Cloning and elucidation of the FR901464 gene cluster revealing a complex acyltransferase-less polyketide synthase using glycerate as starter units

Journal of the American Chemical Society

Volumn 133, Issue 8, 2011, Pages 2452-2462

  Zhang, Feng ^a   He, Hai Yan ^a   Tang, Man Cheng ^a   Tang, Yu Min ^a   Zhou, Qiang ^a   Tang, Gong Li ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CARRIER PROTEINS; ACYLTRANSFERASES; ANTI-TUMORS; BAEYER-VILLIGER REACTION; BIOCHEMICAL CHARACTERIZATION; BIOSYNTHETIC GENE CLUSTER; BIOSYNTHETIC PATHWAY; COMPLEMENTATION; DEGENERATE PRIMERS; DNA SEGMENTS; GENE CLUSTERS; GENE INACTIVATION; IN-SILICO; MULTIPLE DOMAINS; NATURAL PRODUCTS; NONRIBOSOMAL PEPTIDE SYNTHETASES; OPEN READING FRAME; PCR AMPLIFICATION; POLYKETIDE SYNTHASES; POLYKETIDES; PRE-MRNA; PSEUDOMONAS SP; SMALL MOLECULES; SPLICEOSOMES; SYNTHASES;

BIOCHEMISTRY; BIOSYNTHESIS; CLONING; DRUG PRODUCTS; MACHINERY; NUCLEIC ACIDS; PLANTS (BOTANY); POLYMER BLENDS; POLYMERASE CHAIN REACTION; STARTERS;

GENE ENCODING;

ACYL CARRIER PROTEIN; ACYLTRANSFERASE; ANTINEOPLASTIC AGENT; FR 901464; GLYCERIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BAEYER VILLIGER REACTION; DRUG SYNTHESIS; GENE CLUSTER; GENE INACTIVATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PSEUDOMONAS;

CLONING, MOLECULAR; GLYCERIC ACIDS; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; MOLECULAR CONFORMATION; POLYKETIDE SYNTHASES; POLYMERASE CHAIN REACTION; PYRANS; SPIRO COMPOUNDS;

EID: 79952275020     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja105649g     Document Type: Article

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