-
1
-
-
84900800135
-
A reevaluation of the costs of heart failure and its implications for allocation of health resources in the United States
-
Voigt J, Sasha John M, Taylor A, et al. A reevaluation of the costs of heart failure and its implications for allocation of health resources in the United States. Clin Cardiol 2014;37:312-21.
-
(2014)
Clin Cardiol
, vol.37
, pp. 312-321
-
-
Voigt, J.1
Sasha John, M.2
Taylor, A.3
-
2
-
-
84922381210
-
Heart disease and stroke statistics-2015 update: A report from the American Heart Association
-
Mozaffarian D, Benjamin EJ, Go AS, et al. Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circulation 2015;131: e29-322.
-
(2015)
Circulation
, vol.131
, pp. e29-e322
-
-
Mozaffarian, D.1
Benjamin, E.J.2
Go, A.S.3
-
3
-
-
80054739874
-
National and regional trends in heart failure hospitalization and mortality rates for Medicare beneficiaries, 1998-2008
-
Chen J, Normand SL, Wang Y, et al. National and regional trends in heart failure hospitalization and mortality rates for Medicare beneficiaries, 1998-2008. JAMA 2011;306:1669-78.
-
(2011)
JAMA
, vol.306
, pp. 1669-1678
-
-
Chen, J.1
Normand, S.L.2
Wang, Y.3
-
4
-
-
84884294190
-
2013 ACCF/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
-
Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013;62:e147-239.
-
(2013)
J Am Coll Cardiol
, vol.62
, pp. e147-e239
-
-
Yancy, C.W.1
Jessup, M.2
Bozkurt, B.3
-
5
-
-
84872678336
-
Rehospitalization for heart failure: Problems and perspectives
-
Gheorghiade M, Vaduganathan M, Fonarow GC, et al. Rehospitalization for heart failure: problems and perspectives. J Am Coll Cardiol 2013;61:391-403.
-
(2013)
J Am Coll Cardiol
, vol.61
, pp. 391-403
-
-
Gheorghiade, M.1
Vaduganathan, M.2
Fonarow, G.C.3
-
6
-
-
84885185108
-
Learning from recent trials and shaping the future of acute heart failure trials
-
Mentz RJ, Felker GM, Ahmad T, et al. Learning from recent trials and shaping the future of acute heart failure trials. Am Heart J 2013;166:629-35.
-
(2013)
Am Heart J
, vol.166
, pp. 629-635
-
-
Mentz, R.J.1
Felker, G.M.2
Ahmad, T.3
-
7
-
-
84990350734
-
Treating volume overload in acutely decompensated heart failure: Established and novel therapeutic approaches
-
Koniari K, Parissis J, Paraskevaidis I, et al. Treating volume overload in acutely decompensated heart failure: established and novel therapeutic approaches. Eur Heart J Acute Cardiovasc Care 2012;1:256-68.
-
(2012)
Eur Heart J Acute Cardiovasc Care
, vol.1
, pp. 256-268
-
-
Koniari, K.1
Parissis, J.2
Paraskevaidis, I.3
-
8
-
-
77951891036
-
Clinical trials of pharmacological therapies in acute heart failure syndromes: Lessons learned and directions forward
-
Felker GM, Pang PS, Adams KF, et al. Clinical trials of pharmacological therapies in acute heart failure syndromes: lessons learned and directions forward. Circ Heart Fail 2010;3:314-25.
-
(2010)
Circ Heart Fail
, vol.3
, pp. 314-325
-
-
Felker, G.M.1
Pang, P.S.2
Adams, K.F.3
-
9
-
-
7844247177
-
Temporal relationships between hormonal and hemodynamic changes in early human pregnancy
-
Chapman AB, Abraham WT, Zamudio S, et al. Temporal relationships between hormonal and hemodynamic changes in early human pregnancy. Kidney Int 1998;54:2056-63.
-
(1998)
Kidney Int
, vol.54
, pp. 2056-2063
-
-
Chapman, A.B.1
Abraham, W.T.2
Zamudio, S.3
-
10
-
-
79961057515
-
Maternal vasodilation in pregnancy: The emerging role of relaxin
-
Conrad KP. Maternal vasodilation in pregnancy: the emerging role of relaxin. Am J Physiol Regul Integr Comp Physiol 2011;301:R267-275.
-
(2011)
Am J Physiol Regul Integr Comp Physiol
, vol.301
, pp. R267-R275
-
-
Conrad, K.P.1
-
11
-
-
84894575631
-
Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment
-
Jelinic M, Leo CH, Post Uiterweer ED, et al. Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment. FASEB J 2014;28:275-87.
-
(2014)
FASEB J
, vol.28
, pp. 275-287
-
-
Jelinic, M.1
Leo, C.H.2
Post Uiterweer, E.D.3
-
12
-
-
81255152083
-
Effects of relaxin on arterial dilation, remodeling, and mechanical properties
-
Conrad KP, Shroff SG. Effects of relaxin on arterial dilation, remodeling, and mechanical properties. Curr Hypertens Rep 2011;13:409-20.
