Marrow-Derived Stromal Cells Express Genes Encoding a Broad Spectrum of Arteriogenic Cytokines and Promote In Vitro and In Vivo Arteriogenesis Through Paracrine Mechanisms

Circulation Research

Volumn 94, Issue 5, 2004, Pages 678-685

  Kinnaird, Tim ^a   Stabile, E ^a   Burnett, M S ^a   Lee, C W ^a   Barr, S ^a   Fuchs, S ^a   Epstein, S E ^a  

^a WASHINGTON HOSPITAL CENTER   (United States)

Author keywords

Arteriogenesis; Bone marrow cells; Cytokines; Marrow stromal cells

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CYTOKINE; CYTOKINE ANTIBODY; VASCULOTROPIN;

ADULT; ANGIOGENESIS; ANIMAL MODEL; ARTICLE; AUTOAMPUTATION; BIOLOGICAL THERAPY; BONE MARROW CELL; BONE MARROW STROMA CELL; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; COLLATERAL CIRCULATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; DNA MICROARRAY; DOSE RESPONSE; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; HINDLIMB; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOBLOTTING; ISCHEMIA; LEG AMPUTATION; LEG ISCHEMIA; LEG MOVEMENT; MOUSE; MUSCLE ATROPHY; NONHUMAN; NORMAL HUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; STROMA CELL;

ADULT; ANIMALS; BLOOD VESSELS; BONE MARROW CELLS; CELL DIVISION; CELL HYPOXIA; CELL MOVEMENT; CELLS, CULTURED; COLLATERAL CIRCULATION; CULTURE MEDIA, CONDITIONED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; ISCHEMIA; MICE; MICE, INBRED BALB C; MUSCLE, SMOOTH, VASCULAR; MUSCULAR ATROPHY; MYOCYTES, SMOOTH MUSCLE; PARACRINE COMMUNICATION; STROMAL CELLS;

EID: 1642373909     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000118601.37875.AC     Document Type: Article

References (34)

1. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med. 2000;6:389-395.
2. Schaper W, Ito WD. Molecular mechanisms of coronary collateral vessel growth. Circ Res. 1996;79:911-919.
3. Grines CL, Watkins MW, Helmer G, Penny W, Brinker J, Marmur JD, West A, Rade JJ, Marrott P, Hammond HK, Engler RL. Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris. Circulation. 2002;105:1291-1297.
4. Simons M, Annex BH, Laham RJ, Kleiman N, Henry T, Dauerman H, Udelson JE, Gervino EV, Pike M, Whitehouse MJ, Moon T, Chronos NA. Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial. Circulation. 2002;105:788-793.
5. Epstein SE, Fuchs S, Zhou YF, Baffour R, Komowski R. Therapeutic interventions for enhancing collateral development by administration of growth factors: basic principles, early results and potential hazards. Cardiovasc Res. 2001;49:532-542.
6. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Lefi A, Anversa P. Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410: 701-705.
7. Kalka C, Masuda H, Takahashi T, Kalka-Moll WM, Silver M, Kearney M, Li T, Isner JM, Asahara T. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci USA. 2000;97:3422-3427.
8. Wang JS, Shum-Tim D, Chedrawy E, Chiu R. The coronary delivery of marrow stromal cells or myocardial regeneration: pathophysiological and therapeutic implications. J Thorac Cardiovasc Surg. 2001;122:699-705.
9. Tomita S, Li RK, Weisel RD, Mickle DA, Kim EJ, Sakai T, Jia ZQ. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation. 1999;100:II247-II56.
10. Iba O, Matsubara H, Nozawa Y, Fujiyama S, Amano K, Mori Y, Kojima H, Iwasaka T. Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limbs. Circulation. 2002;106: 2019-2025.
11. Kinnaird TD, Stabile E, Burnett MS, Lee CW, Shou M, Barr S, Fuchs S, Epstein S. Local delivery of marrow-defived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation. In press.
12. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284: 143-147.
13. Couffinhal T, Silver M, Zheng LP, Kearney M, Witzenbichler B, Isner JM. Mouse model of angiogenesis. Am J Pathol. 1998;152:1667-1679.
14. Scholz D, Ziegelhoeffer T, Helisch A, Wagner S, Friedrich C, Podzuweit T, Schaper W. Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice. J Mol Cell Cardiol. 2002;34: 775-787.
15. Rutherford RB, Baker JD, Ernst C, Johnston KW, Porter JM, Ahn S, Jones DN. Recommended standards for reports dealing with lower extremity ischemia: revised version. J Vasc Surg. 1997;26:517-538.
16. Dexter TM. Stromal cell associated haemopoiesis. J Cell Physiol Suppl. 1982;1:87-94.
17. Haynesworth SE, Baber MA, Caplan AI. Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro. J Cell Physiol. 1996;166:585-592.
18. Weimar IS, Miranda N, Muller EJ, Hekman A, Kerst JM, de Gast GC, Gerritsen WR. Hepatocyte growth factor is produced by human bone-marrow stromal cells, and promotes proliferation, adhesion and survival of human hematopoietic progenitor cells. Exp Hematol. 1998;26: 885-894.
19. Cheng SL, Zhang SF, Mohan S, Lecanda F, Fausto A, Hunt AH, Canalis E, Avioli LV. Regulation of insulin-like growth factors I and II and their binding proteins in human bone marrow stromal cells by dexamethasone. J Cell Biochem. 1998;71:449-458.
20. Broek IV, Asosingh K, Vanderkerken K, Straetmans N, Van Camp B, Van Riet I. Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2 and -3. Br J Cancer. 2003;88:855-862.
21. Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, Sano M, Takahashi T, Hori S, Abe H, Hata J, Umezawa A, Ogawa S. Cardiomyocytes can be generated from human marrow stromal cells in vitro. J Clin Invest. 1999;103:697-705.
22. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002;418: 41-49.
23. Galmiche MC, Koteliansky VE, Briere J, Herve P, Charbord P. Stromal cells from human long-term marrow cultures are mesenchymal cells that differentiate following a vascular smooth muscle differentiation pathway. Blood. 1993;82:66-76.
24. Reyes M, Dudek A, Jahagirdar B, Koodie L, Marker PH, Verfaillie CM. Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest. 2002;109:337-346.
25. Asahara T, Bauters C, Zheng LP. Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo. Circulation. 1995;92:365-371.
26. Carmeliet P, Moons L, Luttun A, Vincenti V, Compemolle V, De Mol M, Wu Y, Bono F, Devy L, Beck H, Scholz D, Acker T, DiPalma T, Dewerchin M, Noel A, Stalmans I, Barra A, Blacher S, Vandendriessche T, Ponten A, Eriksson U, Plate KH, Foidart JM, Schaper W, Charnock-Jones DS, Hicklin DJ, Herbert JM, Collen D, Persico MG. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med. 2001;7:575-583.
27. Cao R, Brakenhielm E, Pawliuk R, Wariaro D, Post MJ, Wahlberg E, Leboulch P, Cao Y. Angiogenic synergism, vascular stability and improvement of hindlimb ischemia by a combination of PDGF-BB and FGF-2. Nat Med. 2003;5:603-613.
28. Chae JK, Kim I, Lim ST, Chung MJ, Kim WH, Kim HG, Ko JK, Koh GY. Coadministration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vascularization. Arterioscler Thromb Vasc Biol. 2000;20:2573-2578.
29. Al-Khaldi A, Eliopoulos N, Martineau D, Lejeune L, Lachapelle K, Galipeau J. Postnatal bone marrow stromal cells elicit a potent VEGF-dependent neoangiogenic response in vivo. Gene Ther. 2003;10: 621-629.
30. Kamihata H, Matsubara H, Nishiue T, Fujiyama S, Tsutsumi Y, Ozono R, Masaki H, Mori Y, Iba O, Tateishi E, Kosaki A, Shintani S, Murohara T, Imaizumi T, Iwasaka T. Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands and cytokines. Circulation. 2001;104:1046-1052.
31. Li TS, Hamano K, Suzuki K, Ito H, Zempo N, Matsuzaki M. Improved angiogenic potency by implantation of ex-vivo hypoxia pre-stimulated bone marrow cells in rats. Am J Physiol. 2002;293:H468-H473.
32. Fuchs S, Baffour R, Zhou YF, Shou M, Pierre A, Tio FO, Weissman NJ, Leon MB, Epstein SE, Komowski R. Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia. J Am Coll Cardiol. 2001;37:1726-1732.
33. Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, Homma S, Edwards NM, Itescu S. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med. 2001;7:430-436.
34. Rehman J, Li J, Orschell C, March KL. Peripheral blood endothelial progenitor cells are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation. 2003;107:1164-1169.