메뉴 건너뛰기




Volumn 15, Issue 9, 2016, Pages 620-638

Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACETYLSALICYLIC ACID; BATIMASTAT; BOSENTAN; ENALAPRIL; LOSARTAN; NEDOCROMIL; PROPRANOLOL; SERELAXIN; SPIRONOLACTONE;

EID: 84955612078     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd.2016.89     Document Type: Review
Times cited : (257)

References (308)
  • 1
    • 67249152096 scopus 로고    scopus 로고
    • Cardiac fibroblasts: At the heart of myocardial remodeling
    • Porter, K. E., & Turner, N. A. Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol. Ther. 123, 255-278 (2009
    • (2009) Pharmacol. Ther , vol.123 , pp. 255-278
    • Porter, K.E.1    Turner, N.A.2
  • 2
    • 84899113897 scopus 로고    scopus 로고
    • Fibroblast-myocyte electrotonic coupling: Does it occur in native cardiac tissue?
    • Kohl, P., & Gourdie, R. G. Fibroblast-myocyte electrotonic coupling: does it occur in native cardiac tissue? J. Mol. Cell. Cardiol. 70, 37-46 (2014
    • (2014) J. Mol. Cell. Cardiol , vol.70 , pp. 37-46
    • Kohl, P.1    Gourdie, R.G.2
  • 5
    • 84898833444 scopus 로고    scopus 로고
    • Myofibroblasts: Trust your heart and let fate decide
    • Davis, J., & Molkentin, J. D. Myofibroblasts: trust your heart and let fate decide. J. Mol. Cell. Cardiol. 70, 9-18 (2014
    • (2014) J. Mol. Cell. Cardiol , vol.70 , pp. 9-18
    • Davis, J.1    Molkentin, J.D.2
  • 6
    • 84930741570 scopus 로고    scopus 로고
    • Getting to the heart of the matter: New insights into cardiac fibrosis
    • Leask, A. Getting to the heart of the matter: new insights into cardiac fibrosis. Circ. Res. 116, 1269-1276 (2015
    • (2015) Circ. Res , vol.116 , pp. 1269-1276
    • Leask, A.1
  • 7
    • 84878189263 scopus 로고    scopus 로고
    • The origin and arrhythmogenic potential of fibroblasts in cardiac disease
    • Vasquez, C., & Morley, G. E. The origin and arrhythmogenic potential of fibroblasts in cardiac disease. J. Cardiovasc. Transl. Res. 5, 760-767 (2012
    • (2012) J. Cardiovasc. Transl. Res , vol.5 , pp. 760-767
    • Vasquez, C.1    Morley, G.E.2
  • 8
    • 84856173169 scopus 로고    scopus 로고
    • Myocyte-fibroblast electrical coupling: The basis of a stable relationship?
    • Ongstad, E. L., & Gourdie, R. G. Myocyte-fibroblast electrical coupling: the basis of a stable relationship? Cardiovascular Res. 93, 215-217 (2012
    • (2012) Cardiovascular Res , vol.93 , pp. 215-217
    • Ongstad, E.L.1    Gourdie, R.G.2
  • 9
    • 84922381210 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2015 update: A report from the American Heart Association
    • Mozaffarian, D., et al. Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circulation 131, e29-e322 (2015
    • (2015) Circulation , vol.131 , pp. e29-e322
    • Mozaffarian, D.1
  • 10
    • 35748974863 scopus 로고    scopus 로고
    • Myocardial matrix remodeling and the matrix metalloproteinases: Influence on cardiac form and function
    • Spinale, F. G. Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol. Rev. 87, 1285-1342 (2007
    • (2007) Physiol. Rev , vol.87 , pp. 1285-1342
    • Spinale, F.G.1
  • 11
    • 0018427165 scopus 로고
    • The collagen network of the heart
    • Caulfield, J. B., & Borg, T. K. The collagen network of the heart. Lab. Invest. 40, 364-371 (1979
    • (1979) Lab. Invest , vol.40 , pp. 364-371
    • Caulfield, J.B.1    Borg, T.K.2
  • 12
    • 84868138467 scopus 로고    scopus 로고
    • Histo-Anatomical structure of the living isolated rat heart in two contraction states assessed by diffusion tensor MRI
    • Hales, P. W., et al. Histo-Anatomical structure of the living isolated rat heart in two contraction states assessed by diffusion tensor MRI. Prog. Biophys. Mol. Biol. 110, 319-330 (2012
    • (2012) Prog. Biophys. Mol. Biol , vol.110 , pp. 319-330
    • Hales, P.W.1
  • 13
    • 38949168818 scopus 로고    scopus 로고
    • Perfusion-decellularized matrix: Using nature?s platform to engineer a bioartificial heart
    • Ott, H. C., et al. Perfusion-decellularized matrix: using nature?s platform to engineer a bioartificial heart. Nat. Med. 14, 213-221 (2008
    • (2008) Nat. Med , vol.14 , pp. 213-221
    • Ott, H.C.1
  • 14
    • 84939150266 scopus 로고    scopus 로고
    • Acellular human heart matrix: A critical step toward whole heart grafts
    • Sanchez, P. L., et al. Acellular human heart matrix: a critical step toward whole heart grafts. Biomaterials 61, 279-289 (2015
    • (2015) Biomaterials , vol.61 , pp. 279-289
    • Sanchez, P.L.1
  • 15
    • 84883083341 scopus 로고    scopus 로고
    • Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells
    • Lu, T. Y., et al. Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells. Nat. Commun. 4, 2307 (2013
    • (2013) Nat. Commun , vol.4 , pp. 2307
    • Lu, T.Y.1
  • 16
    • 66249110672 scopus 로고    scopus 로고
    • Stabilized collagen scaffolds for heart valve tissue engineering
    • Tedder, M. E., et al. Stabilized collagen scaffolds for heart valve tissue engineering. Tissue Eng. Part A 15, 1257-1268 (2009
    • (2009) Tissue Eng. Part A , vol.15 , pp. 1257-1268
    • Tedder, M.E.1
  • 17
    • 84939510479 scopus 로고    scopus 로고
    • In search of living valve substitutes
    • Yacoub, M. H. In search of living valve substitutes. J. Am. Coll. Cardiol. 66, 889-891 (2015
    • (2015) J. Am. Coll. Cardiol , vol.66 , pp. 889-891
    • Yacoub, M.H.1
  • 18
    • 84962715083 scopus 로고    scopus 로고
    • The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy
    • Mohamed, T. M. A., et al. The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy. Nat. Commun. 7, 11074 (2016
    • (2016) Nat. Commun , vol.7 , pp. 11074
    • Mohamed, T.M.A.1
  • 19
    • 0026747148 scopus 로고
    • Spatial and functional relationship between myocytes and fibroblasts in the rabbit sinoatrial node
    • De Maziere, A. M., van Ginneken, A. C., Wilders, R., Jongsma, H. J., & Bouman, L. N. Spatial and functional relationship between myocytes and fibroblasts in the rabbit sinoatrial node. J. Mol. Cell. Cardiol. 24, 567-578 (1992
    • (1992) J. Mol. Cell. Cardiol , vol.24 , pp. 567-578
    • De Maziere, A.M.1    Van Ginneken, A.C.2    Wilders, R.3    Jongsma, H.J.4    Bouman, L.N.5
  • 20
    • 1842507518 scopus 로고    scopus 로고
    • Fibroblast network in rabbit sinoatrial node: Structural and functional identification of homogeneous and heterogeneous cell coupling
    • Camelliti, P., Green, C. R., LeGrice, I., & Kohl, P. Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling. Circ. Res. 94, 828-835 (2004
    • (2004) Circ. Res , vol.94 , pp. 828-835
    • Camelliti, P.1    Green, C.R.2    LeGrice, I.3    Kohl, P.4
  • 21
    • 77958451496 scopus 로고    scopus 로고
    • Enhanced fibroblast-myocyte interactions in response to cardiac injury
    • Vasquez, C., et al. Enhanced fibroblast-myocyte interactions in response to cardiac injury. Circ. Res. 107, 1011-1020 (2010
    • (2010) Circ. Res , vol.107 , pp. 1011-1020
    • Vasquez, C.1
  • 22
    • 84856191694 scopus 로고    scopus 로고
    • Arrhythmogenic consequences of myofibroblast-myocyte coupling
    • Nguyen, T. P., Xie, Y., Garfinkel, A., Qu, Z., & Weiss, J. N. Arrhythmogenic consequences of myofibroblast-myocyte coupling. Cardiovasc. Res. 93, 242-251 (2012
    • (2012) Cardiovasc. Res , vol.93 , pp. 242-251
    • Nguyen, T.P.1    Xie, Y.2    Garfinkel, A.3    Qu, Z.4    Weiss, J.N.5
  • 23
    • 84962639380 scopus 로고    scopus 로고
    • Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: Role of fibrosis and connexin remodelling
    • Nisbet, A. M., et al. Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: role of fibrosis and connexin remodelling. J. Mol. Cell. Cardiol. 94, 54-64 (2016
    • (2016) J. Mol. Cell. Cardiol , vol.94 , pp. 54-64
    • Nisbet, A.M.1
  • 24
    • 0024477109 scopus 로고
    • Epicardial formation in embryonic chick heart: Computer-Aided reconstruction, scanning, and transmission electron microscopic studies
    • Hiruma, T., & Hirakow, R. Epicardial formation in embryonic chick heart: computer-Aided reconstruction, scanning, and transmission electron microscopic studies. Am. J. Anat. 184, 129-138 (1989
    • (1989) Am. J. Anat , vol.184 , pp. 129-138
    • Hiruma, T.1    Hirakow, R.2
  • 25
    • 0029964385 scopus 로고    scopus 로고
    • Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ
    • Mikawa, T., & Gourdie, R. G. Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ. Dev. Biol. 174, 221-232 (1996
    • (1996) Dev. Biol , vol.174 , pp. 221-232
    • Mikawa, T.1    Gourdie, R.G.2
  • 26
    • 0014602211 scopus 로고
    • Embryonic development of the heart II Formation of the epicardium
    • Manasek, F. J. Embryonic development of the heart. II. Formation of the epicardium. J. Embryol. Exp. Morphol. 22, 333-348 (1969
    • (1969) J. Embryol. Exp. Morphol , vol.22 , pp. 333-348
    • Manasek, F.J.1
  • 27
    • 0032518298 scopus 로고    scopus 로고
    • Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart
    • Dettman, R. W., Denetclaw, W. Jr, Ordahl, C. P., & Bristow, J. Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart. Dev. Biol. 193, 169-181 (1998
    • (1998) Dev. Biol , vol.193 , pp. 169-181
    • Dettman, R.W.1    Denetclaw, W.2    Ordahl, C.P.3    Bristow, J.4
  • 28
    • 0345516018 scopus 로고    scopus 로고
    • Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions
    • Gittenberger de Groot, A. C., Vrancken Peeters, M. P., Mentink, M. M., Gourdie, R. G., & Poelmann, R. E. Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions. Circul. Res. 82, 1043-1052 (1998
    • (1998) Circul. Res , vol.82 , pp. 1043-1052
    • Gittenberger De Groot, A.C.1    Vrancken Peeters, M.P.2    Mentink, M.M.3    Gourdie, R.G.4    Poelmann, R.E.5
  • 29
    • 85006197424 scopus 로고    scopus 로고
    • Fibrosis of the neonatal mouse heart after cryoinjury is accompanied by Wnt signaling activation and epicardial-To mesenchymal transition
    • Mizutani, M., Wu, J. C., & Nusse, R. Fibrosis of the neonatal mouse heart after cryoinjury is accompanied by Wnt signaling activation and epicardial-To mesenchymal transition. J. Am. Heart Assoc. 4, e002457 (2016
    • (2016) J. Am. Heart Assoc , vol.4 , pp. e002457
    • Mizutani, M.1    Wu, J.C.2    Nusse, R.3
  • 30
    • 84973402509 scopus 로고    scopus 로고
    • The proepicardium keeps a potential for glomerular marker expression which supports its evolutionary origin from the pronephros
    • Cano, E., Carmona, R., Velecela, V., Martinez-Estrada, O., & Munoz-Chapuli, R. The proepicardium keeps a potential for glomerular marker expression which supports its evolutionary origin from the pronephros. Evol. Dev. 17, 224-230 (2015
    • (2015) Evol. Dev , vol.17 , pp. 224-230
    • Cano, E.1    Carmona, R.2    Velecela, V.3    Martinez-Estrada, O.4    Munoz-Chapuli, R.5
  • 31
    • 33746970417 scopus 로고    scopus 로고
    • BMP is an important regulator of proepicardial identity in the chick embryo
    • Schlueter, J., Manner, J., & Brand, T. BMP is an important regulator of proepicardial identity in the chick embryo. Dev. Biol. 295, 546-558 (2006
    • (2006) Dev. Biol , vol.295 , pp. 546-558
    • Schlueter, J.1    Manner, J.2    Brand, T.3
  • 32
    • 29444451293 scopus 로고    scopus 로고
    • Epicardial retinoid X receptor α is required for myocardial growth and coronary artery formation
    • Merki, E., et al. Epicardial retinoid X receptor α is required for myocardial growth and coronary artery formation. Proc. Natl Acad. Sci. USA 102, 18455-18460 (2005
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 18455-18460
    • Merki, E.1
  • 33
    • 33644975212 scopus 로고    scopus 로고
    • Transforming growth factor-β induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells
    • Compton, L. A., Potash, D. A., Mundell, N. A., & Barnett, J. V. Transforming growth factor-β induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells. Dev. Dyn. 235, 82-93 (2006
    • (2006) Dev. Dyn , vol.235 , pp. 82-93
    • Compton, L.A.1    Potash, D.A.2    Mundell, N.A.3    Barnett, J.V.4
  • 34
    • 73349108404 scopus 로고    scopus 로고
    • Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and e cadherin
    • Martinez-Estrada, O. M., et al. Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E cadherin. Nat. Genet. 42, 89-93 (2010
    • (2010) Nat. Genet , vol.42 , pp. 89-93
    • Martinez-Estrada, O.M.1
  • 35
    • 84885857490 scopus 로고    scopus 로고
    • Tbx18 regulates development of the epicardium and coronary vessels
    • Wu, S. P., Dong, X. R., Regan, J. N., Su, C., & Majesky, M. W. Tbx18 regulates development of the epicardium and coronary vessels. Dev. Biol. 383, 307-320 (2013
    • (2013) Dev. Biol , vol.383 , pp. 307-320
    • Wu, S.P.1    Dong, X.R.2    Regan, J.N.3    Su, C.4    Majesky, M.W.5
  • 36
    • 84899897293 scopus 로고    scopus 로고
    • Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair
    • Furtado, M. B., et al. Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair. Circ. Res. 114, 1422-1434 (2014
    • (2014) Circ. Res , vol.114 , pp. 1422-1434
    • Furtado, M.B.1
  • 37
    • 83555174793 scopus 로고    scopus 로고
    • TGFβ and BMP 2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway
    • Sanchez, N. S., & Barnett, J. V. TGFβ and BMP 2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway. Cell Signal. 24, 539-548 (2012
    • (2012) Cell Signal , vol.24 , pp. 539-548
    • Sanchez, N.S.1    Barnett, J.V.2
  • 38
    • 84937558186 scopus 로고    scopus 로고
    • Type III TGFβ receptor and Src direct hyaluronan-mediated invasive cell motility
    • Allison, P., Espiritu, D., Barnett, J. V., & Camenisch, T. D. Type III TGFβ receptor and Src direct hyaluronan-mediated invasive cell motility. Cell Signal. 27, 453-459 (2015
    • (2015) Cell Signal , vol.27 , pp. 453-459
    • Allison, P.1    Espiritu, D.2    Barnett, J.V.3    Camenisch, T.D.4
  • 39
    • 79960178341 scopus 로고    scopus 로고
    • FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium
    • Vega-Hernandez, M., Kovacs, A., De Langhe, S., & Ornitz, D. M. FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium. Development 138, 3331-3340 (2011
