C-kit+ cells minimally contribute cardiomyocytes to the heart

Nature

Volumn 509, Issue 7500, 2014, Pages 337-341

  Van Berlo, Jop H ^a,b   Kanisicak, Onur ^a   Maillet, Marjorie ^a   Vagnozzi, Ronald J ^a   Karch, Jason ^a   Lin, Suh Chin J ^a   Middleton, Ryan C ^c   Marbán, Eduardo ^c   Molkentin, Jeffery D ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C KIT PROTEIN; CHIMERIC PROTEIN; COMPLEMENTARY DNA; CRE RECOMBINASE; STEM CELL FACTOR; TAMOXIFEN; UNCLASSIFIED DRUG;

AGING; BIOLOGICAL DEVELOPMENT; CARDIOVASCULAR SYSTEM; CYTOLOGY; GENE EXPRESSION; INJURY; PHYSIOLOGY; PROTEIN; RODENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUSION; CELL LINEAGE; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE LOCUS; HEART DEVELOPMENT; HEART INFARCTION; HEART INJURY; HEART MUSCLE CELL; MALE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGING; ANIMALS; CELL DIFFERENTIATION; CELL FUSION; CELL LINEAGE; ENDOTHELIAL CELLS; FEMALE; HEART; HEART INJURIES; INTEGRASES; MALE; MICE; MODELS, BIOLOGICAL; MYOBLASTS, CARDIAC; MYOCARDIUM; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-KIT; REGENERATION; TAMOXIFEN;

EID: 84900560043     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13309     Document Type: Article

References (29)

1. Laflamme, M. A. & Murry, C. E. Heart regeneration. Nature 473, 326-335 (2011).
2. Orlic, D. et al. Bone marrow cells regenerate infarcted myocardium. Nature 410, 701-705 (2001).
3. Balsam, L. B. et al. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 428, 668-673 (2004).
4. Murry, C. E. et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428, 664-668 (2004).
5. Anversa, P., Kajstura, J., Rota, M. & Leri, A. Regenerating new heart with stem cells. J. Clin. Invest. 123, 62-70 (2013).
6. Beltrami, A. P. et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114, 763-776 (2003).
7. Hosoda, T. et al. Clonality ofmouse and humancardiomyogenesis in vivo. Proc.Natl Acad. Sci. USA 106, 17169-17174 (2009).
8. Ellison, G. M. et al. Adult c-kitpos cardiac stemcells are necessary and sufficient for functional cardiac regeneration and repair. Cell 154, 827-842 (2013).
9. Jesty, S. A. et al. c-kit1 precursors support postinfarction myogenesis in the neonatal, but not adult, heart. Proc. Natl Acad. Sci. USA 109, 13380-13385 (2012).
10. Zaruba, M. M., Soonpaa, M., Reuter, S. & Field, L. J. Cardiomyogenic potential of C-kit1-expressing cells derived from neonatal and adult mouse hearts. Circulation 121, 1992-2000 (2010).
11. Ro, S. et al. A model to study the phenotypic changes of interstitial cells of Cajal in gastrointestinal diseases. Gastroenterology 138, 1068-1078 (2010).
12. Okura, M.,Maeda, H., Nishikawa, S.&Mizoguchi, M. Effects ofmonoclonal anti-c-kit antibody (ACK2) on melanocytes in newborn mice. J. Invest. Dermatol. 105, 322-328 (1995).
13. Sandlow, J. I., Feng, H. L., Cohen, M. B. & Sandra, A. Expression of c-KIT and its ligand, stemcell factor, in normal and subfertile human testicular tissue. J. Androl. 17, 403-408 (1996).
14. Alvarez-Dolado, M. et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425, 968-973 (2003).
15. Matsuura, K. et al. Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle. J. Cell Biol. 167, 351-363 (2004).
16. Nygren, J. M. et al. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nature Med. 10, 494-501 (2004).
17. Oh,H. et al.Cardiacprogenitor cells fromadultmyocardium:homing, differentiation, and fusion after infarction. Proc. Natl Acad. Sci. USA 100, 12313-12318 (2003).
18. Terada, N. et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 416, 542-545 (2002).
19. Peters, E. M., Tobin, D. J., Botchkareva, N., Maurer, M. & Paus, R. Migration of melanoblasts into the developingmurine hair follicle is accompanied by transient c-Kit expression. J. Histochem. Cytochem. 50, 751-766 (2002).
20. Waskow, C., Paul, S., Haller, C., Gassmann, M. & Rodewald, H. R. Viable c-KitW/W mutants reveal pivotal role for c-kit in themaintenance of lymphopoiesis. Immunity 17, 277-288 (2002).
21. Mauduit, C., Hamamah, S. & Benahmed, M. Stem cell factor/c-kit system in spermatogenesis. Hum. Reprod. Update 5, 535-545 (1999).
22. Ro, S. et al. A model to study the phenotypic changes of interstitial cells of Cajal in gastrointestinal diseases. Gastroenterology 138, 1068-1078 (2010).
23. Ye, L. et al. Aging Kit mutant mice develop cardiomyopathy. PLoS ONE 7, e33407 (2012).
24. Bolli, R. et al. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet 378, 1847-1857 (2011).
25. Nagy, A. & Rossant, J. in Gene Targeting: a Practical Approach (ed. Joyner, A. L.) 2nd edn (Oxford Univ. Press, 2000).
26. Liu, Q., Sargent, M. A., York, A. J. & Molkentin, J. D. ASK1 regulates cardiomyocyte deathbutnot hypertrophyin transgenicmice. Circ.Res.105,1110-1117(2009).
27. Nakayama, H. et al. a1G-dependent T-type Ca21 current antagonizes cardiac hypertrophy through aNOS3-dependentmechanismin mice. J. Clin. Invest. 119, 3787-3796 (2009).
28. Hosoda, T. et al. Clonality of mouse and human cardiomyogenesis in vivo. Proc. Natl Acad. Sci. USA 106, 17169-17174 (2009).
29. Karch, J. et al. Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. eLife 2, e00772 (2013).