Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 37, 2015, Pages 11547-11552

  McCulloch, Kathryn M ^a   McCranie, Emilianne K ^b   Smith, Jarrod A ^b   Sarwar, Maruf ^a   Mathieu, Jeannette L ^a   Gitschlag, Bryan L ^a   Du, Yu ^b   Bachmannb, Brian O ^b   Iversona, T M ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Antibiotic biosynthesis; Crystal structure; Nonheme iron ketoglutarate dependent oxygenases; Oxidative cyclization

Indexed keywords

2 OXOGLUTARIC ACID; ANTIBIOTIC AGENT; AVILAMYCIN; EVERNINOMICIN; HYDROGEN; HYGROMYCIN B; ORTHOSOMYCIN; OXYGENASE; UNCLASSIFIED DRUG; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; EVERNIMICIN; METAL; OLIGOSACCHARIDE; OXYGEN; PROTEIN BINDING;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CRYSTAL STRUCTURE; CYCLIZATION; ENZYME SPECIFICITY; GENE DISRUPTION; GENETIC ANALYSIS; MICROMONOSPORA; MICROMONOSPORA CARBONACEA; NONHUMAN; OXIDATION; PHYLOGENY; PRIORITY JOURNAL; STREPTOMYCES HYGROSCOPICUS; STREPTOMYCES VIRIDOCHROMOGENES; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; MULTIGENE FAMILY; OPEN READING FRAME; OXIDATION REDUCTION REACTION; PROTEIN SECONDARY STRUCTURE; REPRODUCIBILITY; STREPTOMYCES; X RAY CRYSTALLOGRAPHY;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; HYDROGEN; HYGROMYCIN B; METALS; MICROMONOSPORA; MULTIGENE FAMILY; OLIGOSACCHARIDES; OPEN READING FRAMES; OXIDATION-REDUCTION; OXYGEN; OXYGENASES; PHYLOGENY; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; REPRODUCIBILITY OF RESULTS; STREPTOMYCES;

EID: 84941662880     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1500964112     Document Type: Article

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