahiel M.A. Delta-amino group hydroxylation of l-ornithine during coelichelin biosynthesis. Org Biomol Chem 2008, 6:1843-1848.
-
(2008)
Org Biomol Chem
, vol.6
, pp. 1843-1848
-
-
Pohlmann, V.1
Marahiel, M.A.2
-
27
-
-
79959933156
-
Consecutive enzymatic modification of ornithine generates the hydroxamate moieties of the siderophore erythrochelin
-
Robbel L., Helmetag V., Knappe T.A., Marahiel M.A. Consecutive enzymatic modification of ornithine generates the hydroxamate moieties of the siderophore erythrochelin. Biochemistry 2011, 50:6073-6080.
-
(2011)
Biochemistry
, vol.50
, pp. 6073-6080
-
-
Robbel, L.1
Helmetag, V.2
Knappe, T.A.3
Marahiel, M.A.4
-
28
-
-
84872603861
-
The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis
-
1609-1609
-
Hollenhorst M.A., Bumpus S.B., Matthews M.L., Bollinger J.M., Kelleher N.L., Walsh C.T. The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis. J Am Chem Soc 2011, 133. 1609-1609.
-
(2011)
J Am Chem Soc
, vol.133
-
-
Hollenhorst, M.A.1
Bumpus, S.B.2
Matthews, M.L.3
Bollinger, J.M.4
Kelleher, N.L.5
Walsh, C.T.6
-
29
-
-
79959459977
-
A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin
-
Giessen T.W., Kraas F.I., Marahiel M.A. A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin. Biochemistry 2011, 50:5680-5692.
-
(2011)
Biochemistry
, vol.50
, pp. 5680-5692
-
-
Giessen, T.W.1
Kraas, F.I.2
Marahiel, M.A.3
-
30
-
-
84856866295
-
Characterization of SfmD as a heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin a biosynthesis
-
Tang M.C., Fu C.Y., Tang G.L. Characterization of SfmD as a heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin a biosynthesis. J Biol Chem 2012, 287:5112-5121.
-
(2012)
J Biol Chem
, vol.287
, pp. 5112-5121
-
-
Tang, M.C.1
Fu, C.Y.2
Tang, G.L.3
-
31
-
-
43949100296
-
Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027
-
Lin S., Van Lanen S.G., Shen B. Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027. J Am Chem Soc 2008, 130:6616-6623.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 6616-6623
-
-
Lin, S.1
Van Lanen, S.G.2
Shen, B.3
-
32
-
-
79959251862
-
Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis
-
Zhang W.J., Ames B.D., Walsh C.T. Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis. Biochemistry 2011, 50:5401-5403.
-
(2011)
Biochemistry
, vol.50
, pp. 5401-5403
-
-
Zhang, W.J.1
Ames, B.D.2
Walsh, C.T.3
-
33
-
-
81355141991
-
Diversity in natural product families is governed by more than enzyme promiscuity alone: establishing control of the pacidamycin portfolio
-
Gruschow S., Rackham E.J., Goss R.J.M. Diversity in natural product families is governed by more than enzyme promiscuity alone: establishing control of the pacidamycin portfolio. Chem Sci 2011, 2:2182-2186.
-
(2011)
Chem Sci
, vol.2
, pp. 2182-2186
-
-
Gruschow, S.1
Rackham, E.J.2
Goss, R.J.M.3
-
34
-
-
54849417588
-
Beta-Hydroxylation of the aspartyl residue in the phytotoxin syringomycin E: characterization of two candidate hydroxylases AspH and SyrP in Pseudomonas syringae
-
Singh G.M., Fortin P.D., Koglin A., Walsh C.T. beta-Hydroxylation of the aspartyl residue in the phytotoxin syringomycin E: characterization of two candidate hydroxylases AspH and SyrP in Pseudomonas syringae. Biochemistry 2008, 47:11310-11320.
-
(2008)
Biochemistry
, vol.47
, pp. 11310-11320
-
-
Singh, G.M.1
Fortin, P.D.2
Koglin, A.3
Walsh, C.T.4
-
35
-
-
70349394353
-
Stereospecific synthesis of threo- and erythro-beta-hydroxyglutamic acid during kutzneride biosynthesis
-
Strieker M., Nolan E.M., Walsh C.T., Marahiel M.A. Stereospecific synthesis of threo- and erythro-beta-hydroxyglutamic acid during kutzneride biosynthesis. J Am Chem Soc 2009, 131:13523-13530.
-
(2009)
J Am Chem Soc
, vol.131
, pp. 13523-13530
-
-
Strieker, M.1
Nolan, E.M.2
Walsh, C.T.3
Marahiel, M.A.4
-
36
-
-
34248576162
-
Mechanistic and structural basis of stereospecific C beta-hydroxylation in calcium-dependent antibiotic, a daptomycin-type lipopeptide
-
Strieker M., Kopp F., Mahlert C., Essen L.O., Marahiel M.A. Mechanistic and structural basis of stereospecific C beta-hydroxylation in calcium-dependent antibiotic, a daptomycin-type lipopeptide. ACS Chem Biol 2007, 2:187-196.
-
(2007)
ACS Chem Biol
, vol.2
, pp. 187-196
-
-
Strieker, M.1
Kopp, F.2
Mahlert, C.3
Essen, L.O.4
Marahiel, M.A.5
-
37
-
-
42149173321
-
Non-heme hydroxylase engineering for simple enzymatic synthesis of l-threo-hydroxyaspartic acid
-
Strieker M., Essen L.O., Walsh C.T., Marahiel M.A. Non-heme hydroxylase engineering for simple enzymatic synthesis of l-threo-hydroxyaspartic acid. Chembiochem 2008, 9:374-376.