-
(2011)
Curr Hypertens Rep
, vol.13
, pp. 409-420
-
-
Conrad, K.P.1
Shroff, S.G.2
-
13
-
-
79959468302
-
Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide
-
McGuane JT, Debrah JE, Sautina L, et al. Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide. Endocrinology 2011;152:2786-96.
-
(2011)
Endocrinology
, vol.152
, pp. 2786-2796
-
-
McGuane, J.T.1
Debrah, J.E.2
Sautina, L.3
-
14
-
-
84898657150
-
Acute intravenous injection of serelaxin (recombinant human relaxin-2) causes rapid and sustained bradykinin-mediated vasorelaxation
-
Leo CH, Jelinic M, Parkington HC, et al. Acute intravenous injection of serelaxin (recombinant human relaxin-2) causes rapid and sustained bradykinin-mediated vasorelaxation. J Am Heart Assoc 2014;3:e000493.
-
(2014)
J Am Heart Assoc
, vol.3
, pp. e000493
-
-
Leo, C.H.1
Jelinic, M.2
Parkington, H.C.3
-
15
-
-
0037428061
-
Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: Attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB
-
Dschietzig T, Bartsch C, Richter C, et al. Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB. Circ Res 2003;92:32-40.
-
(2003)
Circ Res
, vol.92
, pp. 32-40
-
-
Dschietzig, T.1
Bartsch, C.2
Richter, C.3
-
16
-
-
79956361338
-
Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans
-
McGuane JT, Danielson LA, Debrah JE, et al. Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans. Hypertension. 2011;57:1151-60.
-
(2011)
Hypertension.
, vol.57
, pp. 1151-1160
-
-
McGuane, J.T.1
Danielson, L.A.2
Debrah, J.E.3
-
17
-
-
62649155715
-
Intravenous recombinant human relaxin in compensated heart failure: A safety, tolerability, and pharmacodynamic trial
-
Dschietzig T, Teichman S, Unemori E, et al. Intravenous recombinant human relaxin in compensated heart failure: a safety, tolerability, and pharmacodynamic trial. J Card Fail 2009;15:182-90.
-
(2009)
J Card Fail
, vol.15
, pp. 182-190
-
-
Dschietzig, T.1
Teichman, S.2
Unemori, E.3
-
18
-
-
84894276127
-
A randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure
-
Ponikowski P, Mitrovic V, Ruda M, et al. A randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure. Eur Heart J 2014;35:431-41.
-
(2014)
Eur Heart J
, vol.35
, pp. 431-441
-
-
Ponikowski, P.1
Mitrovic, V.2
Ruda, M.3
-
19
-
-
84925721219
-
Renal hemodynamic effects of serelaxin in patients with chronic heart failure: A randomized, placebo-controlled study
-
Voors AA, Dahlke M, Meyer S, et al. Renal hemodynamic effects of serelaxin in patients with chronic heart failure: a randomized, placebo-controlled study. Circ Heart Fail 2014;7:994-1002.
-
(2014)
Circ Heart Fail
, vol.7
, pp. 994-1002
-
-
Voors, A.A.1
Dahlke, M.2
Meyer, S.3
-
20
-
-
65249190276
-
Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): A multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study
-
Teerlink JR, Metra M, Felker GM, et al. Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study. Lancet 2009;373:1429-39.
-
(2009)
Lancet
, vol.373
, pp. 1429-1439
-
-
Teerlink, J.R.1
Metra, M.2
Felker, G.M.3
-
21
-
-
84871986523
-
Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): A randomised, placebo-controlled trial
-
Teerlink JR, Cotter G, Davison BA, et al. Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial. Lancet 2013;381:29-39.
-
(2013)
Lancet
, vol.381
, pp. 29-39
-
-
Teerlink, J.R.1
Cotter, G.2
Davison, B.A.3
-
22
-
-
84908130787
-
Effect of serelaxin on mode of death in acute heart failure: Results from the RELAX-AHF study
-
Felker GM, Teerlink JR, Butler J, et al. Effect of serelaxin on mode of death in acute heart failure: results from the RELAX-AHF study. J Am Coll Cardiol 2014;64:1591-8.
-
(2014)
J Am Coll Cardiol
, vol.64
, pp. 1591-1598
-
-
Felker, G.M.1
Teerlink, J.R.2
Butler, J.3
-
23
-
-
84871927704
-
Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: Correlation with outcomes
-
Metra M, Cotter G, Davison BA, et al. Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: correlation with outcomes. J Am Coll Cardiol 2013;61:196-206.
-
(2013)
J Am Coll Cardiol
, vol.61
, pp. 196-206
-
-
Metra, M.1
Cotter, G.2
Davison, B.A.3
-
24
-
-
84916618655
-
Diuretic response in patients with acute decompensated heart failure: Characteristics and clinical outcome-an analysis from RELAX-AHF
-
Voors AA, Davison BA, Teerlink JR, et al. Diuretic response in patients with acute decompensated heart failure: characteristics and clinical outcome-an analysis from RELAX-AHF. Eur J Heart Fail 2014;16:1230-40.
