Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

Science

Volumn 321, Issue 5895, 2008, Pages 1493-1495

  Chen, Che Hong ^a   Budas, Grant R ^a   Churchill, Eric N ^a   Disatnik, Marie Hélène ^a   Hurley, Thomas D ^b   Mochly Rosen, Daria ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; PROTEIN KINASE C EPSILON;

ALDEHYDE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; DISEASE TREATMENT; DRUG; ENZYME ACTIVITY; INHIBITOR; INJURY; MUTATION; PROTEOMICS; RODENT;

ARTICLE; CORONARY ARTERY BYPASS GRAFT; ENZYME ACTIVATION; GEL ELECTROPHORESIS; HEART MUSCLE ISCHEMIA; INCUBATION TIME; ISOELECTRIC FOCUSING; MITOCHONDRIAL MEMBRANE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; SCREENING TEST;

ALDEHYDE DEHYDROGENASE; ALDEHYDES; AMINO ACID SEQUENCE; ANIMALS; BENZAMIDES; BENZODIOXOLES; CARDIOTONIC AGENTS; CYANAMIDE; ENZYME ACTIVATION; ETHANOL; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NITROGLYCERIN; PHOSPHORYLATION; PROTEIN KINASE C-EPSILON; PROTEOMICS; RATS; RATS, WISTAR;

RATTUS; RODENTIA;

EID: 51749104191     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1158554     Document Type: Article

References (21)

1. R. Bolli, Am. J. Physiol. Heart Circ. Physiol. 292, H19 (2007).
2. J. M. Downey, A. M. Davis, M. V. Cohen, Heart Fail. Rev. 12, 181 (2007).
3. A. Nakano, M. V. Cohen, J. M. Downey, Pharmacol. Ther. 86, 263 (2000).
4. C. H. Chen, M. O. Gray, D. Mochly-Rosen, Proc. Natl. Acad. Sci. U.S.A. 96, 12784 (1999).
5. Materials and methods, further information on data, and additional discussion are available as supporting material on Science Online.
6. M. Jaburek et al., Circ. Res. 99, 878 (2006).
7. M. O. Gray, J. S. Karliner, D. Mochly-Rosen, J. Biol. Chem. 272, 30945 (1997).
8. G. W. Dorn 2nd et al., Proc. Natl. Acad. Sci. U.S.A. 96, 12798 (1999).
9. C. Chen, D. Mochly-Rosen, J. Mol. Cell. Cardiol. 33, 581 (2001).
10. R. A. Deitrich, P. A. Troxell, W. S. Worth, Biochem. Pharmacol. 25, 2733 (1976).
11. Z. Chen et al., Proc. Natl. Acad. Sci. U.S.A. 102, 12159 (2005).
12. M. Hill et al., Circulation 104, 694 (2001).
13. H. N. Larson, H. Weiner, T. D. Hurley, J. Biol. Chem. 280, 30550 (2005).
14. G. Duester et al., Proc. Natl. Acad. Sci. U.S.A. 81, 4055 (1984).
15. L. C. Hsu, K. Tani, T. Fujiyoshi, K. Kurachi, A. Yoshida, Proc. Natl. Acad. Sci. U.S.A. 82, 3771 (1985).
16. P. Blasi et al., Mol. Genet. Metab. 76, 348 (2002).
17. P. Eaton, J. M. Li, D. J. Hearse, M. J. Shattock, Am. J. Physiol. 276, H935 (1999).
18. J. A. Doorn, T. D. Hurley, D. R. Petersen, Chem. Res. Toxicol. 19, 102 (2006).
19. D. T. Lucas, L. I. Szweda, Proc. Natl. Acad. Sci. U.S.A. 95, 510 (1998).
20. J. Chen, G. I. Henderson, G. L. Freeman, J. Mol. Cell. Cardiol. 33, 1919 (2001).
21. We thank K. Inagaki and C. L. Murriel for initial studies; D. Solow-Cordero for the high-throughput screen; and F. Conti, D. Cheng, and A. Masoud Sadaghiani for the biochemical characterization of Alda-1. Supported by NIH grant AA11147 (to D.M.-R.) and by Stanford's SPARK Program (C.-H.C.). D.M.-R. is the founder and a shareholder of KAI Pharmaceuticals; however, none of the work described here was done in collaboration with, or with support from, this company. C.-H.C., T.D.H., and D.M.-R. are listed as inventors in three pending patents filed by Stanford University that are related to this work.