    • (2011) Development , vol.138 , pp. 3331-3340
    • Vega-Hernandez, M.1    Kovacs, A.2    De Langhe, S.3    Ornitz, D.M.4
  • 40
    • 79958799319 scopus 로고    scopus 로고
    • Epicardial-derived cell epithelial-To mesenchymal transition and fate specification require PDGF receptor signaling
    • Smith, C. L., Baek, S. T., Sung, C. Y., & Tallquist, M. D. Epicardial-derived cell epithelial-To mesenchymal transition and fate specification require PDGF receptor signaling. Circ. Res. 108, e15-e26 (2011
    • (2011) Circ. Res , vol.108 , pp. e15-e26
    • Smith, C.L.1    Baek, S.T.2    Sung, C.Y.3    Tallquist, M.D.4
  • 41
    • 84928042243 scopus 로고    scopus 로고
    • Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state
    • Artamonov, M. V., et al. Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state. J. Biol. Chem. 290, 10353-10367 (2015
    • (2015) J. Biol. Chem , vol.290 , pp. 10353-10367
    • Artamonov, M.V.1
  • 42
    • 0037447925 scopus 로고    scopus 로고
    • Inhibition of α4 integrin stimulates epicardial-mesenchymal transformation and alters migration and cell fate of epicardially derived mesenchyme
    • Dettman, R. W., Pae, S. H., Morabito, C., & Bristow, J. Inhibition of α4 integrin stimulates epicardial-mesenchymal transformation and alters migration and cell fate of epicardially derived mesenchyme. Dev. Biol. 257, 315-328 (2003
    • (2003) Dev. Biol , vol.257 , pp. 315-328
    • Dettman, R.W.1    Pae, S.H.2    Morabito, C.3    Bristow, J.4
  • 43
    • 84888257749 scopus 로고    scopus 로고
    • Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition
    • Benesh, E. C., et al. Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition. Mol. Biol. Cell 24, 3496-3510 (2013
    • (2013) Mol. Biol. Cell , vol.24 , pp. 3496-3510
    • Benesh, E.C.1
  • 44
    • 84896923673 scopus 로고    scopus 로고
    • The cAMP-binding Popdc proteins have a redundant function in the heart
    • Brand, T., Simrick, S. L., Poon, K. L., & Schindler, R. F. The cAMP-binding Popdc proteins have a redundant function in the heart. Biochem. Soc. Trans. 42, 295-301 (2014
    • (2014) Biochem. Soc. Trans , vol.42 , pp. 295-301
    • Brand, T.1    Simrick, S.L.2    Poon, K.L.3    Schindler, R.F.4
  • 45
    • 0033010832 scopus 로고    scopus 로고
    • A role for serum response factor in coronary smooth muscle differentiation from proepicardial cells
    • Landerholm, T. E., et al. A role for serum response factor in coronary smooth muscle differentiation from proepicardial cells. Development 126, 2053-2062 (1999
    • (1999) Development , vol.126 , pp. 2053-2062
    • Landerholm, T.E.1
  • 46
    • 84861394103 scopus 로고    scopus 로고
    • The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors
    • Acharya, A., et al. The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors. Development 139, 2139-2149 (2012
    • (2012) Development , vol.139 , pp. 2139-2149
    • Acharya, A.1
  • 47
    • 84877791390 scopus 로고    scopus 로고
    • Tcf21 regulates the specification and maturation of proepicardial cells
    • Tandon, P., Miteva, Y. V., Kuchenbrod, L. M., Cristea, I. M., & Conlon, F. L. Tcf21 regulates the specification and maturation of proepicardial cells. Development 140, 2409-2421 (2013
    • (2013) Development , vol.140 , pp. 2409-2421
    • Tandon, P.1    Miteva, Y.V.2    Kuchenbrod, L.M.3    Cristea, I.M.4    Conlon, F.L.5
  • 48
    • 84918515802 scopus 로고    scopus 로고
    • Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels
    • Trembley, M. A., Velasquez, L. S., de Mesy Bentley, K. L., & Small, E. M. Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels. Development 142, 21-30 (2015
    • (2015) Development , vol.142 , pp. 21-30
    • Trembley, M.A.1    Velasquez, L.S.2    De Mesy Bentley, K.L.3    Small, E.M.4
  • 49
    • 84868700353 scopus 로고    scopus 로고
    • Pericyte-like progenitors show high immaturity and engraftment potential as compared with mesenchymal stem cells
    • Bouacida, A., et al. Pericyte-like progenitors show high immaturity and engraftment potential as compared with mesenchymal stem cells. PLoS ONE 7, e48648 (2012
    • (2012) PLoS ONE , vol.7 , pp. e48648
    • Bouacida, A.1
  • 50
    • 84955286490 scopus 로고    scopus 로고
    • Pericytes are progenitors for coronary artery smooth muscle
    • Volz, K. S., et al. Pericytes are progenitors for coronary artery smooth muscle. eLife 4, e10036 (2015
    • (2015) ELife , vol.4 , pp. e10036
    • Volz, K.S.1
  • 51
    • 84927943104 scopus 로고    scopus 로고
    • Type 1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner
    • Birbrair, A., et al. Type 1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Stem Cell Res. Ther. 5, 122 (2014
    • (2014) Stem Cell Res. Ther , vol.5 , pp. 122
    • Birbrair, A.1
  • 52
    • 0029061401 scopus 로고
    • Molecular regulation of atrioventricular valvuloseptal morphogenesis
    • Eisenberg, L. M., & Markwald, R. R. Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circul. Res. 77, 1-6 (1995
    • (1995) Circul. Res , vol.77 , pp. 1-6
    • Eisenberg, L.M.1    Markwald, R.R.2
  • 53
    • 0037775854 scopus 로고    scopus 로고
    • Neural crest and cardiovascular development: A 20 year perspective
    • Hutson, M. R., & Kirby, M. L. Neural crest and cardiovascular development: a 20 year perspective. Birth Defects Res. C Embryo Today 69, 2-13 (2003
    • (2003) Birth Defects Res. C Embryo Today , vol.69 , pp. 2-13
    • Hutson, M.R.1    Kirby, M.L.2
  • 54
    • 77954761365 scopus 로고    scopus 로고
    • Tissue-Tissue interactions during morphogenesis of the outflow tract
    • Rentschler, S., Jain, R., & Epstein, J. A. Tissue-Tissue interactions during morphogenesis of the outflow tract. Pediatr. Cardiol. 31, 408-413 (2010
    • (2010) Pediatr. Cardiol , vol.31 , pp. 408-413
    • Rentschler, S.1    Jain, R.2    Epstein, J.A.3
  • 55
    • 84910111838 scopus 로고    scopus 로고
    • Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation
    • Ali, S. R., et al. Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation. Circ. Res. 115, 625-635 (2014
    • (2014) Circ. Res , vol.115 , pp. 625-635
    • Ali, S.R.1
  • 56
    • 0033429649 scopus 로고    scopus 로고
    • Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage
    • Cheng, G., et al. Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage. Development 126, 5041-5049 (1999
    • (1999) Development , vol.126 , pp. 5041-5049
    • Cheng, G.1
  • 57
    • 0031011870 scopus 로고    scopus 로고
    • Expression of smooth muscle alpha-Actin in mesenchymal cells during formation of avian endocardial cushion tissue: A role for transforming growth factor β3
    • Nakajima, Y., Mironov, V., Yamagishi, T., Nakamura, H., & Markwald, R. R. Expression of smooth muscle alpha-Actin in mesenchymal cells during formation of avian endocardial cushion tissue: a role for transforming growth factor β3. Dev. Dyn. 209, 296-309 (1997
    • (1997) Dev. Dyn , vol.209 , pp. 296-309
    • Nakajima, Y.1    Mironov, V.2    Yamagishi, T.3    Nakamura, H.4    Markwald, R.R.5
  • 58
    • 0033735048 scopus 로고    scopus 로고
    • Effect of a highly selective endothelin-converting enzyme inhibitor on cardiac remodeling in rats after myocardial infarction
    • Martin, P., Tzanidis, A., Stein-Oakley, A., & Krum, H. Effect of a highly selective endothelin-converting enzyme inhibitor on cardiac remodeling in rats after myocardial infarction. J. Cardiovasc. Pharmacol. 36, S367-S370 (2000
    • (2000) J. Cardiovasc. Pharmacol , vol.36 , pp. S367-S370
    • Martin, P.1    Tzanidis, A.2    Stein-Oakley, A.3    Krum, H.4
  • 59
    • 0031194295 scopus 로고    scopus 로고
    • Angiotensin II stimulated expression of transforming growth factor β1 in cardiac fibroblasts and myofibroblasts
    • Campbell, S. E., & Katwa, L. C. Angiotensin II stimulated expression of transforming growth factor β1 in cardiac fibroblasts and myofibroblasts. J. Mol. Cell. Cardiol. 29, 1947-1958 (1997
    • (1997) J. Mol. Cell. Cardiol , vol.29 , pp. 1947-1958
    • Campbell, S.E.1    Katwa, L.C.2
  • 60
    • 34250373313 scopus 로고    scopus 로고
    • Cx43 mediates TGF-β signaling through competitive Smads binding to microtubules
    • Dai, P., Nakagami, T., Tanaka, H., Hitomi, T., & Takamatsu, T. Cx43 mediates TGF-β signaling through competitive Smads binding to microtubules. Mol. Biol. Cell 18, 2264-2273 (2007
    • (2007) Mol. Biol. Cell , vol.18 , pp. 2264-2273
    • Dai, P.1    Nakagami, T.2    Tanaka, H.3    Hitomi, T.4    Takamatsu, T.5
  • 61
    • 63049134111 scopus 로고    scopus 로고
    • Cx43 contributes to TGF-β signaling to regulate differentiation of cardiac fibroblasts into myofibroblasts
    • Asazuma-Nakamura, Y., et al. Cx43 contributes to TGF-β signaling to regulate differentiation of cardiac fibroblasts into myofibroblasts. Exp. Cell Res. 315, 1190-1199 (2009
    • (2009) Exp. Cell Res , vol.315 , pp. 1190-1199
    • Asazuma-Nakamura, Y.1
  • 62
    • 84922723051 scopus 로고    scopus 로고
    • SMAD-independent down-regulation of caveolin 1 by TGF-β: Effects on proliferation and survival of myofibroblasts
    • Sanders, Y. Y., et al. SMAD-independent down-regulation of caveolin 1 by TGF-β: effects on proliferation and survival of myofibroblasts. PLoS ONE 10, e0116995 (2015
    • (2015) PLoS ONE , vol.10 , pp. e0116995
    • Sanders, Y.Y.1
  • 63
    • 83155180443 scopus 로고    scopus 로고
    • Endogenous thrombospondin 1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism
    • Xia, Y., et al. Endogenous thrombospondin 1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism. Hypertension 58, 902-911 (2011
    • (2011) Hypertension , vol.58 , pp. 902-911
    • Xia, Y.1
  • 64
    • 77649274059 scopus 로고    scopus 로고
    • Cardiac extracellular matrix remodeling: Fibrillar collagens and secreted protein acidic and rich in cysteine (SPARC
    • McCurdy, S., Baicu, C. F., Heymans, S., & Bradshaw, A. D. Cardiac extracellular matrix remodeling: fibrillar collagens and secreted protein acidic and rich in cysteine (SPARC). J. Mol. Cell. Cardiol. 48, 544-549 (2010
    • (2010) J. Mol. Cell. Cardiol , vol.48 , pp. 544-549
    • McCurdy, S.1    Baicu, C.F.2    Heymans, S.3    Bradshaw, A.D.4
  • 65
    • 34548371401 scopus 로고    scopus 로고
    • Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling
    • Oka, T., et al. Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ. Res. 101, 313-321 (2007
    • (2007) Circ. Res , vol.101 , pp. 313-321
    • Oka, T.1
  • 66
    • 34249794560 scopus 로고    scopus 로고
    • Eplerenone attenuates myocardial fibrosis in the angiotensin II induced hypertensive mouse: Involvement of tenascin C induced by aldosterone-mediated inflammation
    • Nishioka, T., et al. Eplerenone attenuates myocardial fibrosis in the angiotensin II induced hypertensive mouse: involvement of tenascin C induced by aldosterone-mediated inflammation. J. Cardiovasc. Pharmacol. 49, 261-268 (2007
    • (2007) J. Cardiovasc. Pharmacol , vol.49 , pp. 261-268
    • Nishioka, T.1
  • 67
    • 18144380288 scopus 로고    scopus 로고
    • Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation
    • Grotendorst, G. R., & Duncan, M. R. Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation. FASEB J. 19, 729-738 (2005
    • (2005) FASEB J. , vol.19 , pp. 729-738
    • Grotendorst, G.R.1    Duncan, M.R.2
  • 68
    • 84959535607 scopus 로고    scopus 로고
    • Plakophilin 2 loss promotes TGF β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes
    • Dubash, A. D., et al. Plakophilin 2 loss promotes TGF β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. J. Cell Biol. 212, 425-438 (2016
    • (2016) J. Cell Biol , vol.212 , pp. 425-438
    • Dubash, A.D.1
  • 69
    • 84976364301 scopus 로고    scopus 로고
    • Matricellular protein CCN5 reverses established cardiac fibrosis
    • Jeong, D., et al. Matricellular protein CCN5 reverses established cardiac fibrosis. J. Am. Coll. Cardiol. 67, 1556-1568 (2016
    • (2016) J. Am. Coll. Cardiol , vol.67 , pp. 1556-1568
    • Jeong, D.1
  • 70
    • 84965014087 scopus 로고    scopus 로고
    • Targeted ablation of periostin-expressing activated fibroblasts prevents adverse cardiac remodeling in mice
    • Kaur, H., et al. Targeted ablation of periostin-expressing activated fibroblasts prevents adverse cardiac remodeling in mice. Circ. Res. http://dx.doi.org/10.1161/CIRCRESAHA.116.308643 (2016
    • (2016) Circ. Res
    • Kaur, H.1
  • 71
    • 84885599487 scopus 로고    scopus 로고
    • Stretch-induced upregulation of connective tissue growth factor in rabbit cardiomyocytes
    • Blaauw, E., et al. Stretch-induced upregulation of connective tissue growth factor in rabbit cardiomyocytes. J. Cardiovasc. Transl. Res. 6, 861-869 (2013
    • (2013) J. Cardiovasc. Transl. Res , vol.6 , pp. 861-869
    • Blaauw, E.1
  • 72
    • 84859652373 scopus 로고    scopus 로고
    • Regional mechanics determine collagen fiber structure in healing myocardial infarcts
    • Fomovsky, G. M., Rouillard, A. D., & Holmes, J. W. Regional mechanics determine collagen fiber structure in healing myocardial infarcts. J. Mol. Cell. Cardiol. 52, 1083-1090 (2012
    • (2012) J. Mol. Cell. Cardiol , vol.52 , pp. 1083-1090
    • Fomovsky, G.M.1    Rouillard, A.D.2    Holmes, J.W.3
  • 73
    • 77952398280 scopus 로고    scopus 로고
    • FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex
    • Dalla Costa, A. P., et al. FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex. Cardiovasc. Res. 86, 421-431 (2010
    • (2010) Cardiovasc. Res , vol.86 , pp. 421-431
    • Dalla Costa, A.P.1
  • 74
    • 0037373465 scopus 로고    scopus 로고
    • Activation and inactivation of a non-selective cation conductance by local mechanical deformation of acutely isolated cardiac fibroblasts
    • Kamkin, A., Kiseleva, I., & Isenberg, G. Activation and inactivation of a non-selective cation conductance by local mechanical deformation of acutely isolated cardiac fibroblasts. Cardiovasc. Res. 57, 793-803 (2003
    • (2003) Cardiovasc. Res , vol.57 , pp. 793-803
