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Volumn 485, Issue 7400, 2012, Pages 599-604

Heart repair by reprogramming non-myocytes with cardiac transcription factors

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR HAND2; TRANSCRIPTION FACTOR MEF2C; TRANSCRIPTION FACTOR TBX5; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; PROTEIN S 100; S100A4 PROTEIN, MOUSE; TCF21 PROTEIN, MOUSE;

EID: 84863626782     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11139     Document Type: Article
Times cited : (947)

References (41)
  • 1
    • 33646799069 scopus 로고    scopus 로고
    • Global and regional burden of disease and risk factors, 2001: Systematic analysis of population health data
    • Lopez, A. D., Mathers, C. D., Ezzati, M., Jamison, D. T. & Murray, C. J. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367, 1747-1757 (2006).
    • (2006) Lancet , vol.367 , pp. 1747-1757
    • Lopez, A.D.1    Mathers, C.D.2    Ezzati, M.3    Jamison, D.T.4    Murray, C.J.5
  • 2
    • 79952065525 scopus 로고    scopus 로고
    • Transient regenerative potential of the neonatal mouse heart
    • Porrello, E. R. et al. Transient regenerative potential of the neonatal mouse heart. Science 331, 1078-1080 (2011).
    • (2011) Science , vol.331 , pp. 1078-1080
    • Porrello, E.R.1
  • 3
    • 33644633638 scopus 로고    scopus 로고
    • The future of regenerative therapy in patients with chronic heart failure
    • Yacoub, M., Suzuki, K. & Rosenthal, N. The future of regenerative therapy in patients with chronic heart failure. Nat. Clin. Pract. Cardiovasc. Med. 3 (Suppl. 1), S133-S135 (2006).
    • (2006) Nat. Clin. Pract. Cardiovasc. Med. , vol.3 , Issue.SUPPL. 1
    • Yacoub, M.1    Suzuki, K.2    Rosenthal, N.3
  • 4
    • 67349200024 scopus 로고    scopus 로고
    • Cell-based therapy for heart disease: A clinically oriented perspective
    • Menasche, P. Cell-based therapy for heart disease: a clinically oriented perspective. Mol. Ther. 17, 758-766 (2009).
    • (2009) Mol. Ther. , vol.17 , pp. 758-766
    • Menasche, P.1
  • 5
    • 84863184724 scopus 로고    scopus 로고
    • Challenges for heart disease stem cell therapy
    • Hoover-Plow, J. & Gong, Y. Challenges for heart disease stem cell therapy. Vasc. Health Risk Manag. 8, 99-113 (2012).
    • (2012) Vasc. Health Risk Manag. , vol.8 , pp. 99-113
    • Hoover-Plow, J.1    Gong, Y.2
  • 6
    • 84860200127 scopus 로고    scopus 로고
    • Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure: The FOCUS-CCTRN trial
    • Perin, E. C. et al. Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure: the FOCUS-CCTRN trial. J. Am. Med. Assoc., (2012).
    • (2012) J. Am. Med. Assoc.
    • Perin, E.C.1
  • 7
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006).
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 8
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu, J. et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920 (2007).
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1
  • 9
    • 0024294014 scopus 로고
    • MyoD1: A nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts
    • Tapscott, S. J. et al. MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts. Science 242, 405-411 (1988).
    • (1988) Science , vol.242 , pp. 405-411
    • Tapscott, S.J.1
  • 10
    • 0037795465 scopus 로고    scopus 로고
    • Myocardin is a master regulator of smooth muscle gene expression
    • Wang, Z., Wang, D. Z., Pipes, G. C. & Olson, E. N. Myocardin is a master regulator of smooth muscle gene expression. Proc. Natl Acad. Sci. USA 100, 7129-7134 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7129-7134
    • Wang, Z.1    Wang, D.Z.2    Pipes, G.C.3    Olson, E.N.4
  • 11
    • 77649162059 scopus 로고    scopus 로고
    • Direct conversion of fibroblasts to functional neurons by defined factors
    • Vierbuchen, T. et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035-1041 (2010).
    • (2010) Nature , vol.463 , pp. 1035-1041
    • Vierbuchen, T.1
  • 12
    • 80051674431 scopus 로고    scopus 로고
    • Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
    • Caiazzo, M. et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 476, 224-227 (2011).
    • (2011) Nature , vol.476 , pp. 224-227
    • Caiazzo, M.1
  • 13
    • 0141653901 scopus 로고    scopus 로고
    • Ventricular remodeling after infarction and the extracellular collagen matrix: When is enough enough?
    • Jugdutt, B. I. Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough? Circulation 108, 1395-1403 (2003).
    • (2003) Circulation , vol.108 , pp. 1395-1403
