Metabolic engineering of Escherichia coli to produce (2S, 3R, 4S)-4-hydroxyisoleucine

Applied Microbiology and Biotechnology

Volumn 88, Issue 3, 2010, Pages 719-726

  Smirnov, Sergey V ^a   Kodera, Tomohiro ^b   Samsonova, Natalya N ^a   Kotlyarova, Veronika A ^a   Rushkevich, Natalya Yu ^a   Kivero, Alexander D ^a   Sokolov, Pavel M ^a   Hibi, Makoto ^c   Ogawa, Jun ^c   Shimizu, Sakayu ^c  

^a Ajinomoto Genetika Research Institute   (Russian Federation)

^b AJINOMOTO CO INC   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

4 hydroxyisoleucine; Biotransformation; Diabetes; Dioxygenase; Escherichia coli

Indexed keywords

4-HYDROXYISOLEUCINE; BIOTRANSFORMATION; DIABETES; DIOXYGENASES; HYDROXYLASES; ISOCITRATE DEHYDROGENASE; KETOGLUTARATE; L-ISOLEUCINE; METABOLIC ENGINEERING; SUCCINATE SYNTHESIS;

AMINO ACIDS; BIOCONVERSION; ESCHERICHIA COLI; GROWTH KINETICS;

CLONING;

4 HYDROXYISOLEUCINE; ISOCITRATE DEHYDROGENASE; ISOCITRATE LYASE; ISOLEUCINE; OXOGLUTARATE DEHYDROGENASE; SUCCINIC ACID;

AMINO ACID; BIOTRANSFORMATION; COLIFORM BACTERIUM; DIABETES; ENZYME ACTIVITY; GLUCOSE; METABOLISM;

ANIMAL CELL; ARTICLE; BACTERIAL STRAIN; BIOTRANSFORMATION; CELL GROWTH; CULTURE MEDIUM; ESCHERICHIA COLI; METABOLIC ENGINEERING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; BASE SEQUENCE; BIOTRANSFORMATION; CLONING, MOLECULAR; DIOXYGENASES; ESCHERICHIA COLI; FERMENTATION; GENE EXPRESSION REGULATION, BACTERIAL; ISOLEUCINE; KETOGLUTARATE DEHYDROGENASE COMPLEX; MOLECULAR SEQUENCE DATA;

ESCHERICHIA COLI;

EID: 78149357549     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-2772-3     Document Type: Article

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