    • Kamkin, A.1    Kiseleva, I.2    Isenberg, G.3
  • 75
    • 84861677745 scopus 로고    scopus 로고
    • Calcium and mechanically induced potentials in fibroblasts of rat atrium
    • Kiseleva, I., Kamkin, A., Kohl, P., & Lab, M. J. Calcium and mechanically induced potentials in fibroblasts of rat atrium. Cardiovasc. Res. 32, 98-111 (1996
    • (1996) Cardiovasc. Res , vol.32 , pp. 98-111
    • Kiseleva, I.1    Kamkin, A.2    Kohl, P.3    Lab, M.J.4
  • 76
    • 84955311191 scopus 로고    scopus 로고
    • Cardiac mechano-gated ion channels and arrhythmias
    • Peyronnet, R., Nerbonne, J. M., & Kohl, P. Cardiac mechano-gated ion channels and arrhythmias. Circ. Res. 118, 311-329 (2016
    • (2016) Circ. Res , vol.118 , pp. 311-329
    • Peyronnet, R.1    Nerbonne, J.M.2    Kohl, P.3
  • 77
    • 76849087987 scopus 로고    scopus 로고
    • Myocardial remodeling after infarction: The role of myofibroblasts
    • van den Borne, S. W., et al. Myocardial remodeling after infarction: the role of myofibroblasts. Nat. Rev. Cardiol. 7, 30-37 (2010
    • (2010) Nat. Rev. Cardiol , vol.7 , pp. 30-37
    • Van Den Borne, S.W.1
  • 79
    • 0031033468 scopus 로고    scopus 로고
    • In vivo responses of macrophages and myofibroblasts in the healing following isoproterenol-induced myocardial injury in rats
    • Nakatsuji, S., Yamate, J., Kuwamura, M., Kotani, T., & Sakuma, S. In vivo responses of macrophages and myofibroblasts in the healing following isoproterenol-induced myocardial injury in rats. Virchows Arch. 430, 63-69 (1997
    • (1997) Virchows Arch , vol.430 , pp. 63-69
    • Nakatsuji, S.1    Yamate, J.2    Kuwamura, M.3    Kotani, T.4    Sakuma, S.5
  • 80
    • 84974628220 scopus 로고    scopus 로고
    • Alternatively activated macrophages determine repair of the infarcted adult murine heart
    • Shiraishi, M., et al. Alternatively activated macrophages determine repair of the infarcted adult murine heart. J. Clin. Invest. http://dx.doi.org/10.1172/JCI85782 (2016
    • (2016) J. Clin. Invest
    • Shiraishi, M.1
  • 81
    • 0028173386 scopus 로고
    • The alpha-smooth muscle actin-positive cells in healing human myocardial scars
    • Willems, I. E., Havenith, M. G., De Mey, J. G., & Daemen, M. J. The alpha-smooth muscle actin-positive cells in healing human myocardial scars. Am. J. Pathol. 145, 868-875 (1994
    • (1994) Am. J. Pathol , vol.145 , pp. 868-875
    • Willems, I.E.1    Havenith, M.G.2    De Mey, J.G.3    Daemen, M.J.4
  • 82
    • 84947745483 scopus 로고    scopus 로고
    • Monocyte and macrophage contributions to cardiac remodeling
    • Hulsmans, M., Sam, F., & Nahrendorf, M. Monocyte and macrophage contributions to cardiac remodeling. J. Mol. Cell. Cardiol. 93, 149-155 (2016
    • (2016) J. Mol. Cell. Cardiol , vol.93 , pp. 149-155
    • Hulsmans, M.1    Sam, F.2    Nahrendorf, M.3
  • 83
    • 71549122284 scopus 로고    scopus 로고
    • Mouse strain determines the outcome of wound healing after myocardial infarction
    • van den Borne, S. W., et al. Mouse strain determines the outcome of wound healing after myocardial infarction. Cardiovasc. Res. 84, 273-282 (2009
    • (2009) Cardiovasc. Res , vol.84 , pp. 273-282
    • Van Den Borne, S.W.1
  • 85
    • 74749090075 scopus 로고    scopus 로고
    • Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart
    • Zhou, B., von Gise, A., Ma, Q., Hu, Y. W., & Pu, W. T. Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev. Biol. 338, 251-261 (2010
    • (2010) Dev. Biol , vol.338 , pp. 251-261
    • Zhou, B.1    Von Gise, A.2    Ma, Q.3    Hu, Y.W.4    Pu, W.T.5
  • 86
    • 84903762014 scopus 로고    scopus 로고
    • Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis
    • Moore-Morris, T., et al. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J. Clin. Invest. 124, 2921-2934 (2014
    • (2014) J. Clin. Invest , vol.124 , pp. 2921-2934
    • Moore-Morris, T.1
  • 87
    • 84929190546 scopus 로고    scopus 로고
    • Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells form myocardial infarction scar
    • Ruiz-Villalba, A., et al. Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells form myocardial infarction scar. J. Am. Coll. Cardiol. 65, 2057-2066 (2015
    • (2015) J. Am. Coll. Cardiol , vol.65 , pp. 2057-2066
    • Ruiz-Villalba, A.1
  • 88
    • 33751572502 scopus 로고    scopus 로고
    • Bone marrow-derived cells contribute to infarct remodelling
    • Mollmann, H., et al. Bone marrow-derived cells contribute to infarct remodelling. Cardiovasc. Res. 71, 661-671 (2006
    • (2006) Cardiovasc. Res , vol.71 , pp. 661-671
    • Mollmann, H.1
  • 89
    • 33845666582 scopus 로고    scopus 로고
    • Recruitment of new cells into the postnatal heart: Potential modification of phenotype by periostin
    • Visconti, R. P., & Markwald, R. R. Recruitment of new cells into the postnatal heart: potential modification of phenotype by periostin. Ann. NY Acad. Sci. 1080, 19-33 (2006
    • (2006) Ann. NY Acad. Sci , vol.1080 , pp. 19-33
    • Visconti, R.P.1    Markwald, R.R.2
  • 90
    • 84878201717 scopus 로고    scopus 로고
    • Origin of developmental precursors dictates the pathophysiologic role of cardiac fibroblasts
    • Crawford, J. R., Haudek, S. B., Cieslik, K. A., Trial, J., & Entman, M. L. Origin of developmental precursors dictates the pathophysiologic role of cardiac fibroblasts. J. Cardiovasc. Transl. Res. 5, 749-759 (2012
    • (2012) J. Cardiovasc. Transl. Res , vol.5 , pp. 749-759
    • Crawford, J.R.1    Haudek, S.B.2    Cieslik, K.A.3    Trial, J.4    Entman, M.L.5
  • 91
    • 84898828108 scopus 로고    scopus 로고
    • Adverse fibrosis in the aging heart depends on signaling between myeloid and mesenchymal cells; Role of inflammatory fibroblasts
    • Cieslik, K. A., Trial, J., Crawford, J. R., Taffet, G. E., & Entman, M. L. Adverse fibrosis in the aging heart depends on signaling between myeloid and mesenchymal cells; role of inflammatory fibroblasts. J. Mol. Cell. Cardiol. 70, 56-63 (2014
    • (2014) J. Mol. Cell. Cardiol , vol.70 , pp. 56-63
    • Cieslik, K.A.1    Trial, J.2    Crawford, J.R.3    Taffet, G.E.4    Entman, M.L.5
  • 92
    • 84937545762 scopus 로고    scopus 로고
    • Tumor necrosis factor: A mechanistic link between angiotensin-II induced cardiac inflammation and fibrosis
    • Duerrschmid, C., Trial, J., Wang, Y., Entman, M. L., & Haudek, S. B. Tumor necrosis factor: a mechanistic link between angiotensin-II induced cardiac inflammation and fibrosis. Circ. Heart Fail. 8, 352-361 (2015
    • (2015) Circ. Heart Fail , vol.8 , pp. 352-361
    • Duerrschmid, C.1    Trial, J.2    Wang, Y.3    Entman, M.L.4    Haudek, S.B.5
  • 93
    • 34547676391 scopus 로고    scopus 로고
    • Endothelial-To mesenchymal transition contributes to cardiac fibrosis
    • Zeisberg, E. M., et al. Endothelial-To mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13, 952-961 (2007
    • (2007) Nat. Med , vol.13 , pp. 952-961
    • Zeisberg, E.M.1
  • 94
    • 84899044784 scopus 로고    scopus 로고
    • Cardiac fibroblast in development and wound healing
    • Deb, A., & Ubil, E. Cardiac fibroblast in development and wound healing. J. Mol. Cell. Cardiol. 70, 47-55 (2014
    • (2014) J. Mol. Cell. Cardiol , vol.70 , pp. 47-55
    • Deb, A.1    Ubil, E.2
  • 95
    • 84955582038 scopus 로고    scopus 로고
    • Fibroblast-myocyte coupling in the heart: Potential relevance for therapeutic interventions
    • Ongstad, E., & Kohl, P. Fibroblast-myocyte coupling in the heart: potential relevance for therapeutic interventions. J. Mol. Cell. Cardiol. 91, 238-246 (2016
    • (2016) J. Mol. Cell. Cardiol , vol.91 , pp. 238-246
    • Ongstad, E.1    Kohl, P.2
  • 96
    • 84870202567 scopus 로고    scopus 로고
    • Cardiac regenerative capacity and mechanisms
    • Kikuchi, K., & Poss, K. D. Cardiac regenerative capacity and mechanisms. Annu. Rev. Cell Dev. Biol. 28, 719-741 (2012
    • (2012) Annu. Rev. Cell Dev. Biol , vol.28 , pp. 719-741
    • Kikuchi, K.1    Poss, K.D.2
  • 97
    • 84929130857 scopus 로고    scopus 로고
    • The winding road to regenerating the human heart
    • Gerbin, K. A., & Murry, C. E. The winding road to regenerating the human heart. Cardiovasc. Pathol. 24, 133-140 (2015
    • (2015) Cardiovasc. Pathol , vol.24 , pp. 133-140
    • Gerbin, K.A.1    Murry, C.E.2
  • 98
    • 79952065525 scopus 로고    scopus 로고
    • Transient regenerative potential of the neonatal mouse heart
    • Porrello, E. R., et al. Transient regenerative potential of the neonatal mouse heart. Science 331, 1078-1080 (2011
    • (2011) Science , vol.331 , pp. 1078-1080
    • Porrello, E.R.1
  • 99
    • 84937540570 scopus 로고    scopus 로고
    • Defining the limit of embryonic heart regeneration
    • Nakada, Y., Kimura, W., & Sadek, H. A. Defining the limit of embryonic heart regeneration. Circulation 132, 77-78 (2015
    • (2015) Circulation , vol.132 , pp. 77-78
    • Nakada, Y.1    Kimura, W.2    Sadek, H.A.3
  • 100
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 101
    • 84930812429 scopus 로고    scopus 로고
    • Direct cardiac reprogramming: Progress and challenges in basic biology and clinical applications
    • Sadahiro, T., Yamanaka, S., & Ieda, M. Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications. Circ. Res. 116, 1378-1391 (2015
    • (2015) Circ. Res , vol.116 , pp. 1378-1391
    • Sadahiro, T.1    Yamanaka, S.2    Ieda, M.3
  • 102
    • 77955321344 scopus 로고    scopus 로고
    • Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
    • Ieda, M., et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142, 375-386 (2010
    • (2010) Cell , vol.142 , pp. 375-386
    • Ieda, M.1
  • 103
    • 84863629484 scopus 로고    scopus 로고
    • In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes
    • Qian, L., et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature 485, 593-598 (2012
    • (2012) Nature , vol.485 , pp. 593-598
    • Qian, L.1
  • 104
    • 84863626782 scopus 로고    scopus 로고
    • Heart repair by reprogramming non-myocytes with cardiac transcription factors
    • Song, K., et al. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 485, 599-604 (2012
    • (2012) Nature , vol.485 , pp. 599-604
    • Song, K.1
  • 105
    • 84861642380 scopus 로고    scopus 로고
    • MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes
    • Jayawardena, T. M., et al. MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. Circ. Res. 110, 1465-1473 (2012
    • (2012) Circ. Res , vol.110 , pp. 1465-1473
    • Jayawardena, T.M.1
  • 106
    • 79959819263 scopus 로고    scopus 로고
    • De novo cardiomyocytes from within the activated adult heart after injury
    • Smart, N., et al. De novo cardiomyocytes from within the activated adult heart after injury. Nature 474, 640-644 (2011
    • (2011) Nature , vol.474 , pp. 640-644
    • Smart, N.1
  • 107
    • 84878990835 scopus 로고    scopus 로고
    • Thymosin β4 and cardiac regeneration: Are we missing a beat?
    • Gajzer, D. C., Balbin, J., & Chaudhry, H. W. Thymosin β4 and cardiac regeneration: are we missing a beat? Stem Cell Rev. 9, 303-312 (2013
    • (2013) Stem Cell Rev , vol.9 , pp. 303-312
    • Gajzer, D.C.1    Balbin, J.2    Chaudhry, H.W.3
  • 108
    • 85027957068 scopus 로고    scopus 로고
    • Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4 Mef2c, and Tbx5
    • Chen, J. X., et al. Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ. Res. 111, 50-55 (2012
    • (2012) Circ. Res , vol.111 , pp. 50-55
    • Chen, J.X.1
  • 109
    • 84922105989 scopus 로고    scopus 로고
    • Stoichiometry of Gata4 Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming
    • Wang, L., et al. Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming. Circ. Res. 116, 237-244 (2015
    • (2015) Circ. Res , vol.116 , pp. 237-244
    • Wang, L.1
  • 110
    • 84875848994 scopus 로고    scopus 로고
    • Reprogramming of human fibroblasts toward a cardiac fate
    • Nam, Y. J., et al. Reprogramming of human fibroblasts toward a cardiac fate. Proc. Natl Acad. Sci. USA 110, 5588-5593 (2013
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 5588-5593
    • Nam, Y.J.1
  • 111
    • 84904580766 scopus 로고    scopus 로고
    • MiR 133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures
    • Muraoka, N., et al. MiR 133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures. EMBO J. 33, 1565-1581 (2014
    • (2014) EMBO J. , vol.33 , pp. 1565-1581
    • Muraoka, N.1
  • 112
    • 84947087360 scopus 로고    scopus 로고
    • RNA-mediated reprogramming of primary adult human dermal fibroblasts into c kit+ cardiac progenitor cells
    • Pratico, E. D., et al. RNA-mediated reprogramming of primary adult human dermal fibroblasts into c kit+ cardiac progenitor cells. Stem Cells Dev. 24, 2622-2633 (2015
    • (2015) Stem Cells Dev , vol.24 , pp. 2622-2633
    • Pratico, E.D.1
  • 113
    • 84908431264 scopus 로고    scopus 로고
    • Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors
    • Nam, Y. J., et al. Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors. Development 141, 4267-4278 (2014
    • (2014) Development , vol.141 , pp. 4267-4278
    • Nam, Y.J.1
  • 114
    • 84896303301 scopus 로고    scopus 로고
    • Inhibition of TGFβ signaling increases direct conversion of fibroblasts to induced cardiomyocytes
    • Ifkovits, J. L., Addis, R. C., Epstein, J. A., & Gearhart, J. D. Inhibition of TGFβ signaling increases direct conversion of fibroblasts to induced cardiomyocytes. PLoS ONE 9, e89678 (2014
    • (2014) PLoS ONE , vol.9 , pp. e89678
    • Ifkovits, J.L.1    Addis, R.C.2    Epstein, J.A.3    Gearhart, J.D.4
  • 115
    • 84942939090 scopus 로고    scopus 로고
    • Akt1/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes
    • Zhou, H., Dickson, M. E., Kim, M. S., Bassel-Duby, R., & Olson, E. N. Akt1/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes. Proc. Natl Acad. Sci. USA 112, 11864-11869 (2015
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 11864-11869
    • Zhou, H.1    Dickson, M.E.2    Kim, M.S.3    Bassel-Duby, R.4    Olson, E.N.5
  • 116
    • 35548968013 scopus 로고    scopus 로고
    • Scarring in the heart-A reversible phenomenon?