    • Jugdutt, B.I.1
  • 14
    • 33749361499 scopus 로고    scopus 로고
    • Gene regulatory networks in the evolution and development of the heart
    • Olson, E. N. Gene regulatory networks in the evolution and development of the heart. Science 313, 1922-1927 (2006).
    • (2006) Science , vol.313 , pp. 1922-1927
    • Olson, E.N.1
  • 15
    • 78650681563 scopus 로고    scopus 로고
    • Mesp1: A key regulator of cardiovascular lineage commitment
    • Bondue, A. & Blanpain, C. Mesp1: a key regulator of cardiovascular lineage commitment. Circ. Res. 107, 1414-1427 (2010).
    • (2010) Circ. Res. , vol.107 , pp. 1414-1427
    • Bondue, A.1    Blanpain, C.2
  • 16
    • 77955321344 scopus 로고    scopus 로고
    • Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
    • Ieda, M. et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142, 375-386 (2010).
    • (2010) Cell , vol.142 , pp. 375-386
    • Ieda, M.1
  • 17
    • 11144241812 scopus 로고    scopus 로고
    • Cooperative interaction between the basic helix-loop-helix transcription factor dHAND and myocyte enhancer factor 2Cregulatesmyocardial gene expression
    • Zang, M. X., Li, Y., Wang, H., Wang, J. B. & Jia, H. T. Cooperative interaction between the basic helix-loop-helix transcription factor dHAND and myocyte enhancer factor 2Cregulatesmyocardial gene expression. J. Biol. Chem. 279, 54258-54263 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 54258-54263
    • Zang, M.X.1    Li, Y.2    Wang, H.3    Wang, J.B.4    Jia, H.T.5
  • 18
    • 0037025326 scopus 로고    scopus 로고
    • The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism
    • Dai, Y. S., Cserjesi, P., Markham, B. E. & Molkentin, J. D. The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. J. Biol. Chem. 277, 24390-24398 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 24390-24398
    • Dai, Y.S.1    Cserjesi, P.2    Markham, B.E.3    Molkentin, J.D.4
  • 19
    • 0043267988 scopus 로고    scopus 로고
    • GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
    • Garg, V. et al. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature 424, 443-447 (2003).
    • (2003) Nature , vol.424 , pp. 443-447
    • Garg, V.1
  • 20
    • 64649085563 scopus 로고    scopus 로고
    • Physical interaction between TBX5 and MEF2C is required for early heart development
    • Ghosh, T. K. et al. Physical interaction between TBX5 and MEF2C is required for early heart development. Mol. Cell. Biol. 29, 2205-2218 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 2205-2218
    • Ghosh, T.K.1
  • 21
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren, L. et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7, 618-630 (2010).
    • (2010) Cell Stem Cell , vol.7 , pp. 618-630
    • Warren, L.1
  • 22
    • 67249152096 scopus 로고    scopus 로고
    • Cardiac fibroblasts: At the heart of myocardial remodeling
    • Porter, K. E. & Turner, N. A. Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol. Ther. 123, 255-278 (2009).
    • (2009) Pharmacol. Ther. , vol.123 , pp. 255-278
    • Porter, K.E.1    Turner, N.A.2
  • 23
    • 0033657058 scopus 로고    scopus 로고
    • Myocardial injury-induced fibroblast proliferation facilitates retroviral-mediated gene transfer to the rat heart in vivo
    • Byun, J. et al. Myocardial injury-induced fibroblast proliferation facilitates retroviral-mediated gene transfer to the rat heart in vivo. J. Gene Med. 2, 2-10 (2000).
    • (2000) J. Gene Med. , vol.2 , pp. 2-10
    • Byun, J.1
  • 24
    • 0842288323 scopus 로고    scopus 로고
    • TGF-b signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    • Bhowmick, N. A. et al. TGF-b signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303, 848-851 (2004).
    • (2004) Science , vol.303 , pp. 848-851
    • Bhowmick, N.A.1
  • 25
    • 34547676391 scopus 로고    scopus 로고
    • Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
    • Zeisberg, E. M. et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nature Med. 13, 952-961 (2007).
    • (2007) Nature Med. , vol.13 , pp. 952-961
    • Zeisberg, E.M.1
  • 26
    • 34249873891 scopus 로고    scopus 로고
    • S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes
    • Schneider, M. et al. S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes. Cardiovasc. Res. 75, 40-50 (2007).
    • (2007) Cardiovasc. Res. , vol.75 , pp. 40-50
    • Schneider, M.1
  • 27
    • 79953903083 scopus 로고    scopus 로고
    • Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair
    • Loffredo, F. S. et al. Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell 8, 389-398 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 389-398
