SyrB2 in syringomycin E biosynthesis is a nonheme FeII α-ketoglutarate- and O2-dependent halogenase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 29, 2005, Pages 10111-10116

  Vaillancourt, Frédéric H ^a   Yin, Jun ^a   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Enzymology; Natural product biosynthesis; Organohalogen

Indexed keywords

2 OXOGLUTARIC ACID; CARBON; CHLORIDE; CHLORINE 36; DNA; ENZYME; FERROUS ION; HALOGENASE; ISOINDOLE DERIVATIVE; NATURAL PRODUCT; ORGANOHALOGEN DERIVATIVE; OXYGEN; PLANT TOXIN; PROTEIN; SYRINGOMYCIN E; THIOL ESTER HYDROLASE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CHLORINATION; CHROMATOGRAPHY; CONTROLLED STUDY; HALOGENATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

CHLORIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; DNA PRIMERS; FERROUS COMPOUNDS; FLUORESCENCE; KETOGLUTARIC ACIDS; MASS SPECTROMETRY; MODELS, CHEMICAL; OXYGEN; PEPTIDE SYNTHASES; PEPTIDES, CYCLIC; PLASMIDS; PSEUDOMONAS SYRINGAE;

PSEUDOMONAS SYRINGAE PV. SYRINGAE;

EID: 22544479980     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0504412102     Document Type: Article

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