    • Towbin, J. A. Scarring in the heart-A reversible phenomenon? N. Engl. J. Med. 357, 1767-1768 (2007
    • (2007) N. Engl. J. Med , vol.357 , pp. 1767-1768
    • Towbin, J.A.1
  • 117
    • 84874719002 scopus 로고    scopus 로고
    • Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy
    • Gulati, A., et al. Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy. JAMA 309, 896-908 (2013
    • (2013) JAMA , vol.309 , pp. 896-908
    • Gulati, A.1
  • 118
    • 84864182823 scopus 로고    scopus 로고
    • Assessment of myocardial scarring improves risk stratification in patients evaluated for cardiac defibrillator implantation
    • Klem, I., et al. Assessment of myocardial scarring improves risk stratification in patients evaluated for cardiac defibrillator implantation. J. Am. Coll. Cardiol. 60, 408-420 (2012
    • (2012) J. Am. Coll. Cardiol , vol.60 , pp. 408-420
    • Klem, I.1
  • 119
    • 78650112036 scopus 로고    scopus 로고
    • The extent of irreversible myocardial damage and the potential for left ventricular repair after primary percutaneous coronary intervention
    • Esposito, G., Dellegrottaglie, S., & Chiariello, M. The extent of irreversible myocardial damage and the potential for left ventricular repair after primary percutaneous coronary intervention. Am. Heart J. 160, S4-S10 (2010
    • (2010) Am. Heart J. , vol.160 , pp. S4-S10
    • Esposito, G.1    Dellegrottaglie, S.2    Chiariello, M.3
  • 120
    • 84881630526 scopus 로고    scopus 로고
    • Cardioprotection and myocardial reperfusion: Pitfalls to clinical application
    • Vander Heide, R. S., & Steenbergen, C. Cardioprotection and myocardial reperfusion: pitfalls to clinical application. Circ. Res. 113, 464-477 (2013
    • (2013) Circ. Res , vol.113 , pp. 464-477
    • Vander Heide, R.S.1    Steenbergen, C.2
  • 121
    • 0022970945 scopus 로고
    • Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
    • Murry, C. E., Jennings, R. B., & Reimer, K. A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74, 1124-1136 (1986
    • (1986) Circulation , vol.74 , pp. 1124-1136
    • Murry, C.E.1    Jennings, R.B.2    Reimer, K.A.3
  • 122
    • 84941314655 scopus 로고    scopus 로고
    • Novel therapeutics in myocardial infarction: Targeting microvascular dysfunction and reperfusion injury
    • Fordyce, C. B., Gersh, B. J., Stone, G. W., & Granger, C. B. Novel therapeutics in myocardial infarction: targeting microvascular dysfunction and reperfusion injury. Trends Pharmacol. Sci. 36, 605-615 (2015
    • (2015) Trends Pharmacol. Sci , vol.36 , pp. 605-615
    • Fordyce, C.B.1    Gersh, B.J.2    Stone, G.W.3    Granger, C.B.4
  • 123
    • 84924090415 scopus 로고    scopus 로고
    • The nhlbi-sponsored consortium for preclinical assessment of cardioprotective therapies (caesar): A new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs
    • Jones, S. P., et al. The NHLBI-sponsored Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs. Circ. Res. 116, 572-586 (2015
    • (2015) Circ. Res , vol.116 , pp. 572-586
    • Jones, S.P.1
  • 125
    • 67349145405 scopus 로고    scopus 로고
    • Preconditioning and postconditioning: Underlying mechanisms and clinical application
    • Hausenloy, D. J., & Yellon, D. M. Preconditioning and postconditioning: underlying mechanisms and clinical application. Atherosclerosis 204, 334-341 (2009
    • (2009) Atherosclerosis , vol.204 , pp. 334-341
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 126
    • 0034095009 scopus 로고    scopus 로고
    • Role of K+ATP channels in ischemic preconditioning and cardioprotection
    • Duncker, D. J., & Verdouw, P. D. Role of K+ATP channels in ischemic preconditioning and cardioprotection. Cardiovasc. Drugs Ther. 14, 7-16 (2000
    • (2000) Cardiovasc. Drugs Ther , vol.14 , pp. 7-16
    • Duncker, D.J.1    Verdouw, P.D.2
  • 127
    • 51749104191 scopus 로고    scopus 로고
    • Activation of aldehyde dehydrogenase 2 reduces ischemic damage to the heart
    • Chen, C. H., et al. Activation of aldehyde dehydrogenase 2 reduces ischemic damage to the heart. Science 321, 1493-1495 (2008
    • (2008) Science , vol.321 , pp. 1493-1495
    • Chen, C.H.1
  • 128
    • 84942777656 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species at the heart of the matter: New therapeutic approaches for cardiovascular diseases
    • Kornfeld, O. S., et al. Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases. Circ. Res. 116, 1783-1799 (2015
    • (2015) Circ. Res , vol.116 , pp. 1783-1799
    • Kornfeld, O.S.1
  • 129
    • 84959543552 scopus 로고    scopus 로고
    • Targeting myocardial reperfusion injuries with cyclosporine in the CIRCUS Trial-Pharmacological reasons for failure
    • Monassier, L., Ayme-Dietrich, E., Aubertin-Kirch, G., & Pathak, A. Targeting myocardial reperfusion injuries with cyclosporine in the CIRCUS Trial-pharmacological reasons for failure. Fundam. Clin. Pharmacol. 30, 191-193 (2015
    • (2015) Fundam. Clin. Pharmacol , vol.30 , pp. 191-193
    • Monassier, L.1    Ayme-Dietrich, E.2    Aubertin-Kirch, G.3    Pathak, A.4
  • 130
    • 84922632326 scopus 로고    scopus 로고
    • PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
    • Das, A., Durrant, D., Salloum, F. N., Xi, L., & Kukreja, R. C. PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer. Pharmacol. Ther. 147, 12-21 (2015
    • (2015) Pharmacol. Ther , vol.147 , pp. 12-21
    • Das, A.1    Durrant, D.2    Salloum, F.N.3    Xi, L.4    Kukreja, R.C.5
  • 131
    • 84918821762 scopus 로고    scopus 로고
    • Potential role of cardiac chloride channels and transporters as novel therapeutic targets
    • Adkins, G. B., & Curtis, M. J. Potential role of cardiac chloride channels and transporters as novel therapeutic targets. Pharmacol. Ther. 145, 67-75 (2015
    • (2015) Pharmacol. Ther , vol.145 , pp. 67-75
    • Adkins, G.B.1    Curtis, M.J.2
  • 132
    • 84930666218 scopus 로고    scopus 로고
    • The cardioprotective effects of hydrogen sulfide in heart diseases: From molecular mechanisms to therapeutic potential
    • Shen, Y., Shen, Z., Luo, S., Guo, W., & Zhu, Y. Z. The cardioprotective effects of hydrogen sulfide in heart diseases: from molecular mechanisms to therapeutic potential. Oxid. Med. Cell. Longev. 2015, 925167 (2015
    • (2015) Oxid. Med. Cell. Longev , vol.2015 , pp. 925167
    • Shen, Y.1    Shen, Z.2    Luo, S.3    Guo, W.4    Zhu, Y.Z.5
  • 133
    • 84928623386 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling
    • Das, A., et al. Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling. Bas. Res. Cardiol. 110, 31 (2015
    • (2015) Bas. Res. Cardiol , vol.110 , pp. 31
    • Das, A.1
  • 134
    • 76349119210 scopus 로고    scopus 로고
    • Protein S nitrosylation and cardioprotection
    • Sun, J., & Murphy, E. Protein S nitrosylation and cardioprotection. Circ. Res. 106, 285-296 (2010
    • (2010) Circ. Res , vol.106 , pp. 285-296
    • Sun, J.1    Murphy, E.2
  • 135
    • 84921027622 scopus 로고    scopus 로고
    • Cardiac myocyte-specific transgenic ecSOD targets mitochondria to protect against Ca2+ induced permeability transition
    • Luo, J., Obal, D., Dimova, N., Tang, X. L., & Rokosh, G. Cardiac myocyte-specific transgenic ecSOD targets mitochondria to protect against Ca2+ induced permeability transition. Front. Physiol. 4, 295 (2013
    • (2013) Front. Physiol , vol.4 , pp. 295
    • Luo, J.1    Obal, D.2    Dimova, N.3    Tang, X.L.4    Rokosh, G.5
  • 136
    • 84865568181 scopus 로고    scopus 로고
    • Single intravenous low-dose injections of connexin 43 mimetic peptides protect ischemic heart in vivo against myocardial infarction
    • Hawat, G., Helie, P., & Baroudi, G. Single intravenous low-dose injections of connexin 43 mimetic peptides protect ischemic heart in vivo against myocardial infarction. J. Mol. Cell. Cardiol. 53, 559-566 (2012
    • (2012) J. Mol. Cell. Cardiol , vol.53 , pp. 559-566
    • Hawat, G.1    Helie, P.2    Baroudi, G.3
  • 137
    • 84869863191 scopus 로고    scopus 로고
    • Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury
    • Wang, N., et al. Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Bas. Res. Cardiol. 108, 309 (2013
    • (2013) Bas. Res. Cardiol , vol.108 , pp. 309
    • Wang, N.1
  • 138
    • 79955501784 scopus 로고    scopus 로고
    • Connexin 43 connexon to gap junction transition is regulated by zonula occludens 1
    • Rhett, J. M., Jourdan, J., & Gourdie, R. G. Connexin 43 connexon to gap junction transition is regulated by zonula occludens 1. Mol. Biol. Cell 22, 1516-1528 (2011
    • (2011) Mol. Biol. Cell , vol.22 , pp. 1516-1528
    • Rhett, J.M.1    Jourdan, J.2    Gourdie, R.G.3
  • 139
    • 84906940516 scopus 로고    scopus 로고
    • Novel therapeutic strategies for cardioprotection
    • Sluijter, J. P., et al. Novel therapeutic strategies for cardioprotection. Pharmacol. Ther. 144, 60-70 (2014
    • (2014) Pharmacol. Ther , vol.144 , pp. 60-70
    • Sluijter, J.P.1
  • 140
    • 84859802065 scopus 로고    scopus 로고
    • Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels
    • Desplantez, T., Verma, V., Leybaert, L., Evans, W. H., & Weingart, R. Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels. Pharmacol. Res. 65, 546-552 (2012
    • (2012) Pharmacol. Res , vol.65 , pp. 546-552
    • Desplantez, T.1    Verma, V.2    Leybaert, L.3    Evans, W.H.4    Weingart, R.5
  • 141
    • 84941179189 scopus 로고    scopus 로고
    • Battle of the hemichannels-Connexins and pannexins in ischemic brain injury
    • Davidson, J. O., Green, C. R., Bennet, L., & Gunn, A. J. Battle of the hemichannels-connexins and pannexins in ischemic brain injury. Int. J. Dev. Neurosci. 45, 66-74 (2014
    • (2014) Int. J. Dev. Neurosci , vol.45 , pp. 66-74
    • Davidson, J.O.1    Green, C.R.2    Bennet, L.3    Gunn, A.J.4
  • 142
    • 84940529193 scopus 로고    scopus 로고
    • Adult bone marrow cell therapy for ischemic heart disease: Evidence and insights from randomized controlled trials
    • Afzal, M. R., et al. Adult bone marrow cell therapy for ischemic heart disease: evidence and insights from randomized controlled trials. Circ. Res. 117, 558-575 (2015
    • (2015) Circ. Res , vol.117 , pp. 558-575
    • Afzal, M.R.1
  • 143
    • 84936979255 scopus 로고    scopus 로고
    • Use of mesenchymal stem cells for therapy of cardiac disease
    • Karantalis, V., & Hare, J. M. Use of mesenchymal stem cells for therapy of cardiac disease. Circ. Res. 116, 1413-1430 (2015
    • (2015) Circ. Res , vol.116 , pp. 1413-1430
    • Karantalis, V.1    Hare, J.M.2
  • 144
    • 84898992845 scopus 로고    scopus 로고
    • Impact of intracoronary bone marrow cell therapy on left ventricular function in the setting of ST segment elevation myocardial infarction: A collaborative meta-Analysis
    • Delewi, R., et al. Impact of intracoronary bone marrow cell therapy on left ventricular function in the setting of ST segment elevation myocardial infarction: a collaborative meta-Analysis. Eur. Heart J. 35, 989-998 (2014
    • (2014) Eur. Heart J. , vol.35 , pp. 989-998
    • Delewi, R.1
  • 145
    • 84930349421 scopus 로고    scopus 로고
    • Cardiac cell therapy: Lost in meta-Analyses
    • Assmus, B., Dimmeler, S., & Zeiher, A. M. Cardiac cell therapy: lost in meta-Analyses. Circ. Res. 116, 1291-1292 (2015
    • (2015) Circ. Res , vol.116 , pp. 1291-1292
    • Assmus, B.1    Dimmeler, S.2    Zeiher, A.M.3
  • 146
    • 84929003354 scopus 로고    scopus 로고
    • Meta-Analysis of cell-based cardiac studies (accrue) in patients with acute myocardial infarction based on individual patient data
    • Gyongyosi, M., et al. Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data. Circ. Res. 116, 1346-1360 (2015
    • (2015) Circ. Res , vol.116 , pp. 1346-1360
    • Gyongyosi, M.1
  • 148
    • 82255175382 scopus 로고    scopus 로고
    • Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): Initial results of a randomised phase 1 trial
    • Bolli, R., et al. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet 378, 1847-1857 (2011
    • (2011) Lancet , vol.378 , pp. 1847-1857
    • Bolli, R.1
  • 149
    • 84858019974 scopus 로고    scopus 로고
    • Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): A prospective, randomised Phase 1 trial
    • Makkar, R. R., et al. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised Phase 1 trial. Lancet 379, 895-904 (2012
    • (2012) Lancet , vol.379 , pp. 895-904
    • Makkar, R.R.1
  • 150
    • 64249107059 scopus 로고    scopus 로고
    • Evidence for cardiomyocyte renewal in humans
    • Bergmann, O., et al. Evidence for cardiomyocyte renewal in humans. Science 324, 98-102 (2009
    • (2009) Science , vol.324 , pp. 98-102
    • Bergmann, O.1
  • 151
    • 84882759023 scopus 로고    scopus 로고
    • Adult c kitpos cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair
    • Ellison, G. M., et al. Adult c kitpos cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair. Cell 154, 827-842 (2013
    • (2013) Cell , vol.154 , pp. 827-842
    • Ellison, G.M.1
  • 152
    • 84900560043 scopus 로고    scopus 로고
    • C kit+ cells minimally contribute cardiomyocytes to the heart
    • van Berlo, J. H., et al. c kit+ cells minimally contribute cardiomyocytes to the heart. Nature 509, 337-341 (2014
    • (2014) Nature , vol.509 , pp. 337-341
    • Van Berlo, J.H.1
  • 153
    • 77952241680 scopus 로고    scopus 로고
    • Cardiomyogenic potential of c kit+-expressing cells derived from neonatal and adult mouse hearts
    • Zaruba, M. M., Soonpaa, M., Reuter, S., & Field, L. J. Cardiomyogenic potential of c kit+-expressing cells derived from neonatal and adult mouse hearts. Circulation 121, 1992-2000 (2010
    • (2010) Circulation , vol.121 , pp. 1992-2000
    • Zaruba, M.M.1    Soonpaa, M.2    Reuter, S.3    Field, L.J.4
  • 154
    • 84946143551 scopus 로고    scopus 로고
    • Resident c kit+ cells in the heart are not cardiac stem cells