    • Loffredo, F.S.1
  • 28
    • 0027254716 scopus 로고
    • Gap junctions
    • Beyer, E. C. Gap junctions. Int. Rev. Cytol. 137C, 1-37 (1993).
    • (1993) Int. Rev. Cytol. , vol.137 C , pp. 1-37
    • Beyer, E.C.1
  • 30
    • 80455174669 scopus 로고    scopus 로고
    • Efficient inducible Cre-mediated recombination in Tcf21 cell lineages in the heart and kidney
    • Acharya, A., Baek, S. T., Banfi, S., Eskiocak, B. & Tallquist, M. D. Efficient inducible Cre-mediated recombination in Tcf21 cell lineages in the heart and kidney. Genesis 49, 870-877 (2011).
    • (2011) Genesis , vol.49 , pp. 870-877
    • Acharya, A.1    Baek, S.T.2    Banfi, S.3    Eskiocak, B.4    Tallquist, M.D.5
  • 31
    • 34547699399 scopus 로고    scopus 로고
    • Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury
    • Hsieh, P. C. et al. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nature Med. 13, 970-974 (2007).
    • (2007) Nature Med. , vol.13 , pp. 970-974
    • Hsieh, P.C.1
  • 32
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to b-cells
    • Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D. A. In vivo reprogramming of adult pancreatic exocrine cells to b-cells. Nature 455, 627-632 (2008).
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5
  • 33
    • 67949121985 scopus 로고    scopus 로고
    • Physical and functional interaction between calcineurin and the cardiac L-type Ca21 channel
    • Tandan, S. et al. Physical and functional interaction between calcineurin and the cardiac L-type Ca21 channel. Circ. Res. 105, 51-60 (2009).
    • (2009) Circ. Res. , vol.105 , pp. 51-60
    • Tandan, S.1
  • 34
    • 13544272476 scopus 로고    scopus 로고
    • Postnatal isl11 cardioblasts enter fully differentiated cardiomyocyte lineages
    • Laugwitz, K. L. et al. Postnatal isl11 cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 433, 647-653 (2005).
    • (2005) Nature , vol.433 , pp. 647-653
    • Laugwitz, K.L.1
  • 35
    • 16844367242 scopus 로고    scopus 로고
    • Aberrant localization of intracellular organelles, Ca21 signaling, and exocytosis in Mist1 null mice
    • Luo, X. et al. Aberrant localization of intracellular organelles, Ca21 signaling, and exocytosis in Mist1 null mice. J. Biol. Chem. 280, 12668-12675 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 12668-12675
    • Luo, X.1
  • 36
    • 0021895138 scopus 로고
    • A new generation of Ca21 indicators with greatly improved fluorescence properties
    • Grynkiewicz, G., Poenie, M. & Tsien, R. Y. A new generation of Ca21 indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450 (1985).
    • (1985) J. Biol. Chem. , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 37
    • 68549092547 scopus 로고    scopus 로고
    • Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes
    • Hardy, M. E. et al. Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes. J. Pharmacol. Toxicol. Methods 60, 94-106 (2009).
    • (2009) J. Pharmacol. Toxicol. Methods , vol.60 , pp. 94-106
    • Hardy, M.E.1
  • 38
    • 0029071190 scopus 로고
    • Efficient screening of retroviral cDNAexpression libraries
    • Kitamura, T. et al. Efficient screening of retroviral cDNAexpression libraries. Proc. Natl Acad. Sci. USA 92, 9146-9150 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 9146-9150
    • Kitamura, T.1
  • 39
    • 0026342911 scopus 로고
    • Tissue-specific regulation of the a-myosin heavy chain gene promoter in transgenic mice
    • Subramaniam, A. et al. Tissue-specific regulation of the a-myosin heavy chain gene promoter in transgenic mice. J. Biol. Chem. 266, 24613-24620 (1991).
    • (1991) J. Biol. Chem. , vol.266 , pp. 24613-24620
    • Subramaniam, A.1
  • 40
    • 0035816733 scopus 로고    scopus 로고
    • Temporally regulated and tissue-specific genemanipulations in the adult andembryonic heart using a tamoxifen-inducible Cre protein
    • Sohal, D. S. et al. Temporally regulated and tissue-specific genemanipulations in the adult andembryonic heart using a tamoxifen-inducible Cre protein. Circ. Res. 89, 20-25 (2001).
    • (2001) Circ. Res. , vol.89 , pp. 20-25
    • Sohal, D.S.1
  • 41
    • 79251625088 scopus 로고    scopus 로고
    • A dynamic notch injury response activates epicardium and contributes to fibrosis repair
    • Russell, J. L. et al. A dynamic notch injury response activates epicardium and contributes to fibrosis repair. Circ. Res. 108, 51-59 (2011).
    • (2011) Circ. Res. , vol.108 , pp. 51-59
    • Russell, J.L.1


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