-
(2008)
Chembiochem
, vol.9
, pp. 374-376
-
-
Strieker, M.1
Essen, L.O.2
Walsh, C.T.3
Marahiel, M.A.4
-
38
-
-
79952270689
-
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum
-
Gao X., Chooi Y.-H., Ames B.D., Wang P., Walsh C.T., Tang Y. Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. J Am Chem Soc 2011, 133:2729-2741.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 2729-2741
-
-
Gao, X.1
Chooi, Y.-H.2
Ames, B.D.3
Wang, P.4
Walsh, C.T.5
Tang, Y.6
-
39
-
-
77957269196
-
Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis
-
Ames B.D., Liu X., Walsh C.T. Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis. Biochemistry 2010, 49:8564-8576.
-
(2010)
Biochemistry
, vol.49
, pp. 8564-8576
-
-
Ames, B.D.1
Liu, X.2
Walsh, C.T.3
-
40
-
-
79959398536
-
Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites
-
Haynes S.W., Ames B.D., Gao X., Tang Y., Walsh C.T. Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites. Biochemistry 2011, 50:5668-5679.
-
(2011)
Biochemistry
, vol.50
, pp. 5668-5679
-
-
Haynes, S.W.1
Ames, B.D.2
Gao, X.3
Tang, Y.4
Walsh, C.T.5
-
41
-
-
80053579138
-
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus
-
Ames B.D., Haynes S.W., Gao X., Evans B.S., Kelleher N.L., Tang Y., Walsh C.T. Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry 2011, 50:8756-8769.
-
(2011)
Biochemistry
, vol.50
, pp. 8756-8769
-
-
Ames, B.D.1
Haynes, S.W.2
Gao, X.3
Evans, B.S.4
Kelleher, N.L.5
Tang, Y.6
Walsh, C.T.7
-
42
-
-
84862908013
-
Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids
-
Li S., Finefield J.M., Sunderhaus J.D., McAfoos T.J., Williams R.M., Sherman D.H. Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids. J Am Chem Soc 2012, 134:788-791.
-
(2012)
J Am Chem Soc
, vol.134
, pp. 788-791
-
-
Li, S.1
Finefield, J.M.2
Sunderhaus, J.D.3
McAfoos, T.J.4
Williams, R.M.5
Sherman, D.H.6
-
43
-
-
77952542213
-
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms
-
Koketsu K., Watanabe K., Suda H., Oguri H., Oikawa H. Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms. Nat Chem Biol 2010, 6:408-410.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 408-410
-
-
Koketsu, K.1
Watanabe, K.2
Suda, H.3
Oguri, H.4
Oikawa, H.5
-
44
-
-
0037011396
-
Mechanistic studies of HPP epoxidase: configuration of the substrate governs its enzymatic fate
-
Zhao Z., Liu P., Murakami K., Kuzuyama T., Seto H., Liu H.W. Mechanistic studies of HPP epoxidase: configuration of the substrate governs its enzymatic fate. Angew Chem Int Ed Engl 2002, 41:4529-4532.
-
(2002)
Angew Chem Int Ed Engl
, vol.41
, pp. 4529-4532
-
-
Zhao, Z.1
Liu, P.2
Murakami, K.3
Kuzuyama, T.4
Seto, H.5
Liu, H.W.6
-
45
-
-
79960609487
-
Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis
-
Yun D., Dey M., Higgins L.J., Yan F., Liu H.W., Drennan C.L. Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis. J Am Chem Soc 2011, 133:11262-11269.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 11262-11269
-
-
Yun, D.1
Dey, M.2
Higgins, L.J.3
Yan, F.4
Liu, H.W.5
Drennan, C.L.6
-
46
-
-
79960683560
-
Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes
-
Carlson J.C., Li S., Gunatilleke S.S., Anzai Y., Burr D.A., Podust L.M., Sherman D.H. Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes. Nat Chem 2011, 3:628-633.
-
(2011)
Nat Chem
, vol.3
, pp. 628-633
-
-
Carlson, J.C.1
Li, S.2
Gunatilleke, S.S.3
Anzai, Y.4
Burr, D.A.5
Podust, L.M.6
Sherman, D.H.7
-
47
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ro D.K., Paradise E.M., Ouellet M., Fisher K.J., Newman K.L., Ndungu J.M., Ho K.A., Eachus R.A., Ham T.S., Kirby J., et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 2006, 440:940-943.
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ro, D.K.1
Paradise, E.M.2
Ouellet, M.3
Fisher, K.J.4
Newman, K.L.5
Ndungu, J.M.6
Ho, K.A.7
Eachus, R.A.8
Ham, T.S.9
Kirby, J.10
-
48
-
-
79957753066
-
Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA
-
Barriuso J., Nguyen D.T., Li J.W., Roberts J.N., MacNevin G., Chaytor J.L., Marcus S.L., Vederas J.C., Ro D.K. Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA. J Am Chem Soc 2011, 133:8078-8081.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 8078-8081
-
-
Barriuso, J.1
Nguyen, D.T.2
Li, J.W.3
Roberts, J.N.4
MacNevin, G.5
Chaytor, J.L.6
Marcus, S.L.7
Vederas, J.C.8
Ro, D.K.9
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