    • Sultana, N., et al. Resident c kit+ cells in the heart are not cardiac stem cells. Nat. Commun. 6, 8701 (2015
    • (2015) Nat. Commun , vol.6 , pp. 8701
    • Sultana, N.1
  • 155
    • 84953358910 scopus 로고    scopus 로고
    • Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes
    • Liu, Q., et al. Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes. Cell Res. 26, 119-130 (2016
    • (2016) Cell Res , vol.26 , pp. 119-130
    • Liu, Q.1
  • 156
    • 84888135216 scopus 로고    scopus 로고
    • Sca1 derived cells are a source of myocardial renewal in the murine adult heart
    • Uchida, S., et al. Sca1 derived cells are a source of myocardial renewal in the murine adult heart. Stem Cell Rep. 1, 397-410 (2013
    • (2013) Stem Cell Rep , vol.1 , pp. 397-410
    • Uchida, S.1
  • 157
    • 84899769612 scopus 로고    scopus 로고
    • Doubts over heart stem-cell therapy
    • Abbott, A. Doubts over heart stem-cell therapy. Nature 509, 15-16 (2014
    • (2014) Nature , vol.509 , pp. 15-16
    • Abbott, A.1
  • 158
    • 67349206322 scopus 로고    scopus 로고
    • Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis
    • Burchfield, J. S., & Dimmeler, S. Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis. Fibrogen. Tissue Repair 1, 4 (2008
    • (2008) Fibrogen. Tissue Repair , vol.1 , pp. 4
    • Burchfield, J.S.1    Dimmeler, S.2
  • 159
    • 1642373909 scopus 로고    scopus 로고
    • Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms
    • Kinnaird, T., et al. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ. Res. 94, 678-685 (2004
    • (2004) Circ. Res , vol.94 , pp. 678-685
    • Kinnaird, T.1
  • 160
    • 10744224147 scopus 로고    scopus 로고
    • Mesenchymal stem cell injection induces cardiac nerve sprouting and increased tenascin expression in a Swine model of myocardial infarction
    • Pak, H. N., et al. Mesenchymal stem cell injection induces cardiac nerve sprouting and increased tenascin expression in a Swine model of myocardial infarction. J. Cardiovasc. Electrophysiol. 14, 841-848 (2003
    • (2003) J. Cardiovasc. Electrophysiol , vol.14 , pp. 841-848
    • Pak, H.N.1
  • 161
    • 73949094216 scopus 로고    scopus 로고
    • CXCR4 expression determines functional activity of bone marrow-derived mononuclear cells for therapeutic neovascularization in acute ischemia
    • Seeger, F. H., et al. CXCR4 expression determines functional activity of bone marrow-derived mononuclear cells for therapeutic neovascularization in acute ischemia. Arterioscler. Thromb. Vasc. Biol. 29, 1802-1809 (2009
    • (2009) Arterioscler. Thromb. Vasc. Biol , vol.29 , pp. 1802-1809
    • Seeger, F.H.1
  • 162
    • 61449140349 scopus 로고    scopus 로고
    • Paracrine action mediate the antifibrotic effect of transplanted mesenchymal stem cells in a rat model of global heart failure
    • Li, L., et al. Paracrine action mediate the antifibrotic effect of transplanted mesenchymal stem cells in a rat model of global heart failure. Mol. Biol. Rep. 36, 725-731 (2009
    • (2009) Mol. Biol. Rep , vol.36 , pp. 725-731
    • Li, L.1
  • 163
    • 33646252939 scopus 로고    scopus 로고
    • Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement
    • Gnecchi, M., et al. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J. 20, 661-669 (2006
    • (2006) FASEB J. , vol.20 , pp. 661-669
    • Gnecchi, M.1
  • 164
    • 77956330820 scopus 로고    scopus 로고
    • Expression and secretion of interleukin 1β, tumour necrosis factor-α and interleukin 10 by hypoxia-And serum-deprivation-stimulated mesenchymal stem cells
    • Li, Z., Wei, H., Deng, L., Cong, X., & Chen, X. Expression and secretion of interleukin 1β, tumour necrosis factor-α and interleukin 10 by hypoxia-And serum-deprivation-stimulated mesenchymal stem cells. FEBS J. 277, 3688-3698 (2010
    • (2010) FEBS J. , vol.277 , pp. 3688-3698
    • Li, Z.1    Wei, H.2    Deng, L.3    Cong, X.4    Chen, X.5
  • 165
    • 84905911026 scopus 로고    scopus 로고
    • Hypoxia preconditioned mesenchymal stem cells prevent cardiac fibroblast activation and collagen production via leptin
    • Chen, P., et al. Hypoxia preconditioned mesenchymal stem cells prevent cardiac fibroblast activation and collagen production via leptin. PLoS ONE 9, e103587 (2014
    • (2014) PLoS ONE , vol.9 , pp. e103587
    • Chen, P.1
  • 166
    • 84922609359 scopus 로고    scopus 로고
    • Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction
    • Korf-Klingebiel, M., et al. Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. Nat. Med. 21, 140-149 (2015
    • (2015) Nat. Med , vol.21 , pp. 140-149
    • Korf-Klingebiel, M.1
  • 167
    • 84895444013 scopus 로고    scopus 로고
    • Exosomes and cardiac repair after myocardial infarction
    • Sahoo, S., & Losordo, D. W. Exosomes and cardiac repair after myocardial infarction. Circ. Res. 114, 333-344 (2014
    • (2014) Circ. Res , vol.114 , pp. 333-344
    • Sahoo, S.1    Losordo, D.W.2
  • 168
    • 84901771653 scopus 로고    scopus 로고
    • Stimulation of endogenous cardioblasts by exogenous cell therapy after myocardial infarction
    • Malliaras, K., et al. Stimulation of endogenous cardioblasts by exogenous cell therapy after myocardial infarction. EMBO Mol. Med. 6, 760-777 (2014
    • (2014) EMBO Mol. Med , vol.6 , pp. 760-777
    • Malliaras, K.1
  • 169
    • 84905739577 scopus 로고    scopus 로고
    • Translational strategies and challenges in regenerative medicine
    • Dimmeler, S., Ding, S., Rando, T. A., & Trounson, A. Translational strategies and challenges in regenerative medicine. Nat. Med. 20, 814-821 (2014
    • (2014) Nat. Med , vol.20 , pp. 814-821
    • Dimmeler, S.1    Ding, S.2    Rando, T.A.3    Trounson, A.4
  • 171
    • 84925851378 scopus 로고    scopus 로고
    • A century of cholesterol and coronaries: From plaques to genes to statins
    • Goldstein, J. L., & Brown, M. S. A century of cholesterol and coronaries: from plaques to genes to statins. Cell 161, 161-172 (2015
    • (2015) Cell , vol.161 , pp. 161-172
    • Goldstein, J.L.1    Brown, M.S.2
  • 172
    • 0035902491 scopus 로고    scopus 로고
    • Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy
    • Patel, R., et al. Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation 104, 317-324 (2001
    • (2001) Circulation , vol.104 , pp. 317-324
    • Patel, R.1
  • 173
    • 0035964390 scopus 로고    scopus 로고
    • Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme A reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction
    • Bauersachs, J., Galuppo, P., Fraccarollo, D., Christ, M., & Ertl, G. Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme A reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction. Circulation 104, 982-985 (2001
    • (2001) Circulation , vol.104 , pp. 982-985
    • Bauersachs, J.1    Galuppo, P.2    Fraccarollo, D.3    Christ, M.4    Ertl, G.5
  • 174
    • 84856195866 scopus 로고    scopus 로고
    • Long-Term statin therapy in patients with systolic heart failure and normal cholesterol: Effects on elevated serum markers of collagen turnover, inflammation, and B type natriuretic peptide
    • Abulhul, E., et al. Long-Term statin therapy in patients with systolic heart failure and normal cholesterol: effects on elevated serum markers of collagen turnover, inflammation, and B type natriuretic peptide. Clin. Ther. 34, 91-100 (2012
    • (2012) Clin. Ther , vol.34 , pp. 91-100
    • Abulhul, E.1
  • 175
    • 33847658228 scopus 로고    scopus 로고
    • Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure
    • Shiroshita-Takeshita, A., et al. Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure. Cardiovasc. Res. 74, 75-84 (2007
    • (2007) Cardiovasc. Res , vol.74 , pp. 75-84
    • Shiroshita-Takeshita, A.1
  • 176
    • 0032926937 scopus 로고    scopus 로고
    • Treatment of idiopathic pulmonary fibrosis with a new antifibrotic agent, pirfenidone: Results of a prospective, open-label Phase II study
    • Raghu, G., Johnson, W. C., Lockhart, D., & Mageto, Y. Treatment of idiopathic pulmonary fibrosis with a new antifibrotic agent, pirfenidone: results of a prospective, open-label Phase II study. Am. J. Respir. Crit. Care Med. 159, 1061-1069 (1999
    • (1999) Am. J. Respir. Crit. Care Med , vol.159 , pp. 1061-1069
    • Raghu, G.1    Johnson, W.C.2    Lockhart, D.3    Mageto, Y.4
  • 177
    • 84890290138 scopus 로고    scopus 로고
    • Single-Target RNA interference for the blockade of multiple interacting proinflammatory and profibrotic pathways in cardiac fibroblasts
    • Tank, J., et al. Single-Target RNA interference for the blockade of multiple interacting proinflammatory and profibrotic pathways in cardiac fibroblasts. J. Mol. Cell. Cardiol. 66, 141-156 (2014
    • (2014) J. Mol. Cell. Cardiol , vol.66 , pp. 141-156
    • Tank, J.1
  • 178
    • 84902288558 scopus 로고    scopus 로고
    • Connective tissue growth factor inhibition attenuates left ventricular remodeling and dysfunction in pressure overload-induced heart failure
    • Szabo, Z., et al. Connective tissue growth factor inhibition attenuates left ventricular remodeling and dysfunction in pressure overload-induced heart failure. Hypertension 63, 1235-1240 (2014
    • (2014) Hypertension , vol.63 , pp. 1235-1240
    • Szabo, Z.1
  • 179
    • 0036185827 scopus 로고    scopus 로고
    • Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA-salt hypertensive rats
    • Mirkovic, S., et al. Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA-salt hypertensive rats. Br. J. Pharmacol. 135, 961-968 (2002
    • (2002) Br. J. Pharmacol , vol.135 , pp. 961-968
    • Mirkovic, S.1
  • 180
    • 2542466164 scopus 로고    scopus 로고
    • Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats
    • Kagitani, S., et al. Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats. J. Hypertens. 22, 1007-1015 (2004
    • (2004) J. Hypertens , vol.22 , pp. 1007-1015
    • Kagitani, S.1
  • 181
    • 79957888881 scopus 로고    scopus 로고
    • Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload
    • Koitabashi, N., et al. Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload. J. Clin. Invest. 121, 2301-2312 (2011
    • (2011) J. Clin. Invest , vol.121 , pp. 2301-2312
    • Koitabashi, N.1
  • 182
    • 80053144553 scopus 로고    scopus 로고
    • Chymase inhibition reduces infarction and matrix metalloproteinase 9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion
    • Oyamada, S., Bianchi, C., Takai, S., Chu, L. M., & Sellke, F. W. Chymase inhibition reduces infarction and matrix metalloproteinase 9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion. J. Pharmacol. Exp. Ther. 339, 143-151 (2011
    • (2011) J. Pharmacol. Exp. Ther , vol.339 , pp. 143-151
    • Oyamada, S.1    Bianchi, C.2    Takai, S.3    Chu, L.M.4    Sellke, F.W.5
  • 183
    • 33748942060 scopus 로고    scopus 로고
    • Impact of blockade of histamine H2 receptors on chronic heart failure revealed by retrospective and prospective randomized studies
    • Kim, J., et al. Impact of blockade of histamine H2 receptors on chronic heart failure revealed by retrospective and prospective randomized studies. J. Am. Coll. Cardiol. 48, 1378-1384 (2006
    • (2006) J. Am. Coll. Cardiol , vol.48 , pp. 1378-1384
    • Kim, J.1
  • 184
    • 0242286636 scopus 로고    scopus 로고
    • Anti-monocyte chemoattractant protein 1 gene therapy attenuates left ventricular remodeling and failure after experimental myocardial infarction
    • Hayashidani, S., et al. Anti-monocyte chemoattractant protein 1 gene therapy attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation 108, 2134-2140 (2003
    • (2003) Circulation , vol.108 , pp. 2134-2140
    • Hayashidani, S.1
  • 185
    • 72449132876 scopus 로고    scopus 로고
    • Induction of the CXC chemokine interferon-γ-inducible protein 10 regulates the reparative response following myocardial infarction
    • Bujak, M., et al. Induction of the CXC chemokine interferon-γ-inducible protein 10 regulates the reparative response following myocardial infarction. Circ. Res. 105, 973-983 (2009
    • (2009) Circ. Res , vol.105 , pp. 973-983
    • Bujak, M.1
  • 186
    • 84892641923 scopus 로고    scopus 로고
    • The profibrotic role of endothelin 1: Is the door still open for the treatment of fibrotic diseases?
    • Rodriguez-Pascual, F., Busnadiego, O., & Gonzalez-Santamaria, J. The profibrotic role of endothelin 1: is the door still open for the treatment of fibrotic diseases? Life Sci. 118, 156-164 (2014
    • (2014) Life Sci , vol.118 , pp. 156-164
    • Rodriguez-Pascual, F.1    Busnadiego, O.2    Gonzalez-Santamaria, J.3
  • 187
    • 33847727030 scopus 로고    scopus 로고
    • Chronic blockade of angiotensin II AT1 receptors increased cell to cell communication, reduced fibrosis and improved impulse propagation in the failing heart
    • De Mello, W. C., & Specht, P. Chronic blockade of angiotensin II AT1 receptors increased cell to cell communication, reduced fibrosis and improved impulse propagation in the failing heart. J. Renin Angiotensin Aldosterone Syst. 7, 201-205 (2006
    • (2006) J. Renin Angiotensin Aldosterone Syst , vol.7 , pp. 201-205
    • De Mello, W.C.1    Specht, P.2
  • 188
    • 33644871478 scopus 로고    scopus 로고
    • Impact of the angiotensin II receptor antagonist, losartan, on myocardial fibrosis in patients with end-stage renal disease: Assessment by ultrasonic integrated backscatter and biochemical markers
    • Shibasaki, Y., et al. Impact of the angiotensin II receptor antagonist, losartan, on myocardial fibrosis in patients with end-stage renal disease: assessment by ultrasonic integrated backscatter and biochemical markers. Hypertens. Res. 28, 787-795 (2005
    • (2005) Hypertens. Res , vol.28 , pp. 787-795
    • Shibasaki, Y.1
  • 189
    • 84875891536 scopus 로고    scopus 로고
    • Targeting the wnt/frizzled signaling pathway after myocardial infarction: A new tool in the therapeutic toolbox?
