Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

Nature

Volumn 436, Issue 7054, 2005, Pages 1191-1194

  Vaillancourt, Frédéric H ^a   Yeh, Ellen ^a   Vosburg, David A ^a,c   O'Connor, Sarah E ^a,b   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVEY MUDD COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; BIOSYNTHESIS; CATALYSTS; CHLORINATION; HALOGENATION; IODINE; IRON; PATHOLOGY;

BIOLOGICAL CATALYSTS; CORONAMIC ACID; CRYPTIC CHLORINATION;

ENZYMES;

2 OXOGLUTARIC ACID; ACYLTRANSFERASE; ALIPHATIC COMPOUND; AMINE; BROMINE; CARBOXYL GROUP; CHLORINE; CORONAMIC ACID; CORONATINE; CYCLOPROPANE DERIVATIVE; IODINE; ISOLEUCINE; NATURAL PRODUCT; NONHEME IRON PROTEIN; PEPTIDE SYNTHASE; PLANT TOXIN; PROTEIN; PROTEIN CMAA; PROTEIN CMAB; PROTEIN CMAC; PROTEIN CMAD; PROTEIN CMAE; UNCLASSIFIED DRUG;

ENZYME;

AMINO ACID SYNTHESIS; ARTICLE; CATALYST; CHLORINATION; COVALENT BOND; ELIMINATION REACTION; ENZYME ACTIVITY; ENZYME MECHANISM; HALOGENATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PSEUDOMONAS SYRINGAE; REACTION ANALYSIS; TOXIN SYNTHESIS;

ACYLTRANSFERASES; AMINO ACIDS; BACTERIAL PROTEINS; CATALYSIS; CHLORINE; ENZYMES; HEME; INDENES; IRON; ISOLEUCINE; PSEUDOMONAS SYRINGAE; VALINE;

PSEUDOMONAS SYRINGAE;

EID: 24144485937     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03797     Document Type: Article

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