The nonribosomal peptide synthetase enzyme DdaD tethers N β-fumaramoyl-l -2,3-diaminopropionate for Fe(II)/α- ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis

Journal of the American Chemical Society

Volumn 132, Issue 44, 2010, Pages 15773-15781

  Hollenhorst, Marie A ^a   Bumpus, Stefanie B ^b   Matthews, Megan L ^c   Bollinger Jr , J Martin ^c   Kelleher, Neil L ^b,d   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATION; ANTIBIOTIC BIOSYNTHESIS; COVALENTLY BOUND; DIOXYGENASES; GENE CLUSTERS; KETOGLUTARATE; L-VALINE; NATURAL ANTIBIOTICS; NONRIBOSOMAL PEPTIDE SYNTHETASES; OXIDATIVE MODIFICATION; PANTOEA AGGLOMERANS; THIOESTERS; THIOLATION;

AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; PEPTIDES;

ANTIBIOTICS;

2 OXOGLUTARIC ACID; ADENOSINE TRIPHOSPHATE; DDAC PROTEIN; DDAD PROTEIN; IRON; PROPIONIC ACID DERIVATIVE; PROTEIN; SYNTHETASE; THIOESTER; UNCLASSIFIED DRUG; VALINE;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CHEMICAL MODIFICATION; COVALENT BOND; EPOXIDATION; HYDROLYSIS; NUCLEOTIDE SEQUENCE; OXIDATION;

ANTI-BACTERIAL AGENTS; EPOXY COMPOUNDS; IRON; KETOGLUTARIC ACIDS; MOLECULAR STRUCTURE; MULTIGENE FAMILY; PANTOEA; PEPTIDE SYNTHASES;

EID: 78149245165     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja1072367     Document Type: Article

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