    • Daskalopoulos, E. P., Hermans, K. C., Janssen, B. J., & Matthijs Blankesteijn, W. Targeting the Wnt/frizzled signaling pathway after myocardial infarction: a new tool in the therapeutic toolbox? Trends Cardiovasc. Med. 23, 121-127 (2013
    • (2013) Trends Cardiovasc. Med , vol.23 , pp. 121-127
    • Daskalopoulos, E.P.1    Hermans, K.C.2    Janssen, B.J.3    Matthijs Blankesteijn, W.4
  • 190
    • 78650489190 scopus 로고    scopus 로고
    • Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction
    • He, W., et al. Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. Proc. Natl Acad. Sci. USA 107, 21110-21115 (2010
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 21110-21115
    • He, W.1
  • 191
    • 0033200361 scopus 로고    scopus 로고
    • The Ski oncoprotein interacts with the Smad proteins to repress TGFβ signaling
    • Luo, K., et al. The Ski oncoprotein interacts with the Smad proteins to repress TGFβ signaling. Genes Dev. 13, 2196-2206 (1999
    • (1999) Genes Dev , vol.13 , pp. 2196-2206
    • Luo, K.1
  • 192
    • 78651368993 scopus 로고    scopus 로고
    • Antifibrotic properties of c Ski and its regulation of cardiac myofibroblast phenotype and contractility
    • Cunnington, R. H., et al. Antifibrotic properties of c Ski and its regulation of cardiac myofibroblast phenotype and contractility. Am. J. Physiol. Cell Physiol. 300, C176-C186 (2011
    • (2011) Am. J. Physiol. Cell Physiol , vol.300 , pp. C176-C186
    • Cunnington, R.H.1
  • 193
    • 67649130137 scopus 로고    scopus 로고
    • The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis
    • Espira, L., et al. The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis. J. Mol. Cell. Cardiol. 47, 188-195 (2009
    • (2009) J. Mol. Cell. Cardiol , vol.47 , pp. 188-195
    • Espira, L.1
  • 194
    • 84866332702 scopus 로고    scopus 로고
    • β 3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse
    • Balasubramanian, S., et al. β3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse. PLoS ONE 7, e45076 (2012
    • (2012) PLoS ONE , vol.7 , pp. e45076
    • Balasubramanian, S.1
  • 195
    • 84907485564 scopus 로고    scopus 로고
    • Caveolin 1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction
    • Shivshankar, P., et al. Caveolin 1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction. J. Mol. Cell. Cardiol. 76, 84-93 (2014
    • (2014) J. Mol. Cell. Cardiol , vol.76 , pp. 84-93
    • Shivshankar, P.1
  • 196
    • 84897999113 scopus 로고    scopus 로고
    • Role of caveolin 1 in atrial fibrillation as an anti-fibrotic signaling molecule in human atrial fibroblasts
    • Yi, S. L., Liu, X. J., Zhong, J. Q., & Zhang, Y. Role of caveolin 1 in atrial fibrillation as an anti-fibrotic signaling molecule in human atrial fibroblasts. PLoS ONE 9, e85144 (2014
    • (2014) PLoS ONE , vol.9 , pp. e85144
    • Yi, S.L.1    Liu, X.J.2    Zhong, J.Q.3    Zhang, Y.4
  • 197
    • 70449099467 scopus 로고    scopus 로고
    • C Ski Smurf2, and Arkadia as regulators of TGF-β signaling: New targets for managing myofibroblast function and cardiac fibrosis
    • Cunnington, R. H., Nazari, M., & Dixon, I. M. c Ski, Smurf2, and Arkadia as regulators of TGF-β signaling: new targets for managing myofibroblast function and cardiac fibrosis. Can. J. Physiol. Pharmacol. 87, 764-772 (2009
    • (2009) Can. J. Physiol. Pharmacol , vol.87 , pp. 764-772
    • Cunnington, R.H.1    Nazari, M.2    Dixon, I.M.3
  • 198
    • 84871869933 scopus 로고    scopus 로고
    • Common threads in cardiac fibrosis, infarct scar formation, and wound healing
    • Czubryt, M. P. Common threads in cardiac fibrosis, infarct scar formation, and wound healing. Fibrogen. Tissue Repair 5, 19 (2012
    • (2012) Fibrogen. Tissue Repair , vol.5 , pp. 19
    • Czubryt, M.P.1
  • 199
    • 45849084990 scopus 로고    scopus 로고
    • Antifibrotic properties of caveolin 1 scaffolding domain in vitro and in vivo
    • Tourkina, E., et al. Antifibrotic properties of caveolin 1 scaffolding domain in vitro and in vivo. Am. J. Physiol. Lung Cell. Mol. Physiol. 294, L843-L861 (2008
    • (2008) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.294 , pp. L843-L861
    • Tourkina, E.1
  • 200
    • 84905324964 scopus 로고    scopus 로고
    • Emerging role of serelaxin in the therapeutic armamentarium for heart failure
    • Varr, B. C., & Maurer, M. S. Emerging role of serelaxin in the therapeutic armamentarium for heart failure. Curr. Atheroscler. Rep. 16, 447 (2014
    • (2014) Curr. Atheroscler. Rep , vol.16 , pp. 447
    • Varr, B.C.1    Maurer, M.S.2
  • 201
    • 84902324106 scopus 로고    scopus 로고
    • Serelaxin: A potential new drug for the treatment of acute heart failure
    • Neverova, N., & Teerlink, J. R. Serelaxin: a potential new drug for the treatment of acute heart failure. Expert Opin. Investig. Drugs 23, 1017-1026 (2014
    • (2014) Expert Opin. Investig. Drugs , vol.23 , pp. 1017-1026
    • Neverova, N.1    Teerlink, J.R.2
  • 202
    • 84959020583 scopus 로고    scopus 로고
    • Serelaxin and acute heart failure
    • Tietjens, J., & Teerlink, J. R. Serelaxin and acute heart failure. Heart 102, 95-99 (2016
    • (2016) Heart , vol.102 , pp. 95-99
    • Tietjens, J.1    Teerlink, J.R.2
  • 203
    • 84930573098 scopus 로고    scopus 로고
    • Inhibitory effects of relaxin on cardiac fibroblast-To myofibroblast transition: An electrophysiological study
    • Squecco, R., et al. Inhibitory effects of relaxin on cardiac fibroblast-To myofibroblast transition: an electrophysiological study. Exp. Physiol. 100, 652-666 (2015
    • (2015) Exp. Physiol , vol.100 , pp. 652-666
    • Squecco, R.1
  • 204
    • 84877989995 scopus 로고    scopus 로고
    • Relaxin prevents cardiac fibroblast-myofibroblast transition via notch 1 mediated inhibition of TGF-β/Smad3 signaling
    • Sassoli, C., et al. Relaxin prevents cardiac fibroblast-myofibroblast transition via notch 1 mediated inhibition of TGF-β/Smad3 signaling. PLoS ONE 8, e63896 (2013
    • (2013) PLoS ONE , vol.8 , pp. e63896
    • Sassoli, C.1
  • 205
    • 77649253288 scopus 로고    scopus 로고
    • MicroRNAs add a new dimension to cardiovascular disease
    • Small, E. M., Frost, R. J., & Olson, E. N. MicroRNAs add a new dimension to cardiovascular disease. Circulation 121, 1022-1032 (2010
    • (2010) Circulation , vol.121 , pp. 1022-1032
    • Small, E.M.1    Frost, R.J.2    Olson, E.N.3
  • 206
    • 84855244103 scopus 로고    scopus 로고
    • MicroRNA therapeutics in cardiovascular medicine
    • Thum, T. MicroRNA therapeutics in cardiovascular medicine. EMBO Mol. Med. 4, 3-14 (2012
    • (2012) EMBO Mol. Med , vol.4 , pp. 3-14
    • Thum, T.1
  • 207
    • 51349141401 scopus 로고    scopus 로고
    • Dysregulation of microRNAs after myocardial infarction reveals a role of miR 29 in cardiac fibrosis
    • van Rooij, E., et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR 29 in cardiac fibrosis. Proc. Natl Acad. Sci. USA 105, 13027-13032 (2008
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 13027-13032
    • Van Rooij, E.1
  • 208
    • 57749168828 scopus 로고    scopus 로고
    • MicroRNA 21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • Thum, T., et al. MicroRNA 21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456, 980-984 (2008
    • (2008) Nature , vol.456 , pp. 980-984
    • Thum, T.1
  • 209
    • 84871569496 scopus 로고    scopus 로고
    • Role for microRNA 21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure
    • Cardin, S., et al. Role for microRNA 21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure. Circ. Arrhythm. Electrophysiol. 5, 1027-1035 (2012
    • (2012) Circ. Arrhythm. Electrophysiol , vol.5 , pp. 1027-1035
    • Cardin, S.1
  • 210
    • 78049432896 scopus 로고    scopus 로고
    • Stress-dependent cardiac remodeling occurs in the absence of microRNA 21 in mice
    • Patrick, D. M., et al. Stress-dependent cardiac remodeling occurs in the absence of microRNA 21 in mice. J. Clin. Invest. 120, 3912-3916 (2010
    • (2010) J. Clin. Invest , vol.120 , pp. 3912-3916
    • Patrick, D.M.1
  • 211
    • 84962251251 scopus 로고    scopus 로고
    • ClinicalTrials.gov
    • US National Library of Medicine. ClinicalTrials.gov http://www.clinicaltrials.gov/ct2/show/NCT02136862 (2016
    • (2016) US National Library of Medicine
  • 212
    • 84923585184 scopus 로고    scopus 로고
    • MicroRNAs in myocardial infarction
    • Boon, R. A., & Dimmeler, S. MicroRNAs in myocardial infarction. Nat. Rev. Cardiol. 12, 135-142 (2015
    • (2015) Nat. Rev. Cardiol , vol.12 , pp. 135-142
    • Boon, R.A.1    Dimmeler, S.2
  • 213
    • 84874700585 scopus 로고    scopus 로고
    • MicroRNA 34a regulates cardiac ageing and function
    • Boon, R. A., et al. MicroRNA 34a regulates cardiac ageing and function. Nature 495, 107-110 (2013
    • (2013) Nature , vol.495 , pp. 107-110
    • Boon, R.A.1
  • 214
    • 84899128394 scopus 로고    scopus 로고
    • Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy
    • Bang, C., et al. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J. Clin. Invest. 124, 2136-2146 (2014
    • (2014) J. Clin. Invest , vol.124 , pp. 2136-2146
    • Bang, C.1
  • 215
    • 74949131620 scopus 로고    scopus 로고
    • Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload
    • Takeda, N., et al. Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J. Clin. Invest. 120, 254-265 (2010
    • (2010) J. Clin. Invest , vol.120 , pp. 254-265
    • Takeda, N.1
  • 216
    • 41649102599 scopus 로고    scopus 로고
    • Differential behaviors of atrial versus ventricular fibroblasts: A potential role for platelet-derived growth factor in atrial-ventricular remodeling differences
    • Burstein, B., Libby, E., Calderone, A., & Nattel, S. Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences. Circulation 117, 1630-1641 (2008).
    • (2008) Circulation , vol.117 , pp. 1630-1641
    • Burstein, B.1    Libby, E.2    Calderone, A.3    Nattel, S.4
  • 217
    • 84865583134 scopus 로고    scopus 로고
    • A distinct de novo expression of Nav1.5 sodium channels in human atrial fibroblasts differentiated into myofibroblasts
    • Chatelier, A., et al. A distinct de novo expression of Nav1.5 sodium channels in human atrial fibroblasts differentiated into myofibroblasts. J. Physiol. 590, 4307-4319 (2012
    • (2012) J. Physiol , vol.590 , pp. 4307-4319
    • Chatelier, A.1
  • 218
    • 0034677796 scopus 로고    scopus 로고
    • Atrial but not ventricular fibrosis in mice expressing a mutant transforming growth factor-β1 transgene in the heart
    • Nakajima, H., et al. Atrial but not ventricular fibrosis in mice expressing a mutant transforming growth factor-β1 transgene in the heart. Circ. Res. 86, 571-579 (2000
    • (2000) Circ. Res , vol.86 , pp. 571-579
    • Nakajima, H.1
  • 219
    • 2942689981 scopus 로고    scopus 로고
    • Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF β1
    • Verheule, S., et al. Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF β1. Circ. Res. 94, 1458-1465 (2004
    • (2004) Circ. Res , vol.94 , pp. 1458-1465
    • Verheule, S.1
  • 221
    • 84923605285 scopus 로고    scopus 로고
    • Arrhythmia management for the adult patient with congenital heart disease: An update and analytical review
    • Moore, J. P. Arrhythmia management for the adult patient with congenital heart disease: an update and analytical review. Minerva Pediatr. 66, 415-439 (2014
    • (2014) Minerva Pediatr , vol.66 , pp. 415-439
    • Moore, J.P.1
  • 223
    • 84908661481 scopus 로고    scopus 로고
    • Coupled agent-based and finite-element models for predicting scar structure following myocardial infarction
    • Rouillard, A. D., & Holmes, J. W. Coupled agent-based and finite-element models for predicting scar structure following myocardial infarction. Prog. Biophys. Mol. Biol. 115, 235-243 (2014
    • (2014) Prog. Biophys. Mol. Biol , vol.115 , pp. 235-243
    • Rouillard, A.D.1    Holmes, J.W.2
  • 224
    • 84871861251 scopus 로고    scopus 로고
    • Optimized local infarct restraint improves left ventricular function and limits remodeling
    • Koomalsingh, K. J., et al. Optimized local infarct restraint improves left ventricular function and limits remodeling. Ann. Thorac. Surg. 95, 155-162 (2013
    • (2013) Ann. Thorac. Surg , vol.95 , pp. 155-162
    • Koomalsingh, K.J.1
  • 225
    • 84864607095 scopus 로고    scopus 로고
    • Anisotropic reinforcement of acute anteroapical infarcts improves pump function
    • Fomovsky, G. M., Clark, S. A., Parker, K. M., Ailawadi, G., & Holmes, J. W. Anisotropic reinforcement of acute anteroapical infarcts improves pump function. Circ. Heart Fail. 5, 515-522 (2012
    • (2012) Circ. Heart Fail , vol.5 , pp. 515-522
    • Fomovsky, G.M.1    Clark, S.A.2    Parker, K.M.3    Ailawadi, G.4    Holmes, J.W.5
  • 226
    • 2342638317 scopus 로고    scopus 로고
    • Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction
    • Christman, K. L., Fok, H. H., Sievers, R. E., Fang, Q., & Lee, R. J. Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction. Tissue Eng. 10, 403-409 (2004
    • (2004) Tissue Eng , vol.10 , pp. 403-409
    • Christman, K.L.1    Fok, H.H.2    Sievers, R.E.3    Fang, Q.4    Lee, R.J.5
  • 227
    • 77954924259 scopus 로고    scopus 로고
    • Injectable hydrogel properties influence infarct expansion and extent of postinfarction left ventricular remodeling in an ovine model
    • Ifkovits, J. L., et al. Injectable hydrogel properties influence infarct expansion and extent of postinfarction left ventricular remodeling in an ovine model. Proc. Natl Acad. Sci. USA 107, 11507-11512 (2010
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 11507-11512
    • Ifkovits, J.L.1
  • 228
    • 82955222839 scopus 로고    scopus 로고
    • Biomaterials for the treatment of myocardial infarction: A 5 year update
    • Rane, A. A., & Christman, K. L. Biomaterials for the treatment of myocardial infarction: a 5 year update. J. Am. Coll. Cardiol. 58, 2615-2629 (2011
    • (2011) J. Am. Coll. Cardiol , vol.58 , pp. 2615-2629
    • Rane, A.A.1    Christman, K.L.2
  • 229
    • 84932650176 scopus 로고    scopus 로고
    • Building a better infarct: Modulation of collagen cross-linking to increase infarct stiffness and reduce left ventricular dilation post-myocardial infarction
    • Voorhees, A. P., et al. Building a better infarct: modulation of collagen cross-linking to increase infarct stiffness and reduce left ventricular dilation post-myocardial infarction. J. Mol. Cell. Cardiol. 85, 229-239 (2015
    • (2015) J. Mol. Cell. Cardiol , vol.85 , pp. 229-239
    • Voorhees, A.P.1
  • 230
    • 84901290130 scopus 로고    scopus 로고
    • Injectable and bioresponsive hydrogels for on demand matrix metalloproteinase inhibition
    • Purcell, B. P., et al. Injectable and bioresponsive hydrogels for on demand matrix metalloproteinase inhibition. Nat. Mater. 13, 653-661 (2014
    • (2014) Nat. Mater , vol.13 , pp. 653-661
    • Purcell, B.P.1
  • 231
    • 84896350465 scopus 로고    scopus 로고
    • Local hydrogel release of recombinant TIMP 3 attenuates adverse left ventricular remodeling after experimental myocardial infarction
    • 223ra21
    • Eckhouse, S. R., et al. Local hydrogel release of recombinant TIMP 3 attenuates adverse left ventricular remodeling after experimental myocardial infarction. Sci. Transl. Med. 6, 223ra21 (2014
    • (2014) Sci. Transl. Med , vol.6
    • Eckhouse, S.R.1
  • 232
    • 78650137388 scopus 로고    scopus 로고