-
(2014)
Eur J Heart Fail
, vol.16
, pp. 1230-1240
-
-
Voors, A.A.1
Davison, B.A.2
Teerlink, J.R.3
-
25
-
-
84897987576
-
Representativeness of RELAX-AHF clinical trial population in acute heart failure
-
Wang TS, Hellkamp AS, Patel CB, et al. Representativeness of RELAX-AHF clinical trial population in acute heart failure. Circ Cardiovasc Qual Outcomes 2014;7:259-68.
-
(2014)
Circ Cardiovasc Qual Outcomes
, vol.7
, pp. 259-268
-
-
Wang, T.S.1
Hellkamp, A.S.2
Patel, C.B.3
-
26
-
-
84890096177
-
Effects of serelaxin in subgroups of patients with acute heart failure: Results from RELAX-AHF
-
Metra M, Ponikowski P, Cotter G, et al. Effects of serelaxin in subgroups of patients with acute heart failure: results from RELAX-AHF. Eur Heart J 2013;34:3128-36.
-
(2013)
Eur Heart J
, vol.34
, pp. 3128-3136
-
-
Metra, M.1
Ponikowski, P.2
Cotter, G.3
-
27
-
-
84898544373
-
Serelaxin in acute heart failure patients with preserved left ventricular ejection fraction: Results from the RELAX-AHF trial
-
Filippatos G, Teerlink JR, Farmakis D, et al. Serelaxin in acute heart failure patients with preserved left ventricular ejection fraction: results from the RELAX-AHF trial. Eur Heart J 2014;35:1041-50.
-
(2014)
Eur Heart J
, vol.35
, pp. 1041-1050
-
-
Filippatos, G.1
Teerlink, J.R.2
Farmakis, D.3
-
29
-
-
84880998969
-
Risk following hospitalization in stable chronic systolic heart failure
-
Abrahamsson P, Swedberg K, Borer JS, et al. Risk following hospitalization in stable chronic systolic heart failure. Eur J Heart Fail 2013;15:885-91.
-
(2013)
Eur J Heart Fail
, vol.15
, pp. 885-891
-
-
Abrahamsson, P.1
Swedberg, K.2
Borer, J.S.3
-
30
-
-
0037454137
-
Heart failure etiology and response to milrinone in decompensated heart failure: Results from the OPTIME-CHF study
-
Felker GM, Benza RL, Chandler AB, et al. Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study. J Am Coll Cardiol 2003;41:997-1003.
-
(2003)
J Am Coll Cardiol
, vol.41
, pp. 997-1003
-
-
Felker, G.M.1
Benza, R.L.2
Chandler, A.B.3
-
31
-
-
84918793876
-
Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II induced hypertension
-
Sasser JM, Cunningham MW Jr, Baylis C. Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II induced hypertension. Am J Physiol Renal Physiol 2014:307:F1355-62.
-
(2014)
Am J Physiol Renal Physiol
, vol.307
, pp. F1355-F1362
-
-
Sasser, J.M.1
Cunningham, M.W.2
Baylis, C.3
-
32
-
-
23844466328
-
Effect of relaxin on myocardial ischemia injury induced by isoproterenol
-
Zhang J, Qi YF, Geng B, et al. Effect of relaxin on myocardial ischemia injury induced by isoproterenol. Peptides 2005;26:1632-9.
-
(2005)
Peptides
, vol.26
, pp. 1632-1639
-
-
Zhang, J.1
Qi, Y.F.2
Geng, B.3
-
33
-
-
84904514461
-
Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease
-
Samuel CS, Bodaragama H, Chew JY, et al. Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease. Hypertension 2014;64:315-22.
-
(2014)
Hypertension
, vol.64
, pp. 315-322
-
-
Samuel, C.S.1
Bodaragama, H.2
Chew, J.Y.3
-
34
-
-
76849113368
-
Cardiovascular effects of relaxin: From basic science to clinical therapy
-
Du XJ, Bathgate RA, Samuel CS, et al. Cardiovascular effects of relaxin: from basic science to clinical therapy. Nat Rev Cardiol 2010;7:48-58.
-
(2010)
Nat Rev Cardiol
, vol.7
, pp. 48-58
-
-
Du, X.J.1
Bathgate, R.A.2
Samuel, C.S.3
-
35
-
-
84857612703
-
Relaxin promotes growth and maturation of mouse neonatal cardiomyocytes in vitro: Clues for cardiac regeneration
-
Nistri S, Pini A, Sassoli C, et al. Relaxin promotes growth and maturation of mouse neonatal cardiomyocytes in vitro: clues for cardiac regeneration. J Cell Mol Med 2012;16:507-19.
-
(2012)
J Cell Mol Med
, vol.16
, pp. 507-519
-
-
Nistri, S.1
Pini, A.2
Sassoli, C.3
|