    • Effect of peri-infarct pacing early after myocardial infarction: Results of the prevention of myocardial enlargement and dilatation post myocardial infarction study
    • Chung, E. S., et al. Effect of peri-infarct pacing early after myocardial infarction: results of the prevention of myocardial enlargement and dilatation post myocardial infarction study. Circ. Heart Fail. 3, 650-658 (2010
    • (2010) Circ. Heart Fail , vol.3 , pp. 650-658
    • Chung, E.S.1
  • 233
    • 0035450162 scopus 로고    scopus 로고
    • Cardiac morphology and blood pressure in the adult zebrafish
    • Hu, N., Yost, H. J., & Clark, E. B. Cardiac morphology and blood pressure in the adult zebrafish. Anat. Rec. 264, 1-12 (2001
    • (2001) Anat. Rec , vol.264 , pp. 1-12
    • Hu, N.1    Yost, H.J.2    Clark, E.B.3
  • 234
    • 39549107343 scopus 로고    scopus 로고
    • Periostin is essential for cardiac healing after acute myocardial infarction
    • Shimazaki, M., et al. Periostin is essential for cardiac healing after acute myocardial infarction. J. Exp. Med. 205, 295-303 (2008
    • (2008) J. Exp. Med , vol.205 , pp. 295-303
    • Shimazaki, M.1
  • 235
    • 84898638465 scopus 로고    scopus 로고
    • Reoxygenation-derived toxic reactive oxygen/nitrogen species modulate the contribution of bone marrow progenitor cells to remodeling after myocardial infarction
    • Moldovan, N. I., et al. Reoxygenation-derived toxic reactive oxygen/nitrogen species modulate the contribution of bone marrow progenitor cells to remodeling after myocardial infarction. J. Am. Heart Assoc. 3, e000471 (2014
    • (2014) J. Am. Heart Assoc , vol.3 , pp. e000471
    • Moldovan, N.I.1
  • 236
    • 84984677820 scopus 로고    scopus 로고
    • Periostin inhibitory compositions for myocardial regeneration, methods of delivery, and methods of using same
    • Patent US20100291188 A1
    • Norris, R. A., Gourdie, R. G., O'Quinn, M. P., & Markwald, R. R. Periostin inhibitory compositions for myocardial regeneration, methods of delivery, and methods of using same. US Patent US20100291188 A1 (2008
    • (2008) US
    • Norris, R.A.1    Gourdie, R.G.2    O'Quinn, M.P.3    Markwald, R.R.4
  • 237
    • 84965222410 scopus 로고
    • Case of heart-block, with fibrous degeneration and partial obliteration of the bundle of His
    • Bramwell, B. A. Case of heart-block, with fibrous degeneration and partial obliteration of the bundle of His. Br. Med. J. 1, 995-996 (1909
    • (1909) Br. Med. J. , vol.1 , pp. 995-996
    • Bramwell, B.A.1
  • 238
    • 84917689824 scopus 로고    scopus 로고
    • Structural and functional recoupling of atrial and ventricular myocardium: New conduits for electrical flow
    • Kohl, P. Structural and functional recoupling of atrial and ventricular myocardium: new conduits for electrical flow. J. Am. Coll. Cardiol. 64, 2586-2588 (2014
    • (2014) J. Am. Coll. Cardiol , vol.64 , pp. 2586-2588
    • Kohl, P.1
  • 239
    • 0014646672 scopus 로고
    • Synchronized beating of and electrotonic transmission between myocardial cells mediated by heterotypic strain cells in monolayer culture
    • Goshima, K. Synchronized beating of and electrotonic transmission between myocardial cells mediated by heterotypic strain cells in monolayer culture. Exp. Cell Res. 58, 420-426 (1969
    • (1969) Exp. Cell Res , vol.58 , pp. 420-426
    • Goshima, K.1
  • 240
    • 0042232510 scopus 로고    scopus 로고
    • Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin
    • Gaudesius, G., Miragoli, M., Thomas, S. P., & Rohr, S. Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin. Circ. Res. 93, 421-428 (2003
    • (2003) Circ. Res , vol.93 , pp. 421-428
    • Gaudesius, G.1    Miragoli, M.2    Thomas, S.P.3    Rohr, S.4
  • 241
    • 0031845793 scopus 로고    scopus 로고
    • Recipient-To donor atrioatrial conduction after orthotopic heart transplantation: Surface electrocardiographic features and estimated prevalence
    • Lefroy, D. C., et al. Recipient-To donor atrioatrial conduction after orthotopic heart transplantation: surface electrocardiographic features and estimated prevalence. Am. J. Cardiol. 82, 444-450 (1998
    • (1998) Am. J. Cardiol , vol.82 , pp. 444-450
    • Lefroy, D.C.1
  • 242
    • 21744455720 scopus 로고    scopus 로고
    • Congenital and surgically acquired Wolff-Parkinson-White syndrome in patients with tricuspid atresia
    • Hager, A., et al. Congenital and surgically acquired Wolff-Parkinson-White syndrome in patients with tricuspid atresia. J. Thorac. Cardiovasc. Surg. 130, 48-53 (2005
    • (2005) J. Thorac. Cardiovasc. Surg , vol.130 , pp. 48-53
    • Hager, A.1
  • 243
    • 11144346203 scopus 로고    scopus 로고
    • Structural and functional characterisation of cardiac fibroblasts
    • Camelliti, P., Borg, T. K., & Kohl, P. Structural and functional characterisation of cardiac fibroblasts. Cardiovasc. Res. 65, 40-51 (2005
    • (2005) Cardiovasc. Res , vol.65 , pp. 40-51
    • Camelliti, P.1    Borg, T.K.2    Kohl, P.3
  • 244
    • 1942494484 scopus 로고    scopus 로고
    • Organization of fibroblasts in the heart
    • Goldsmith, E. C., et al.organization of fibroblasts in the heart. Dev. Dyn. 230, 787-794 (2004
    • (2004) Dev. Dyn , vol.230 , pp. 787-794
    • Goldsmith, E.C.1
  • 245
    • 84942465705 scopus 로고    scopus 로고
    • Crosstalk of cardiomyocytes and fibroblasts in co cultures
    • Rother, J., et al. Crosstalk of cardiomyocytes and fibroblasts in co cultures. Open Biol. 5, 150038 (2015
    • (2015) Open Biol , vol.5 , pp. 150038
    • Rother, J.1
  • 246
    • 84857533145 scopus 로고    scopus 로고
    • Fibroblast-myocyte connections in the heart
    • Kohl, P., & Camelliti, P. Fibroblast-myocyte connections in the heart. Heart Rhythm 9, 461-464 (2012
    • (2012) Heart Rhythm , vol.9 , pp. 461-464
    • Kohl, P.1    Camelliti, P.2
  • 247
    • 80052899396 scopus 로고    scopus 로고
    • Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes
    • He, K., et al. Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes. Cardiovasc. Res. 92, 39-47 (2011
    • (2011) Cardiovasc. Res , vol.92 , pp. 39-47
    • He, K.1
  • 248
    • 84941341276 scopus 로고    scopus 로고
    • Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: An experimental and modeling study
    • Veeraraghavan, R., et al. Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: an experimental and modeling study. Pflugers Arch. 467, 2093-2105 (2015
    • (2015) Pflugers Arch , vol.467 , pp. 2093-2105
    • Veeraraghavan, R.1
  • 249
    • 84880038524 scopus 로고    scopus 로고
    • The perinexus: Sign-post on the path to a new model of cardiac conduction
    • Rhett, J. M., Veeraraghavan, R., Poelzing, S., & Gourdie, R. G. The perinexus: sign-post on the path to a new model of cardiac conduction? Trends Cardiovasc. Med. 23, 222-228 (2013
    • (2013) Trends Cardiovasc Med , vol.23 , pp. 222-228
    • Rhett, J.M.1    Veeraraghavan, R.2    Poelzing, S.3    Gourdie, R.G.4
  • 250
    • 0041414320 scopus 로고    scopus 로고
    • Heterogeneous cell coupling in the heart: An electrophysiological role for fibroblasts
    • Kohl, P. Heterogeneous cell coupling in the heart: an electrophysiological role for fibroblasts. Circ. Res. 93, 381-383 (2003
    • (2003) Circ. Res , vol.93 , pp. 381-383
    • Kohl, P.1
  • 251
    • 0030185894 scopus 로고    scopus 로고
    • Mechanosensitive connective tissue: Potential influence on heart rhythm
    • Kohl, P., & Noble, D. Mechanosensitive connective tissue: potential influence on heart rhythm. Cardiovasc. Res. 32, 62-68 (1996
    • (1996) Cardiovasc. Res , vol.32 , pp. 62-68
    • Kohl, P.1    Noble, D.2
  • 252
    • 33846508259 scopus 로고    scopus 로고
    • A mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts
    • MacCannell, K. A., et al. A mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts. Biophys. J. 92, 4121-4132 (2007
    • (2007) Biophys. J. , vol.92 , pp. 4121-4132
    • MacCannell, K.A.1
  • 253
    • 84898770430 scopus 로고    scopus 로고
    • Cardiac fibrosis and arrhythmogenesis: The road to repair is paved with perils
    • Nguyen, T. P., Qu, Z., & Weiss, J. N. Cardiac fibrosis and arrhythmogenesis: the road to repair is paved with perils. J. Mol. Cell. Cardiol. 70, 83-91 (2014
    • (2014) J. Mol. Cell. Cardiol , vol.70 , pp. 83-91
    • Nguyen, T.P.1    Qu, Z.2    Weiss, J.N.3
  • 254
    • 1942438638 scopus 로고    scopus 로고
    • Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction
    • Camelliti, P., Devlin, G. P., Matthews, K. G., Kohl, P., & Green, C. R. Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction. Cardiovasc. Res. 62, 415-425 (2004
    • (2004) Cardiovasc. Res , vol.62 , pp. 415-425
    • Camelliti, P.1    Devlin, G.P.2    Matthews, K.G.3    Kohl, P.4    Green, C.R.5
  • 256
    • 84878526899 scopus 로고    scopus 로고
    • Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts
    • Benamer, N., et al. Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts. Am. J. Physiol. Heart Circ. Physiol. 304, H1231-H1239 (2013
    • (2013) Am. J. Physiol. Heart Circ. Physiol , vol.304 , pp. H1231-H1239
    • Benamer, N.1
  • 257
    • 44949135059 scopus 로고    scopus 로고
    • Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: Insights from a microstructure model
    • Jacquemet, V., & Henriquez, C. S. Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model. Am. J. Physiol. Heart Circ. Physiol. 294, H2040-H2052 (2008
    • (2008) Am. J. Physiol. Heart Circ. Physiol , vol.294 , pp. H2040-H2052
    • Jacquemet, V.1    Henriquez, C.S.2
  • 258
    • 37449006539 scopus 로고    scopus 로고
    • Electrophysiological modeling of fibroblasts and their interaction with myocytes
    • Sachse, F. B., Moreno, A. P., & Abildskov, J. A. Electrophysiological modeling of fibroblasts and their interaction with myocytes. Ann. Biomed. Eng. 36, 41-56 (2008
    • (2008) Ann. Biomed. Eng , vol.36 , pp. 41-56
    • Sachse, F.B.1    Moreno, A.P.2    Abildskov, J.A.3
  • 259
    • 70449109710 scopus 로고    scopus 로고
    • Electrotonic coupling between human atrial myocytes and fibroblasts alters myocyte excitability and repolarization
    • Maleckar, M. M., Greenstein, J. L., Giles, W. R., & Trayanova, N. A. Electrotonic coupling between human atrial myocytes and fibroblasts alters myocyte excitability and repolarization. Biophys. J. 97, 2179-2190 (2009
    • (2009) Biophys. J. , vol.97 , pp. 2179-2190
    • Maleckar, M.M.1    Greenstein, J.L.2    Giles, W.R.3    Trayanova, N.A.4
  • 260
    • 70350484963 scopus 로고    scopus 로고
    • Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: A computational study
    • Xie, Y., et al. Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: a computational study. Heart Rhythm 6, 1641-1649 (2009
    • (2009) Heart Rhythm , vol.6 , pp. 1641-1649
    • Xie, Y.1
  • 261
    • 84864266812 scopus 로고    scopus 로고
    • High-resolution 3 dimensional reconstruction of the infarct border zone: Impact of structural remodeling on electrical activation
    • Rutherford, S. L., Trew, M. L., Sands, G. B., LeGrice, I. J., & Smaill, B. H. High-resolution 3 dimensional reconstruction of the infarct border zone: impact of structural remodeling on electrical activation. Circ. Res. 111, 301-311 (2012
    • (2012) Circ. Res , vol.111 , pp. 301-311
    • Rutherford, S.L.1    Trew, M.L.2    Sands, G.B.3    LeGrice, I.J.4    Smaill, B.H.5
  • 262
    • 84856030636 scopus 로고    scopus 로고
    • The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: Implications for electrogram-based catheter ablation
    • Ashihara, T., et al. The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: implications for electrogram-based catheter ablation. Circ. Res. 110, 275-284 (2012
    • (2012) Circ. Res , vol.110 , pp. 275-284
    • Ashihara, T.1
  • 263
    • 84965186011 scopus 로고    scopus 로고
    • Structural contributions to fibrillatory rotors in a patient-derived computational model of the atria
    • Gonzales, M. J., Vincent, K. P., Rappel, W. J., Narayan, S. M., & McCulloch, A. D. Structural contributions to fibrillatory rotors in a patient-derived computational model of the atria. Europace 16 (Suppl 4.), iv3-iv10 (2014
    • (2014) Europace , vol.16 , pp. iv3-iv10
    • Gonzales, M.J.1    Vincent, K.P.2    Rappel, W.J.3    Narayan, S.M.4    McCulloch, A.D.5
  • 264
    • 84923303407 scopus 로고    scopus 로고
    • Virtual electrophysiological study of atrial fibrillation in fibrotic remodeling
    • McDowell, K. S., et al. Virtual electrophysiological study of atrial fibrillation in fibrotic remodeling. PLoS ONE 10, e0117110 (2015
    • (2015) PLoS ONE , vol.10 , pp. e0117110
    • McDowell, K.S.1
  • 266
    • 58049190516 scopus 로고    scopus 로고
    • Panoramic imaging reveals basic mechanisms of induction and termination of ventricular tachycardia in rabbit heart with chronic infarction: Implications for low-voltage cardioversion
    • Ripplinger, C. M., Lou, Q., Li, W., Hadley, J., & Efimov, I. R. Panoramic imaging reveals basic mechanisms of induction and termination of ventricular tachycardia in rabbit heart with chronic infarction: implications for low-voltage cardioversion. Heart Rhythm 6, 87-97 (2009
    • (2009) Heart Rhythm , vol.6 , pp. 87-97
    • Ripplinger, C.M.1    Lou, Q.2    Li, W.3    Hadley, J.4    Efimov, I.R.5
  • 267
    • 37549040139 scopus 로고    scopus 로고
    • Prevention of adverse electrical and mechanical remodeling with biventricular pacing in a rabbit model of myocardial infarction
    • Saba, S., et al. Prevention of adverse electrical and mechanical remodeling with biventricular pacing in a rabbit model of myocardial infarction. Heart Rhythm 5, 124-130 (2008
    • (2008) Heart Rhythm , vol.5 , pp. 124-130
    • Saba, S.1
  • 269
    • 84923294507 scopus 로고    scopus 로고
    • Cell-specific expression of voltage-sensitive protein confirms cardiac myocyte to non-myocyte electrotonic coupling in healed murine infarct border tissue
    • Quinn, T. A., et al. Cell-specific expression of voltage-sensitive protein confirms cardiac myocyte to non-myocyte electrotonic coupling in healed murine infarct border tissue. Circulation 130, A11749 (2014
    • (2014) Circulation , vol.130 , pp. A11749
    • Quinn, T.A.1
  • 270
    • 36949035990 scopus 로고    scopus 로고
    • Engraftment of connexin 43 expressing cells prevents post-infarct arrhythmia
    • Roell, W., et al. Engraftment of connexin 43 expressing cells prevents post-infarct arrhythmia. Nature 450, 819-824 (2007
    • (2007) Nature , vol.450 , pp. 819-824
    • Roell, W.1
  • 271
    • 79953059185 scopus 로고    scopus 로고
    • A peptide mimetic of the connexin43 carboxyl-Terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury
    • O'Quinn, M. P., Palatinus, J. A., Harris, B. S., & Hewett, K. W., & Gourdie, R. G. A peptide mimetic of the connexin43 carboxyl-Terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury. Circ. Res. 108, 704-715 (2011
    • (2011) Circ. Res , vol.108 , pp. 704-715
    • O'Quinn, M.P.1    Palatinus, J.A.2    Harris, B.S.3    Hewett, K.W.4    Gourdie, R.G.5
  • 272
    • 33745728752 scopus 로고    scopus 로고
    • Cardiac conduction through engineered tissue
    • Choi, Y. H., et al. Cardiac conduction through engineered tissue. Am. J. Pathol. 169, 72-85 (2006
    • (2006) Am. J. Pathol , vol.169 , pp. 72-85
    • Choi, Y.H.1
  • 273
    • 38049161741 scopus 로고    scopus 로고
    • Radiofrequency ablation of atrial fibrillation: Is the persistence of all intraprocedural targets necessary for long-Term maintenance of sinus rhythm?
    • Pratola, C., Baldo, E., Notarstefano, P., Toselli, T., & Ferrari, R. Radiofrequency ablation of atrial fibrillation: Is the persistence of all intraprocedural targets necessary for long-Term maintenance of sinus rhythm? Circulation 117, 136-143 (2008
    • (2008) Circulation , vol.117 , pp. 136-143
    • Pratola, C.1    Baldo, E.2    Notarstefano, P.3    Toselli, T.4    Ferrari, R.5
  • 274
    • 39549093147 scopus 로고    scopus 로고
    • Cell therapy for modification of the myocardial electrophysiological substrate
    • Yankelson, L., et al. Cell therapy for modification of the myocardial electrophysiological substrate. Circulation 117, 720-731 (2008
    • (2008) Circulation , vol.117 , pp. 720-731
    • Yankelson, L.1
  • 275
    • 84922708088 scopus 로고    scopus 로고
    • A micropeptide encoded by a putative long noncoding RNA regulates muscle performance
    • Anderson, D. M., et al. A micropeptide encoded by a putative long noncoding RNA regulates muscle performance. Cell 160, 595-606 (2015
    • (2015) Cell , vol.160 , pp. 595-606
    • Anderson, D.M.1
  • 276
    • 84887608899 scopus 로고    scopus 로고
    • Autoregulation of connexin43 gap junction formation by internally translated isoforms
    • Smyth, J., W., & Shaw, R. M. Autoregulation of connexin43 gap junction formation by internally translated isoforms. Cell Rep. 5, 611-618 (2013
    • (2013) Cell Rep , vol.5 , pp. 611-618
    • Smyth, J.W.1    Shaw, R.M.2
  • 277
    • 84905398904 scopus 로고    scopus 로고
    • Internal ribosomal entry site (IRES) activity generates endogenous carboxyl-Terminal domains of Cx43 and is responsive to hypoxic conditions
    • Ul Hussain, M., et al. Internal ribosomal entry site (IRES) activity generates endogenous carboxyl-Terminal domains of Cx43 and is responsive to hypoxic conditions. J. Biol. Chem. 289, 20979-20990 (2014
    • (2014) J. Biol. Chem , vol.289 , pp. 20979-20990
    • Ul Hussain, M.1
  • 278
    • 33747131851 scopus 로고    scopus 로고
    • Matrix metalloproteinase 7 affects connexin 43 levels, electrical conduction, and survival after myocardial infarction
    • Lindsey, M. L., et al. Matrix metalloproteinase 7 affects connexin 43 levels, electrical conduction, and survival after myocardial infarction. Circulation 113, 2919-2928 (2006
    • (2006) Circulation , vol.113 , pp. 2919-2928
    • Lindsey, M.L.1
  • 279
    • 84939865125 scopus 로고    scopus 로고
    • Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells
    • Soares, A. R., et al. Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells. Sci. Rep. 5, 13243 (2015
    • (2015) Sci. Rep , vol.5 , pp. 13243
    • Soares, A.R.1
  • 280
    • 84940639650 scopus 로고    scopus 로고
    • Transformative impact of proteomics on cardiovascular health and disease: A scientific statement from the American Heart Association
    • Lindsey, M. L., et al. Transformative impact of proteomics on cardiovascular health and disease: a scientific statement from the American Heart Association. Circulation 132, 852-872 (2015
    • (2015) Circulation , vol.132 , pp. 852-872
    • Lindsey, M.L.1
  • 281
    • 0016590595 scopus 로고
    • Sturctural analysis of endocardial cytodifferentiation
    • Markwald, R. R., Fitzharris, T. P., & Smith, W. N. Sturctural analysis of endocardial cytodifferentiation. Dev. Biol. 42, 160-180 (1975
    • (1975) Dev. Biol , vol.42 , pp. 160-180
    • Markwald, R.R.1    Fitzharris, T.P.2    Smith, W.N.3
  • 282
    • 0024384098 scopus 로고
    • Single channel currents of homo-And heterologous gap junctions between cardiac fibroblasts and myocytes
    • Rook, M. B., Jongsma, H. J., & de Jonge, B. Single channel currents of homo-And heterologous gap junctions between cardiac fibroblasts and myocytes. Pflugers Arch. 414, 95-98 (1989
    • (1989) Pflugers Arch , vol.414 , pp. 95-98
    • Rook, M.B.1    Jongsma, H.J.2    De Jonge, B.3
  • 283
    • 0024413336 scopus 로고
    • Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor β
    • Potts, J. D., & Runyan, R. B. Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor β. Dev. Biol. 134, 392-401 (1989
    • (1989) Dev. Biol , vol.134 , pp. 392-401
    • Potts, J.D.1    Runyan, R.B.2
  • 284
    • 0026311119 scopus 로고
    • A growth factor for cardiac myocytes is produced by cardiac nonmyocytes
    • Long, C. S., Henrich, C. J., & Simpson, P. C. A growth factor for cardiac myocytes is produced by cardiac nonmyocytes. Cell Regul. 2, 1081-1095 (1991
    • (1991) Cell Regul , vol.2 , pp. 1081-1095
    • Long, C.S.1    Henrich, C.J.2    Simpson, P.C.3
  • 285
    • 0028533619 scopus 로고
    • Mechanosensitive fibroblasts in the sino-Atrial node region of rat heart: Interaction with cardiomyocytes and possible role
    • Kohl, P., Kamkin, A. G., Kiseleva, I. S., & Noble, D. Mechanosensitive fibroblasts in the sino-Atrial node region of rat heart: interaction with cardiomyocytes and possible role. Exp. Physiol. 79, 943-956 (1994
    • (1994) Exp. Physiol , vol.79 , pp. 943-956
    • Kohl, P.1    Kamkin, A.G.2    Kiseleva, I.S.3    Noble, D.4
  • 286
    • 0035370474 scopus 로고    scopus 로고
    • Positive and negative regulation of epicardial-mesenchymal transformation during avian heart development
    • Morabito, C. J., Dettman, R. W., Kattan, J., Collier, J. M., & Bristow, J. Positive and negative regulation of epicardial-mesenchymal transformation during avian heart development. Dev. Biol. 234, 204-215 (2001
    • (2001) Dev. Biol , vol.234 , pp. 204-215
    • Morabito, C.J.1    Dettman, R.W.2    Kattan, J.3    Collier, J.M.4    Bristow, J.5
  • 287
    • 0037058848 scopus 로고    scopus 로고
    • Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (topcare-Ami
    • Assmus, B., et al. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation 106, 3009-3017 (2002
    • (2002) Circulation , vol.106 , pp. 3009-3017
    • Assmus, B.1
  • 288
    • 0038701741 scopus 로고    scopus 로고
    • Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure
    • Perin, E. C., et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 107, 2294-2302 (2003
    • (2003) Circulation , vol.107 , pp. 2294-2302
    • Perin, E.C.1
  • 289
    • 33645287075 scopus 로고    scopus 로고
    • An in vivo analysis of hematopoietic stem cell potential: Hematopoietic origin of cardiac valve interstitial cells
    • Visconti, R. P., et al. An in vivo analysis of hematopoietic stem cell potential: hematopoietic origin of cardiac valve interstitial cells. Circ. Res. 98, 690-696 (2006
    • (2006) Circ. Res , vol.98 , pp. 690-696
    • Visconti, R.P.1
  • 290
    • 84915748230 scopus 로고    scopus 로고
    • The history of coronary reperfusion
    • Van de Werf, F. The history of coronary reperfusion. Eur. Heart J. 35, 2510-2515 (2014
    • (2014) Eur. Heart J. , vol.35 , pp. 2510-2515
    • Van De Werf, F.1
  • 291
    • 0034727695 scopus 로고    scopus 로고
    • Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: Insights from the randomized aldactone evaluation study (RALES
    • Zannad, F., Alla, F., Dousset, B., Perez, A., & Pitt, B. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Circulation 102, 2700-2706 (2000
    • (2000) Circulation , vol.102 , pp. 2700-2706
    • Zannad, F.1    Alla, F.2    Dousset, B.3    Perez, A.4    Pitt, B.5
  • 292
    • 33646750164 scopus 로고    scopus 로고
    • Cardioprotective effects of bosentan, a mixed endothelin type A and B receptor antagonist, during myocardial ischaemia and reperfusion in rats
    • Singh, A. D., Amit, S., Kumar, O. S., Rajan, M., & Mukesh, N. Cardioprotective effects of bosentan, a mixed endothelin type A and B receptor antagonist, during myocardial ischaemia and reperfusion in rats. Basic Clin. Pharmacol. Toxicol. 98, 604-610 (2006
    • (2006) Basic Clin. Pharmacol. Toxicol , vol.98 , pp. 604-610
    • Singh, A.D.1    Amit, S.2    Kumar, O.S.3    Rajan, M.4    Mukesh, N.5
  • 293
    • 68149159125 scopus 로고    scopus 로고
    • β-Blocker use for the stages of heart failure
    • Klapholz, M. β-blocker use for the stages of heart failure. Mayo Clin. Proc. 84, 718-729 (2009
    • (2009) Mayo Clin. Proc , vol.84 , pp. 718-729
    • Klapholz, M.1
  • 294
    • 84896534110 scopus 로고    scopus 로고
    • Acetylsalicylic acid inhibits IL 18-induced cardiac fibroblast migration through the induction of RECK
    • Siddesha, J. M., et al. Acetylsalicylic acid inhibits IL 18-induced cardiac fibroblast migration through the induction of RECK. J. Cell. Physiol. 229, 845-855 (2014
    • (2014) J. Cell. Physiol , vol.229 , pp. 845-855
    • Siddesha, J.M.1
  • 295
    • 65349122338 scopus 로고    scopus 로고
    • Peroxisome proliferator-Activated receptor γ-independent effects of thiazolidinediones on human cardiac myofibroblast function
    • Mughal, R. S., et al. Peroxisome proliferator-Activated receptor γ-independent effects of thiazolidinediones on human cardiac myofibroblast function. Clin. Exp. Pharmacol. Physiol. 36, 478-486 (2009
    • (2009) Clin. Exp. Pharmacol. Physiol , vol.36 , pp. 478-486
    • Mughal, R.S.1
  • 296
    • 31344456635 scopus 로고    scopus 로고
    • The importance of estimating the therapeutic index in the development of matrix metalloproteinase inhibitors
    • Peterson, J. T. The importance of estimating the therapeutic index in the development of matrix metalloproteinase inhibitors. Cardiovasc. Res. 69, 677-687 (2006
    • (2006) Cardiovasc. Res , vol.69 , pp. 677-687
    • Peterson, J.T.1
  • 297
    • 74949085470 scopus 로고    scopus 로고
    • Cardiac mast cells cause atrial fibrillation through PDGF A mediated fibrosis in pressure-overloaded mouse hearts
    • Liao, C. H., et al. Cardiac mast cells cause atrial fibrillation through PDGF A mediated fibrosis in pressure-overloaded mouse hearts. J. Clin. Invest. 120, 242-253 (2010
    • (2010) J. Clin. Invest , vol.120 , pp. 242-253
    • Liao, C.H.1
  • 298
    • 67049100694 scopus 로고    scopus 로고
    • Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart
    • Levick, S. P., et al. Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart. Hypertension 53, 1041-1047 (2009
    • (2009) Hypertension , vol.53 , pp. 1041-1047
    • Levick, S.P.1
  • 299
    • 84903955622 scopus 로고    scopus 로고
    • The ten advances that have defined modern cardiology
    • Braunwald, E. The ten advances that have defined modern cardiology. Trends Cardiovasc. Med. 24, 179-183 (2014
    • (2014) Trends Cardiovasc. Med , vol.24 , pp. 179-183
    • Braunwald, E.1
  • 300
    • 21244458428 scopus 로고    scopus 로고
    • Reduction of myocardial scar size after implantation of mesenchymal stem cells in rats: What is the mechanism?
    • Jaquet, K., et al. Reduction of myocardial scar size after implantation of mesenchymal stem cells in rats: what is the mechanism? Stem Cells Dev. 14, 299-309 (2005
    • (2005) Stem Cells Dev , vol.14 , pp. 299-309
    • Jaquet, K.1
  • 301
    • 84919705703 scopus 로고    scopus 로고
    • Application of adipose-derived stem cells in heart disease
    • Chen, L., Qin, F., Ge, M., Shu, Q., & Xu, J. Application of adipose-derived stem cells in heart disease. J. Cardiovasc. Transl Res. 7, 651-663 (2014
    • (2014) J. Cardiovasc. Transl Res , vol.7 , pp. 651-663
    • Chen, L.1    Qin, F.2    Ge, M.3    Shu, Q.4    Xu, J.5
  • 302
    • 84924123511 scopus 로고    scopus 로고
    • Molecular basis of cardioprotection: Signal transduction in ischemic pre-, post-, and remote conditioning
    • Heusch, G. Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning. Circ. Res. 116, 674-699 (2015
    • (2015) Circ. Res , vol.116 , pp. 674-699
    • Heusch, G.1
  • 303
    • 84884732436 scopus 로고    scopus 로고
    • Direct cardiac reprogramming: From developmental biology to cardiac regeneration
    • Qian, L., & Srivastava, D. Direct cardiac reprogramming: from developmental biology to cardiac regeneration. Circ. Res. 113, 915-921 (2013
    • (2013) Circ. Res , vol.113 , pp. 915-921
    • Qian, L.1    Srivastava, D.2
  • 304
    • 84884805212 scopus 로고    scopus 로고
    • Patching the heart: Cardiac repair from within and outside
    • Ye, L., Zimmermann, W. H., Garry, D. J., & Zhang, J. Patching the heart: cardiac repair from within and outside. Circ. Res. 113, 922-932 (2013
    • (2013) Circ. Res , vol.113 , pp. 922-932
    • Ye, L.1    Zimmermann, W.H.2    Garry, D.J.3    Zhang, J.4
  • 305
    • 67649998366 scopus 로고    scopus 로고
    • MicroRNA 92a controls angiogenesis and functional recovery of ischemic tissues in mice
    • Bonauer, A., et al. MicroRNA 92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 324, 1710-1713 (2009
    • (2009) Science , vol.324 , pp. 1710-1713
    • Bonauer, A.1
  • 306
    • 84927685999 scopus 로고    scopus 로고
    • Recombinant tissue plasminogen activators (rtPA): A review
    • Gurman, P., et al. Recombinant tissue plasminogen activators (rtPA): a review. Clin. Pharmacol. Ther. 97, 274-285 (2015
    • (2015) Clin. Pharmacol. Ther , vol.97 , pp. 274-285
    • Gurman, P.1
  • 307
    • 34548411652 scopus 로고    scopus 로고
    • Ventricular preexcitation modulates strain and attenuates cardiac remodeling in a swine model of myocardial infarction
    • Shuros, A. C., et al. Ventricular preexcitation modulates strain and attenuates cardiac remodeling in a swine model of myocardial infarction. Circulation 116, 1162-1169 (2007
    • (2007) Circulation , vol.116 , pp. 1162-1169
    • Shuros, A.C.1
  • 308
    • 84900428277 scopus 로고    scopus 로고
    • High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy
    • Bugyei-Twum, A., et al. High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy. Cardiovasc. Diabetol. 13, 89 (2014
    • (2014) Cardiovasc. Diabetol , vol.13 , pp. 89
    • Bugyei-Twum, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.